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The map label for this gene is ilvD

Identifier: 146284324

GI number: 146284324

Start: 4350453

End: 4352291

Strand: Direct

Name: ilvD

Synonym: PST_4012

Alternate gene names: 146284324

Gene position: 4350453-4352291 (Clockwise)

Preceding gene: 146284322

Following gene: 146284327

Centisome position: 95.25

GC content: 66.34

Gene sequence:

>1839_bases
ATGCCTGATTACCGTTCGAAAACCTCCACGCACGGCCGCAACATGGCCGGTGCCCGGGCGCTGTGGCGCGCCACCGGCAT
GAAGGACGAAGACTTCAAGAAGCCGATCATCGCCATCGCCAACTCCTTCACCCAGTTCGTCCCCGGCCACGTGCATCTGA
AAGACATGGGCCAGCTGGTCGCCCGCGAGATCGAGAAGCACGGCGGCGTGGCCAAGGAATTCAACACCATCGCGGTCGAC
GACGGCATCGCCATGGGTCACGACGGCATGCTCTATTCGCTGCCGTCGCGCGAGATCATCGCCGACTCGGTCGAATACAT
GGTCAATGCGCATTGCGCCGACGCCATCGTCTGCATCAGCAACTGCGACAAGATCACCCCCGGCATGCTGATGGCCGCGC
TGCGCCTGAACATCCCGGTGGTGTTCGTCTCCGGCGGGCCGATGGAAGCCGGCAAGACCAAGCTGGCCAACCACGGCCTG
GACCTGGTCGACGCCATGGTGGTGGCGGCCGACGACTCCTGCTCCGACGAGAAGGTCGCCGAGTACGAGCGCAGCGCCTG
CCCGACCTGCGGCAGCTGCTCGGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAAGCCCTCGGCCTGTCCCTGC
CGGGCAACGGCACCACGCTGGCCACCCACGCCGACCGCGAGCAGCTGTTCCTGCGCGCCGGGCGTATCGCCGTCGAGCTG
TGCAAGCGTTACTACCAGGACGGCGACGAGTCCGTGCTGCCGCGCAACGTGGCCAGCCGCAAGGCCTTCGAAAACGCCAT
GACCCTGGACATCGCCATGGGCGGGTCGACCAACACCATCCTGCACCTCCTGGCCGCAGCCCAGGAAGCCGAGGTTGACT
TCGACCTGCGCGACATCGACGCGCTGTCGCGCAAGGTGCCGCAGCTGTGCAAGGTGGCGCCGAACATCCAGAAGTACCAC
ATGGAAGACGTGCACCGCGCCGGCGGCATCTTCTCCATCCTCGGCGAGCTGGCCCGCGGCGGCCTGCTGCACACCGATGC
TTCCACCGTGCACAGCCCGAGCATGGCCGATGCCATCGCCGAATGGGACATCACCCAGACCCAGGACGAAGCGGTACATA
CCTTCTTCAAGGCCGGCCCGGCGGGCATCCCGACCCAGGTCGCCTTCAGCCAGGCCACCCGCTGGCCGAGCCTGGACTTG
GATCGCGCCGAAGGCTGCATCCGCAGTGTCGAGCATGCCTATTCCCAGGAAGGCGGCCTGGCGGTGCTCTACGGCAACAT
CGCCCTCGATGGCTGCGTGGTGAAGACCGCCGGGGTGGACGAATCCATCCACGTCTTCGAAGGCACGGCGAAGATCTTCG
AGAGCCAGGACAGCGCCGTGAAGGGCATCCTCAATGACGAAGTGAAGGCTGGCGACATCGTCATCATCCGCTACGAAGGC
CCGAAGGGCGGCCCGGGCATGCAGGAAATGCTCTACCCGACCTCGTACCTGAAGTCCAAGGGCCTCGGCAAGGAATGCGC
CCTGCTCACCGACGGCCGCTTCTCCGGCGGCACCTCGGGCCTGTCCATCGGCCATGCCTCGCCGGAAGCGGCCGCGGGTG
GCGCCATCGGCCTGGTGCAGGACGGCGACAAGGTGCTGATCGACATTCCCAACCGCAGCATCCAGCTGCAGGTGTCGGAT
GAAGAGCTGGCCCACCGCCGCATCGAGCAGGACAAGAAGGGCTGGAAGCCGGCGCAGCCGCGTGCGCGCAAGGTCTCAAC
CGCGCTCAAGGCCTACGCCCTGCTGGCCACCAGCGCCGACAAGGGCGCGGTGCGCGACAAGGCGATGCTGGACGGCTGA

Upstream 100 bases:

>100_bases
CGGCCCCTTCCGAACGCACGGTCATCCTCCGTTGCATCCGGCACAGGCGTTGCTCACCATACGCATACCTCCGTTTACCT
GATTAGCCGCAGGAACCGTC

Downstream 100 bases:

>100_bases
TCACCTGCCGCAGCCGCAACAAAAAAGCCCGACCTTGTGTCGGGCTTTTCATGCGCGCTATTCGGTAATCGCCGGCTCCA
GCCGTATGCCGTCGATCTGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLVAREIEKHGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLANHGL
DLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREQLFLRAGRIAVEL
CKRYYQDGDESVLPRNVASRKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVDFDLRDIDALSRKVPQLCKVAPNIQKYH
MEDVHRAGGIFSILGELARGGLLHTDASTVHSPSMADAIAEWDITQTQDEAVHTFFKAGPAGIPTQVAFSQATRWPSLDL
DRAEGCIRSVEHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGTAKIFESQDSAVKGILNDEVKAGDIVIIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSIQLQVSD
EELAHRRIEQDKKGWKPAQPRARKVSTALKAYALLATSADKGAVRDKAMLDG

Sequences:

>Translated_612_residues
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLVAREIEKHGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLANHGL
DLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREQLFLRAGRIAVEL
CKRYYQDGDESVLPRNVASRKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVDFDLRDIDALSRKVPQLCKVAPNIQKYH
MEDVHRAGGIFSILGELARGGLLHTDASTVHSPSMADAIAEWDITQTQDEAVHTFFKAGPAGIPTQVAFSQATRWPSLDL
DRAEGCIRSVEHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGTAKIFESQDSAVKGILNDEVKAGDIVIIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSIQLQVSD
EELAHRRIEQDKKGWKPAQPRARKVSTALKAYALLATSADKGAVRDKAMLDG
>Mature_611_residues
PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLVAREIEKHGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLANHGLD
LVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREQLFLRAGRIAVELC
KRYYQDGDESVLPRNVASRKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVDFDLRDIDALSRKVPQLCKVAPNIQKYHM
EDVHRAGGIFSILGELARGGLLHTDASTVHSPSMADAIAEWDITQTQDEAVHTFFKAGPAGIPTQVAFSQATRWPSLDLD
RAEGCIRSVEHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGTAKIFESQDSAVKGILNDEVKAGDIVIIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSIQLQVSDE
ELAHRRIEQDKKGWKPAQPRARKVSTALKAYALLATSADKGAVRDKAMLDG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=74.3922204213938, Blast_Score=948, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=509, Percent_Identity=30.8447937131631, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786464, Length=527, Percent_Identity=30.9297912713473, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1788157, Length=546, Percent_Identity=29.4871794871795, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=607, Percent_Identity=37.3970345963756, Blast_Score=359, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_PSEU5 (A4VRN4)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001174477.1
- STRING:   A4VRN4
- GeneID:   5096971
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_4012
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   A4VRN4
- ProtClustDB:   PRK12448
- BioCyc:   PSTU379731:PST_4012-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65419; Mature: 65288

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKHGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEEC
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLANHGLDLVDAMVVAADDSCSDEKVA
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHEECCCCCCCHHHH
EYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREQLFLRAGRIAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
CKRYYQDGDESVLPRNVASRKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVDFDLRDID
HHHHHCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHH
ALSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDASTVHSPSMADAIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCCCCCCHHHHHHH
EWDITQTQDEAVHTFFKAGPAGIPTQVAFSQATRWPSLDLDRAEGCIRSVEHAYSQEGGL
HCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCE
AVLYGNIALDGCVVKTAGVDESIHVFEGTAKIFESQDSAVKGILNDEVKAGDIVIIRYEG
EEEECCEEECCEEEEECCCCCCEEEEHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQ
CCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DGDKVLIDIPNRSIQLQVSDEELAHRRIEQDKKGWKPAQPRARKVSTALKAYALLATSAD
CCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCC
KGAVRDKAMLDG
CCCCCCHHCCCC
>Mature Secondary Structure 
PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKHGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEEC
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLANHGLDLVDAMVVAADDSCSDEKVA
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHEECCCCCCCHHHH
EYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREQLFLRAGRIAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
CKRYYQDGDESVLPRNVASRKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVDFDLRDID
HHHHHCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHH
ALSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDASTVHSPSMADAIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCCCCCCHHHHHHH
EWDITQTQDEAVHTFFKAGPAGIPTQVAFSQATRWPSLDLDRAEGCIRSVEHAYSQEGGL
HCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCE
AVLYGNIALDGCVVKTAGVDESIHVFEGTAKIFESQDSAVKGILNDEVKAGDIVIIRYEG
EEEECCEEECCEEEEECCCCCCEEEEHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQ
CCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DGDKVLIDIPNRSIQLQVSDEELAHRRIEQDKKGWKPAQPRARKVSTALKAYALLATSAD
CCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCC
KGAVRDKAMLDG
CCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA