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The map label for this gene is pth [H]

Identifier: 146298889

GI number: 146298889

Start: 1276305

End: 1276982

Strand: Direct

Name: pth [H]

Synonym: Fjoh_1128

Alternate gene names: 146298889

Gene position: 1276305-1276982 (Clockwise)

Preceding gene: 146298888

Following gene: 146298890

Centisome position: 20.93

GC content: 32.3

Gene sequence:

>678_bases
ATGATAAAATGGATAACAAAACTGTTTTCATCAATACCAAAAGAAGAGAACACAGAAGATAATATAAAACCGGAAGTTCA
CGAACACCAAAAAAACAATATAAAAAACGTGAGTAAAAAATATTTAATCGTAGGATTAGGAAACATAGGCGCTGAATACG
TAAACACGCGACACAATATTGGATTTAAAGTGTTAGACTTTTTGGCCAAAAAAGAAGGACTTTCATTCGAAACCGTAAAA
TTAGGTTCTTTGGCTGAATACAAATTCAAAGGCAGAACTTTCTTTCTGCTTAAACCAAATACTTACATGAATTTAAGCGG
AAAGGCTGTAAAATATTGGATGGATAAGGAAAATATTCCATTAGAGAATATTTTGGTTATTACAGACGATTTAAATCTTT
CTTTTGGAACAATTCGTATCAAGCCAAAAGGAAGCGATGGTGGTCACAACGGACTTAAAAACATCAATTTAGTTCTAAAT
ACACAAAATTATACCCGATATAGATTTGGTATCAGCGATCAATTCAAAAAAGGACAGCAGATAGATTATGTTTTAGGAGA
ATGGAATGCTGAAGAAGAAGCAAAACTGCCTGAGCGTTTAGAAGTTTCAGCAGAAATTATAAAAACTTTTGGAACGGCAG
GTTTAGAAAATACCATGACGACATTTAATGGAAAATAA

Upstream 100 bases:

>100_bases
GGTTAAATCACAAATGGTAAACAATTATCTAATTCCTACATTCCCAAATTATCTAATTATCCAATTGCCACATTCTCTAA
TTAATCTTACTTTTGCAAAC

Downstream 100 bases:

>100_bases
AGATTTTCAGATGTTTATATTGTAAAAATGTAAATTATCAGTGAATTTAATTCAATTATAACGAAATAGTATTTTCAATT
CCAAAGTTAAATGTCTAAAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIKWITKLFSSIPKEENTEDNIKPEVHEHQKNNIKNVSKKYLIVGLGNIGAEYVNTRHNIGFKVLDFLAKKEGLSFETVK
LGSLAEYKFKGRTFFLLKPNTYMNLSGKAVKYWMDKENIPLENILVITDDLNLSFGTIRIKPKGSDGGHNGLKNINLVLN
TQNYTRYRFGISDQFKKGQQIDYVLGEWNAEEEAKLPERLEVSAEIIKTFGTAGLENTMTTFNGK

Sequences:

>Translated_225_residues
MIKWITKLFSSIPKEENTEDNIKPEVHEHQKNNIKNVSKKYLIVGLGNIGAEYVNTRHNIGFKVLDFLAKKEGLSFETVK
LGSLAEYKFKGRTFFLLKPNTYMNLSGKAVKYWMDKENIPLENILVITDDLNLSFGTIRIKPKGSDGGHNGLKNINLVLN
TQNYTRYRFGISDQFKKGQQIDYVLGEWNAEEEAKLPERLEVSAEIIKTFGTAGLENTMTTFNGK
>Mature_225_residues
MIKWITKLFSSIPKEENTEDNIKPEVHEHQKNNIKNVSKKYLIVGLGNIGAEYVNTRHNIGFKVLDFLAKKEGLSFETVK
LGSLAEYKFKGRTFFLLKPNTYMNLSGKAVKYWMDKENIPLENILVITDDLNLSFGTIRIKPKGSDGGHNGLKNINLVLN
TQNYTRYRFGISDQFKKGQQIDYVLGEWNAEEEAKLPERLEVSAEIIKTFGTAGLENTMTTFNGK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=177, Percent_Identity=27.683615819209, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787455, Length=177, Percent_Identity=38.9830508474576, Blast_Score=85, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 25642; Mature: 25642

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKWITKLFSSIPKEENTEDNIKPEVHEHQKNNIKNVSKKYLIVGLGNIGAEYVNTRHNI
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCC
GFKVLDFLAKKEGLSFETVKLGSLAEYKFKGRTFFLLKPNTYMNLSGKAVKYWMDKENIP
CHHHHHHHHHHCCCCEEEEECCCEEEEEECCCEEEEECCCEEEECCCCEEEEEECCCCCC
LENILVITDDLNLSFGTIRIKPKGSDGGHNGLKNINLVLNTQNYTRYRFGISDQFKKGQQ
CCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHCCCCE
IDYVLGEWNAEEEAKLPERLEVSAEIIKTFGTAGLENTMTTFNGK
EEEEEECCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEECCCC
>Mature Secondary Structure
MIKWITKLFSSIPKEENTEDNIKPEVHEHQKNNIKNVSKKYLIVGLGNIGAEYVNTRHNI
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCC
GFKVLDFLAKKEGLSFETVKLGSLAEYKFKGRTFFLLKPNTYMNLSGKAVKYWMDKENIP
CHHHHHHHHHHCCCCEEEEECCCEEEEEECCCEEEEECCCEEEECCCCEEEEEECCCCCC
LENILVITDDLNLSFGTIRIKPKGSDGGHNGLKNINLVLNTQNYTRYRFGISDQFKKGQQ
CCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHCCCCE
IDYVLGEWNAEEEAKLPERLEVSAEIIKTFGTAGLENTMTTFNGK
EEEEEECCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA