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The map label for this gene is ggt [H]

Identifier: 146284316

GI number: 146284316

Start: 4341229

End: 4342962

Strand: Direct

Name: ggt [H]

Synonym: PST_4004

Alternate gene names: 146284316

Gene position: 4341229-4342962 (Clockwise)

Preceding gene: 146284315

Following gene: 146284321

Centisome position: 95.05

GC content: 70.47

Gene sequence:

>1734_bases
ATGCGCTGGCGGCGACCGACCCGGCGGAGGCTCCTGTTCAGGGTGCTCCACGGCTGGTTCGCCGCCCTGCTGTTACTGGC
CTGCAGCGTCCAGGCCAACCCGCTCGACAATGGTGCCGTCGCCACTGCCCACCCCCTGGCCAGCGAAGTCGGCCGCCAGA
TCCTTGAAGCAGGCGGCAACGCCTTCGACGCCACCGTCGCGGTGAGCGCCGCACTGGCCGTGGTCGAGCCCTATGGCTCG
GGGCTCGGCGGTGGTGGCTTCTTTCTGCTGCGCGAGGCCGCCGAACCGGCCCGTCACGTATTTCTCGACGCCCGCGAGCG
GGCGCCGCGCGCCGCCACGCCGGACCTGTATCTGCGCGACGGGCAGTTCCAGCGCGACCTGTCGCTGAACGGCCCGCTGG
CGGCGGCGATTCCCGGCACGCCAGCGGCGCTGGTCGAGCTCGCCGAACAACGTGGTCGCCTGCCACTCGAGGCAACCCTG
GCGCCGGCCATCGCCCTGGCCCGCGACGGCTTCGAGGTGGATGCGGTGTACCGCCAGCGCGCCAGCTGGCGCCTGGCCGC
ACTGCGTGACGATCCCGAGAGTGCGCGGCTGTTTCTCGACGAAGGCGATCTTCCGGCCGAAGGTCATCTGCTGCGCCAGC
CGGAACTGGCGCAAACCCTGGAGCGACTCGCCAGCAACGGCCGTGACGGCTTCTATCGCGGCGAACTGGCACAGAAGCTG
GTCCAGGGCGTACGTGCGGCCGGCGGCATCTGGTCGCTGGACGACCTGGCCGACTACCGCACCGTGGAGCGCGAGCCCCT
GCGGTTCGCCCTGGCCGATGGCCGCGAGCTGATCGGTGCGCCGCCGCCCTCGGCCGGCGGGGTGATCCTCGCGCAGAGCC
TGGGCATCCTCGAACGCCTCGCCTGGCGTGAGGCCGAACCGCTGCAGCGCAGCCACCTGGTGGTCGAGGCATTGCGTCGC
GCGTACCGTGACCGCGGGCTGCTGGGCGATCCCGATTTCGTCGCCGCACCGATCGAGCGGCTGTTGTCCGCGCGCTACCT
GGACCAGCTGGCCGCCGCCATCGACCGCGAGCACGCCACCCCGAGCAGCGACCTGCCACCGGCACCACGCTGGCGCGAGG
GCGAGCACACCACGCATTTCGCCGTGATCGATGCCGAAGGCAATGCGGTGGCGGCGACGCTGTCGCTGAACATGATGTTT
GGCGCCGCCTTCACCGTGCCCGGCACCGGGGTACTGCTCAACGACGAGATGGACGATTTCGCCGCCGACATCGACGGCAG
CAACGCCTACGGTCTGGAAGGCAGCAGCGCCAACGCCATCGCCGGGGGCAAGCGGCCGTTGTCGAGCATGAGCCCGACCT
TCATCGAGAGCCGCGAGGAATTCACCGCTTTCGGCACCCCCGGCGGCAGTCGCATTCCCAGCATGGTGCTGCTCTCGGCA
CTGTCTTACCTGGATGGCGAGCCGGTGCAGGCCTGGCCGGCAGTGCCGCGCTATCACCATCAGTACCTGCCGGATGTGCT
GCAGTACGAAGCCGATGCCTTCAGCCCGGCGCAGCTGGACGCGCTACGTGCCCGCGGCCACCAGCCCAGGCTGATCGAGC
GCGACTACGGCAATCAGCAGGTGCTCTACTGGCACAAGCCGAGCGGCCAGGTCGAGGCGGCCAGCGACCCGCGCGGGATC
GGCCGCGCGCTGAACGTGCCGGCACGGCGCCAGCCGATCACGGCTGCACAATGA

Upstream 100 bases:

>100_bases
AGCAGGTCTGCCCGGTAGACTGCATCCCGCTCGACGAGAACAACGTCGAGAGCAAGGACGAACTGATGCAGAAATACCTG
ATCATCACCGGCAAGGCGTG

Downstream 100 bases:

>100_bases
CCGGGCCGTCGTCCGCCGCCAGCTGCCGCAGCTGACGCGTCAGCTCGTGGCCCTCGCCCAGCAGCAGGGCGTTGCGCAGG
CTCTGGATGATGCGGCTGGC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MRWRRPTRRRLLFRVLHGWFAALLLLACSVQANPLDNGAVATAHPLASEVGRQILEAGGNAFDATVAVSAALAVVEPYGS
GLGGGGFFLLREAAEPARHVFLDARERAPRAATPDLYLRDGQFQRDLSLNGPLAAAIPGTPAALVELAEQRGRLPLEATL
APAIALARDGFEVDAVYRQRASWRLAALRDDPESARLFLDEGDLPAEGHLLRQPELAQTLERLASNGRDGFYRGELAQKL
VQGVRAAGGIWSLDDLADYRTVEREPLRFALADGRELIGAPPPSAGGVILAQSLGILERLAWREAEPLQRSHLVVEALRR
AYRDRGLLGDPDFVAAPIERLLSARYLDQLAAAIDREHATPSSDLPPAPRWREGEHTTHFAVIDAEGNAVAATLSLNMMF
GAAFTVPGTGVLLNDEMDDFAADIDGSNAYGLEGSSANAIAGGKRPLSSMSPTFIESREEFTAFGTPGGSRIPSMVLLSA
LSYLDGEPVQAWPAVPRYHHQYLPDVLQYEADAFSPAQLDALRARGHQPRLIERDYGNQQVLYWHKPSGQVEAASDPRGI
GRALNVPARRQPITAAQ

Sequences:

>Translated_577_residues
MRWRRPTRRRLLFRVLHGWFAALLLLACSVQANPLDNGAVATAHPLASEVGRQILEAGGNAFDATVAVSAALAVVEPYGS
GLGGGGFFLLREAAEPARHVFLDARERAPRAATPDLYLRDGQFQRDLSLNGPLAAAIPGTPAALVELAEQRGRLPLEATL
APAIALARDGFEVDAVYRQRASWRLAALRDDPESARLFLDEGDLPAEGHLLRQPELAQTLERLASNGRDGFYRGELAQKL
VQGVRAAGGIWSLDDLADYRTVEREPLRFALADGRELIGAPPPSAGGVILAQSLGILERLAWREAEPLQRSHLVVEALRR
AYRDRGLLGDPDFVAAPIERLLSARYLDQLAAAIDREHATPSSDLPPAPRWREGEHTTHFAVIDAEGNAVAATLSLNMMF
GAAFTVPGTGVLLNDEMDDFAADIDGSNAYGLEGSSANAIAGGKRPLSSMSPTFIESREEFTAFGTPGGSRIPSMVLLSA
LSYLDGEPVQAWPAVPRYHHQYLPDVLQYEADAFSPAQLDALRARGHQPRLIERDYGNQQVLYWHKPSGQVEAASDPRGI
GRALNVPARRQPITAAQ
>Mature_577_residues
MRWRRPTRRRLLFRVLHGWFAALLLLACSVQANPLDNGAVATAHPLASEVGRQILEAGGNAFDATVAVSAALAVVEPYGS
GLGGGGFFLLREAAEPARHVFLDARERAPRAATPDLYLRDGQFQRDLSLNGPLAAAIPGTPAALVELAEQRGRLPLEATL
APAIALARDGFEVDAVYRQRASWRLAALRDDPESARLFLDEGDLPAEGHLLRQPELAQTLERLASNGRDGFYRGELAQKL
VQGVRAAGGIWSLDDLADYRTVEREPLRFALADGRELIGAPPPSAGGVILAQSLGILERLAWREAEPLQRSHLVVEALRR
AYRDRGLLGDPDFVAAPIERLLSARYLDQLAAAIDREHATPSSDLPPAPRWREGEHTTHFAVIDAEGNAVAATLSLNMMF
GAAFTVPGTGVLLNDEMDDFAADIDGSNAYGLEGSSANAIAGGKRPLSSMSPTFIESREEFTAFGTPGGSRIPSMVLLSA
LSYLDGEPVQAWPAVPRYHHQYLPDVLQYEADAFSPAQLDALRARGHQPRLIERDYGNQQVLYWHKPSGQVEAASDPRGI
GRALNVPARRQPITAAQ

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=33.3955223880597, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=33.3955223880597, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=33.3955223880597, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=33.3955223880597, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI113429324, Length=526, Percent_Identity=31.9391634980989, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI113429326, Length=531, Percent_Identity=31.638418079096, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=29.94555353902, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=30.1270417422868, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI109148539, Length=547, Percent_Identity=29.7989031078611, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI153266907, Length=550, Percent_Identity=28.1818181818182, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI30581157, Length=225, Percent_Identity=32, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI30581155, Length=225, Percent_Identity=32, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI218505805, Length=226, Percent_Identity=30.5309734513274, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789856, Length=536, Percent_Identity=40.2985074626866, Blast_Score=344, Evalue=9e-96,
Organism=Caenorhabditis elegans, GI72000294, Length=498, Percent_Identity=31.9277108433735, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI212646519, Length=500, Percent_Identity=31.8, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=527, Percent_Identity=33.0170777988615, Blast_Score=202, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI193208245, Length=499, Percent_Identity=30.8617234468938, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193208247, Length=499, Percent_Identity=30.8617234468938, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17542894, Length=525, Percent_Identity=30.4761904761905, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17564448, Length=425, Percent_Identity=25.8823529411765, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI72001497, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=229, Percent_Identity=25.764192139738, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=553, Percent_Identity=27.124773960217, Blast_Score=154, Evalue=4e-38,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=33.4637964774951, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24642670, Length=541, Percent_Identity=29.5748613678373, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642666, Length=541, Percent_Identity=29.5748613678373, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161077878, Length=541, Percent_Identity=29.5748613678373, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161077880, Length=541, Percent_Identity=29.5748613678373, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI45551474, Length=541, Percent_Identity=29.5748613678373, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161077496, Length=513, Percent_Identity=31.7738791423002, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI18859741, Length=517, Percent_Identity=28.6266924564797, Blast_Score=145, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62460; Mature: 62460

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWRRPTRRRLLFRVLHGWFAALLLLACSVQANPLDNGAVATAHPLASEVGRQILEAGGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
AFDATVAVSAALAVVEPYGSGLGGGGFFLLREAAEPARHVFLDARERAPRAATPDLYLRD
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEC
GQFQRDLSLNGPLAAAIPGTPAALVELAEQRGRLPLEATLAPAIALARDGFEVDAVYRQR
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHC
ASWRLAALRDDPESARLFLDEGDLPAEGHLLRQPELAQTLERLASNGRDGFYRGELAQKL
CCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
VQGVRAAGGIWSLDDLADYRTVEREPLRFALADGRELIGAPPPSAGGVILAQSLGILERL
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHH
AWREAEPLQRSHLVVEALRRAYRDRGLLGDPDFVAAPIERLLSARYLDQLAAAIDREHAT
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSSDLPPAPRWREGEHTTHFAVIDAEGNAVAATLSLNMMFGAAFTVPGTGVLLNDEMDDF
CCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEEEHEEEEEECCCCCEEECCCHHHH
AADIDGSNAYGLEGSSANAIAGGKRPLSSMSPTFIESREEFTAFGTPGGSRIPSMVLLSA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHEECCCCCCCHHHHHHHHHH
LSYLDGEPVQAWPAVPRYHHQYLPDVLQYEADAFSPAQLDALRARGHQPRLIERDYGNQQ
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCE
VLYWHKPSGQVEAASDPRGIGRALNVPARRQPITAAQ
EEEEECCCCCEECCCCCCCCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRWRRPTRRRLLFRVLHGWFAALLLLACSVQANPLDNGAVATAHPLASEVGRQILEAGGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
AFDATVAVSAALAVVEPYGSGLGGGGFFLLREAAEPARHVFLDARERAPRAATPDLYLRD
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEC
GQFQRDLSLNGPLAAAIPGTPAALVELAEQRGRLPLEATLAPAIALARDGFEVDAVYRQR
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHC
ASWRLAALRDDPESARLFLDEGDLPAEGHLLRQPELAQTLERLASNGRDGFYRGELAQKL
CCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
VQGVRAAGGIWSLDDLADYRTVEREPLRFALADGRELIGAPPPSAGGVILAQSLGILERL
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHH
AWREAEPLQRSHLVVEALRRAYRDRGLLGDPDFVAAPIERLLSARYLDQLAAAIDREHAT
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSSDLPPAPRWREGEHTTHFAVIDAEGNAVAATLSLNMMFGAAFTVPGTGVLLNDEMDDF
CCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEEEHEEEEEECCCCCEEECCCHHHH
AADIDGSNAYGLEGSSANAIAGGKRPLSSMSPTFIESREEFTAFGTPGGSRIPSMVLLSA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHEECCCCCCCHHHHHHHHHH
LSYLDGEPVQAWPAVPRYHHQYLPDVLQYEADAFSPAQLDALRARGHQPRLIERDYGNQQ
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCE
VLYWHKPSGQVEAASDPRGIGRALNVPARRQPITAAQ
EEEEECCCCCEECCCCCCCCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]