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The map label for this gene is mmgB [H]

Identifier: 146301190

GI number: 146301190

Start: 4115202

End: 4116089

Strand: Direct

Name: mmgB [H]

Synonym: Fjoh_3448

Alternate gene names: 146301190

Gene position: 4115202-4116089 (Clockwise)

Preceding gene: 146301189

Following gene: 146301191

Centisome position: 67.5

GC content: 35.59

Gene sequence:

>888_bases
ATGAAAACAATAGCTGTAATTGGAGCAGGAACAATGGGTAACGGAATTGCCCACACTTTTGCACAAAGCGGATTTACCGT
AAAATTAATCGATGTTTCTGAAAAATCATTAGATAAAGGAATGGCAACAATTGCTGCCAACTTAGACCGTATGTTATCTA
AAGGAACGATTACTCAGGAAGATGTTGCCAAAACTATTACCAATATCATCACTTATACAGATTTAAAAGACGGTGTTGTT
GGAGTTGATTTAGTAGTAGAAGCAGCAACTGAAAACGTTGAATTAAAACTAAATATATTTAAGCAATTAAACGAATATTG
CTCGCACAATACCATTTTAGCAACCAATACTTCTTCTATTTCAATTACACAAATCGGAGCTGTTGTGGCACATCCTGAAC
GTGTTATCGGAATGCACTTTATGAATCCTGTACCGATCATGAAATTGGTTGAAATCATCCGCGGATATAATACCAGCGAT
GAAGTAACTAAAATCATCATGACTTTATCTGAAAAATTAGGTAAAGTTCCTGTAGAAGTAAACGATTATCCAGGTTTTGT
AGCAAACAGAATTTTAATGCCAATGCTAAACGAAGCCATCGAAACGTTATATAATAAAGTTGCCGGAGTTTACGAAATAG
ATACGGTAATGAAATTAGGAATGGGACACCCAATGGGACCACTTCAATTGGCCGATTTTATTGGACTTGATGTTTGTCTT
GCAATTCTAAATGTAATGTACGACGGATTCAAAAATCCTAAATATGCTCCTTGCCCGCTTTTAGTAAATATGGTAAGAGC
TGGTAAACTTGGGGTTAAATCCGGTGAAGGTTTTTACGATTACAGCGAAAGCAAAAAAGCTGAGAAAATCTCGAAACAGT
TTTTATAA

Upstream 100 bases:

>100_bases
TTCGATAAATAGTTTTAAAAAAATCAAAATAAATTAGCCACGAATTCACGAATTATTTGGTGAATTCGTGGCTAAATCAT
AAAAAAATATCTAGCAAAAA

Downstream 100 bases:

>100_bases
AAAAGAAATATCATGTCGATTCAATCGAATTTAAATACAATTAAAGCAACTTTACCTGAACACGTAACTCTAGTTGCCGT
TTCAAAAACAAAACCTGTTT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKTIAVIGAGTMGNGIAHTFAQSGFTVKLIDVSEKSLDKGMATIAANLDRMLSKGTITQEDVAKTITNIITYTDLKDGVV
GVDLVVEAATENVELKLNIFKQLNEYCSHNTILATNTSSISITQIGAVVAHPERVIGMHFMNPVPIMKLVEIIRGYNTSD
EVTKIIMTLSEKLGKVPVEVNDYPGFVANRILMPMLNEAIETLYNKVAGVYEIDTVMKLGMGHPMGPLQLADFIGLDVCL
AILNVMYDGFKNPKYAPCPLLVNMVRAGKLGVKSGEGFYDYSESKKAEKISKQFL

Sequences:

>Translated_295_residues
MKTIAVIGAGTMGNGIAHTFAQSGFTVKLIDVSEKSLDKGMATIAANLDRMLSKGTITQEDVAKTITNIITYTDLKDGVV
GVDLVVEAATENVELKLNIFKQLNEYCSHNTILATNTSSISITQIGAVVAHPERVIGMHFMNPVPIMKLVEIIRGYNTSD
EVTKIIMTLSEKLGKVPVEVNDYPGFVANRILMPMLNEAIETLYNKVAGVYEIDTVMKLGMGHPMGPLQLADFIGLDVCL
AILNVMYDGFKNPKYAPCPLLVNMVRAGKLGVKSGEGFYDYSESKKAEKISKQFL
>Mature_295_residues
MKTIAVIGAGTMGNGIAHTFAQSGFTVKLIDVSEKSLDKGMATIAANLDRMLSKGTITQEDVAKTITNIITYTDLKDGVV
GVDLVVEAATENVELKLNIFKQLNEYCSHNTILATNTSSISITQIGAVVAHPERVIGMHFMNPVPIMKLVEIIRGYNTSD
EVTKIIMTLSEKLGKVPVEVNDYPGFVANRILMPMLNEAIETLYNKVAGVYEIDTVMKLGMGHPMGPLQLADFIGLDVCL
AILNVMYDGFKNPKYAPCPLLVNMVRAGKLGVKSGEGFYDYSESKKAEKISKQFL

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=42.3611111111111, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=40.5228758169935, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI20127408, Length=292, Percent_Identity=33.9041095890411, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=31.3993174061433, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=31.3993174061433, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI115430219, Length=232, Percent_Identity=26.2931034482759, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1787661, Length=299, Percent_Identity=41.1371237458194, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI1790281, Length=288, Percent_Identity=37.8472222222222, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788682, Length=275, Percent_Identity=33.8181818181818, Blast_Score=154, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=39.7260273972603, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.9790940766551, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17549919, Length=284, Percent_Identity=36.9718309859155, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17508953, Length=291, Percent_Identity=34.7079037800687, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=34.7079037800687, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=291, Percent_Identity=34.7079037800687, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=295, Percent_Identity=33.8983050847458, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=32.0284697508897, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=287, Percent_Identity=29.2682926829268, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193203623, Length=199, Percent_Identity=25.1256281407035, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533614, Length=199, Percent_Identity=25.1256281407035, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583077, Length=294, Percent_Identity=33.6734693877551, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24583079, Length=294, Percent_Identity=33.6734693877551, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI19921000, Length=294, Percent_Identity=33.6734693877551, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=29.3617021276596, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=25.5605381165919, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32114; Mature: 32114

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIAVIGAGTMGNGIAHTFAQSGFTVKLIDVSEKSLDKGMATIAANLDRMLSKGTITQE
CCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHH
DVAKTITNIITYTDLKDGVVGVDLVVEAATENVELKLNIFKQLNEYCSHNTILATNTSSI
HHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCEEEEHHHHHHHHHHHCCCCEEEECCCCE
SITQIGAVVAHPERVIGMHFMNPVPIMKLVEIIRGYNTSDEVTKIIMTLSEKLGKVPVEV
EHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
NDYPGFVANRILMPMLNEAIETLYNKVAGVYEIDTVMKLGMGHPMGPLQLADFIGLDVCL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AILNVMYDGFKNPKYAPCPLLVNMVRAGKLGVKSGEGFYDYSESKKAEKISKQFL
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTIAVIGAGTMGNGIAHTFAQSGFTVKLIDVSEKSLDKGMATIAANLDRMLSKGTITQE
CCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHH
DVAKTITNIITYTDLKDGVVGVDLVVEAATENVELKLNIFKQLNEYCSHNTILATNTSSI
HHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCEEEEHHHHHHHHHHHCCCCEEEECCCCE
SITQIGAVVAHPERVIGMHFMNPVPIMKLVEIIRGYNTSDEVTKIIMTLSEKLGKVPVEV
EHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
NDYPGFVANRILMPMLNEAIETLYNKVAGVYEIDTVMKLGMGHPMGPLQLADFIGLDVCL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AILNVMYDGFKNPKYAPCPLLVNMVRAGKLGVKSGEGFYDYSESKKAEKISKQFL
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]