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The map label for this gene is adhc1 [H]

Identifier: 146301037

GI number: 146301037

Start: 3935796

End: 3936854

Strand: Reverse

Name: adhc1 [H]

Synonym: Fjoh_3293

Alternate gene names: 146301037

Gene position: 3936854-3935796 (Counterclockwise)

Preceding gene: 146301043

Following gene: 146301028

Centisome position: 64.57

GC content: 37.49

Gene sequence:

>1059_bases
ATGAATACAAGTAACACAAAAGCATTTGGTACAAAAGCAGCAGACGCATTGCTGGAAGAAATGACAATTGCACGCAGAGA
GGTTTTGGCAAAAGATGTTGAGATCGAAATTTTATACTGCGGTGTATGCCATTCTGATTTACATACAGCCAGAAATGACT
GGGGAGGAAGCCAATATCCGGCAGTTCCGGGGCATGAAATTGTAGGAAGGGTAACGAAAGTAGGAAACGAAGTTACGAAA
CTTAAAGTCGGCGATTTAGCAGGAGTGGGCTGTATGGTTGATTCTTGTCATACCTGCGAAAGCTGTAAACAAGATTTGGA
ACAATATTGTTTAAACGGATTTACAGGAACTTACAATGGTAAGGATAAAAATATTGGCGGACACACTTTTGGCGGTTATT
CTGAGAAAGTGGTAGTTGATGAGCATTTTGTTTTAAAAGTGCCTTCAAATTTAAATTTAGCTGCTGTTGCACCTTTACTT
TGTGCAGGAATTACAACCTGGTCACCTTTGAGACACTGGAAAGTTGGGAAAGGAAGTAAAGTTGCTGTTGTCGGCTTAGG
CGGACTTGGACACATGGCAATTAAACTGGCAAAAGGTTTAGGTGCCGAAGTAACTTTGTTTTCAAGAACTCCGGATAAAA
TACAAGATGCAATCGATTTGGGCGCTGATTCTGTAATTATTTCTACAGATGACCAGCAAATGAAATCAGTACACGGAAAA
TATGATCTTATTATTGATACAGTTCCTTATGTACATGATGTTAATCCTTATGTTTCTACTTTAAACATCAACGGAACTCT
TGTATTAGTTGGTTACTTAGGAGGTTTAGAACCAATTTTAAATTCAGTGCCAATGATTATGGGAAGAAAATCTGTTGCGG
GTTCTGTAATTGGAGGTATTGCAGAAACACAAGAAATGCTTGATTTTTGCGGTGAACATAATATCGTTTCAGAAATTGAA
ATTATTAAAATGCAGGAAATCAACGAAGCGTATGAAAGAATGCTGAAAAGCGATGTAAGATATCGTTTTGTAATTGATAT
GGATTCTCTTAAATCTTAA

Upstream 100 bases:

>100_bases
ATGTTTTGAAATTGTTTGAATTTCATAAGTAAATGTTTCTTTTCTGTTATTTTAAGGAAGAAAGCTGTTTTAATTTTACA
ACTTAATAATCTAAAAAAAT

Downstream 100 bases:

>100_bases
ATAAAGATTAAAAAGGCAAAAAAGGCTTTCTGAAAATTATTTTCAGAAAGCCTTTTTTATTTAGATGAATGAACCTTTCG
GGATGAAATATTTATAGATT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNTSNTKAFGTKAADALLEEMTIARREVLAKDVEIEILYCGVCHSDLHTARNDWGGSQYPAVPGHEIVGRVTKVGNEVTK
LKVGDLAGVGCMVDSCHTCESCKQDLEQYCLNGFTGTYNGKDKNIGGHTFGGYSEKVVVDEHFVLKVPSNLNLAAVAPLL
CAGITTWSPLRHWKVGKGSKVAVVGLGGLGHMAIKLAKGLGAEVTLFSRTPDKIQDAIDLGADSVIISTDDQQMKSVHGK
YDLIIDTVPYVHDVNPYVSTLNINGTLVLVGYLGGLEPILNSVPMIMGRKSVAGSVIGGIAETQEMLDFCGEHNIVSEIE
IIKMQEINEAYERMLKSDVRYRFVIDMDSLKS

Sequences:

>Translated_352_residues
MNTSNTKAFGTKAADALLEEMTIARREVLAKDVEIEILYCGVCHSDLHTARNDWGGSQYPAVPGHEIVGRVTKVGNEVTK
LKVGDLAGVGCMVDSCHTCESCKQDLEQYCLNGFTGTYNGKDKNIGGHTFGGYSEKVVVDEHFVLKVPSNLNLAAVAPLL
CAGITTWSPLRHWKVGKGSKVAVVGLGGLGHMAIKLAKGLGAEVTLFSRTPDKIQDAIDLGADSVIISTDDQQMKSVHGK
YDLIIDTVPYVHDVNPYVSTLNINGTLVLVGYLGGLEPILNSVPMIMGRKSVAGSVIGGIAETQEMLDFCGEHNIVSEIE
IIKMQEINEAYERMLKSDVRYRFVIDMDSLKS
>Mature_352_residues
MNTSNTKAFGTKAADALLEEMTIARREVLAKDVEIEILYCGVCHSDLHTARNDWGGSQYPAVPGHEIVGRVTKVGNEVTK
LKVGDLAGVGCMVDSCHTCESCKQDLEQYCLNGFTGTYNGKDKNIGGHTFGGYSEKVVVDEHFVLKVPSNLNLAAVAPLL
CAGITTWSPLRHWKVGKGSKVAVVGLGGLGHMAIKLAKGLGAEVTLFSRTPDKIQDAIDLGADSVIISTDDQQMKSVHGK
YDLIIDTVPYVHDVNPYVSTLNINGTLVLVGYLGGLEPILNSVPMIMGRKSVAGSVIGGIAETQEMLDFCGEHNIVSEIE
IIKMQEINEAYERMLKSDVRYRFVIDMDSLKS

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=26.5753424657534, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=26.7029972752044, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=26.158038147139, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=25.9052924791086, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=25.9052924791086, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4501939, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI71565152, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI156523966, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786518, Length=345, Percent_Identity=53.6231884057971, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87082401, Length=350, Percent_Identity=37.1428571428571, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=30.9904153354633, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788407, Length=255, Percent_Identity=28.2352941176471, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=28.6245353159851, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786825, Length=252, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787863, Length=264, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788075, Length=281, Percent_Identity=27.7580071174377, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=315, Percent_Identity=27.3015873015873, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=27.5964391691395, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=327, Percent_Identity=28.1345565749235, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=28.1842818428184, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=365, Percent_Identity=27.1232876712329, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=27.7628032345013, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=236, Percent_Identity=31.3559322033898, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=26.9565217391304, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=38.125, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319949, Length=324, Percent_Identity=37.962962962963, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323961, Length=337, Percent_Identity=30.5637982195846, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=30.0859598853868, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=29.9703264094956, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=323, Percent_Identity=30.6501547987616, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319258, Length=229, Percent_Identity=31.4410480349345, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=26.3440860215054, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=384, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737897, Length=251, Percent_Identity=28.6852589641434, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38061; Mature: 38061

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSNTKAFGTKAADALLEEMTIARREVLAKDVEIEILYCGVCHSDLHTARNDWGGSQYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHCCCCCCCCC
AVPGHEIVGRVTKVGNEVTKLKVGDLAGVGCMVDSCHTCESCKQDLEQYCLNGFTGTYNG
CCCCHHHHHHHHHHCCHHEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
KDKNIGGHTFGGYSEKVVVDEHFVLKVPSNLNLAAVAPLLCAGITTWSPLRHWKVGKGSK
CCCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCE
VAVVGLGGLGHMAIKLAKGLGAEVTLFSRTPDKIQDAIDLGADSVIISTDDQQMKSVHGK
EEEEEECCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEEECCHHHHHHHCCC
YDLIIDTVPYVHDVNPYVSTLNINGTLVLVGYLGGLEPILNSVPMIMGRKSVAGSVIGGI
EEEEEECCCCEECCCCCEEEEECCCEEEEEEECCCHHHHHHCCCHHHCCHHHHHHHHHHH
AETQEMLDFCGEHNIVSEIEIIKMQEINEAYERMLKSDVRYRFVIDMDSLKS
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCC
>Mature Secondary Structure
MNTSNTKAFGTKAADALLEEMTIARREVLAKDVEIEILYCGVCHSDLHTARNDWGGSQYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHCCCCCCCCC
AVPGHEIVGRVTKVGNEVTKLKVGDLAGVGCMVDSCHTCESCKQDLEQYCLNGFTGTYNG
CCCCHHHHHHHHHHCCHHEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
KDKNIGGHTFGGYSEKVVVDEHFVLKVPSNLNLAAVAPLLCAGITTWSPLRHWKVGKGSK
CCCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCE
VAVVGLGGLGHMAIKLAKGLGAEVTLFSRTPDKIQDAIDLGADSVIISTDDQQMKSVHGK
EEEEEECCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEEECCHHHHHHHCCC
YDLIIDTVPYVHDVNPYVSTLNINGTLVLVGYLGGLEPILNSVPMIMGRKSVAGSVIGGI
EEEEEECCCCEECCCCCEEEEECCCEEEEEEECCCHHHHHHCCCHHHCCHHHHHHHHHHH
AETQEMLDFCGEHNIVSEIEIIKMQEINEAYERMLKSDVRYRFVIDMDSLKS
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]