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The map label for this gene is cbh [H]

Identifier: 146300581

GI number: 146300581

Start: 3364541

End: 3365593

Strand: Reverse

Name: cbh [H]

Synonym: Fjoh_2831

Alternate gene names: 146300581

Gene position: 3365593-3364541 (Counterclockwise)

Preceding gene: 146300582

Following gene: 146300579

Centisome position: 55.2

GC content: 36.66

Gene sequence:

>1053_bases
ATGAAATTAAAAAAGAGATTATCAGCAATTGCAGCTTTATTGAGTATTCTGTTTATGCAGGAAGCTTTTCCTTGTACTAG
AATAGTTTACGAAGGTTTAAACGGCACTATTATAACTGCCCGTTCTATGGACTGGAAAGGCGAAATTCCAGCTAATTTAT
GGCTTTTTCCAAGAGGAATAGAACGATTTGGCGAAGCAGGAAACAATTCGGTTACATGGAAATCAAAATACGGAAGTGTT
GTAACTAGTTCTTGGGATATTGCTTCTTCTGACGGAATGAATGAAAAAGGTCTTGCCGGTAATCTTTTATGGCTGGTAGA
ATCTGCATATCCTAAATTTGTAAAAAACGGCCCTGTAAAAGGACTTGCTGTTTCTTTATGGCTGCAGTACGTTTTGGATA
ATTATTCAACCGTTGCCGAAGCCGTAAGCGCTTTAGAGAAAAAAGATTTTGTTGTGGCATCGTCACATATTCCGGGAACA
GATATTTTTGCAACCGTGCATTTGTCTTTATCAGATTCAACTGGAGATAATGCTATTTTTGAATATATTAATGGAAATCT
GGTTATTCATCATGATCGAAAATATGTTGCCATGACTAACTCCCCTATTTTTGATCACCAATTGGCAATTAATACCTATT
GGCAGAGTATTCCGGGAACAATTATGCTGCCGGGAACAAATCGTGCGGCAGATCGTTTTGTAAGGGCTTCCTATTATATT
GATGCAATCCCCAAAACAGATAATACAAGAACTGCCCTTGCCAGTGTTTTTGGTGTAATTAGAAATTGCTCTGTTCCGCT
TGGAATTTCCTCAGAAACAGAACCTAATATTTCTTCTACAAGATGGAGAACTGTCGCAGATCATAAAAATCTGGTTTATT
ATTTTGATAATGTACTAAACCCCAATGTAGTTTGGGTTGAGTTTAGTAAACTGGATTTTACTGAAAAAGGAAAAGTAAAA
AAACTCAGCTTGGCGAATAACGAAAATTATTCTGGAGAATCGTCTATGAATTTTAAACCTACAGCAACATTCAAATTCGC
CGGACTAGATTAA

Upstream 100 bases:

>100_bases
AATTAAAATTACTGATATACTGTAAGTTATTACTTCTAAAATTATTAAATTAGCTGTGCTTAAGGCAAACAATCAAATTT
TAAATTTTAATACCACCATT

Downstream 100 bases:

>100_bases
ACGTTAACCATAAAATTATAAACCCCTCTAAAGTCTTATTTTAGAGGGGTTTTATTTATTCTCTTAATATCTTTTCCATT
TTTCTGCCTTTTGCCAATTC

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKLKKRLSAIAALLSILFMQEAFPCTRIVYEGLNGTIITARSMDWKGEIPANLWLFPRGIERFGEAGNNSVTWKSKYGSV
VTSSWDIASSDGMNEKGLAGNLLWLVESAYPKFVKNGPVKGLAVSLWLQYVLDNYSTVAEAVSALEKKDFVVASSHIPGT
DIFATVHLSLSDSTGDNAIFEYINGNLVIHHDRKYVAMTNSPIFDHQLAINTYWQSIPGTIMLPGTNRAADRFVRASYYI
DAIPKTDNTRTALASVFGVIRNCSVPLGISSETEPNISSTRWRTVADHKNLVYYFDNVLNPNVVWVEFSKLDFTEKGKVK
KLSLANNENYSGESSMNFKPTATFKFAGLD

Sequences:

>Translated_350_residues
MKLKKRLSAIAALLSILFMQEAFPCTRIVYEGLNGTIITARSMDWKGEIPANLWLFPRGIERFGEAGNNSVTWKSKYGSV
VTSSWDIASSDGMNEKGLAGNLLWLVESAYPKFVKNGPVKGLAVSLWLQYVLDNYSTVAEAVSALEKKDFVVASSHIPGT
DIFATVHLSLSDSTGDNAIFEYINGNLVIHHDRKYVAMTNSPIFDHQLAINTYWQSIPGTIMLPGTNRAADRFVRASYYI
DAIPKTDNTRTALASVFGVIRNCSVPLGISSETEPNISSTRWRTVADHKNLVYYFDNVLNPNVVWVEFSKLDFTEKGKVK
KLSLANNENYSGESSMNFKPTATFKFAGLD
>Mature_350_residues
MKLKKRLSAIAALLSILFMQEAFPCTRIVYEGLNGTIITARSMDWKGEIPANLWLFPRGIERFGEAGNNSVTWKSKYGSV
VTSSWDIASSDGMNEKGLAGNLLWLVESAYPKFVKNGPVKGLAVSLWLQYVLDNYSTVAEAVSALEKKDFVVASSHIPGT
DIFATVHLSLSDSTGDNAIFEYINGNLVIHHDRKYVAMTNSPIFDHQLAINTYWQSIPGTIMLPGTNRAADRFVRASYYI
DAIPKTDNTRTALASVFGVIRNCSVPLGISSETEPNISSTRWRTVADHKNLVYYFDNVLNPNVVWVEFSKLDFTEKGKVK
KLSLANNENYSGESSMNFKPTATFKFAGLD

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 38838; Mature: 38838

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKKRLSAIAALLSILFMQEAFPCTRIVYEGLNGTIITARSMDWKGEIPANLWLFPRGI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECHHH
ERFGEAGNNSVTWKSKYGSVVTSSWDIASSDGMNEKGLAGNLLWLVESAYPKFVKNGPVK
HHHCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEHHCHHHHHCCCCC
GLAVSLWLQYVLDNYSTVAEAVSALEKKDFVVASSHIPGTDIFATVHLSLSDSTGDNAIF
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCCCCCCEE
EYINGNLVIHHDRKYVAMTNSPIFDHQLAINTYWQSIPGTIMLPGTNRAADRFVRASYYI
EEECCCEEEEECCEEEEEECCCCCCCEEEHHHHHHCCCCEEEECCCCHHHHHHHEEEEEE
DAIPKTDNTRTALASVFGVIRNCSVPLGISSETEPNISSTRWRTVADHKNLVYYFDNVLN
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCC
PNVVWVEFSKLDFTEKGKVKKLSLANNENYSGESSMNFKPTATFKFAGLD
CCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKLKKRLSAIAALLSILFMQEAFPCTRIVYEGLNGTIITARSMDWKGEIPANLWLFPRGI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECHHH
ERFGEAGNNSVTWKSKYGSVVTSSWDIASSDGMNEKGLAGNLLWLVESAYPKFVKNGPVK
HHHCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEHHCHHHHHCCCCC
GLAVSLWLQYVLDNYSTVAEAVSALEKKDFVVASSHIPGTDIFATVHLSLSDSTGDNAIF
HHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCCCCCCEE
EYINGNLVIHHDRKYVAMTNSPIFDHQLAINTYWQSIPGTIMLPGTNRAADRFVRASYYI
EEECCCEEEEECCEEEEEECCCCCCCEEEHHHHHHCCCCEEEECCCCHHHHHHHEEEEEE
DAIPKTDNTRTALASVFGVIRNCSVPLGISSETEPNISSTRWRTVADHKNLVYYFDNVLN
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCC
PNVVWVEFSKLDFTEKGKVKKLSLANNENYSGESSMNFKPTATFKFAGLD
CCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]