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The map label for this gene is pmrA [H]

Identifier: 146299380

GI number: 146299380

Start: 1869309

End: 1869995

Strand: Direct

Name: pmrA [H]

Synonym: Fjoh_1620

Alternate gene names: 146299380

Gene position: 1869309-1869995 (Clockwise)

Preceding gene: 146299379

Following gene: 146299381

Centisome position: 30.66

GC content: 33.92

Gene sequence:

>687_bases
ATGCCTTGTTTTATGAATGTTTTAATTGTAGAAGATAATAAAGAGCTTGCCGTTGAAGTTTACGACTTTTTGAGCAAAGC
AGGTTATATCTGTAAAATTGCGAATAATTGTGCCGATGCTCTCGAAGAATTTGGAAGTAATGATTATGATGCTATGCTGC
TTGATCTTGGTTTGCCGGACGGAGATGGTTTTGAGGTTTTGCAGACCATTCGAAAAACAAAATCAAAAATTGCAGTAATT
GTACTTACTGCCCGCGGTGAACTAGATGATAGAATTAATGGACTTCATTTGGGAGCTGATGATTATTTAACGAAACCTTT
TGCTTTGACAGAATTGGCTGCCAGATTGTTTGCCGTAATCCGACGAATTCATGGTTTTACTTTAAATAACTTAAGTATTC
ACGGTTTTTTGCTGCAGCTTCAGGATTATAAAGTGAGTTTTAATGAGGTGCCTTTGAGTTTAACAAAAAAGGAATTTGAT
ATTTTTCAATATTTGGTTTTGAATAAAAACAGAGTAATTACAAGACTGCAATTAACAGAACATATTTGGGGCGATATTCT
GGAAATAAATTCAGATTCTAATTTTATAGATGTGCATGTTCGAAACCTTCGAAAAAAATTAGACAAACACACTTCAATAG
ATTGGTTTGAAACGGTTCGAAATGTGGGGTATCGTATTAATGAATAA

Upstream 100 bases:

>100_bases
AAGAAGCTGATAAAGAAATTTGTCAGCTTTTTTTATTCGTTAATTTTTTAATAATGTGCAGCCGGACTTTTGATAATTGA
TTAATTTTAGTTGCACATAA

Downstream 100 bases:

>100_bases
ATAGATTTTTGTGAAGATAAAACATCAATTAGCCATTTTTAATGCACTAACAAGATTGCTGGTGATTTTGATTTTGTGGC
TCATGCTTCCTATTTTGGTC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MPCFMNVLIVEDNKELAVEVYDFLSKAGYICKIANNCADALEEFGSNDYDAMLLDLGLPDGDGFEVLQTIRKTKSKIAVI
VLTARGELDDRINGLHLGADDYLTKPFALTELAARLFAVIRRIHGFTLNNLSIHGFLLQLQDYKVSFNEVPLSLTKKEFD
IFQYLVLNKNRVITRLQLTEHIWGDILEINSDSNFIDVHVRNLRKKLDKHTSIDWFETVRNVGYRINE

Sequences:

>Translated_228_residues
MPCFMNVLIVEDNKELAVEVYDFLSKAGYICKIANNCADALEEFGSNDYDAMLLDLGLPDGDGFEVLQTIRKTKSKIAVI
VLTARGELDDRINGLHLGADDYLTKPFALTELAARLFAVIRRIHGFTLNNLSIHGFLLQLQDYKVSFNEVPLSLTKKEFD
IFQYLVLNKNRVITRLQLTEHIWGDILEINSDSNFIDVHVRNLRKKLDKHTSIDWFETVRNVGYRINE
>Mature_227_residues
PCFMNVLIVEDNKELAVEVYDFLSKAGYICKIANNCADALEEFGSNDYDAMLLDLGLPDGDGFEVLQTIRKTKSKIAVIV
LTARGELDDRINGLHLGADDYLTKPFALTELAARLFAVIRRIHGFTLNNLSIHGFLLQLQDYKVSFNEVPLSLTKKEFDI
FQYLVLNKNRVITRLQLTEHIWGDILEINSDSNFIDVHVRNLRKKLDKHTSIDWFETVRNVGYRINE

Specific function: Member of the two-component regulatory system pmrB/pmrA involved in regulation of virulence. Unphosphorylated pmrA represses extracellular enzyme genes. Phosphorylation of pmrA by pmrB relieves such repression, which leads to activation of extracellular e

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=37.2727272727273, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=33.4841628959276, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=37.0535714285714, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=34.2222222222222, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=36.036036036036, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=31.5555555555556, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=33.1818181818182, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.5291479820628, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.4801762114537, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=31.390134529148, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=29.646017699115, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=29.0748898678414, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=24.7863247863248, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=34.2857142857143, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26125; Mature: 25994

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCFMNVLIVEDNKELAVEVYDFLSKAGYICKIANNCADALEEFGSNDYDAMLLDLGLPD
CCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEECCCC
GDGFEVLQTIRKTKSKIAVIVLTARGELDDRINGLHLGADDYLTKPFALTELAARLFAVI
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHH
RRIHGFTLNNLSIHGFLLQLQDYKVSFNEVPLSLTKKEFDIFQYLVLNKNRVITRLQLTE
HHHCCCEECCEEEEEEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHH
HIWGDILEINSDSNFIDVHVRNLRKKLDKHTSIDWFETVRNVGYRINE
HHCCCEEEECCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PCFMNVLIVEDNKELAVEVYDFLSKAGYICKIANNCADALEEFGSNDYDAMLLDLGLPD
CCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEECCCC
GDGFEVLQTIRKTKSKIAVIVLTARGELDDRINGLHLGADDYLTKPFALTELAARLFAVI
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHH
RRIHGFTLNNLSIHGFLLQLQDYKVSFNEVPLSLTKKEFDIFQYLVLNKNRVITRLQLTE
HHHCCCEECCEEEEEEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHH
HIWGDILEINSDSNFIDVHVRNLRKKLDKHTSIDWFETVRNVGYRINE
HHCCCEEEECCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14617142 [H]