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The map label for this gene is crtE [H]

Identifier: 146284189

GI number: 146284189

Start: 4198909

End: 4199799

Strand: Direct

Name: crtE [H]

Synonym: PST_3877

Alternate gene names: 146284189

Gene position: 4198909-4199799 (Clockwise)

Preceding gene: 146284183

Following gene: 146284190

Centisome position: 91.93

GC content: 68.57

Gene sequence:

>891_bases
ATGCAAACGCAGAACTCCAGTCTCCCGCTTCCGCAATGCGACAACCTGCTGCGTCTGCGCCGACAGGTCGACGAGCGACT
GGCGCTGCGCCTGCCATTTCCGGAATCGGAGCTGGACACCGTCACCCAGGCCCTGCGCGAAGGCACCCTGGCGCCCGGCA
AGCGGCTCAGGCCGTTGCTGCTTCTGCTGGCACTGGGCGATCTGGATGCCGATCCGGCGATCGGTCTGGATCCGGCCTGC
GCGCTGGAGATGATCCATGCCGCCTCGCTGTTTCTCGACGACATGCCCTGCATGGACAACGCCAGCCTGCGCCGCGGCCA
GCCGACCATCCACCTGCGCTTCGGCGAGGATGTCGCCGTGCTCGCCTCGGTGGCTCTGCTCAGCCATGCCTACGGCATCA
CTGCCATGGCGCCAAGCCTGAGCCCGCGCCAGCGCAACGATGCGGTCGCACTCTTGGCCAGGGCGGTGGGCGCGCAGGGG
CTGGTCCGCGGCCAGTTCCGCGACCTGCACGGCACAGGGCAGTCGCAGCAGCTGGATGCGGTAATCGCCACCAATCAACT
GAAGACCGGCTCACTGTTCACCGCCGCACTGGAGCTGGCGGCCTTGCTGGTCGGTGCCGACCGCGCGCTGACCGCGCACC
TGCGCGGTTTCGCCAGCGAGCTGGGCATGGCCTTTCAACTGCTCGACGACATCGCCGACGGCCTGAGCCCCGAGCAGACC
GGCAAGGACTGCCAGCAGGATCGGGCCAAGGCCACGGTGGTGTCGCTGCTCGGTCCCCAGGCCGCGCGCCAGCAACTGGC
AACGCATCGCGAAGCGGCACTGATGCACCTGGAAGCGGCCGGGCTGGCCGAGGGCGAACTCGCCTCGCTGATGCGTCAGT
TGCTCGGCTAG

Upstream 100 bases:

>100_bases
CGACGGCACGACTTGTACAACTTTTTGTCAAACCGTCCAATAGTTGTACAACATTATCCGCAACCCTGGTGCTCGGACTG
GGCGCAGCGAGGGCAACGCC

Downstream 100 bases:

>100_bases
GAGGAGGTCGCCCGTGTTGACGCTCCATCAGTGCAATGGATGGAGCTAGGCAATGGAAAACGGGCGTCCTTAGACTCGGG
CCGATAGAAATGGAGGTTGA

Product: geranylgeranyl pyrophosphate synthetase

Products: NA

Alternate protein names: GGPP synthase; Farnesyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MQTQNSSLPLPQCDNLLRLRRQVDERLALRLPFPESELDTVTQALREGTLAPGKRLRPLLLLLALGDLDADPAIGLDPAC
ALEMIHAASLFLDDMPCMDNASLRRGQPTIHLRFGEDVAVLASVALLSHAYGITAMAPSLSPRQRNDAVALLARAVGAQG
LVRGQFRDLHGTGQSQQLDAVIATNQLKTGSLFTAALELAALLVGADRALTAHLRGFASELGMAFQLLDDIADGLSPEQT
GKDCQQDRAKATVVSLLGPQAARQQLATHREAALMHLEAAGLAEGELASLMRQLLG

Sequences:

>Translated_296_residues
MQTQNSSLPLPQCDNLLRLRRQVDERLALRLPFPESELDTVTQALREGTLAPGKRLRPLLLLLALGDLDADPAIGLDPAC
ALEMIHAASLFLDDMPCMDNASLRRGQPTIHLRFGEDVAVLASVALLSHAYGITAMAPSLSPRQRNDAVALLARAVGAQG
LVRGQFRDLHGTGQSQQLDAVIATNQLKTGSLFTAALELAALLVGADRALTAHLRGFASELGMAFQLLDDIADGLSPEQT
GKDCQQDRAKATVVSLLGPQAARQQLATHREAALMHLEAAGLAEGELASLMRQLLG
>Mature_296_residues
MQTQNSSLPLPQCDNLLRLRRQVDERLALRLPFPESELDTVTQALREGTLAPGKRLRPLLLLLALGDLDADPAIGLDPAC
ALEMIHAASLFLDDMPCMDNASLRRGQPTIHLRFGEDVAVLASVALLSHAYGITAMAPSLSPRQRNDAVALLARAVGAQG
LVRGQFRDLHGTGQSQQLDAVIATNQLKTGSLFTAALELAALLVGADRALTAHLRGFASELGMAFQLLDDIADGLSPEQT
GKDCQQDRAKATVVSLLGPQAARQQLATHREAALMHLEAAGLAEGELASLMRQLLG

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=221, Percent_Identity=28.9592760180996, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786623, Length=262, Percent_Identity=39.3129770992366, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1789578, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24651612, Length=229, Percent_Identity=27.9475982532751, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.29 [H]

Molecular weight: Translated: 31565; Mature: 31565

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTQNSSLPLPQCDNLLRLRRQVDERLALRLPFPESELDTVTQALREGTLAPGKRLRPLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
LLLALGDLDADPAIGLDPACALEMIHAASLFLDDMPCMDNASLRRGQPTIHLRFGEDVAV
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEECCHHHH
LASVALLSHAYGITAMAPSLSPRQRNDAVALLARAVGAQGLVRGQFRDLHGTGQSQQLDA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHH
VIATNQLKTGSLFTAALELAALLVGADRALTAHLRGFASELGMAFQLLDDIADGLSPEQT
HHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GKDCQQDRAKATVVSLLGPQAARQQLATHREAALMHLEAAGLAEGELASLMRQLLG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MQTQNSSLPLPQCDNLLRLRRQVDERLALRLPFPESELDTVTQALREGTLAPGKRLRPLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
LLLALGDLDADPAIGLDPACALEMIHAASLFLDDMPCMDNASLRRGQPTIHLRFGEDVAV
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEECCHHHH
LASVALLSHAYGITAMAPSLSPRQRNDAVALLARAVGAQGLVRGQFRDLHGTGQSQQLDA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHH
VIATNQLKTGSLFTAALELAALLVGADRALTAHLRGFASELGMAFQLLDDIADGLSPEQT
HHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GKDCQQDRAKATVVSLLGPQAARQQLATHREAALMHLEAAGLAEGELASLMRQLLG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2254247 [H]