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The map label for this gene is adh [H]

Identifier: 146301903

GI number: 146301903

Start: 4994298

End: 4995323

Strand: Reverse

Name: adh [H]

Synonym: Fjoh_4167

Alternate gene names: 146301903

Gene position: 4995323-4994298 (Counterclockwise)

Preceding gene: 146301904

Following gene: 146301902

Centisome position: 81.93

GC content: 37.04

Gene sequence:

>1026_bases
ATGAAAGCAGTACGATTTTTTGGAACAAACGACGTTAGAATTGTAAATGATCTTGAAAAACCATCGCCAAAAGGAGATGA
GGTACTTTTAAAAATAGGAGGAGCAGGAGTATGCCATTCAGACCTTCATATTATTGATGAAGGAATAGTCTCGGGAGTAA
CATTTACTTTAGGACACGAAAATGCAGGATGGATTGAAGAAATAGGAGATGATGTAAAAGGTTTTAAAAAAGGCGACGCC
GTTTTAGTATACGGTCCCTGGGGATGCGGACATTGTAAACCGTGTCAGCATTCTAATGAAAATTATTGTGACCACCAATC
AGAAATGGCTTACGGAGGCGGATTAGGTTTAAACGGAGGTATGGCAGAGTATATGCTTGTGCCGTCTTCACGATTATTAG
TACCAATTCATGATTTAGATCCCGTAGTTGCAGCACCTTTAACAGATGCCGCTTTAACACCATATTCTGCCATAAAACGT
TCACTTCCAAAATTAATGCCTGATGAATATGTTGTAGTAATAGGAGTAGGTGGTTTAGGACATGTTGCACTTCAAATTTT
ATCAGAAATGTGCTCTTCTGCAATTATTGCCTGCGACATTACTCAGGAAAGATTAGATTTTGCCAAAAAATTAGGAGCTG
CTCATGTCGTTAACTCTATGGATAAAGATGCAGCAGAACAAATACGAAACATTACCGGAATCAAAAAAGCAAAAGTGGTA
ATAGATTTTGTTGGAGCTTCATCAACAATAGATTTAGGAACTAAAATTGTTGGTTTAGACGGAGATTTAACCATTGTAGG
TCTTGGAGGAGGAAAATACGAATACAACATGAATGTACTGCCTTTTGGAGTAAGCATGACCAATCCGTATTGGGGTTCCA
GAACCGAATTAATGGAAGTGATAGGACTTGCACTTCAGAAAAAAATAAAAATTGAAATTCAAAAATTCAAATTAGACGAA
GCTGTTGAAGTGTATGATAAATTAAGAAAAGGGCAAATAAAAGGAAGAGCAGTATTAGTTCCATAA

Upstream 100 bases:

>100_bases
GTTTCGGTTTGAGTTAATAAATTTATAAAATGCCTTAATGACAACATATCGCACTTTTTATTTTAGTAAATTTACTAGTA
TAATTTATAAATAAATTCTC

Downstream 100 bases:

>100_bases
CTAAAAAATAGGGTTTAAAATTGTTTTTGTTTCTTCTGCTAAAAATTAAAAAAAACATAGTTATTGTGTAATAAACAGAT
AATAAAAATGTAAGATATAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKAVRFFGTNDVRIVNDLEKPSPKGDEVLLKIGGAGVCHSDLHIIDEGIVSGVTFTLGHENAGWIEEIGDDVKGFKKGDA
VLVYGPWGCGHCKPCQHSNENYCDHQSEMAYGGGLGLNGGMAEYMLVPSSRLLVPIHDLDPVVAAPLTDAALTPYSAIKR
SLPKLMPDEYVVVIGVGGLGHVALQILSEMCSSAIIACDITQERLDFAKKLGAAHVVNSMDKDAAEQIRNITGIKKAKVV
IDFVGASSTIDLGTKIVGLDGDLTIVGLGGGKYEYNMNVLPFGVSMTNPYWGSRTELMEVIGLALQKKIKIEIQKFKLDE
AVEVYDKLRKGQIKGRAVLVP

Sequences:

>Translated_341_residues
MKAVRFFGTNDVRIVNDLEKPSPKGDEVLLKIGGAGVCHSDLHIIDEGIVSGVTFTLGHENAGWIEEIGDDVKGFKKGDA
VLVYGPWGCGHCKPCQHSNENYCDHQSEMAYGGGLGLNGGMAEYMLVPSSRLLVPIHDLDPVVAAPLTDAALTPYSAIKR
SLPKLMPDEYVVVIGVGGLGHVALQILSEMCSSAIIACDITQERLDFAKKLGAAHVVNSMDKDAAEQIRNITGIKKAKVV
IDFVGASSTIDLGTKIVGLDGDLTIVGLGGGKYEYNMNVLPFGVSMTNPYWGSRTELMEVIGLALQKKIKIEIQKFKLDE
AVEVYDKLRKGQIKGRAVLVP
>Mature_341_residues
MKAVRFFGTNDVRIVNDLEKPSPKGDEVLLKIGGAGVCHSDLHIIDEGIVSGVTFTLGHENAGWIEEIGDDVKGFKKGDA
VLVYGPWGCGHCKPCQHSNENYCDHQSEMAYGGGLGLNGGMAEYMLVPSSRLLVPIHDLDPVVAAPLTDAALTPYSAIKR
SLPKLMPDEYVVVIGVGGLGHVALQILSEMCSSAIIACDITQERLDFAKKLGAAHVVNSMDKDAAEQIRNITGIKKAKVV
IDFVGASSTIDLGTKIVGLDGDLTIVGLGGGKYEYNMNVLPFGVSMTNPYWGSRTELMEVIGLALQKKIKIEIQKFKLDE
AVEVYDKLRKGQIKGRAVLVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=238, Percent_Identity=29.8319327731092, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4501933, Length=238, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4501929, Length=238, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71565154, Length=233, Percent_Identity=29.6137339055794, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI71743840, Length=270, Percent_Identity=25.5555555555556, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI262073058, Length=270, Percent_Identity=25.5555555555556, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4501939, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156523966, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI22538446, Length=279, Percent_Identity=27.5985663082437, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI22538444, Length=279, Percent_Identity=27.5985663082437, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=325, Percent_Identity=30.1538461538462, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788073, Length=264, Percent_Identity=28.7878787878788, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=27.7936962750716, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788407, Length=348, Percent_Identity=22.9885057471264, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=349, Percent_Identity=23.2091690544413, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082125, Length=218, Percent_Identity=30.7339449541284, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788075, Length=296, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI226510992, Length=260, Percent_Identity=26.1538461538462, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787863, Length=279, Percent_Identity=27.5985663082437, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=27.3722627737226, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=261, Percent_Identity=26.0536398467433, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=25.6983240223464, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=27.1084337349398, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=334, Percent_Identity=26.9461077844311, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=263, Percent_Identity=28.1368821292776, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=346, Percent_Identity=26.5895953757225, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=353, Percent_Identity=24.6458923512748, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=27.4566473988439, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=27.1676300578035, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=26.9565217391304, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=363, Percent_Identity=25.068870523416, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=347, Percent_Identity=27.3775216138329, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=315, Percent_Identity=25.0793650793651, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=315, Percent_Identity=25.0793650793651, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=235, Percent_Identity=28.5106382978723, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=27.7611940298507, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=335, Percent_Identity=27.4626865671642, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=367, Percent_Identity=22.3433242506812, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=257, Percent_Identity=27.2373540856031, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137530, Length=258, Percent_Identity=27.906976744186, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737895, Length=236, Percent_Identity=26.271186440678, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36649; Mature: 36649

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVRFFGTNDVRIVNDLEKPSPKGDEVLLKIGGAGVCHSDLHIIDEGIVSGVTFTLGHE
CCEEEEECCCCEEEEECCCCCCCCCCEEEEEECCCCEECCHHHHHHHHHHCCEEEEECCC
NAGWIEEIGDDVKGFKKGDAVLVYGPWGCGHCKPCQHSNENYCDHQSEMAYGGGLGLNGG
CCCHHHHHCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MAEYMLVPSSRLLVPIHDLDPVVAAPLTDAALTPYSAIKRSLPKLMPDEYVVVIGVGGLG
CEEEEEECCCCEEEEECCCCCHHCCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCHH
HVALQILSEMCSSAIIACDITQERLDFAKKLGAAHVVNSMDKDAAEQIRNITGIKKAKVV
HHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHCCCCEEEEE
IDFVGASSTIDLGTKIVGLDGDLTIVGLGGGKYEYNMNVLPFGVSMTNPYWGSRTELMEV
EEEECCCCEEECCEEEEECCCCEEEEEECCCEEEEECEEEEEEEEECCCCCCCHHHHHHH
IGLALQKKIKIEIQKFKLDEAVEVYDKLRKGQIKGRAVLVP
HHHHHHHHEEEEEEEECHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MKAVRFFGTNDVRIVNDLEKPSPKGDEVLLKIGGAGVCHSDLHIIDEGIVSGVTFTLGHE
CCEEEEECCCCEEEEECCCCCCCCCCEEEEEECCCCEECCHHHHHHHHHHCCEEEEECCC
NAGWIEEIGDDVKGFKKGDAVLVYGPWGCGHCKPCQHSNENYCDHQSEMAYGGGLGLNGG
CCCHHHHHCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MAEYMLVPSSRLLVPIHDLDPVVAAPLTDAALTPYSAIKRSLPKLMPDEYVVVIGVGGLG
CEEEEEECCCCEEEEECCCCCHHCCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCHH
HVALQILSEMCSSAIIACDITQERLDFAKKLGAAHVVNSMDKDAAEQIRNITGIKKAKVV
HHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHCCCCEEEEE
IDFVGASSTIDLGTKIVGLDGDLTIVGLGGGKYEYNMNVLPFGVSMTNPYWGSRTELMEV
EEEECCCCEEECCEEEEECCCCEEEEEECCCEEEEECEEEEEEEEECCCCCCCHHHHHHH
IGLALQKKIKIEIQKFKLDEAVEVYDKLRKGQIKGRAVLVP
HHHHHHHHEEEEEEEECHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]