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The map label for this gene is clcB [H]

Identifier: 146302136

GI number: 146302136

Start: 5308463

End: 5310259

Strand: Direct

Name: clcB [H]

Synonym: Fjoh_4402

Alternate gene names: 146302136

Gene position: 5308463-5310259 (Clockwise)

Preceding gene: 146302135

Following gene: 146302137

Centisome position: 87.07

GC content: 41.35

Gene sequence:

>1797_bases
ATGATAAAAATAGTCCTAAAACACCTTTTAAAAGTTAAACATATCCTTATTGAAGGACAGAGAAAATTAACCCGTAAACA
GTTCATTTTTCTCTCCAGCGTACTGATTGGAATTATTGCTGCCTTCGCGGTAATATTTTTAAAGGCTTTTGCTCATTGGG
TCTTTTCCTTTGCAGCTTATATCAACGCAATAGTAAAATTAAGTTTTATAAACAGCATACTTCCTTTGATCGGGATACTG
CTGACTGTACTTGTGGTGAACAGGATCTTAGGAGGCAGCCTAGAAAAAGGGACTTCTCAGATCTTATACATCGTCGCGCG
AAAAGCCAGCATCATCCCTAAAAAACAAATGTACGCCCAGATCATGACCAGTTCCCTTACTGTGGGGCTTGGGGGTTCGG
CCGGGCTGGAGAGTCCAATTGTAATTACCGGTGCCGCCTTTGGTTCCAATTTTGCCCAGCAGTTCAAATTAAGCTACCAG
GAACGGACGCTGCTCATTGGATGCGGGGTTGCAGCCGGTATTGCCGCTGCTTTTAACGCTCCTATAGCCGGTGTGCTTTT
TGCTGTCGAGGTGCTGCTGGTAGATGTTACAATCGCGGCTTTTACCCCTATTATGATTGCCGCTGCAACAGGCGCGCTTG
TTTCAGCGGTGGTCTTAAATGAAAATATACTGCTGGTTTTTAGAGAAAAGCAGACATTTGACTATCATAATATTCCATTT
TACGTGCTGCTGGGACTTTTTACTGGTCTTACAGCGGTTTTCTACGCCAGGAAATTTTTAAAAACAGAACATTTTTTTGC
GCACTTAAAATTTGGCCCCTATAAAAAAGCTTTAATTGGAGGAGCGGTATTGGGAATTCTGATTTTTGTTTTCCCCACCC
TGTTTGGTGAAGGTTATGAAAGCATCAAAATCCTAGCCGATAAGAACCCGGGAGCACTTTTAAAAAACACACTCTTTGAG
CAATACAGCGACAGCAGCTGGATACTGCTGGCTTTCGTTGGATTTTCAATGTTCCTAAAAGCTTTTGCTTCCGGGATAAC
CCTTGGAAGCGGCGGGAACGGCGGGAACTTTGCTCCTTCTTTATTTCTGGGTTCCTATGCTGGATACTTCTTTTCAAAGC
TGTTAAATCTGGCCGGTTTAACCGATCTTCCGATAAGCAACTTTACCCTTGTAGGGATGGCAGGAATTCTCAGCGGGCTG
TTTCATGCCCCGCTGACAGCGATTTTTCTTATTGCCGAAATAACGGGAGGCTACGATCTGATGATACCCCTTATGATTGT
GGCTTCGGTGAGCTTTGCTGTTTCAAAAGGTTTTGAAAAACATTCTCTCGATGTAAAAAACCTTGCCAGAAAAGGAAATG
CCTTCACCAGCAATAAAGACAGCAATATTTTATGCACGCTCAATATTGAGGATCTTGTAAAAAAAGATTATTTAACCCTT
ACAGCAGATCAGGATATGGAAAAGATTTCCGATCTGCTGGCACACTGCGATCAGGTGGTTTTTGGAGTAGTGAGCCAGGA
GAATGAGCTCGAGGGACTGGTTTATTTTGATGACATCAGAGAAATCATTTTTGATACTTCTCAAATTAAAAATACAATGG
TAAAAGATATAATGTTAAAGCCGGTTCAAACTATCTATCTTTTTGACAGCATGGAAACCGTCATGAATAAATTTGAGAAA
AGCAGTAAAATATTTCTCCCTGTGGAAAAAAACGGCAGGTATTATGGTTTTATGACTAAATCAGATATTTTGGAATCCTA
CCGAAACAGGCTTAAATCCATGACATTTGAATACTAA

Upstream 100 bases:

>100_bases
CTTGTTCACTGCAACATAAAAACATTCAAACATAAAACATTCAAACAGCTCCAGCAGGTAAAAAATTAATCCTTCATGAG
CTTTCCAACGCTGCTTACAA

Downstream 100 bases:

>100_bases
ATTTTAGGGATTATTACATCAAACATTTTTGTTCCATGTAATTAAAAAAAATCCAGACTGCATCAAATTTTAAAAAAACA
AGTAAAGAGCCGTTCGATCA

Product: Cl- channel, voltage-gated family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MIKIVLKHLLKVKHILIEGQRKLTRKQFIFLSSVLIGIIAAFAVIFLKAFAHWVFSFAAYINAIVKLSFINSILPLIGIL
LTVLVVNRILGGSLEKGTSQILYIVARKASIIPKKQMYAQIMTSSLTVGLGGSAGLESPIVITGAAFGSNFAQQFKLSYQ
ERTLLIGCGVAAGIAAAFNAPIAGVLFAVEVLLVDVTIAAFTPIMIAAATGALVSAVVLNENILLVFREKQTFDYHNIPF
YVLLGLFTGLTAVFYARKFLKTEHFFAHLKFGPYKKALIGGAVLGILIFVFPTLFGEGYESIKILADKNPGALLKNTLFE
QYSDSSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPSLFLGSYAGYFFSKLLNLAGLTDLPISNFTLVGMAGILSGL
FHAPLTAIFLIAEITGGYDLMIPLMIVASVSFAVSKGFEKHSLDVKNLARKGNAFTSNKDSNILCTLNIEDLVKKDYLTL
TADQDMEKISDLLAHCDQVVFGVVSQENELEGLVYFDDIREIIFDTSQIKNTMVKDIMLKPVQTIYLFDSMETVMNKFEK
SSKIFLPVEKNGRYYGFMTKSDILESYRNRLKSMTFEY

Sequences:

>Translated_598_residues
MIKIVLKHLLKVKHILIEGQRKLTRKQFIFLSSVLIGIIAAFAVIFLKAFAHWVFSFAAYINAIVKLSFINSILPLIGIL
LTVLVVNRILGGSLEKGTSQILYIVARKASIIPKKQMYAQIMTSSLTVGLGGSAGLESPIVITGAAFGSNFAQQFKLSYQ
ERTLLIGCGVAAGIAAAFNAPIAGVLFAVEVLLVDVTIAAFTPIMIAAATGALVSAVVLNENILLVFREKQTFDYHNIPF
YVLLGLFTGLTAVFYARKFLKTEHFFAHLKFGPYKKALIGGAVLGILIFVFPTLFGEGYESIKILADKNPGALLKNTLFE
QYSDSSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPSLFLGSYAGYFFSKLLNLAGLTDLPISNFTLVGMAGILSGL
FHAPLTAIFLIAEITGGYDLMIPLMIVASVSFAVSKGFEKHSLDVKNLARKGNAFTSNKDSNILCTLNIEDLVKKDYLTL
TADQDMEKISDLLAHCDQVVFGVVSQENELEGLVYFDDIREIIFDTSQIKNTMVKDIMLKPVQTIYLFDSMETVMNKFEK
SSKIFLPVEKNGRYYGFMTKSDILESYRNRLKSMTFEY
>Mature_598_residues
MIKIVLKHLLKVKHILIEGQRKLTRKQFIFLSSVLIGIIAAFAVIFLKAFAHWVFSFAAYINAIVKLSFINSILPLIGIL
LTVLVVNRILGGSLEKGTSQILYIVARKASIIPKKQMYAQIMTSSLTVGLGGSAGLESPIVITGAAFGSNFAQQFKLSYQ
ERTLLIGCGVAAGIAAAFNAPIAGVLFAVEVLLVDVTIAAFTPIMIAAATGALVSAVVLNENILLVFREKQTFDYHNIPF
YVLLGLFTGLTAVFYARKFLKTEHFFAHLKFGPYKKALIGGAVLGILIFVFPTLFGEGYESIKILADKNPGALLKNTLFE
QYSDSSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPSLFLGSYAGYFFSKLLNLAGLTDLPISNFTLVGMAGILSGL
FHAPLTAIFLIAEITGGYDLMIPLMIVASVSFAVSKGFEKHSLDVKNLARKGNAFTSNKDSNILCTLNIEDLVKKDYLTL
TADQDMEKISDLLAHCDQVVFGVVSQENELEGLVYFDDIREIIFDTSQIKNTMVKDIMLKPVQTIYLFDSMETVMNKFEK
SSKIFLPVEKNGRYYGFMTKSDILESYRNRLKSMTFEY

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=556, Percent_Identity=23.7410071942446, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI55770840, Length=556, Percent_Identity=23.7410071942446, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87081943, Length=438, Percent_Identity=27.6255707762557, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786350, Length=301, Percent_Identity=29.2358803986711, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665008, Length=548, Percent_Identity=25.5474452554745, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 65592; Mature: 65592

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIVLKHLLKVKHILIEGQRKLTRKQFIFLSSVLIGIIAAFAVIFLKAFAHWVFSFAAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAIVKLSFINSILPLIGILLTVLVVNRILGGSLEKGTSQILYIVARKASIIPKKQMYAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEHEEEHHHHCCCHHHHHHH
IMTSSLTVGLGGSAGLESPIVITGAAFGSNFAQQFKLSYQERTLLIGCGVAAGIAAAFNA
HHHHHHEEECCCCCCCCCCEEEEECHHCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCC
PIAGVLFAVEVLLVDVTIAAFTPIMIAAATGALVSAVVLNENILLVFREKQTFDYHNIPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHH
YVLLGLFTGLTAVFYARKFLKTEHFFAHLKFGPYKKALIGGAVLGILIFVFPTLFGEGYE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SIKILADKNPGALLKNTLFEQYSDSSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPS
EEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHH
LFLGSYAGYFFSKLLNLAGLTDLPISNFTLVGMAGILSGLFHAPLTAIFLIAEITGGYDL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MIPLMIVASVSFAVSKGFEKHSLDVKNLARKGNAFTSNKDSNILCTLNIEDLVKKDYLTL
HHHHHHHHHHHHHHHCCCCHHCCCHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHCCEEE
TADQDMEKISDLLAHCDQVVFGVVSQENELEGLVYFDDIREIIFDTSQIKNTMVKDIMLK
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHC
PVQTIYLFDSMETVMNKFEKSSKIFLPVEKNGRYYGFMTKSDILESYRNRLKSMTFEY
CHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIKIVLKHLLKVKHILIEGQRKLTRKQFIFLSSVLIGIIAAFAVIFLKAFAHWVFSFAAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAIVKLSFINSILPLIGILLTVLVVNRILGGSLEKGTSQILYIVARKASIIPKKQMYAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEHEEEHHHHCCCHHHHHHH
IMTSSLTVGLGGSAGLESPIVITGAAFGSNFAQQFKLSYQERTLLIGCGVAAGIAAAFNA
HHHHHHEEECCCCCCCCCCEEEEECHHCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCC
PIAGVLFAVEVLLVDVTIAAFTPIMIAAATGALVSAVVLNENILLVFREKQTFDYHNIPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHH
YVLLGLFTGLTAVFYARKFLKTEHFFAHLKFGPYKKALIGGAVLGILIFVFPTLFGEGYE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SIKILADKNPGALLKNTLFEQYSDSSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPS
EEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHH
LFLGSYAGYFFSKLLNLAGLTDLPISNFTLVGMAGILSGLFHAPLTAIFLIAEITGGYDL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MIPLMIVASVSFAVSKGFEKHSLDVKNLARKGNAFTSNKDSNILCTLNIEDLVKKDYLTL
HHHHHHHHHHHHHHHCCCCHHCCCHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHCCEEE
TADQDMEKISDLLAHCDQVVFGVVSQENELEGLVYFDDIREIIFDTSQIKNTMVKDIMLK
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHC
PVQTIYLFDSMETVMNKFEKSSKIFLPVEKNGRYYGFMTKSDILESYRNRLKSMTFEY
CHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA