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The map label for this gene is coxA [H]

Identifier: 146284475

GI number: 146284475

Start: 4518919

End: 4520445

Strand: Direct

Name: coxA [H]

Synonym: PST_4164

Alternate gene names: 146284475

Gene position: 4518919-4520445 (Clockwise)

Preceding gene: 146284474

Following gene: 146284476

Centisome position: 98.94

GC content: 63.39

Gene sequence:

>1527_bases
ATGTACCTGTGGTTCAGCTTCTGCGCCTTCCTGCTCGGCGGCTCGATGGCCATGGTGATCCGCGCCGAGCTGTTCCAGCC
GGGTCTGCAGATCGTGCAGCCGGAATTCTTCAACCAGATGACCACCATGCACGGCCTGATCATGGTGTTCGGCGCGGTGA
TGCCGGCCTTCGTCGGCCTGGCCAACTGGATGATCCCGCTGATGATCGGCGCACCGGACATGGCGCTGCCGCGGATGAAC
AACTTCAGTTTCTGGCTGCTGCCGGCCGCCTTCGGCCTGCTGGTCTCGACCCTGTTCATGGAAGGCGGCGGGCCGAACTT
CGGCTGGACCTTCTATGCGCCGCTGTCGACGACCTACGCGCCGGAGTCGGTGACCTTCTTCATCTTCGCCATCCACCTGA
TGGGCATCAGCTCGATCATGGGTGCGATCAACGTGATCGCCACCATCCTCAACCTGCGCGCGCCAGGCATGACGCTGATG
AAGATGCCGCTGTTCGTCTGGACCTGGCTGATCACCGCCTTCCTCCTGATCGCGGTGATGCCGGTGCTGGCGGGCGTGGT
GACCATGATGCTGATGGACATCCACTTCGGCACCAGCTTCTTCAGCGCCGCCGGGGGTGGCGACCCGGTGCTGTTCCAGC
ACGTGTTCTGGTTCTTCGGCCATCCCGAGGTGTACATCATGATCCTGCCGGCCTTTGGCGCGGTCAGCTCGATCATCCCG
GCGTTCAGCCGCAAGCCGCTGTTCGGCTACACCTCGATGGTTTACGCCACCGGCGCGATCGCCTTCCTCTCCTTCATCGT
CTGGGCGCACCACATGTTCACCGTCGGCATCCCGCTGACCGGCGAGCTGTTCTTCATGTACGCCACCATGCTGATCGCCG
TACCCACCGGGGTGAAGGTGTTCAACTGGGTGTCGACGATGTGGCGCGGCTCGCTGACCTTCGAGGCGCCGATGCTGTTC
GCCGTGGCCTTCGTCATCCTCTTCACCATCGGCGGCTTCTCCGGGCTGATGCTGGCCATCGCCCCGGCGGACTTCCAGTA
CCACGACACCTACTTCGTGGTGGCGCACTTCCACTACGTGCTGGTGCCGGGGGCGATCTTCGGCATCTTCGCCTCGGCCT
ACTACTGGCTGCCGAAGTGGACCGGGCACATGTATGACGAGACCCTGGCCAAGCTGCATTTCTGGATGAGCTTCATCGGC
ATGAACCTGGCGTTCTTCCCGATGCACTTCGTTGGCCTGGCCGGCATGCCGCGACGCATCCCCGACTACAACATGATGTT
TGCCAACTTCAACATGGTCTCCAGCGTCGGCGCCTTCATGTTCGGCGCCACCCAGCTCTTGTTCCTGTTCATCGTCATCA
AGTGCATCCGCGGCGGCGCACCCGCACCGGCCAAGCCCTGGGACGGCGCAGAGGGACTGGAATGGAGCGTGCCCTCGCCG
GCGCCTTACCACACCTTCCAAGTGCCGCCGGACATGAGCGATGTGCACGAGCACCGCAAGGGCACCGGCGGGGAGCTGAC
GCCGTGA

Upstream 100 bases:

>100_bases
GATCGACGACCATGGTCATGTCGGGCATGACCACCACCACGGCCCGGCGAAGGGGCTCTCGCGCTGGCTGCTGACCACCA
ATCACAAGGACATCGGCTCG

Downstream 100 bases:

>100_bases
GCATGCATCGGGGTGTGACCGGAGGTTGCCGGGCCGCCCGCAACCCTCGATCGGGGAGGCTGCCATGAACGAGGCCCTGT
CCACTCGGCGGCTGGTCCGC

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MYLWFSFCAFLLGGSMAMVIRAELFQPGLQIVQPEFFNQMTTMHGLIMVFGAVMPAFVGLANWMIPLMIGAPDMALPRMN
NFSFWLLPAAFGLLVSTLFMEGGGPNFGWTFYAPLSTTYAPESVTFFIFAIHLMGISSIMGAINVIATILNLRAPGMTLM
KMPLFVWTWLITAFLLIAVMPVLAGVVTMMLMDIHFGTSFFSAAGGGDPVLFQHVFWFFGHPEVYIMILPAFGAVSSIIP
AFSRKPLFGYTSMVYATGAIAFLSFIVWAHHMFTVGIPLTGELFFMYATMLIAVPTGVKVFNWVSTMWRGSLTFEAPMLF
AVAFVILFTIGGFSGLMLAIAPADFQYHDTYFVVAHFHYVLVPGAIFGIFASAYYWLPKWTGHMYDETLAKLHFWMSFIG
MNLAFFPMHFVGLAGMPRRIPDYNMMFANFNMVSSVGAFMFGATQLLFLFIVIKCIRGGAPAPAKPWDGAEGLEWSVPSP
APYHTFQVPPDMSDVHEHRKGTGGELTP

Sequences:

>Translated_508_residues
MYLWFSFCAFLLGGSMAMVIRAELFQPGLQIVQPEFFNQMTTMHGLIMVFGAVMPAFVGLANWMIPLMIGAPDMALPRMN
NFSFWLLPAAFGLLVSTLFMEGGGPNFGWTFYAPLSTTYAPESVTFFIFAIHLMGISSIMGAINVIATILNLRAPGMTLM
KMPLFVWTWLITAFLLIAVMPVLAGVVTMMLMDIHFGTSFFSAAGGGDPVLFQHVFWFFGHPEVYIMILPAFGAVSSIIP
AFSRKPLFGYTSMVYATGAIAFLSFIVWAHHMFTVGIPLTGELFFMYATMLIAVPTGVKVFNWVSTMWRGSLTFEAPMLF
AVAFVILFTIGGFSGLMLAIAPADFQYHDTYFVVAHFHYVLVPGAIFGIFASAYYWLPKWTGHMYDETLAKLHFWMSFIG
MNLAFFPMHFVGLAGMPRRIPDYNMMFANFNMVSSVGAFMFGATQLLFLFIVIKCIRGGAPAPAKPWDGAEGLEWSVPSP
APYHTFQVPPDMSDVHEHRKGTGGELTP
>Mature_508_residues
MYLWFSFCAFLLGGSMAMVIRAELFQPGLQIVQPEFFNQMTTMHGLIMVFGAVMPAFVGLANWMIPLMIGAPDMALPRMN
NFSFWLLPAAFGLLVSTLFMEGGGPNFGWTFYAPLSTTYAPESVTFFIFAIHLMGISSIMGAINVIATILNLRAPGMTLM
KMPLFVWTWLITAFLLIAVMPVLAGVVTMMLMDIHFGTSFFSAAGGGDPVLFQHVFWFFGHPEVYIMILPAFGAVSSIIP
AFSRKPLFGYTSMVYATGAIAFLSFIVWAHHMFTVGIPLTGELFFMYATMLIAVPTGVKVFNWVSTMWRGSLTFEAPMLF
AVAFVILFTIGGFSGLMLAIAPADFQYHDTYFVVAHFHYVLVPGAIFGIFASAYYWLPKWTGHMYDETLAKLHFWMSFIG
MNLAFFPMHFVGLAGMPRRIPDYNMMFANFNMVSSVGAFMFGATQLLFLFIVIKCIRGGAPAPAKPWDGAEGLEWSVPSP
APYHTFQVPPDMSDVHEHRKGTGGELTP

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=498, Percent_Identity=48.5943775100402, Blast_Score=433, Evalue=1e-121,
Organism=Escherichia coli, GI1786634, Length=507, Percent_Identity=40.0394477317554, Blast_Score=352, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6226519, Length=521, Percent_Identity=46.6410748560461, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6226524, Length=297, Percent_Identity=50.1683501683502, Blast_Score=296, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6226523, Length=221, Percent_Identity=47.9638009049774, Blast_Score=187, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 56380; Mature: 56380

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.7 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
7.7 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLWFSFCAFLLGGSMAMVIRAELFQPGLQIVQPEFFNQMTTMHGLIMVFGAVMPAFVGL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANWMIPLMIGAPDMALPRMNNFSFWLLPAAFGLLVSTLFMEGGGPNFGWTFYAPLSTTYA
HHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
PESVTFFIFAIHLMGISSIMGAINVIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAVM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PVLAGVVTMMLMDIHFGTSFFSAAGGGDPVLFQHVFWFFGHPEVYIMILPAFGAVSSIIP
HHHHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHH
AFSRKPLFGYTSMVYATGAIAFLSFIVWAHHMFTVGIPLTGELFFMYATMLIAVPTGVKV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHH
FNWVSTMWRGSLTFEAPMLFAVAFVILFTIGGFSGLMLAIAPADFQYHDTYFVVAHFHYV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHEEEEECCCCEECCCEEEHHHHHHH
LVPGAIFGIFASAYYWLPKWTGHMYDETLAKLHFWMSFIGMNLAFFPMHFVGLAGMPRRI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
PDYNMMFANFNMVSSVGAFMFGATQLLFLFIVIKCIRGGAPAPAKPWDGAEGLEWSVPSP
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
APYHTFQVPPDMSDVHEHRKGTGGELTP
CCCCEEECCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYLWFSFCAFLLGGSMAMVIRAELFQPGLQIVQPEFFNQMTTMHGLIMVFGAVMPAFVGL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANWMIPLMIGAPDMALPRMNNFSFWLLPAAFGLLVSTLFMEGGGPNFGWTFYAPLSTTYA
HHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
PESVTFFIFAIHLMGISSIMGAINVIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAVM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PVLAGVVTMMLMDIHFGTSFFSAAGGGDPVLFQHVFWFFGHPEVYIMILPAFGAVSSIIP
HHHHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHH
AFSRKPLFGYTSMVYATGAIAFLSFIVWAHHMFTVGIPLTGELFFMYATMLIAVPTGVKV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHH
FNWVSTMWRGSLTFEAPMLFAVAFVILFTIGGFSGLMLAIAPADFQYHDTYFVVAHFHYV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHEEEEECCCCEECCCEEEHHHHHHH
LVPGAIFGIFASAYYWLPKWTGHMYDETLAKLHFWMSFIGMNLAFFPMHFVGLAGMPRRI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
PDYNMMFANFNMVSSVGAFMFGATQLLFLFIVIKCIRGGAPAPAKPWDGAEGLEWSVPSP
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
APYHTFQVPPDMSDVHEHRKGTGGELTP
CCCCEEECCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]