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The map label for this gene is phoR [H]

Identifier: 146299381

GI number: 146299381

Start: 1870078

End: 1871343

Strand: Direct

Name: phoR [H]

Synonym: Fjoh_1621

Alternate gene names: 146299381

Gene position: 1870078-1871343 (Clockwise)

Preceding gene: 146299380

Following gene: 146299382

Centisome position: 30.67

GC content: 31.52

Gene sequence:

>1266_bases
ATGCTTCCTATTTTGGTCGAAAATGTGGTTTACAGACATATCAATAATGGGTTAATTGAAAAAAAGAAGAAATTCATCGA
CCATTTAAATCAGCAGGAGATTAATGATTTTATTGAAAATGAAGATGATTCAACTGAAACCTATTCTCAGTTTTCTACAC
TTCATAACGAGTTTTTGGTTCTTTCGAGAGCGCCGTTTAAACCACATCAAAAAAGAACAAGTTTTAGCAACGAATACCGT
ATTATTGAAGGCGAAGAAAATGAATACCGAATTCTGCAGCATCATTTTAGTTACGAAAATCAAGATTATCAGCTGGAAAT
TGGAAGTAGTTTAAGTGAAGTAAAAGACTTAACTTTTATTATTAAGCTGTTTATAATTGTTGTTTTGGTTGTTATTCTTT
TTGTGACATTTTTGGCAGATACTTTTTATATCGAATATTTGCTGAAACCGTTCTATAAAATCATTGACACCAAAATAAGG
CGAGTCAATGAACCCGAAGTTTTTGACCATACGCCCATAAATGCAAAATCGAGGGATTTTAGAGAACTAGATTTGGTTTT
AAATCAAATGATGGATCGTATTGCTGAGCTTTTCAAAAAAGAAAAACAATTTATTTCGAATGTTTCTCACGAACTTTTAA
CGCCAATTGCTTTATTGAAAAACAAGCTGGAAAATTTATTGCAAAATGACTCTTTAGATGACAATGCAGTTGATAAAATT
GCGGGTTCGTTGAAGACGTTAGATATGCTGAAAAAAATCATCAATAATTTATTGCTGATTTCCAGAATCGAAAACAATCA
ATATGCAGCTAACGAACATGTCAGTTTTCAGGAAATAATAAATGATCTGCAGGAAGATCTTCAGGATCGTATTGATGATA
AAGAAATTCAGTTTGTTAATAAAGCAGGACATGATTTTGCTTTTACGGGAAATAAAACCTTAATTCATATTCTAATTTAT
AATTTGGTTACAAATGCCATTAAGTATAATAAACCTAAGGGAAGCATTATTGTAACAGACGGATTTTTGAACCATCACTA
TTTTATTTCAATAACAGATTCTGGAATTGGTTTAAATGAATCTCAAATCGAAAATATTTTTAACCGATTTGCAAGAGTAA
GTTCTGATCAGGAAGGACAGGGCTTAGGACTTGCTATTGCTAAAAGCATTGCCGTTTTTCATCATATTGAAATAAAAGTT
TCGTCTGTTTTAGGCGAAGGAACAACTTTTACTCTATTGTTCCCGGAAGAACCAAAACACAATTAA

Upstream 100 bases:

>100_bases
TATCGTATTAATGAATAAATAGATTTTTGTGAAGATAAAACATCAATTAGCCATTTTTAATGCACTAACAAGATTGCTGG
TGATTTTGATTTTGTGGCTC

Downstream 100 bases:

>100_bases
AAGTTAATTTTTTCAGATTGGTTCAATCTTCATTTTGTCTTCATTTACTGGTTATATCTTTGAGGTATAAATAATGAAAT
AATAATCAAATAAATCTACA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MLPILVENVVYRHINNGLIEKKKKFIDHLNQQEINDFIENEDDSTETYSQFSTLHNEFLVLSRAPFKPHQKRTSFSNEYR
IIEGEENEYRILQHHFSYENQDYQLEIGSSLSEVKDLTFIIKLFIIVVLVVILFVTFLADTFYIEYLLKPFYKIIDTKIR
RVNEPEVFDHTPINAKSRDFRELDLVLNQMMDRIAELFKKEKQFISNVSHELLTPIALLKNKLENLLQNDSLDDNAVDKI
AGSLKTLDMLKKIINNLLLISRIENNQYAANEHVSFQEIINDLQEDLQDRIDDKEIQFVNKAGHDFAFTGNKTLIHILIY
NLVTNAIKYNKPKGSIIVTDGFLNHHYFISITDSGIGLNESQIENIFNRFARVSSDQEGQGLGLAIAKSIAVFHHIEIKV
SSVLGEGTTFTLLFPEEPKHN

Sequences:

>Translated_421_residues
MLPILVENVVYRHINNGLIEKKKKFIDHLNQQEINDFIENEDDSTETYSQFSTLHNEFLVLSRAPFKPHQKRTSFSNEYR
IIEGEENEYRILQHHFSYENQDYQLEIGSSLSEVKDLTFIIKLFIIVVLVVILFVTFLADTFYIEYLLKPFYKIIDTKIR
RVNEPEVFDHTPINAKSRDFRELDLVLNQMMDRIAELFKKEKQFISNVSHELLTPIALLKNKLENLLQNDSLDDNAVDKI
AGSLKTLDMLKKIINNLLLISRIENNQYAANEHVSFQEIINDLQEDLQDRIDDKEIQFVNKAGHDFAFTGNKTLIHILIY
NLVTNAIKYNKPKGSIIVTDGFLNHHYFISITDSGIGLNESQIENIFNRFARVSSDQEGQGLGLAIAKSIAVFHHIEIKV
SSVLGEGTTFTLLFPEEPKHN
>Mature_421_residues
MLPILVENVVYRHINNGLIEKKKKFIDHLNQQEINDFIENEDDSTETYSQFSTLHNEFLVLSRAPFKPHQKRTSFSNEYR
IIEGEENEYRILQHHFSYENQDYQLEIGSSLSEVKDLTFIIKLFIIVVLVVILFVTFLADTFYIEYLLKPFYKIIDTKIR
RVNEPEVFDHTPINAKSRDFRELDLVLNQMMDRIAELFKKEKQFISNVSHELLTPIALLKNKLENLLQNDSLDDNAVDKI
AGSLKTLDMLKKIINNLLLISRIENNQYAANEHVSFQEIINDLQEDLQDRIDDKEIQFVNKAGHDFAFTGNKTLIHILIY
NLVTNAIKYNKPKGSIIVTDGFLNHHYFISITDSGIGLNESQIENIFNRFARVSSDQEGQGLGLAIAKSIAVFHHIEIKV
SSVLGEGTTFTLLFPEEPKHN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=25.609756097561, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=28.4671532846715, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786600, Length=278, Percent_Identity=29.136690647482, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790551, Length=231, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=27.0742358078603, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789403, Length=339, Percent_Identity=27.1386430678466, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=24.7011952191235, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=28.8702928870293, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=255, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=23.3333333333333, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=23.5555555555556, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=26.3598326359833, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=303, Percent_Identity=22.1122112211221, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPILVENVVYRHINNGLIEKKKKFIDHLNQQEINDFIENEDDSTETYSQFSTLHNEFLV
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHEE
LSRAPFKPHQKRTSFSNEYRIIEGEENEYRILQHHFSYENQDYQLEIGSSLSEVKDLTFI
EECCCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
IKLFIIVVLVVILFVTFLADTFYIEYLLKPFYKIIDTKIRRVNEPEVFDHTPINAKSRDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
RELDLVLNQMMDRIAELFKKEKQFISNVSHELLTPIALLKNKLENLLQNDSLDDNAVDKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AGSLKTLDMLKKIINNLLLISRIENNQYAANEHVSFQEIINDLQEDLQDRIDDKEIQFVN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
KAGHDFAFTGNKTLIHILIYNLVTNAIKYNKPKGSIIVTDGFLNHHYFISITDSGIGLNE
HCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCH
SQIENIFNRFARVSSDQEGQGLGLAIAKSIAVFHHIEIKVSSVLGEGTTFTLLFPEEPKH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHCCCCEEEEECCCCCCC
N
C
>Mature Secondary Structure
MLPILVENVVYRHINNGLIEKKKKFIDHLNQQEINDFIENEDDSTETYSQFSTLHNEFLV
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHEE
LSRAPFKPHQKRTSFSNEYRIIEGEENEYRILQHHFSYENQDYQLEIGSSLSEVKDLTFI
EECCCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
IKLFIIVVLVVILFVTFLADTFYIEYLLKPFYKIIDTKIRRVNEPEVFDHTPINAKSRDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
RELDLVLNQMMDRIAELFKKEKQFISNVSHELLTPIALLKNKLENLLQNDSLDDNAVDKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AGSLKTLDMLKKIINNLLLISRIENNQYAANEHVSFQEIINDLQEDLQDRIDDKEIQFVN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
KAGHDFAFTGNKTLIHILIYNLVTNAIKYNKPKGSIIVTDGFLNHHYFISITDSGIGLNE
HCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCH
SQIENIFNRFARVSSDQEGQGLGLAIAKSIAVFHHIEIKVSSVLGEGTTFTLLFPEEPKH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHCCCCEEEEECCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]