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The map label for this gene is luxQ [H]

Identifier: 146298400

GI number: 146298400

Start: 698889

End: 701330

Strand: Direct

Name: luxQ [H]

Synonym: Fjoh_0637

Alternate gene names: 146298400

Gene position: 698889-701330 (Clockwise)

Preceding gene: 146298399

Following gene: 146298413

Centisome position: 11.46

GC content: 32.15

Gene sequence:

>2442_bases
ATGGAGAGCAAAAAAAGTTACACAGCACTCAAAGTTCTATTCAGCTATGTTGCATTACTTGCTTTGGTTGTAACTGTAGG
GTGGTTTTTATATTCTGAAAATGTAGTTTATAAAAAACTGGAAGATAAAATTGCTCAGGAAAAAACCAAAATCCTGCGTG
TAAGTAAATTGTTTTCGAATGTTTACAAAACAGAAAGTTTAGCCAGACAAACCATTCAGACTAATTCTGAAAAAGATTTT
AAAAGCTACCTTATCGAAACCGATTCTTTAAAAGCCAGAATTGACACTCTAAAACAAATCGTTACCACAGAATATCAAAA
AACACTTTTGGATAGTGTAACGTATTTATTGTCTGAAAAAACAGAAAACATCAGGCAGTTAAAAACCATAAAAAACAAAG
CCGAAGATGAAGTCTCTGTCAATAATGCTATTGATGAGATTACAAAAATGGAGTTTAACCTTCGAAAACTGGAACTTCAG
GATTTTACCAAAAATCCAAATGAGTTAGGAAGTTATCAGCGAAATGTACTGCAGAAATATGTGGATTATTTAAATCAAAA
TATTCCCGACGACAGCACTAACACATTGAGTAAAAAAGCATCGGATTCTATTTTGGCCAATTCTAAAAAACTGCTCAGCA
ACGTAAAAATGAAAGCAGAAAAGAAAAAGGAAACGCTGAATTTTGAAGAAAATAAATTGTTGAAAAATGAAATTGCAATT
TCAGACCAGCTTCGAAAAGTGCTTCGTATTATAGAACGAGAAATTATAATCAACTCAATAAAAAACAATTCCTTAAAAGA
AAAATCACTTAAAAAAGTCAACGAAATTGTGACGGCTTCGGCAATTGCAGGTTTAATTTTGACTCTGTTTTTTTCTGTTT
TAATTGTAAGCGATTATTCAAAATCGCAGGTGTATAAAAAACAGCTTGAGATTGCGAATTTCAAAACCAAGAATTTATTA
AAAAGCCGTGAACAATTAATCTCGACGGTAAGTCATGATTTGAAAACGCCTTTGAGTACTATTGTGGGCTATTCTGAACT
TTTGGGTAATTCTGATATTAATACGAAACAGTCGTATTTTATTAAAAACATCAAAAATTCATCTGAATACATTACACAGC
TGGTTCAGGATTTATTAGACTTTTCGAGAATTGAAGCCGGAAAAATCACTATTGAGAAAGTTCCATTTTTTCTCCCTGAA
ATTATTGAAGATACAGCCCGAAATATCCAGACAGTTTACAAACAAAAAAACATTGATTTGATTATTAATGTAGATGAAAA
ACTGAACACGAGAGTTGTAGGCGATCCGTTTCGACTGAAACAGATTTTGAGCAATATTATTGGGAATGCTTATAAATTTA
CCGAAGAAGGTCATATCAAAATCAGTTCGTATGTTAGTGAAAACGAAAACTTTTTTGTTATTACAATTGAAGATACCGGA
ATTGGAATTGAGAAAGGCAATCTAAAACTCGTTTTTGAAGAGTTTGCCCAAGCGAATGAAAATATCGAAAAGAAATATGG
CGGAACTGGTTTAGGCCTTTCTATCTGCCAAAAGATAATTTCATTTATGGGCGGAAGAATTAGTCTGGAAAGTACTTTTG
GCAAAGGCAGTACATTTGAAATTAAAGTTCCTTTGGTATTTGATCACAACGAAATTACGGTTGAAGAAATCAAGCGAAAC
ATTAATCGAAATACAAAAAAACAAACTTTCATTGTTATTGATGATGATATTAATCTGCTCAATTTAACAAGCGGTGTTTT
AAGACAGGAAAACCACGAAGTATTTTCTTTTACCAGCGCCGGAAAAGCTCTGGAAGCAATTCAGAATACTAAATTCGATT
TTGTGATTACCGATATTCAAATGCCGGAAATTGATGGTTTTATGTTTTTGGAAAAACTTCGCAATTCGTCAAACGGTATA
TATAAAAATCAGCCGGTAATTGCTTTAACCGGAAGAACTGATCTCGATTCTGCTATTTACACCAGAGCTGGTTTTACAAC
GGTAATTAAAAAACCTTATTCTCCAAGAATACTATTAGAAACCATTCAGAATATTTTAGATAATGAAACGCTTCCTGAAG
TTGAAATAAATGATCCCGCAGAGGTTACTTCGCCTCAATTGTATTCGTTAGAAACTCTAAAAGATTTTTTGGGTAATGAT
AATGATGCTTTGAATGATGTTTTAAAAGCTTTTATAATAAGCAGTAACGAAAATTTAGATTTACTTGAAAAAGCGGTTAA
TGAAGAAAATATTCCCGAAATAAATTCTATAGCACACCGAATTGCGCCAATGTTCAAACAGATAGAAGCCCGAGATATTG
GGACAATATTAAAAACATTAGAGCAGAATAATCTGGAAATTTCAGATTTAAGGGATATTTATGCTGCTTTAAAAGCAAAA
ACAACTAAACTATTTACTGCTTTAGAACAGGAAATAGTTTAA

Upstream 100 bases:

>100_bases
TATAAATATTTGGTTTATATTTCCTTTTCTTAAATTGAAATTTTAGATAAATTGCAAGGAATTCAAATATTAAAAAACTT
CCCCAACCCCAATAAATATT

Downstream 100 bases:

>100_bases
TCGATATTGTATTGCTTTAATTTATTGTAAAGTGTTTTTCTGGTAATTTTTAAAAGTTTTGCAGCTTCAGATTTGTTGTT
TTGAGTTCTGTTAAGCGCCT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MESKKSYTALKVLFSYVALLALVVTVGWFLYSENVVYKKLEDKIAQEKTKILRVSKLFSNVYKTESLARQTIQTNSEKDF
KSYLIETDSLKARIDTLKQIVTTEYQKTLLDSVTYLLSEKTENIRQLKTIKNKAEDEVSVNNAIDEITKMEFNLRKLELQ
DFTKNPNELGSYQRNVLQKYVDYLNQNIPDDSTNTLSKKASDSILANSKKLLSNVKMKAEKKKETLNFEENKLLKNEIAI
SDQLRKVLRIIEREIIINSIKNNSLKEKSLKKVNEIVTASAIAGLILTLFFSVLIVSDYSKSQVYKKQLEIANFKTKNLL
KSREQLISTVSHDLKTPLSTIVGYSELLGNSDINTKQSYFIKNIKNSSEYITQLVQDLLDFSRIEAGKITIEKVPFFLPE
IIEDTARNIQTVYKQKNIDLIINVDEKLNTRVVGDPFRLKQILSNIIGNAYKFTEEGHIKISSYVSENENFFVITIEDTG
IGIEKGNLKLVFEEFAQANENIEKKYGGTGLGLSICQKIISFMGGRISLESTFGKGSTFEIKVPLVFDHNEITVEEIKRN
INRNTKKQTFIVIDDDINLLNLTSGVLRQENHEVFSFTSAGKALEAIQNTKFDFVITDIQMPEIDGFMFLEKLRNSSNGI
YKNQPVIALTGRTDLDSAIYTRAGFTTVIKKPYSPRILLETIQNILDNETLPEVEINDPAEVTSPQLYSLETLKDFLGND
NDALNDVLKAFIISSNENLDLLEKAVNEENIPEINSIAHRIAPMFKQIEARDIGTILKTLEQNNLEISDLRDIYAALKAK
TTKLFTALEQEIV

Sequences:

>Translated_813_residues
MESKKSYTALKVLFSYVALLALVVTVGWFLYSENVVYKKLEDKIAQEKTKILRVSKLFSNVYKTESLARQTIQTNSEKDF
KSYLIETDSLKARIDTLKQIVTTEYQKTLLDSVTYLLSEKTENIRQLKTIKNKAEDEVSVNNAIDEITKMEFNLRKLELQ
DFTKNPNELGSYQRNVLQKYVDYLNQNIPDDSTNTLSKKASDSILANSKKLLSNVKMKAEKKKETLNFEENKLLKNEIAI
SDQLRKVLRIIEREIIINSIKNNSLKEKSLKKVNEIVTASAIAGLILTLFFSVLIVSDYSKSQVYKKQLEIANFKTKNLL
KSREQLISTVSHDLKTPLSTIVGYSELLGNSDINTKQSYFIKNIKNSSEYITQLVQDLLDFSRIEAGKITIEKVPFFLPE
IIEDTARNIQTVYKQKNIDLIINVDEKLNTRVVGDPFRLKQILSNIIGNAYKFTEEGHIKISSYVSENENFFVITIEDTG
IGIEKGNLKLVFEEFAQANENIEKKYGGTGLGLSICQKIISFMGGRISLESTFGKGSTFEIKVPLVFDHNEITVEEIKRN
INRNTKKQTFIVIDDDINLLNLTSGVLRQENHEVFSFTSAGKALEAIQNTKFDFVITDIQMPEIDGFMFLEKLRNSSNGI
YKNQPVIALTGRTDLDSAIYTRAGFTTVIKKPYSPRILLETIQNILDNETLPEVEINDPAEVTSPQLYSLETLKDFLGND
NDALNDVLKAFIISSNENLDLLEKAVNEENIPEINSIAHRIAPMFKQIEARDIGTILKTLEQNNLEISDLRDIYAALKAK
TTKLFTALEQEIV
>Mature_813_residues
MESKKSYTALKVLFSYVALLALVVTVGWFLYSENVVYKKLEDKIAQEKTKILRVSKLFSNVYKTESLARQTIQTNSEKDF
KSYLIETDSLKARIDTLKQIVTTEYQKTLLDSVTYLLSEKTENIRQLKTIKNKAEDEVSVNNAIDEITKMEFNLRKLELQ
DFTKNPNELGSYQRNVLQKYVDYLNQNIPDDSTNTLSKKASDSILANSKKLLSNVKMKAEKKKETLNFEENKLLKNEIAI
SDQLRKVLRIIEREIIINSIKNNSLKEKSLKKVNEIVTASAIAGLILTLFFSVLIVSDYSKSQVYKKQLEIANFKTKNLL
KSREQLISTVSHDLKTPLSTIVGYSELLGNSDINTKQSYFIKNIKNSSEYITQLVQDLLDFSRIEAGKITIEKVPFFLPE
IIEDTARNIQTVYKQKNIDLIINVDEKLNTRVVGDPFRLKQILSNIIGNAYKFTEEGHIKISSYVSENENFFVITIEDTG
IGIEKGNLKLVFEEFAQANENIEKKYGGTGLGLSICQKIISFMGGRISLESTFGKGSTFEIKVPLVFDHNEITVEEIKRN
INRNTKKQTFIVIDDDINLLNLTSGVLRQENHEVFSFTSAGKALEAIQNTKFDFVITDIQMPEIDGFMFLEKLRNSSNGI
YKNQPVIALTGRTDLDSAIYTRAGFTTVIKKPYSPRILLETIQNILDNETLPEVEINDPAEVTSPQLYSLETLKDFLGND
NDALNDVLKAFIISSNENLDLLEKAVNEENIPEINSIAHRIAPMFKQIEARDIGTILKTLEQNNLEISDLRDIYAALKAK
TTKLFTALEQEIV

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=411, Percent_Identity=26.5206812652068, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=33.8709677419355, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1788713, Length=460, Percent_Identity=26.5217391304348, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=34.2222222222222, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI48994928, Length=400, Percent_Identity=27.5, Blast_Score=153, Evalue=5e-38,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=28.7610619469027, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=29.3859649122807, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=271, Percent_Identity=28.4132841328413, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=25.7777777777778, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=28.3842794759825, Blast_Score=83, Evalue=8e-17,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=25, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=295, Percent_Identity=24.7457627118644, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=24.6808510638298, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=29.2452830188679, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1790551, Length=204, Percent_Identity=25, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786783, Length=217, Percent_Identity=21.1981566820277, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=81, Percent_Identity=45.679012345679, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 92470; Mature: 92470

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]