Click here to switch to the map view.

The map label for this gene is kefBC [H]

Identifier: 146302146

GI number: 146302146

Start: 5324649

End: 5325803

Strand: Reverse

Name: kefBC [H]

Synonym: Fjoh_4412

Alternate gene names: 146302146

Gene position: 5325803-5324649 (Counterclockwise)

Preceding gene: 146302147

Following gene: 146302139

Centisome position: 87.35

GC content: 39.57

Gene sequence:

>1155_bases
ATGCTCTCACAATTATTCTCGGGGATCGCTGTGCTTTCCCTTATTGTCTTATTGCTGATTTTATTGCTTCGGCGGTTAAA
GCAGCCTTACTTTATCGCCTACATAGCGGCCGGCGTGCTTTTAGGTCCTCAGGTATTTAATATTATCCACAAACCTGATG
TTATATCAGAACTTGGTGAGATAGGGATTATTATTATGATGTTTTCCATTGGAAGCGAGATTGACCTTCAATATCTCACG
CGTAATTTTTACAAGCCGCTGTTGATTTCAGTTGTTCAGGTCGTGCTTAGTTTTATCTGCATGTATTTTGTAGGATCATA
TGCGGGATGGGAAATTACAACAATTGTGTTGACTGCTTTTACAATCAGCATCAGCAGTTCGGCTATTGTATTTCAGTATC
TGGCCAGAACAGGCCAAATTAAAAGTCAGCTCGGCATGATTACCTGCGGTGTATTATTAATGCAGGATATATTGGTTATA
CCTATGATGCTGGCTTTGAATTTTATGTCAGGCGCCGCCGTATCAGCAGTTCAATTGATAAAAGTATGTGCAGGAGGCGT
ACTGATGATTCTTTTTTTGAAAGGGGCTCTGACTAAAAAACTTTTTAAAATTCCGATGCGCAAAGAGATTGCTGCTGACC
ATGAACTGCAGGTTTTTATCGGCTTCAGCATCTGTTTCACAATGGCCTGGATCAGCGGATGGTTTGGCTTGTCTACCGCC
TTTGGTGCTTTTGCTTCAGGAATATTAATCGGGCATGATAAGGCAACCCGCTGGCTGGGGAGTTCCCTTATTCCTTTCAG
GGTATTTTTTATGGCTTTCTTTTTCTTAGCTGTAGGACTGCAGTTGGATATTAATTTTTTTATTCAAAATAAAGGTACAG
TTATATTGATTTCATTTTCAGTACTCTTTATAAACAGCCTGATCAATACCATCCTTTTTAAACTGACCAAGAACTCCTGG
CGAGACAGTTTATATGCGGGGGCACTCTTATCGCAGATAGGGGAATTCAGTTTTATTTTAATGACCATGGCAGCTTCTTT
AAAATTAGTAGAAAATTATACGTATCAAATAACACTGGCTGTAATTACTTCAACTATGATGCTTACTGCAATCTGGCTTA
TGATTATCCAGAGGCTGATTTTCAGGCTGAAATAG

Upstream 100 bases:

>100_bases
AAAATCACCAAGGATGATAGAGATTTCTTAAAAACTTTTATCAATTTTTTTATTGAAAGCTGCCCTATAAAGGCAGCTTT
CTTGATAATAATTTAAAAAT

Downstream 100 bases:

>100_bases
AAATGAAAGATTGTTTTTTTTTGACCGGCAGGGCTGTAATTTCTTTTTCTGGGAATTAGTTTTTTAAAAGCCCCTAAGAA
AAAACATGCCAGTGATAAAT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MLSQLFSGIAVLSLIVLLLILLLRRLKQPYFIAYIAAGVLLGPQVFNIIHKPDVISELGEIGIIIMMFSIGSEIDLQYLT
RNFYKPLLISVVQVVLSFICMYFVGSYAGWEITTIVLTAFTISISSSAIVFQYLARTGQIKSQLGMITCGVLLMQDILVI
PMMLALNFMSGAAVSAVQLIKVCAGGVLMILFLKGALTKKLFKIPMRKEIAADHELQVFIGFSICFTMAWISGWFGLSTA
FGAFASGILIGHDKATRWLGSSLIPFRVFFMAFFFLAVGLQLDINFFIQNKGTVILISFSVLFINSLINTILFKLTKNSW
RDSLYAGALLSQIGEFSFILMTMAASLKLVENYTYQITLAVITSTMMLTAIWLMIIQRLIFRLK

Sequences:

>Translated_384_residues
MLSQLFSGIAVLSLIVLLLILLLRRLKQPYFIAYIAAGVLLGPQVFNIIHKPDVISELGEIGIIIMMFSIGSEIDLQYLT
RNFYKPLLISVVQVVLSFICMYFVGSYAGWEITTIVLTAFTISISSSAIVFQYLARTGQIKSQLGMITCGVLLMQDILVI
PMMLALNFMSGAAVSAVQLIKVCAGGVLMILFLKGALTKKLFKIPMRKEIAADHELQVFIGFSICFTMAWISGWFGLSTA
FGAFASGILIGHDKATRWLGSSLIPFRVFFMAFFFLAVGLQLDINFFIQNKGTVILISFSVLFINSLINTILFKLTKNSW
RDSLYAGALLSQIGEFSFILMTMAASLKLVENYTYQITLAVITSTMMLTAIWLMIIQRLIFRLK
>Mature_384_residues
MLSQLFSGIAVLSLIVLLLILLLRRLKQPYFIAYIAAGVLLGPQVFNIIHKPDVISELGEIGIIIMMFSIGSEIDLQYLT
RNFYKPLLISVVQVVLSFICMYFVGSYAGWEITTIVLTAFTISISSSAIVFQYLARTGQIKSQLGMITCGVLLMQDILVI
PMMLALNFMSGAAVSAVQLIKVCAGGVLMILFLKGALTKKLFKIPMRKEIAADHELQVFIGFSICFTMAWISGWFGLSTA
FGAFASGILIGHDKATRWLGSSLIPFRVFFMAFFFLAVGLQLDINFFIQNKGTVILISFSVLFINSLINTILFKLTKNSW
RDSLYAGALLSQIGEFSFILMTMAASLKLVENYTYQITLAVITSTMMLTAIWLMIIQRLIFRLK

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=370, Percent_Identity=25.6756756756757, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789749, Length=356, Percent_Identity=24.438202247191, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786685, Length=371, Percent_Identity=24.5283018867925, Blast_Score=95, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322367, Length=364, Percent_Identity=22.8021978021978, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 42723; Mature: 42723

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]