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The map label for this gene is bioA [H]

Identifier: 146284256

GI number: 146284256

Start: 4276543

End: 4277793

Strand: Direct

Name: bioA [H]

Synonym: PST_3944

Alternate gene names: 146284256

Gene position: 4276543-4277793 (Clockwise)

Preceding gene: 146284249

Following gene: 146284257

Centisome position: 93.63

GC content: 65.63

Gene sequence:

>1251_bases
GTGAGCTCCTGGTGGGTCAACGTTTTCGGCCATGCCAATCCGCGCATCAATCAGCGCATCAAGGACCAGGTCGACCAGCT
CGAGCACGTGATGCTCGCCGGCTTCAGCCATCAGCCGGTGGTGGAGCTGTCAGAGCGCCTGGTCGCCTTGACGCCGGCCG
GGCTGGAGCGTGTGTTCTACACCGACAACGGCTCCACCGGCATCGAGGTGGCGCTGAAGATGAGCTTCCACTACTGGCGC
AACAGCGGCCGCGAGCGCAAGCAGCGCTTCGTCACGCTGACCAACAGCTATCACGGCGAAACCGTGGCCGCCATGTCGGT
GGGCGACGTGGCACTGTTCACCGACACCTACAAGCCACTGTTGCTGGACACGTTCAAGGTTCCGAGCCCGGACTGCTACT
TGCGGCCCGAAGGCGTCAGCTGGGAAGAACACTCGCGGCAGATGTTCGCGCACATGGAGCAGACCCTGGCCGAGCATCAC
CAGGACATCGCCGCGGTCATCGTCGAGCCGCTGATCCAGGGTGCCGGCGGCATGCGCATGTACCACCCGATCTACCTCAA
GCTGCTGCGCGAGGCCTGCGACCGCTACGAGGTGCACCTCATCCACGACGAGATCGCCGTCGGCTTCGGGCGCACCGGCA
CGATGTTCGCCTGCGAGCAGGCCGGTATCACGCCGGACTTCCTCTGCCTGTCCAAGGCCCTTACCGGCGGCTATCTGCCT
ATGGCCGCTGTGCTCACCACCGACCGCCTGTATCAGGCGTTCTACGACGACTACTCGACCCTGCGCGCCTTTCTTCATTC
GCACACCTACACCGGCAATCCGCTGGCCTGTGCCGCCGCACTGGCGACGCTGGACATCTTCGCCGAGGACAACGTCATCG
AGGCGAACAAGGCGCTGGCCGCACGCATGGCCAGCGCCACCGCGCACCTGGCCGGGCATCCACATGTGGCCGAGGTGCGC
CAGACCGGCATGGCGCTGGCCATCGAGATGGTTCAGGACAAACCCAGCCGTACGGCCTACCCCTGGCAGGAACGTCGCGG
GCTGAAGGTCTACCAGCATGCGCTGGAGCGCGGCGCCCTGCTGCGCCCGCTGGGCAGCGTGGTGTACTTCCTGCCGCCGT
ACTGCATCACCGAAGAGCAGATCGACTTCCTCGCCGCGGTTGCCAGCGAAGGGATCGATATCGCTACCCGCGACACCGTC
CAGGTGGCGATGCCGAGCGGCCTCTATCCGGGCTTCCGCGATCCGGGCTGA

Upstream 100 bases:

>100_bases
CACCCAGATGAAGGACCACGAACAGCTACCGCTGATCCCCATCCGCCGCGGTGAAGGCGTGTGGTTGGAGGACTTCGACG
GCAAGCGCTACCTGGACGCG

Downstream 100 bases:

>100_bases
GCACCACGCCGCGTGCGGCGGCCTGCTGAGCGGGCTGCCGATGCTTTAGACTTGCCTCTCCATCCACCACGCCCTGCCGT
TGCCCTATGCGCCTATCCCG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSSWWVNVFGHANPRINQRIKDQVDQLEHVMLAGFSHQPVVELSERLVALTPAGLERVFYTDNGSTGIEVALKMSFHYWR
NSGRERKQRFVTLTNSYHGETVAAMSVGDVALFTDTYKPLLLDTFKVPSPDCYLRPEGVSWEEHSRQMFAHMEQTLAEHH
QDIAAVIVEPLIQGAGGMRMYHPIYLKLLREACDRYEVHLIHDEIAVGFGRTGTMFACEQAGITPDFLCLSKALTGGYLP
MAAVLTTDRLYQAFYDDYSTLRAFLHSHTYTGNPLACAAALATLDIFAEDNVIEANKALAARMASATAHLAGHPHVAEVR
QTGMALAIEMVQDKPSRTAYPWQERRGLKVYQHALERGALLRPLGSVVYFLPPYCITEEQIDFLAAVASEGIDIATRDTV
QVAMPSGLYPGFRDPG

Sequences:

>Translated_416_residues
MSSWWVNVFGHANPRINQRIKDQVDQLEHVMLAGFSHQPVVELSERLVALTPAGLERVFYTDNGSTGIEVALKMSFHYWR
NSGRERKQRFVTLTNSYHGETVAAMSVGDVALFTDTYKPLLLDTFKVPSPDCYLRPEGVSWEEHSRQMFAHMEQTLAEHH
QDIAAVIVEPLIQGAGGMRMYHPIYLKLLREACDRYEVHLIHDEIAVGFGRTGTMFACEQAGITPDFLCLSKALTGGYLP
MAAVLTTDRLYQAFYDDYSTLRAFLHSHTYTGNPLACAAALATLDIFAEDNVIEANKALAARMASATAHLAGHPHVAEVR
QTGMALAIEMVQDKPSRTAYPWQERRGLKVYQHALERGALLRPLGSVVYFLPPYCITEEQIDFLAAVASEGIDIATRDTV
QVAMPSGLYPGFRDPG
>Mature_415_residues
SSWWVNVFGHANPRINQRIKDQVDQLEHVMLAGFSHQPVVELSERLVALTPAGLERVFYTDNGSTGIEVALKMSFHYWRN
SGRERKQRFVTLTNSYHGETVAAMSVGDVALFTDTYKPLLLDTFKVPSPDCYLRPEGVSWEEHSRQMFAHMEQTLAEHHQ
DIAAVIVEPLIQGAGGMRMYHPIYLKLLREACDRYEVHLIHDEIAVGFGRTGTMFACEQAGITPDFLCLSKALTGGYLPM
AAVLTTDRLYQAFYDDYSTLRAFLHSHTYTGNPLACAAALATLDIFAEDNVIEANKALAARMASATAHLAGHPHVAEVRQ
TGMALAIEMVQDKPSRTAYPWQERRGLKVYQHALERGALLRPLGSVVYFLPPYCITEEQIDFLAAVASEGIDIATRDTVQ
VAMPSGLYPGFRDPG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=404, Percent_Identity=28.2178217821782, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557809, Length=384, Percent_Identity=28.6458333333333, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI284507298, Length=323, Percent_Identity=28.7925696594427, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=28.030303030303, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI37574042, Length=395, Percent_Identity=28.1012658227848, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI226442705, Length=369, Percent_Identity=28.4552845528455, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI24119277, Length=390, Percent_Identity=25.6410256410256, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786991, Length=397, Percent_Identity=41.0579345088161, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI145693181, Length=415, Percent_Identity=30.6024096385542, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=30.0791556728232, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1789016, Length=394, Percent_Identity=26.9035532994924, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788044, Length=381, Percent_Identity=29.1338582677165, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787560, Length=379, Percent_Identity=27.1767810026385, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786349, Length=372, Percent_Identity=25.5376344086022, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564660, Length=408, Percent_Identity=24.7549019607843, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=378, Percent_Identity=27.2486772486773, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=227, Percent_Identity=33.0396475770925, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=393, Percent_Identity=21.882951653944, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=420, Percent_Identity=31.4285714285714, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=29.6019900497512, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=398, Percent_Identity=24.8743718592965, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI161085790, Length=401, Percent_Identity=26.1845386533666, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28574759, Length=412, Percent_Identity=26.4563106796117, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357415, Length=394, Percent_Identity=27.4111675126904, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21356575, Length=362, Percent_Identity=26.7955801104972, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46363; Mature: 46232

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSWWVNVFGHANPRINQRIKDQVDQLEHVMLAGFSHQPVVELSERLVALTPAGLERVFY
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEEECCCCCEEEEE
TDNGSTGIEVALKMSFHYWRNSGRERKQRFVTLTNSYHGETVAAMSVGDVALFTDTYKPL
ECCCCCCEEEEEEEHHHHHHCCCHHHHHHEEEEECCCCCCEEEEEECCCEEEEECCCCCH
LLDTFKVPSPDCYLRPEGVSWEEHSRQMFAHMEQTLAEHHQDIAAVIVEPLIQGAGGMRM
HHEECCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YHPIYLKLLREACDRYEVHLIHDEIAVGFGRTGTMFACEQAGITPDFLCLSKALTGGYLP
HHHHHHHHHHHHHCCEEEEEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHH
MAAVLTTDRLYQAFYDDYSTLRAFLHSHTYTGNPLACAAALATLDIFAEDNVIEANKALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHH
ARMASATAHLAGHPHVAEVRQTGMALAIEMVQDKPSRTAYPWQERRGLKVYQHALERGAL
HHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHCCHH
LRPLGSVVYFLPPYCITEEQIDFLAAVASEGIDIATRDTVQVAMPSGLYPGFRDPG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SSWWVNVFGHANPRINQRIKDQVDQLEHVMLAGFSHQPVVELSERLVALTPAGLERVFY
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEEECCCCCEEEEE
TDNGSTGIEVALKMSFHYWRNSGRERKQRFVTLTNSYHGETVAAMSVGDVALFTDTYKPL
ECCCCCCEEEEEEEHHHHHHCCCHHHHHHEEEEECCCCCCEEEEEECCCEEEEECCCCCH
LLDTFKVPSPDCYLRPEGVSWEEHSRQMFAHMEQTLAEHHQDIAAVIVEPLIQGAGGMRM
HHEECCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YHPIYLKLLREACDRYEVHLIHDEIAVGFGRTGTMFACEQAGITPDFLCLSKALTGGYLP
HHHHHHHHHHHHHCCEEEEEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHH
MAAVLTTDRLYQAFYDDYSTLRAFLHSHTYTGNPLACAAALATLDIFAEDNVIEANKALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHH
ARMASATAHLAGHPHVAEVRQTGMALAIEMVQDKPSRTAYPWQERRGLKVYQHALERGAL
HHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHCCHH
LRPLGSVVYFLPPYCITEEQIDFLAAVASEGIDIATRDTVQVAMPSGLYPGFRDPG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]