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The map label for this gene is pfpI [H]

Identifier: 146284321

GI number: 146284321

Start: 4347207

End: 4347746

Strand: Direct

Name: pfpI [H]

Synonym: PST_4009

Alternate gene names: 146284321

Gene position: 4347207-4347746 (Clockwise)

Preceding gene: 146284316

Following gene: 146284322

Centisome position: 95.18

GC content: 64.44

Gene sequence:

>540_bases
ATGTCCCAATCTCTCAACGGCAAACGCGTGGCCATTCTGGTGACCGACGGTTTCGAGCAGGTCGAGCTGACCGGACCCAA
GGAGGCGCTGGAAAAGGCCGGCGCAACCGCCGAGATCATCTCCGCCAAGAACGGCGAGGTGACCGGCTGGAACCACACCA
CCCCGGCCTCCAAGTTCCATGTCGACAACACCTTCGACAGCGTCCGCATGGAGGATTACGACGCCGTGCTGCTGCCCGGC
GGCGTGGTCAATTCCGACACCATCCGCACCGACAAAACCGCGCAGAAGCTGGTCCGGGCGGCGGCGGATGCGAACAAGCC
CATCGCGGTGATCTGCCATGGCGGCTGGCTGCTGATCTCCGCCGACCTGGTCAAAGGCAAGCGCATGACCAGCTGGCCCT
CGCTCACCGACGACCTGAAGAATGCCGGCGCCGAGTGGGTTGACGAGCAGGTGGTGGTCGATGGCCACCTCATCAGTAGC
CGCAAGCCCGATGACATCCCGGCATTCAGCCAGGCGCTGATCGACGCGCTGTCCGCCTGA

Upstream 100 bases:

>100_bases
GCTATCGGCAGGAAAGGGCGAACTTTGGCTGAGATGTGGGTCCCATTTCAAGTGACTCGCATTCGGCGAGTGTTACCGAC
AGACAGACGGAGGTAAGCCC

Downstream 100 bases:

>100_bases
GCGAGGCATCGACAGGCACGCGGCGGGCGTTTTTCCTACGACCTCAGCGCATGCGGCGGGCCGCTCGTTTAGAATGCCCG
TCTTTTTTCCGGAGCCCTGC

Product: protease PfpI

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSQSLNGKRVAILVTDGFEQVELTGPKEALEKAGATAEIISAKNGEVTGWNHTTPASKFHVDNTFDSVRMEDYDAVLLPG
GVVNSDTIRTDKTAQKLVRAAADANKPIAVICHGGWLLISADLVKGKRMTSWPSLTDDLKNAGAEWVDEQVVVDGHLISS
RKPDDIPAFSQALIDALSA

Sequences:

>Translated_179_residues
MSQSLNGKRVAILVTDGFEQVELTGPKEALEKAGATAEIISAKNGEVTGWNHTTPASKFHVDNTFDSVRMEDYDAVLLPG
GVVNSDTIRTDKTAQKLVRAAADANKPIAVICHGGWLLISADLVKGKRMTSWPSLTDDLKNAGAEWVDEQVVVDGHLISS
RKPDDIPAFSQALIDALSA
>Mature_178_residues
SQSLNGKRVAILVTDGFEQVELTGPKEALEKAGATAEIISAKNGEVTGWNHTTPASKFHVDNTFDSVRMEDYDAVLLPGG
VVNSDTIRTDKTAQKLVRAAADANKPIAVICHGGWLLISADLVKGKRMTSWPSLTDDLKNAGAEWVDEQVVVDGHLISSR
KPDDIPAFSQALIDALSA

Specific function: Functions in the protection against aldehyde-stress, possibly by degrading damaged proteins [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PfpI endopeptidase domain [H]

Homologues:

Organism=Escherichia coli, GI87082219, Length=174, Percent_Identity=39.0804597701149, Blast_Score=125, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571932, Length=171, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006286
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 19153; Mature: 19022

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSLNGKRVAILVTDGFEQVELTGPKEALEKAGATAEIISAKNGEVTGWNHTTPASKFH
CCCCCCCCEEEEEEECCCCEEEECCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEE
VDNTFDSVRMEDYDAVLLPGGVVNSDTIRTDKTAQKLVRAAADANKPIAVICHGGWLLIS
ECCCCCCCEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEEEE
ADLVKGKRMTSWPSLTDDLKNAGAEWVDEQVVVDGHLISSRKPDDIPAFSQALIDALSA
EEHHCCCCCCCCCCHHHHHHHCCHHHCCCEEEECCEEECCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQSLNGKRVAILVTDGFEQVELTGPKEALEKAGATAEIISAKNGEVTGWNHTTPASKFH
CCCCCCCEEEEEEECCCCEEEECCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEE
VDNTFDSVRMEDYDAVLLPGGVVNSDTIRTDKTAQKLVRAAADANKPIAVICHGGWLLIS
ECCCCCCCEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEEEE
ADLVKGKRMTSWPSLTDDLKNAGAEWVDEQVVVDGHLISSRKPDDIPAFSQALIDALSA
EEHHCCCCCCCCCCHHHHHHHCCHHHCCCEEEECCEEECCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377; 10568751 [H]