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The map label for this gene is strD [H]

Identifier: 146298825

GI number: 146298825

Start: 1207284

End: 1208300

Strand: Direct

Name: strD [H]

Synonym: Fjoh_1064

Alternate gene names: 146298825

Gene position: 1207284-1208300 (Clockwise)

Preceding gene: 146298824

Following gene: 146298826

Centisome position: 19.8

GC content: 35.0

Gene sequence:

>1017_bases
ATGAAAATAATCGTCCCAATGGCAGGTCGCGGCTCAAGACTTCGCCCACATACATTAACAGTTCCAAAACCATTAATTCC
AGTTGCTGGAAAATCAATCGTTCACCGTTTGGTTGAAGATATTGCCAAAATATTAAAAGAGCCAATCGAAGAAGTGGCTT
TTATTCTGGGCGATGAAGCTTTTTTTGGAGCAGATGTAGTAGAAAGTCTTGAAGATTTAGCAAAAGGACTTGGAGCAAAA
GCTTCTATATATCGTCAGGATCAGCCTTTAGGAACAGGACACGCTATTATGTGTGCAAAAGATTCTTTATCAGGACCTGC
AGTTATCGCTTATGCAGATACTTTAATCAGAGCCGATTTTGAACTTGATCCTTCTGCAGATGCTGTAATCTGGGTAAAAC
AAGTAGAACAGCCTGAAGCTTTTGGAGTTGTAAAATTAAATCAGAATACTGAAATTATAGAATTGGTTGAAAAACCAAAA
GAGTTTGTAAGTGATTTAGCCGTTATTGGAATTTACTATTTTAAAGAAGTCGGCGATTTGAAAAAAGAACTTCAAGGCGT
TTTAGACAACAACATTCAAAATGGAGGAGAATACCAAATTAACGACGGAATCAAAGCCATGATGGCAAACGGTAAAGTTT
TTAAAACCGGAAGCGTTGACGAATGGATGGACTGTGGAAACAAAGATGTTACAGTAGAAACTAATACAAGAATGTTAGGC
TTTTTACATAATGACGGAGAACATTTAGTAGATCAAAATGTGGTATTAGATAATTCTACTATTATTCCACCATGTTTTAT
TGGAGAAAATGTAGTACTTAAAAACACCACAATCGGGCCTAATGTTTCGATAGGAAATGGATGTCATGTAACAGACAGTA
CTATTAAAAATAGCTTAATACAAACGTATTCTCAAATAAAAAATGCTAACTTAGATAATGCAATGATTGGAAATCATGTG
AGTTATGATGGAAAATTTACCAGTATAAGCATTGGAGATTATTCAGTTTTAGAATAA

Upstream 100 bases:

>100_bases
AATTACTAAATGTTGTAGAATTCTCTGCGAATTTTAAAATTAAAACTTGAACTAACCAAACAGGAGATTTTTAAATCTTC
ACACATAAAAATAGAATTAC

Downstream 100 bases:

>100_bases
AAAATAAATTCGTTTTCGTATAAATGAAATCGTAAAAAGATGAAAAAAAGGGTTTTGATAATTTTATTTTTTGCTTTGTT
AAGCAATGCAGCTTCGGTTT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKIIVPMAGRGSRLRPHTLTVPKPLIPVAGKSIVHRLVEDIAKILKEPIEEVAFILGDEAFFGADVVESLEDLAKGLGAK
ASIYRQDQPLGTGHAIMCAKDSLSGPAVIAYADTLIRADFELDPSADAVIWVKQVEQPEAFGVVKLNQNTEIIELVEKPK
EFVSDLAVIGIYYFKEVGDLKKELQGVLDNNIQNGGEYQINDGIKAMMANGKVFKTGSVDEWMDCGNKDVTVETNTRMLG
FLHNDGEHLVDQNVVLDNSTIIPPCFIGENVVLKNTTIGPNVSIGNGCHVTDSTIKNSLIQTYSQIKNANLDNAMIGNHV
SYDGKFTSISIGDYSVLE

Sequences:

>Translated_338_residues
MKIIVPMAGRGSRLRPHTLTVPKPLIPVAGKSIVHRLVEDIAKILKEPIEEVAFILGDEAFFGADVVESLEDLAKGLGAK
ASIYRQDQPLGTGHAIMCAKDSLSGPAVIAYADTLIRADFELDPSADAVIWVKQVEQPEAFGVVKLNQNTEIIELVEKPK
EFVSDLAVIGIYYFKEVGDLKKELQGVLDNNIQNGGEYQINDGIKAMMANGKVFKTGSVDEWMDCGNKDVTVETNTRMLG
FLHNDGEHLVDQNVVLDNSTIIPPCFIGENVVLKNTTIGPNVSIGNGCHVTDSTIKNSLIQTYSQIKNANLDNAMIGNHV
SYDGKFTSISIGDYSVLE
>Mature_338_residues
MKIIVPMAGRGSRLRPHTLTVPKPLIPVAGKSIVHRLVEDIAKILKEPIEEVAFILGDEAFFGADVVESLEDLAKGLGAK
ASIYRQDQPLGTGHAIMCAKDSLSGPAVIAYADTLIRADFELDPSADAVIWVKQVEQPEAFGVVKLNQNTEIIELVEKPK
EFVSDLAVIGIYYFKEVGDLKKELQGVLDNNIQNGGEYQINDGIKAMMANGKVFKTGSVDEWMDCGNKDVTVETNTRMLG
FLHNDGEHLVDQNVVLDNSTIIPPCFIGENVVLKNTTIGPNVSIGNGCHVTDSTIKNSLIQTYSQIKNANLDNAMIGNHV
SYDGKFTSISIGDYSVLE

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=344, Percent_Identity=25.2906976744186, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI11761621, Length=331, Percent_Identity=25.9818731117825, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1790224, Length=250, Percent_Identity=26, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=327, Percent_Identity=25.3822629969419, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=340, Percent_Identity=25.8823529411765, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21355443, Length=340, Percent_Identity=26.7647058823529, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24644084, Length=340, Percent_Identity=26.7647058823529, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 36756; Mature: 36756

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVPMAGRGSRLRPHTLTVPKPLIPVAGKSIVHRLVEDIAKILKEPIEEVAFILGDEA
CEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FFGADVVESLEDLAKGLGAKASIYRQDQPLGTGHAIMCAKDSLSGPAVIAYADTLIRADF
HCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEECCCCCCCEEEEEEHHHHEECC
ELDPSADAVIWVKQVEQPEAFGVVKLNQNTEIIELVEKPKEFVSDLAVIGIYYFKEVGDL
CCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKELQGVLDNNIQNGGEYQINDGIKAMMANGKVFKTGSVDEWMDCGNKDVTVETNTRMLG
HHHHHHHHHCCCCCCCCEEECCCCEEEEECCEEEECCCCHHHHHCCCCEEEEEECCEEEE
FLHNDGEHLVDQNVVLDNSTIIPPCFIGENVVLKNTTIGPNVSIGNGCHVTDSTIKNSLI
EEECCCCHHHCCCEEECCCCCCCCEECCCCEEEECCCCCCCCCCCCCCEECHHHHHHHHH
QTYSQIKNANLDNAMIGNHVSYDGKFTSISIGDYSVLE
HHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKIIVPMAGRGSRLRPHTLTVPKPLIPVAGKSIVHRLVEDIAKILKEPIEEVAFILGDEA
CEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FFGADVVESLEDLAKGLGAKASIYRQDQPLGTGHAIMCAKDSLSGPAVIAYADTLIRADF
HCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEECCCCCCCEEEEEEHHHHEECC
ELDPSADAVIWVKQVEQPEAFGVVKLNQNTEIIELVEKPKEFVSDLAVIGIYYFKEVGDL
CCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKELQGVLDNNIQNGGEYQINDGIKAMMANGKVFKTGSVDEWMDCGNKDVTVETNTRMLG
HHHHHHHHHCCCCCCCCEEECCCCEEEEECCEEEECCCCHHHHHCCCCEEEEEECCEEEE
FLHNDGEHLVDQNVVLDNSTIIPPCFIGENVVLKNTTIGPNVSIGNGCHVTDSTIKNSLI
EEECCCCHHHCCCEEECCCCCCCCEECCCCEEEECCCCCCCCCCCCCCEECHHHHHHHHH
QTYSQIKNANLDNAMIGNHVSYDGKFTSISIGDYSVLE
HHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]