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The map label for this gene is resA [H]

Identifier: 146299771

GI number: 146299771

Start: 2349575

End: 2350711

Strand: Direct

Name: resA [H]

Synonym: Fjoh_2011

Alternate gene names: 146299771

Gene position: 2349575-2350711 (Clockwise)

Preceding gene: 146299770

Following gene: 146299772

Centisome position: 38.54

GC content: 33.6

Gene sequence:

>1137_bases
ATGAAAAGTACAATCTTAAAATCGTCATTAATTGTATTGGCACTTGCATCTGTAACTACTTCTTGCTCTAAAAAAGAAGG
TTACACAATCAACGGTACTATTGCCGGATTAGATAAAGGAATGGTTTATCTTGAAAACACAGATGAAAAAGGAAATAAAC
AAATAGCAGATTCTGCACAAATTAAAGAAGGAGGAACTTTTACTTTTGAAGGAAAAGTTTCAGAACCTTTACTATATACT
CTTAAATTAAAAGGAGAAGATTATGGAGCTTTCTTTCTTTTAGAGAACGAAGACATTAAAATTGAAGCTAAAAAAGATTC
TATTTTTAAAGCTAAAATCAGTGGAGCGCGGCAAAATGATATTTACAAATCATACTACGATAACGAATTCAAAAAAATCC
AGAATATCGCTGGTCCTGTTTATAAATTATCTGACTCCTTAACTCAAAACGGAAAAGTAAAATTAACAGCTGAACAGCAA
ACCATGATGGATAAAAAATGGAAAGATCTTGCCGCTTTTGCTGATGATTTAACCGATAAATACATCCGAAAAAATAAAGA
TAAAGTAGGTGCTGCTTTAATAATCAATGACCGAATTGTATCGTATGGAACTCCGGAACAGGTAAAAATGTATTATGCCG
TTTTATCTCCAGACGTACAAAAATCAATTTACGGAAAACAGTTAAAAGAAGCCATCGACCTTAACGAAAAAACAGCAGTA
GGCGTTACAGCTCCAGAGTTTTCTCAAACCGATATTGACGGAAAAGTAGTGAATCTTTCAGATTACAAAGGAAAATATGT
TTTAGTTGATTTTTGGGCTTCTTGGTGCGGACCATGCCGAAAAGAAAATCCAAACGTAGTTTTAGCTTATAAAACCTATC
ACGAAAAAGGATTTGATGTTTTGGGAGTTTCTTTAGATGATAAAAAGAACCTTTGGCAGAAAGCAATCGAAAAAGACGGT
TTAACCTGGACTCATGTTTCTGATTTAAAAGGATGGCAGAACGAAGCTGCTGTTTTATACGGAGTAAAAATGGTGCCAAC
GAATTACTTAATTGGTCCAGACGGAAAAATCGTTGCTAAAAACCTTAGAGAAGCAGAATTACAATCTAAACTAAAAGAAA
TCTTCAGCAAATCGTAA

Upstream 100 bases:

>100_bases
TTAATTTTAAGTTTATAGCCGCAGTTTACAGTCTCAATCAACACTGTAACTGAAAACTGGGACTGAAAACTGAGACAAAA
AAACTAAAAAAATAACTCAC

Downstream 100 bases:

>100_bases
ATTAGTATTCAGTCGCAGTTTTCAGTCGCAGTCTCAGTTTGGTTTAATCTGTTCAGTCGATAACTGAAAACTGCGACTGC
GACTGAAAACTCAAGAAAAA

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: Acceptor; H2O; oxidized thioredoxin [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKSTILKSSLIVLALASVTTSCSKKEGYTINGTIAGLDKGMVYLENTDEKGNKQIADSAQIKEGGTFTFEGKVSEPLLYT
LKLKGEDYGAFFLLENEDIKIEAKKDSIFKAKISGARQNDIYKSYYDNEFKKIQNIAGPVYKLSDSLTQNGKVKLTAEQQ
TMMDKKWKDLAAFADDLTDKYIRKNKDKVGAALIINDRIVSYGTPEQVKMYYAVLSPDVQKSIYGKQLKEAIDLNEKTAV
GVTAPEFSQTDIDGKVVNLSDYKGKYVLVDFWASWCGPCRKENPNVVLAYKTYHEKGFDVLGVSLDDKKNLWQKAIEKDG
LTWTHVSDLKGWQNEAAVLYGVKMVPTNYLIGPDGKIVAKNLREAELQSKLKEIFSKS

Sequences:

>Translated_378_residues
MKSTILKSSLIVLALASVTTSCSKKEGYTINGTIAGLDKGMVYLENTDEKGNKQIADSAQIKEGGTFTFEGKVSEPLLYT
LKLKGEDYGAFFLLENEDIKIEAKKDSIFKAKISGARQNDIYKSYYDNEFKKIQNIAGPVYKLSDSLTQNGKVKLTAEQQ
TMMDKKWKDLAAFADDLTDKYIRKNKDKVGAALIINDRIVSYGTPEQVKMYYAVLSPDVQKSIYGKQLKEAIDLNEKTAV
GVTAPEFSQTDIDGKVVNLSDYKGKYVLVDFWASWCGPCRKENPNVVLAYKTYHEKGFDVLGVSLDDKKNLWQKAIEKDG
LTWTHVSDLKGWQNEAAVLYGVKMVPTNYLIGPDGKIVAKNLREAELQSKLKEIFSKS
>Mature_378_residues
MKSTILKSSLIVLALASVTTSCSKKEGYTINGTIAGLDKGMVYLENTDEKGNKQIADSAQIKEGGTFTFEGKVSEPLLYT
LKLKGEDYGAFFLLENEDIKIEAKKDSIFKAKISGARQNDIYKSYYDNEFKKIQNIAGPVYKLSDSLTQNGKVKLTAEQQ
TMMDKKWKDLAAFADDLTDKYIRKNKDKVGAALIINDRIVSYGTPEQVKMYYAVLSPDVQKSIYGKQLKEAIDLNEKTAV
GVTAPEFSQTDIDGKVVNLSDYKGKYVLVDFWASWCGPCRKENPNVVLAYKTYHEKGFDVLGVSLDDKKNLWQKAIEKDG
LTWTHVSDLKGWQNEAAVLYGVKMVPTNYLIGPDGKIVAKNLREAELQSKLKEIFSKS

Specific function: Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalent

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: 920 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: NA

Molecular weight: Translated: 42271; Mature: 42271

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTILKSSLIVLALASVTTSCSKKEGYTINGTIAGLDKGMVYLENTDEKGNKQIADSAQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
IKEGGTFTFEGKVSEPLLYTLKLKGEDYGAFFLLENEDIKIEAKKDSIFKAKISGARQND
CCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEECCCCEEEEEECCCCCCC
IYKSYYDNEFKKIQNIAGPVYKLSDSLTQNGKVKLTAEQQTMMDKKWKDLAAFADDLTDK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
YIRKNKDKVGAALIINDRIVSYGTPEQVKMYYAVLSPDVQKSIYGKQLKEAIDLNEKTAV
HHHCCCCCCCEEEEEECEEEECCCCHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEE
GVTAPEFSQTDIDGKVVNLSDYKGKYVLVDFWASWCGPCRKENPNVVLAYKTYHEKGFDV
EEECCCCCCCCCCCEEEEECCCCCCEEEEEEHHHHCCCCCCCCCCEEEEEEEECCCCCEE
LGVSLDDKKNLWQKAIEKDGLTWTHVSDLKGWQNEAAVLYGVKMVPTNYLIGPDGKIVAK
EEEEECCHHHHHHHHHHHCCCEEEEHHHCCCCCCCCEEEEEEEECCCCEEECCCCCEEHH
NLREAELQSKLKEIFSKS
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSTILKSSLIVLALASVTTSCSKKEGYTINGTIAGLDKGMVYLENTDEKGNKQIADSAQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
IKEGGTFTFEGKVSEPLLYTLKLKGEDYGAFFLLENEDIKIEAKKDSIFKAKISGARQND
CCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEECCCCEEEEEECCCCCCC
IYKSYYDNEFKKIQNIAGPVYKLSDSLTQNGKVKLTAEQQTMMDKKWKDLAAFADDLTDK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
YIRKNKDKVGAALIINDRIVSYGTPEQVKMYYAVLSPDVQKSIYGKQLKEAIDLNEKTAV
HHHCCCCCCCEEEEEECEEEECCCCHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEE
GVTAPEFSQTDIDGKVVNLSDYKGKYVLVDFWASWCGPCRKENPNVVLAYKTYHEKGFDV
EEECCCCCCCCCCCEEEEECCCCCCEEEEEEHHHHCCCCCCCCCCEEEEEEEECCCCCEE
LGVSLDDKKNLWQKAIEKDGLTWTHVSDLKGWQNEAAVLYGVKMVPTNYLIGPDGKIVAK
EEEEECCHHHHHHHHHHHCCCEEEEHHHCCCCCCCCEEEEEEEECCCCEEECCCCCEEHH
NLREAELQSKLKEIFSKS
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced acceptor; H2O2; reduced thioredoxin [C]

Specific reaction: reduced acceptor + H2O2 = Acceptor + H2O reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: Oxidoreductases; Acting on a peroxide as acceptor; Peroxidase [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA