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The map label for this gene is pgm [H]

Identifier: 146284463

GI number: 146284463

Start: 4504504

End: 4506168

Strand: Direct

Name: pgm [H]

Synonym: PST_4152

Alternate gene names: 146284463

Gene position: 4504504-4506168 (Clockwise)

Preceding gene: 146284460

Following gene: 146284465

Centisome position: 98.62

GC content: 69.01

Gene sequence:

>1665_bases
ATGAGCATCGCCCCCAACGCCGGACGCCTGCCCGACCCGCACACCCTGACTCATCTGCCGCGCCTGGTGGCGCGCTACTA
CAGCGACCGGCCGGACCCGTCCGACCCGGCGCAGCAGGTGGCGTTCGGCACCTCCGGGCATCGCGGTTCCTCGCTCAAGG
GCAGCTTCAACGAGTGGCACATCCTCGCCACCACCCAGGCGATCTGCGATTACCGCCGCCAGGAGGGCATCGACGGCCCG
CTGTTCATGGGCATGGACACCCATGCGCTGTCCGAGCCGGCGTTCGTCTCGGCACTGGAAGTGCTGGCGGCCAACGGCAT
CGAGACGCGCATCGACGCCGGTTGCCCGGAAACCGGCGGCGAGCCGGGCTATACCCCGACCCCGGCGATCTCCAACGCGA
TCCTCAGCTACAACCGCGGCCGCACGAGAGGGCTGGCCGACGGCATCGTCATCACGCCGTCGCACAACCCGCCGGGCGAT
GGCGGCTTCAAGTACAACCCCACCAATGGCGGCCCGGCCGACACCGGCGTGACCAAGTGGATTCAGGAGCGCGCCAATGC
GCTACTGGTCGCCGGTCTCGATGGCGTCAAGCGCATGGATTACCGCCAGGCGCTCAAGGCCGCCACCACCCAGCGCTTCG
ATTTCATCGACGCCTATGTCGGCGGGCTCGAGCGGGTGATCGACCTCGACGCCATCCGCGGCTCGGGCCTGAAGTTCGCT
GTCGACCCGCTGGGCGGCGCCGGTGTGCACTATTGGCCGCGCATCGCCGAGCGCTTCGGCCTGCCGCTGGAGGTGCTGTC
CACGGTGGTCGACCCGACCTTCCGCTTCATGCGCCTGGACTGGGACGGCACGATCCGCATGGACTGCAGCTCGCCGCACG
CCATGGCCGGGCTGATCGAGAACAAGGACCGCTTCGACGTGGCCTTCGCCTGCGACACCGACCATGACCGCCACGGCATC
GTCACCCGCTCCGGCGGGCTGATGAACCCCAACCATTACCTGGCGGTGGCCATCGAATACCTGTTCACCCATCGCCCGGG
CTGGAGCGCCGAGGCCGGCATCGGCAAGACGCTGGTGTCTTCGTCGATGATCGACCGTGTTGCCGCCGGCATCGACCGCC
GTCTGGTGGAGGTACCGGTGGGCTTCAAGTGGTTCGTCGACGGCCTGATGGATGGCAGCCTGGGCTTCGGCGGCGAGGAG
TCGGCCGGCGCTTCGTTCCTCGACAAGCAGGGCGGCGCCTGGTCCACCGACAAGGACGGGCTGATCCTCGGCCTGCTGGC
GGCGGAGATCACCGCAGTCACCGGCAAGGACCCGAGCGAACGCTACCAGGCGCTGACCGACCGCTTCGGCGCGCCGGTGT
ACCAGCGCATCGACGCCGCGGCCAATCGCGAGCAGAAGGCACGCCTGGGCAAGCTGTCGGCATCGCAGGTCTCGGCGAAG
GAGCTGGCCGGCCAGCCGATCACGCGCATCCTCACCGAGGCACCGGGCAACGGCGCAGCCATCGGCGGGCTGAAGGTGGA
AACGGCGAACGGCTGGTTCGCCGCGCGGCCGTCCGGCACCGAGGACGTGTACAAGATCTACGCCGAAAGCTTCGAGGGCG
AAGCGCACCTGGCACGCATCCAGGCCGAGGCCAAGGCGCTGGTGGACTCGGTGCTGGCCGGCTGA

Upstream 100 bases:

>100_bases
CGGTCTTAGCTCTGAATAAACGACGCCGACTGGCGTTTCATTCGCTCTTCGCCGCGCCCGGATCGGCCGGCGCATCGCCT
TCTTCACAAAGGACCGCCCC

Downstream 100 bases:

>100_bases
GGCTCACGGCCCCACGCCGGGCTATCGCTGCTGGCGGTCGCTGATGCTGACCGCCAGCTGTGCAGCTTCGACTTCGTCGG
TGAGGTAGCGGCTGTGGCCC

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSIAPNAGRLPDPHTLTHLPRLVARYYSDRPDPSDPAQQVAFGTSGHRGSSLKGSFNEWHILATTQAICDYRRQEGIDGP
LFMGMDTHALSEPAFVSALEVLAANGIETRIDAGCPETGGEPGYTPTPAISNAILSYNRGRTRGLADGIVITPSHNPPGD
GGFKYNPTNGGPADTGVTKWIQERANALLVAGLDGVKRMDYRQALKAATTQRFDFIDAYVGGLERVIDLDAIRGSGLKFA
VDPLGGAGVHYWPRIAERFGLPLEVLSTVVDPTFRFMRLDWDGTIRMDCSSPHAMAGLIENKDRFDVAFACDTDHDRHGI
VTRSGGLMNPNHYLAVAIEYLFTHRPGWSAEAGIGKTLVSSSMIDRVAAGIDRRLVEVPVGFKWFVDGLMDGSLGFGGEE
SAGASFLDKQGGAWSTDKDGLILGLLAAEITAVTGKDPSERYQALTDRFGAPVYQRIDAAANREQKARLGKLSASQVSAK
ELAGQPITRILTEAPGNGAAIGGLKVETANGWFAARPSGTEDVYKIYAESFEGEAHLARIQAEAKALVDSVLAG

Sequences:

>Translated_554_residues
MSIAPNAGRLPDPHTLTHLPRLVARYYSDRPDPSDPAQQVAFGTSGHRGSSLKGSFNEWHILATTQAICDYRRQEGIDGP
LFMGMDTHALSEPAFVSALEVLAANGIETRIDAGCPETGGEPGYTPTPAISNAILSYNRGRTRGLADGIVITPSHNPPGD
GGFKYNPTNGGPADTGVTKWIQERANALLVAGLDGVKRMDYRQALKAATTQRFDFIDAYVGGLERVIDLDAIRGSGLKFA
VDPLGGAGVHYWPRIAERFGLPLEVLSTVVDPTFRFMRLDWDGTIRMDCSSPHAMAGLIENKDRFDVAFACDTDHDRHGI
VTRSGGLMNPNHYLAVAIEYLFTHRPGWSAEAGIGKTLVSSSMIDRVAAGIDRRLVEVPVGFKWFVDGLMDGSLGFGGEE
SAGASFLDKQGGAWSTDKDGLILGLLAAEITAVTGKDPSERYQALTDRFGAPVYQRIDAAANREQKARLGKLSASQVSAK
ELAGQPITRILTEAPGNGAAIGGLKVETANGWFAARPSGTEDVYKIYAESFEGEAHLARIQAEAKALVDSVLAG
>Mature_553_residues
SIAPNAGRLPDPHTLTHLPRLVARYYSDRPDPSDPAQQVAFGTSGHRGSSLKGSFNEWHILATTQAICDYRRQEGIDGPL
FMGMDTHALSEPAFVSALEVLAANGIETRIDAGCPETGGEPGYTPTPAISNAILSYNRGRTRGLADGIVITPSHNPPGDG
GFKYNPTNGGPADTGVTKWIQERANALLVAGLDGVKRMDYRQALKAATTQRFDFIDAYVGGLERVIDLDAIRGSGLKFAV
DPLGGAGVHYWPRIAERFGLPLEVLSTVVDPTFRFMRLDWDGTIRMDCSSPHAMAGLIENKDRFDVAFACDTDHDRHGIV
TRSGGLMNPNHYLAVAIEYLFTHRPGWSAEAGIGKTLVSSSMIDRVAAGIDRRLVEVPVGFKWFVDGLMDGSLGFGGEES
AGASFLDKQGGAWSTDKDGLILGLLAAEITAVTGKDPSERYQALTDRFGAPVYQRIDAAANREQKARLGKLSASQVSAKE
LAGQPITRILTEAPGNGAAIGGLKVETANGWFAARPSGTEDVYKIYAESFEGEAHLARIQAEAKALVDSVLAG

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=443, Percent_Identity=27.9909706546275, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI21361621, Length=444, Percent_Identity=27.7027027027027, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI133922562, Length=420, Percent_Identity=26.4285714285714, Blast_Score=93, Evalue=8e-19,
Organism=Escherichia coli, GI1786904, Length=552, Percent_Identity=60.1449275362319, Blast_Score=643, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535441, Length=407, Percent_Identity=27.7641277641278, Blast_Score=94, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322722, Length=542, Percent_Identity=28.5977859778598, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323752, Length=575, Percent_Identity=25.2173913043478, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17864244, Length=518, Percent_Identity=25.8687258687259, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59297; Mature: 59166

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00710 PGM_PMM ; PS01067 SECE_SEC61G

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAPNAGRLPDPHTLTHLPRLVARYYSDRPDPSDPAQQVAFGTSGHRGSSLKGSFNEWH
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEE
ILATTQAICDYRRQEGIDGPLFMGMDTHALSEPAFVSALEVLAANGIETRIDAGCPETGG
EEEEHHHHHHHHHHCCCCCCEEECCCHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCC
EPGYTPTPAISNAILSYNRGRTRGLADGIVITPSHNPPGDGGFKYNPTNGGPADTGVTKW
CCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCHHHHHHH
IQERANALLVAGLDGVKRMDYRQALKAATTQRFDFIDAYVGGLERVIDLDAIRGSGLKFA
HHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VDPLGGAGVHYWPRIAERFGLPLEVLSTVVDPTFRFMRLDWDGTIRMDCSSPHAMAGLIE
ECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHHC
NKDRFDVAFACDTDHDRHGIVTRSGGLMNPNHYLAVAIEYLFTHRPGWSAEAGIGKTLVS
CCCCEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SSMIDRVAAGIDRRLVEVPVGFKWFVDGLMDGSLGFGGEESAGASFLDKQGGAWSTDKDG
HHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
LILGLLAAEITAVTGKDPSERYQALTDRFGAPVYQRIDAAANREQKARLGKLSASQVSAK
EEEEEHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHCCCHHHHHHH
ELAGQPITRILTEAPGNGAAIGGLKVETANGWFAARPSGTEDVYKIYAESFEGEAHLARI
HHCCCCHHHHHHCCCCCCEEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCHHHHHH
QAEAKALVDSVLAG
HHHHHHHHHHHHCC
>Mature Secondary Structure 
SIAPNAGRLPDPHTLTHLPRLVARYYSDRPDPSDPAQQVAFGTSGHRGSSLKGSFNEWH
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEE
ILATTQAICDYRRQEGIDGPLFMGMDTHALSEPAFVSALEVLAANGIETRIDAGCPETGG
EEEEHHHHHHHHHHCCCCCCEEECCCHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCC
EPGYTPTPAISNAILSYNRGRTRGLADGIVITPSHNPPGDGGFKYNPTNGGPADTGVTKW
CCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCHHHHHHH
IQERANALLVAGLDGVKRMDYRQALKAATTQRFDFIDAYVGGLERVIDLDAIRGSGLKFA
HHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VDPLGGAGVHYWPRIAERFGLPLEVLSTVVDPTFRFMRLDWDGTIRMDCSSPHAMAGLIE
ECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHHC
NKDRFDVAFACDTDHDRHGIVTRSGGLMNPNHYLAVAIEYLFTHRPGWSAEAGIGKTLVS
CCCCEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SSMIDRVAAGIDRRLVEVPVGFKWFVDGLMDGSLGFGGEESAGASFLDKQGGAWSTDKDG
HHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
LILGLLAAEITAVTGKDPSERYQALTDRFGAPVYQRIDAAANREQKARLGKLSASQVSAK
EEEEEHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHCCCHHHHHHH
ELAGQPITRILTEAPGNGAAIGGLKVETANGWFAARPSGTEDVYKIYAESFEGEAHLARI
HHCCCCHHHHHHCCCCCCEEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCHHHHHH
QAEAKALVDSVLAG
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8025683 [H]