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The map label for this gene is coxB [H]

Identifier: 146284474

GI number: 146284474

Start: 4517686

End: 4518795

Strand: Direct

Name: coxB [H]

Synonym: PST_4163

Alternate gene names: 146284474

Gene position: 4517686-4518795 (Clockwise)

Preceding gene: 146284473

Following gene: 146284475

Centisome position: 98.91

GC content: 63.6

Gene sequence:

>1110_bases
ATGGGGCTTGGGCTTTCGGCAGTATTTGGCCAGGCCCAGGCGGCCTGGGACGTGAACATGCGCTCCGGCGCCACCGACGT
CAGTCGGTCGGTGTTCGATCTGCACATGACCATCTTCTGGATCTGCGTGGTCATCGGCGTGCTGGTGTTCGGCGTGATGA
TCTATTCGATGATCGCGCACCGCCGCTCCAAGCGTCAGCAATCGGCCAACTTCCACGAAAACACCCGCGTCGAGGTGCTC
TGGACGGTCATCCCGCTGCTGATCCTGGTGGGCATGGCGATCCCGGCGACGCGCACGCTGATCCACATCTACGACTCCAG
CGAATCGGACGTGGATGTGCAGATCACCGGCTACCAGTGGAAGTGGCACTACAAGTATCTGGGCGAGGACGTGGAGTTCT
TCAGCAACCTCACCACGCCGCGCGAGCAGATCAACAACCAGTCGCCCAAGGGCGAGCATTACCTGCTGGAAGTCGACGAG
CCGCTGGTGATCCCGGCCGGTGCCAAGGTCCGCTTCCTGATCACCGCGGCGGACGTGATCCACTCCTGGTGGGTACCGGA
TCTGGCGGTGAAGAAGGACGCCATTCCCGGTTTCATCAATGAATCCTGGACCCGCGTCGAGCAGCCGGGCATCTACCGCG
GCCAGTGCACCGAACTCTGCGGCAAGGACCACGGCTTCATGCCGGTGGTGGTGGAGGTCAAGTCGCAGGAGGACTACGCC
AGCTGGCTCGGCGAGAAGAAGGCCGAGGCCGCCAAGCTGGCTGAACTGACCAGCAAGGAATGGACGCTGGAAGAGCTCTC
CGAGCGCGGCCAGAAGGTCTACCAGACCGCCTGCGCCTCGTGCCACCAGGCCGGTGGCGAAGGCATCCCGCCGATGTTCC
CGGCCCTCAAGGGCTCGGCCATCGCCACCGGCGACGTCGAGGCGCACATCGACATAGTCGTCAACGGCAAGCCGGGCACC
GCCATGGCGGCGTTCGGCAAGCAGCTGTCGGAGGTCGATCTGGCTGCCGTCATCACCTACGAGCGCAACGCCTGGGGCAA
CAACACGGGCGACATGGTCACGCCGAAAGACGTGCTCGACTTCAAACAGGCCGAAGAAGCCACCCAGTAA

Upstream 100 bases:

>100_bases
GGTTTCCCCGGCCAGCCGATTCTCGGCGGTGCGATGGCGGTCGGCGGGATAACAAGAATCATAAGGGGAACCCGCAATGT
CTCGACATCCATGCATCTGG

Downstream 100 bases:

>100_bases
GAGGATCAGGTGATGAGTGCAGTGATCGACGACCATGGTCATGTCGGGCATGACCACCACCACGGCCCGGCGAAGGGGCT
CTCGCGCTGGCTGCTGACCA

Product: cytochrome c oxidase, subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MGLGLSAVFGQAQAAWDVNMRSGATDVSRSVFDLHMTIFWICVVIGVLVFGVMIYSMIAHRRSKRQQSANFHENTRVEVL
WTVIPLLILVGMAIPATRTLIHIYDSSESDVDVQITGYQWKWHYKYLGEDVEFFSNLTTPREQINNQSPKGEHYLLEVDE
PLVIPAGAKVRFLITAADVIHSWWVPDLAVKKDAIPGFINESWTRVEQPGIYRGQCTELCGKDHGFMPVVVEVKSQEDYA
SWLGEKKAEAAKLAELTSKEWTLEELSERGQKVYQTACASCHQAGGEGIPPMFPALKGSAIATGDVEAHIDIVVNGKPGT
AMAAFGKQLSEVDLAAVITYERNAWGNNTGDMVTPKDVLDFKQAEEATQ

Sequences:

>Translated_369_residues
MGLGLSAVFGQAQAAWDVNMRSGATDVSRSVFDLHMTIFWICVVIGVLVFGVMIYSMIAHRRSKRQQSANFHENTRVEVL
WTVIPLLILVGMAIPATRTLIHIYDSSESDVDVQITGYQWKWHYKYLGEDVEFFSNLTTPREQINNQSPKGEHYLLEVDE
PLVIPAGAKVRFLITAADVIHSWWVPDLAVKKDAIPGFINESWTRVEQPGIYRGQCTELCGKDHGFMPVVVEVKSQEDYA
SWLGEKKAEAAKLAELTSKEWTLEELSERGQKVYQTACASCHQAGGEGIPPMFPALKGSAIATGDVEAHIDIVVNGKPGT
AMAAFGKQLSEVDLAAVITYERNAWGNNTGDMVTPKDVLDFKQAEEATQ
>Mature_368_residues
GLGLSAVFGQAQAAWDVNMRSGATDVSRSVFDLHMTIFWICVVIGVLVFGVMIYSMIAHRRSKRQQSANFHENTRVEVLW
TVIPLLILVGMAIPATRTLIHIYDSSESDVDVQITGYQWKWHYKYLGEDVEFFSNLTTPREQINNQSPKGEHYLLEVDEP
LVIPAGAKVRFLITAADVIHSWWVPDLAVKKDAIPGFINESWTRVEQPGIYRGQCTELCGKDHGFMPVVVEVKSQEDYAS
WLGEKKAEAAKLAELTSKEWTLEELSERGQKVYQTACASCHQAGGEGIPPMFPALKGSAIATGDVEAHIDIVVNGKPGTA
MAAFGKQLSEVDLAAVITYERNAWGNNTGDMVTPKDVLDFKQAEEATQ

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=227, Percent_Identity=31.7180616740088, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6226540, Length=234, Percent_Identity=30.7692307692308, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 40891; Mature: 40760

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGLSAVFGQAQAAWDVNMRSGATDVSRSVFDLHMTIFWICVVIGVLVFGVMIYSMIAH
CCCCHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRSKRQQSANFHENTRVEVLWTVIPLLILVGMAIPATRTLIHIYDSSESDVDVQITGYQW
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEEEEE
KWHYKYLGEDVEFFSNLTTPREQINNQSPKGEHYLLEVDEPLVIPAGAKVRFLITAADVI
EEEHHHHCCHHHHHHCCCCCHHHHCCCCCCCCEEEEEECCCEEEECCCCEEEEEEHHHHH
HSWWVPDLAVKKDAIPGFINESWTRVEQPGIYRGQCTELCGKDHGFMPVVVEVKSQEDYA
HHCCCCCHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCHHHH
SWLGEKKAEAAKLAELTSKEWTLEELSERGQKVYQTACASCHQAGGEGIPPMFPALKGSA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCE
IATGDVEAHIDIVVNGKPGTAMAAFGKQLSEVDLAAVITYERNAWGNNTGDMVTPKDVLD
EEECCCEEEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHHH
FKQAEEATQ
HHHHHHCCC
>Mature Secondary Structure 
GLGLSAVFGQAQAAWDVNMRSGATDVSRSVFDLHMTIFWICVVIGVLVFGVMIYSMIAH
CCCHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRSKRQQSANFHENTRVEVLWTVIPLLILVGMAIPATRTLIHIYDSSESDVDVQITGYQW
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEEEEE
KWHYKYLGEDVEFFSNLTTPREQINNQSPKGEHYLLEVDEPLVIPAGAKVRFLITAADVI
EEEHHHHCCHHHHHHCCCCCHHHHCCCCCCCCEEEEEECCCEEEECCCCEEEEEEHHHHH
HSWWVPDLAVKKDAIPGFINESWTRVEQPGIYRGQCTELCGKDHGFMPVVVEVKSQEDYA
HHCCCCCHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCHHHH
SWLGEKKAEAAKLAELTSKEWTLEELSERGQKVYQTACASCHQAGGEGIPPMFPALKGSA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCE
IATGDVEAHIDIVVNGKPGTAMAAFGKQLSEVDLAAVITYERNAWGNNTGDMVTPKDVLD
EEECCCEEEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHHH
FKQAEEATQ
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA