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The map label for this gene is nhaA2

Identifier: 146302139

GI number: 146302139

Start: 5313337

End: 5314563

Strand: Reverse

Name: nhaA2

Synonym: Fjoh_4405

Alternate gene names: 146302139

Gene position: 5314563-5313337 (Counterclockwise)

Preceding gene: 146302146

Following gene: 146302117

Centisome position: 87.17

GC content: 44.74

Gene sequence:

>1227_bases
ATGGATCTTCTTGGCATTTTAAGCCCTAATGCCTATTTTTGTTCAATGGCAAAACTTATAAATCTCAAAATTTTCACGCA
TTTTTTCCGATCTTCCGCAGCAGGAGGGATTCTGCTTTTAATTTGTGTGCTGGTTTCTCTTATAGTGGCCAATACGGGGC
TCGGAGTACATTTTAATGATTTTCTGGGGTATCCTTTGGGATTTGAAGCAGCGGGCCTGCAGCTGCGGTATCCGATCCTG
CTGTGGATCAACGATGGTTTGATGGCTGTTTTTTTTCTCCTGGTAGGTCTTGAAATAAAAAGGGAAGTGATAGAAGGTGA
GCTTTCTTCTCTTCGCCATGCCGCCCTGCCGGTTCTGGCAGCTGTTGGAGGGGTTATCATTCCCGCATTGATTTACTTTC
TTTTTAACGGACAAAGTCCTGATACTGCCAAAGGATGGGGAATCCCAATGGCTACCGATATTGCTTTTGCTCTTGGAATA
CTTTCCCTTTTAGGAGATAAGGTTCCCTCAGGGCTTAAAATATTCCTTGCCGCCCTGGCCATAGTGGATGATCTGATTGC
CATTTTGGTTATCGCGGTTTTTTATTCCTCGGAACTTCATTTTCTGTATCTGGGTTATGCAGGGGGAATATTTGTACTAC
TTATGGTTTTTAACCGCTTGGGGGTTAAGAATTTATTTTTTTATCTCCTGCCCGGTGCGGTGATGTGGTATTTTATACAC
CATTCAGGGATTCATGCCACGATAGCCGGAGTGCTTACGGCCTTAACGCTTCCCACTAACCAAGAAGACAAGGATTCCCC
TTTGGAAAAGCTGGAACATGCTTTGGCTCGTCCGGTAAATTTTATCATCATGCCTGTTTTTGCACTGGCCAATACTAACA
TCGCTTTTGAATCCGAAATGCTGCAGGGACTTACCGGTAATCTCGGACTTGGAATTATTCTGGGGCTTGTCCTGGGCAAA
CCCATTGGTATCTTTGTAATGTCATGGCTCTCGGTGAAGATCAGGGCTGCTGATCTGCCTGCTCAGACCACATGGACTCA
TGTACTTGGACTGGGGCTTTTAGGCGGAATCGGCTTTACCATGTCCATCTTTATAGCACTATTGTCTTTTCAGGAGCAGG
CCTATCAGAATGAAGCTAAGTTTGCCATATTAACAGCCTCTGTACTTGCCGGTGCAGCAGGCTTTATCCTGCTGAGCTCG
TATAATAAAAATAAACAGGAACAGTAG

Upstream 100 bases:

>100_bases
AAGAGGGTCTAATTAGTGTGCCTTTGCAAAATAATCTTACTTACGTGATTGGCCCTAACTGGCATTATTAATAATACTGG
GTGCTGGTTCATTTTTATGC

Downstream 100 bases:

>100_bases
TTTTTGTTGATTCTTTCTAAAAGGGCTTACTGTCTTTTAAACAATGCGGCATCTTTCACTAAAAGACGTTCATTGAGCCA
TTTGGTCAGTTTTTCACTAT

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MDLLGILSPNAYFCSMAKLINLKIFTHFFRSSAAGGILLLICVLVSLIVANTGLGVHFNDFLGYPLGFEAAGLQLRYPIL
LWINDGLMAVFFLLVGLEIKREVIEGELSSLRHAALPVLAAVGGVIIPALIYFLFNGQSPDTAKGWGIPMATDIAFALGI
LSLLGDKVPSGLKIFLAALAIVDDLIAILVIAVFYSSELHFLYLGYAGGIFVLLMVFNRLGVKNLFFYLLPGAVMWYFIH
HSGIHATIAGVLTALTLPTNQEDKDSPLEKLEHALARPVNFIIMPVFALANTNIAFESEMLQGLTGNLGLGIILGLVLGK
PIGIFVMSWLSVKIRAADLPAQTTWTHVLGLGLLGGIGFTMSIFIALLSFQEQAYQNEAKFAILTASVLAGAAGFILLSS
YNKNKQEQ

Sequences:

>Translated_408_residues
MDLLGILSPNAYFCSMAKLINLKIFTHFFRSSAAGGILLLICVLVSLIVANTGLGVHFNDFLGYPLGFEAAGLQLRYPIL
LWINDGLMAVFFLLVGLEIKREVIEGELSSLRHAALPVLAAVGGVIIPALIYFLFNGQSPDTAKGWGIPMATDIAFALGI
LSLLGDKVPSGLKIFLAALAIVDDLIAILVIAVFYSSELHFLYLGYAGGIFVLLMVFNRLGVKNLFFYLLPGAVMWYFIH
HSGIHATIAGVLTALTLPTNQEDKDSPLEKLEHALARPVNFIIMPVFALANTNIAFESEMLQGLTGNLGLGIILGLVLGK
PIGIFVMSWLSVKIRAADLPAQTTWTHVLGLGLLGGIGFTMSIFIALLSFQEQAYQNEAKFAILTASVLAGAAGFILLSS
YNKNKQEQ
>Mature_408_residues
MDLLGILSPNAYFCSMAKLINLKIFTHFFRSSAAGGILLLICVLVSLIVANTGLGVHFNDFLGYPLGFEAAGLQLRYPIL
LWINDGLMAVFFLLVGLEIKREVIEGELSSLRHAALPVLAAVGGVIIPALIYFLFNGQSPDTAKGWGIPMATDIAFALGI
LSLLGDKVPSGLKIFLAALAIVDDLIAILVIAVFYSSELHFLYLGYAGGIFVLLMVFNRLGVKNLFFYLLPGAVMWYFIH
HSGIHATIAGVLTALTLPTNQEDKDSPLEKLEHALARPVNFIIMPVFALANTNIAFESEMLQGLTGNLGLGIILGLVLGK
PIGIFVMSWLSVKIRAADLPAQTTWTHVLGLGLLGGIGFTMSIFIALLSFQEQAYQNEAKFAILTASVLAGAAGFILLSS
YNKNKQEQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=377, Percent_Identity=47.4801061007958, Blast_Score=315, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA2_FLAJ1 (A5FBK7)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001196730.1
- ProteinModelPortal:   A5FBK7
- SMR:   A5FBK7
- STRING:   A5FBK7
- GeneID:   5093922
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_4405
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   YFALRDL
- ProtClustDB:   CLSK2537963
- BioCyc:   FJOH376686:FJOH_4405-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 43973; Mature: 43973

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0x12e01d3c)-; HASH(0x126cc444)-; HASH(0xf9c26ec)-; HASH(0x1224a454)-; HASH(0x12e01dfc)-; HASH(0x1267fd30)-; HASH(0x11a2ec5c)-; HASH(0x126e9fb8)-; HASH(0x12dffe44)-; HASH(0x12def5e0)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLGILSPNAYFCSMAKLINLKIFTHFFRSSAAGGILLLICVLVSLIVANTGLGVHFND
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHH
FLGYPLGFEAAGLQLRYPILLWINDGLMAVFFLLVGLEIKREVIEGELSSLRHAALPVLA
HCCCCCCCCCCCEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGGVIIPALIYFLFNGQSPDTAKGWGIPMATDIAFALGILSLLGDKVPSGLKIFLAALA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVDDLIAILVIAVFYSSELHFLYLGYAGGIFVLLMVFNRLGVKNLFFYLLPGAVMWYFIH
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
HSGIHATIAGVLTALTLPTNQEDKDSPLEKLEHALARPVNFIIMPVFALANTNIAFESEM
HCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHH
LQGLTGNLGLGIILGLVLGKPIGIFVMSWLSVKIRAADLPAQTTWTHVLGLGLLGGIGFT
HHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHH
MSIFIALLSFQEQAYQNEAKFAILTASVLAGAAGFILLSSYNKNKQEQ
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCH
>Mature Secondary Structure
MDLLGILSPNAYFCSMAKLINLKIFTHFFRSSAAGGILLLICVLVSLIVANTGLGVHFND
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHH
FLGYPLGFEAAGLQLRYPILLWINDGLMAVFFLLVGLEIKREVIEGELSSLRHAALPVLA
HCCCCCCCCCCCEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGGVIIPALIYFLFNGQSPDTAKGWGIPMATDIAFALGILSLLGDKVPSGLKIFLAALA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVDDLIAILVIAVFYSSELHFLYLGYAGGIFVLLMVFNRLGVKNLFFYLLPGAVMWYFIH
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
HSGIHATIAGVLTALTLPTNQEDKDSPLEKLEHALARPVNFIIMPVFALANTNIAFESEM
HCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHH
LQGLTGNLGLGIILGLVLGKPIGIFVMSWLSVKIRAADLPAQTTWTHVLGLGLLGGIGFT
HHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHH
MSIFIALLSFQEQAYQNEAKFAILTASVLAGAAGFILLSSYNKNKQEQ
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA