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The map label for this gene is sda-2 [H]

Identifier: 146283876

GI number: 146283876

Start: 3847877

End: 3849253

Strand: Direct

Name: sda-2 [H]

Synonym: PST_3559

Alternate gene names: 146283876

Gene position: 3847877-3849253 (Clockwise)

Preceding gene: 146283875

Following gene: 146283877

Centisome position: 84.25

GC content: 68.41

Gene sequence:

>1377_bases
ATGTCCCTCAGTGTCTTCGACCTGTTCAAGATCGGTATCGGCCCGTCCAGTTCGCACACGGTGGGCCCGATGCGCGCCGC
CCTGCGCTTTGCCGAAGGCCTGCGCCGTGACGGGCAGCTGACAGCGACCCGCGCCATCAAGGTCGAGCTGTACGGCTCGC
TCGGCGCTACCGGCAAGGGCCACGGCAGCGACAAGGCCGTGCTGCTCGGGCTGGAGGGCGAACATCCCGAATCGGTGGAT
ACCGACAGCATCCCGGCGCGCCTGGCGACGATCCGCGAGCGTGGCGAACTGCGCCTGCTCGGCGAGCACCCGATCCCGTT
CGACAGCCGGGCGCAGCTGGCCTTCATCCGCCGGCCGCTGCCCTTCCACCCCAACGGTCTGATCTTCCGCGCCTTCGACG
CCGCCGGCCTGCAGCTCTGTAGCCGCGAGTACTACTCGGTGGGTGGCGGATTCGTGGTCGACGAGCAGGCCGCCGGCAGC
GATCGCATCGTCGAGGACGCCACCGCACTGGCCTACCCCTTTCGCAGCGCTGCCGAGCTGCTCGATCACTGCGCTGCCCA
TGGGCTGTCCATCAGCCAGCTGATGCTCGCCAACGAGGCCGCCTGGCGGCCGGAAGCAGAGACCCGCAGTGGCCTGCTGC
GCATCTGGCAGGTCATGCAGGATTGCGTCGAGGCCGGCTGCCGTACCGAAGGCGTGATGCCCGGCGGCCTCAAGGTGCGT
CGCCGCGCGGCGGGCCTGTATCGCCAGCTCAGCGAACACCCCGAGGCCAACCTGCGCGATGCGCTCAACGTTCTCGACTG
GGTCGATCTCTATGCGCTGGCGGTCAACGAGGAAAACGCCAGCGGCGGGCGCGTGGTCACGGCGCCCACCAATGGCGCGG
CGGGCATCATTCCGGCGCTGCTGCATTACTACATGCGCTTCGTCCCGGGTGCGGACGAGGACGGCGTGGTGCGCTTCCTG
CTCACCGCCGCCGCCATCGGCATCCTCTACAAGGAGAACGCTTCGATTTCCGGCGCCGAGGTGGGCTGCCAGGGCGAGGT
AGGCGTGGCCTGTTCGATGGCTGCCGGCGCCCTGTGCGAAGTGCTCGGCGGCACGCCACAACAGGTCGAGAACGCCGCCG
AAATCGGCATGGAACACAACCTCGGGCTGACCTGCGACCCGGTCGGCGGGCTGGTGCAGGTGCCCTGCATCGAGCGCAAC
GCCATGGGCGCGGTGAAGGCGATCAACGCCGCGCGCATGGCCTTGCGCGGCGATGGCCGACACTTCATCTCGCTGGACAA
GGTGATCCGCACCATGCGCCAGACCGGCGCCGACATGAAGAGCAAGTACAAGGAAACCGCCCGCGGCGGTCTGGCGGTGA
ACATCATCGAGTGCTGA

Upstream 100 bases:

>100_bases
GGCGCCGCGACCGCCCAGAACGACAACGAAAGCCTTCCCGATCAACCTTGACGGGCGGCCGAGGGTCTAGGCTTATACAA
GCCTCGCCTGGAGCCTCCCA

Downstream 100 bases:

>100_bases
GGACATGGGCCGCGCCACGCGAGCCGGCCGCACAGTAATCGCGTGCGCAAAGCCGTATCATCCGTTCGGCAGCACTGCTC
GGCAGCGATGGACTCCCTGC

Product: L-serine dehydratase, iron-sulfur-dependent, single chain form

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSLSVFDLFKIGIGPSSSHTVGPMRAALRFAEGLRRDGQLTATRAIKVELYGSLGATGKGHGSDKAVLLGLEGEHPESVD
TDSIPARLATIRERGELRLLGEHPIPFDSRAQLAFIRRPLPFHPNGLIFRAFDAAGLQLCSREYYSVGGGFVVDEQAAGS
DRIVEDATALAYPFRSAAELLDHCAAHGLSISQLMLANEAAWRPEAETRSGLLRIWQVMQDCVEAGCRTEGVMPGGLKVR
RRAAGLYRQLSEHPEANLRDALNVLDWVDLYALAVNEENASGGRVVTAPTNGAAGIIPALLHYYMRFVPGADEDGVVRFL
LTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGALCEVLGGTPQQVENAAEIGMEHNLGLTCDPVGGLVQVPCIERN
AMGAVKAINAARMALRGDGRHFISLDKVIRTMRQTGADMKSKYKETARGGLAVNIIEC

Sequences:

>Translated_458_residues
MSLSVFDLFKIGIGPSSSHTVGPMRAALRFAEGLRRDGQLTATRAIKVELYGSLGATGKGHGSDKAVLLGLEGEHPESVD
TDSIPARLATIRERGELRLLGEHPIPFDSRAQLAFIRRPLPFHPNGLIFRAFDAAGLQLCSREYYSVGGGFVVDEQAAGS
DRIVEDATALAYPFRSAAELLDHCAAHGLSISQLMLANEAAWRPEAETRSGLLRIWQVMQDCVEAGCRTEGVMPGGLKVR
RRAAGLYRQLSEHPEANLRDALNVLDWVDLYALAVNEENASGGRVVTAPTNGAAGIIPALLHYYMRFVPGADEDGVVRFL
LTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGALCEVLGGTPQQVENAAEIGMEHNLGLTCDPVGGLVQVPCIERN
AMGAVKAINAARMALRGDGRHFISLDKVIRTMRQTGADMKSKYKETARGGLAVNIIEC
>Mature_457_residues
SLSVFDLFKIGIGPSSSHTVGPMRAALRFAEGLRRDGQLTATRAIKVELYGSLGATGKGHGSDKAVLLGLEGEHPESVDT
DSIPARLATIRERGELRLLGEHPIPFDSRAQLAFIRRPLPFHPNGLIFRAFDAAGLQLCSREYYSVGGGFVVDEQAAGSD
RIVEDATALAYPFRSAAELLDHCAAHGLSISQLMLANEAAWRPEAETRSGLLRIWQVMQDCVEAGCRTEGVMPGGLKVRR
RAAGLYRQLSEHPEANLRDALNVLDWVDLYALAVNEENASGGRVVTAPTNGAAGIIPALLHYYMRFVPGADEDGVVRFLL
TAAAIGILYKENASISGAEVGCQGEVGVACSMAAGALCEVLGGTPQQVENAAEIGMEHNLGLTCDPVGGLVQVPCIERNA
MGAVKAINAARMALRGDGRHFISLDKVIRTMRQTGADMKSKYKETARGGLAVNIIEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=455, Percent_Identity=56.7032967032967, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=54.1850220264317, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1789161, Length=457, Percent_Identity=53.6105032822757, Blast_Score=473, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48846; Mature: 48714

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSVFDLFKIGIGPSSSHTVGPMRAALRFAEGLRRDGQLTATRAIKVELYGSLGATGKG
CCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCCC
HGSDKAVLLGLEGEHPESVDTDSIPARLATIRERGELRLLGEHPIPFDSRAQLAFIRRPL
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCC
PFHPNGLIFRAFDAAGLQLCSREYYSVGGGFVVDEQAAGSDRIVEDATALAYPFRSAAEL
CCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCHHHHHHH
LDHCAAHGLSISQLMLANEAAWRPEAETRSGLLRIWQVMQDCVEAGCRTEGVMPGGLKVR
HHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RRAAGLYRQLSEHPEANLRDALNVLDWVDLYALAVNEENASGGRVVTAPTNGAAGIIPAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCHHHHHHH
LHYYMRFVPGADEDGVVRFLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGALCE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VLGGTPQQVENAAEIGMEHNLGLTCDPVGGLVQVPCIERNAMGAVKAINAARMALRGDGR
HHCCCHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
HFISLDKVIRTMRQTGADMKSKYKETARGGLAVNIIEC
EEEEHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
SLSVFDLFKIGIGPSSSHTVGPMRAALRFAEGLRRDGQLTATRAIKVELYGSLGATGKG
CCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCCC
HGSDKAVLLGLEGEHPESVDTDSIPARLATIRERGELRLLGEHPIPFDSRAQLAFIRRPL
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCC
PFHPNGLIFRAFDAAGLQLCSREYYSVGGGFVVDEQAAGSDRIVEDATALAYPFRSAAEL
CCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCHHHHHHH
LDHCAAHGLSISQLMLANEAAWRPEAETRSGLLRIWQVMQDCVEAGCRTEGVMPGGLKVR
HHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RRAAGLYRQLSEHPEANLRDALNVLDWVDLYALAVNEENASGGRVVTAPTNGAAGIIPAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCHHHHHHH
LHYYMRFVPGADEDGVVRFLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGALCE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VLGGTPQQVENAAEIGMEHNLGLTCDPVGGLVQVPCIERNAMGAVKAINAARMALRGDGR
HHCCCHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
HFISLDKVIRTMRQTGADMKSKYKETARGGLAVNIIEC
EEEEHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]