Click here to switch to the map view.

The map label for this gene is yfhQ [H]

Identifier: 146299295

GI number: 146299295

Start: 1774092

End: 1775126

Strand: Direct

Name: yfhQ [H]

Synonym: Fjoh_1535

Alternate gene names: 146299295

Gene position: 1774092-1775126 (Clockwise)

Preceding gene: 146299290

Following gene: 146299298

Centisome position: 29.1

GC content: 34.4

Gene sequence:

>1035_bases
ATGAATTTTCATAACAGGCTGATAAAATGGTATTTACAAAACAAACGGGATCTTCCATGGCGAAAAACAGCCAATCCGTA
CCATATTTGGCTCTCAGAAATTATGCTGCAACAAACCAGAGTTGTGCAAGGAATGCCTTACTTTTTTGCTTTTACGCAAG
AATTTCCAACTGTTTTTGACCTCGCAAATGCCTCCGAAGAACAAGTTTTAAAACTTTGGCAGGGACTGGGATATTACTCA
AGAGCCAGAAATCTGCATAATACTGCTAAGTATATTGCTTATGAGCTAAATGGAGTTTTTCCTGAAACCTATAAAGAGCT
GCTTAATTTAAAAGGTGTTGGTGAATATACTGCGGCTGCAATTGCTTCTTTTTCTTATAATGAAGCCGTTCCGGTCGTCG
ATGGCAATGTTTTTAGGGTGCTTTCCCGCTATTTTGATATAGAATCAGATATTGCACTCCCTGCGTCTAAAAAAGAATTT
GCTGCGCTGGCTTATGAATTAATGCCTAAAAATGATCCGGCAACTTTTAATCAGGCAATTATGGAATTTGGTGCGCTGCA
ATGCGTGCCTAAAAGCCCCAATTGTACTATATGTATCTTTAATGAGAGCTGTCTGGCTTTACAAAAAAAGAAAGTCGACA
TTCTTCCTGTTAAATCCAAGAAGGTTAAAATTACCAATCGATTTTTTAATTATTTTGTTTTAGAAGATAGTTTAGGAAAT
ACAGCTATACAAAAAAGAACAGCAAAAGGTATTTGGCATAATTTATACGAATTCCCGCTTTTAGAAACCAGTGAAATTGT
AGATTTTGATTATATTTCTAATGCAGTACAAAATCAGGTGTTTCCTGTATATACTATATTAAGTGTTGAAGAATGCGCTG
AAGCTGCGGTAATACATAAGCTTTCACACCAGCATCTGCATATTCAGTTTTGGAAAATTAAAATAAAGGAGAATATAAAG
GAAGGAATTGAATTTGAAAAAATTAAAACTTTTCCTTTTCCTATTGTAATTTATAATTTTATAGAGAAGTTATAA

Upstream 100 bases:

>100_bases
TTGAGTTTGCAAATATAGGAATTAAAAAAATAATTAATCAAGCTAATTCGTTAAATTTTAATTACATAAACATTTACTTT
TGCATTTTAAGGATTTGACG

Downstream 100 bases:

>100_bases
TAAAAAACCGACTGTCAAGTCGGTTTTTTATTTATACGCCTGCAGTCGCGTATTGAATTATTCTAACAACAATTCCAACA
GCAAAACCAATTAAAGCCAT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNFHNRLIKWYLQNKRDLPWRKTANPYHIWLSEIMLQQTRVVQGMPYFFAFTQEFPTVFDLANASEEQVLKLWQGLGYYS
RARNLHNTAKYIAYELNGVFPETYKELLNLKGVGEYTAAAIASFSYNEAVPVVDGNVFRVLSRYFDIESDIALPASKKEF
AALAYELMPKNDPATFNQAIMEFGALQCVPKSPNCTICIFNESCLALQKKKVDILPVKSKKVKITNRFFNYFVLEDSLGN
TAIQKRTAKGIWHNLYEFPLLETSEIVDFDYISNAVQNQVFPVYTILSVEECAEAAVIHKLSHQHLHIQFWKIKIKENIK
EGIEFEKIKTFPFPIVIYNFIEKL

Sequences:

>Translated_344_residues
MNFHNRLIKWYLQNKRDLPWRKTANPYHIWLSEIMLQQTRVVQGMPYFFAFTQEFPTVFDLANASEEQVLKLWQGLGYYS
RARNLHNTAKYIAYELNGVFPETYKELLNLKGVGEYTAAAIASFSYNEAVPVVDGNVFRVLSRYFDIESDIALPASKKEF
AALAYELMPKNDPATFNQAIMEFGALQCVPKSPNCTICIFNESCLALQKKKVDILPVKSKKVKITNRFFNYFVLEDSLGN
TAIQKRTAKGIWHNLYEFPLLETSEIVDFDYISNAVQNQVFPVYTILSVEECAEAAVIHKLSHQHLHIQFWKIKIKENIK
EGIEFEKIKTFPFPIVIYNFIEKL
>Mature_344_residues
MNFHNRLIKWYLQNKRDLPWRKTANPYHIWLSEIMLQQTRVVQGMPYFFAFTQEFPTVFDLANASEEQVLKLWQGLGYYS
RARNLHNTAKYIAYELNGVFPETYKELLNLKGVGEYTAAAIASFSYNEAVPVVDGNVFRVLSRYFDIESDIALPASKKEF
AALAYELMPKNDPATFNQAIMEFGALQCVPKSPNCTICIFNESCLALQKKKVDILPVKSKKVKITNRFFNYFVLEDSLGN
TAIQKRTAKGIWHNLYEFPLLETSEIVDFDYISNAVQNQVFPVYTILSVEECAEAAVIHKLSHQHLHIQFWKIKIKENIK
EGIEFEKIKTFPFPIVIYNFIEKL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=216, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI6912520, Length=216, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI115298654, Length=216, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI115298652, Length=216, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI115298650, Length=216, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI190358497, Length=216, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1789331, Length=265, Percent_Identity=38.8679245283019, Blast_Score=204, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39917; Mature: 39917

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFHNRLIKWYLQNKRDLPWRKTANPYHIWLSEIMLQQTRVVQGMPYFFAFTQEFPTVFD
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEHHHCCHHHH
LANASEEQVLKLWQGLGYYSRARNLHNTAKYIAYELNGVFPETYKELLNLKGVGEYTAAA
HCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCHHHHHH
IASFSYNEAVPVVDGNVFRVLSRYFDIESDIALPASKKEFAALAYELMPKNDPATFNQAI
HHHCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
MEFGALQCVPKSPNCTICIFNESCLALQKKKVDILPVKSKKVKITNRFFNYFVLEDSLGN
HHHCCEEEECCCCCEEEEEECCHHHHHHHCCCEEEECCCCEEEEEEEEEEEEEEECCCCC
TAIQKRTAKGIWHNLYEFPLLETSEIVDFDYISNAVQNQVFPVYTILSVEECAEAAVIHK
HHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHH
LSHQHLHIQFWKIKIKENIKEGIEFEKIKTFPFPIVIYNFIEKL
HCCCEEEEEEEEEEEHHHHHCCCCCHHEECCCCHHHHHHHHHHC
>Mature Secondary Structure
MNFHNRLIKWYLQNKRDLPWRKTANPYHIWLSEIMLQQTRVVQGMPYFFAFTQEFPTVFD
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEHHHCCHHHH
LANASEEQVLKLWQGLGYYSRARNLHNTAKYIAYELNGVFPETYKELLNLKGVGEYTAAA
HCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCHHHHHH
IASFSYNEAVPVVDGNVFRVLSRYFDIESDIALPASKKEFAALAYELMPKNDPATFNQAI
HHHCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
MEFGALQCVPKSPNCTICIFNESCLALQKKKVDILPVKSKKVKITNRFFNYFVLEDSLGN
HHHCCEEEECCCCCEEEEEECCHHHHHHHCCCEEEECCCCEEEEEEEEEEEEEEECCCCC
TAIQKRTAKGIWHNLYEFPLLETSEIVDFDYISNAVQNQVFPVYTILSVEECAEAAVIHK
HHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHH
LSHQHLHIQFWKIKIKENIKEGIEFEKIKTFPFPIVIYNFIEKL
HCCCEEEEEEEEEEEHHHHHCCCCCHHEECCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]