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The map label for this gene is copS [H]

Identifier: 146283708

GI number: 146283708

Start: 3665845

End: 3667182

Strand: Direct

Name: copS [H]

Synonym: PST_3391

Alternate gene names: 146283708

Gene position: 3665845-3667182 (Clockwise)

Preceding gene: 146283707

Following gene: 146283712

Centisome position: 80.26

GC content: 50.82

Gene sequence:

>1338_bases
ATGTTCATGTCTGTGGTGGTTGTAGTTCTCACCATAGCTGGGCTGAGCTTCAATTTGCTTAGCCAGCATCACTTCGAAGT
GTTGGATCGGCAGGCCTTGGTGGAGAAGCTCGAATCGACCAAGAAAATTTTCAATAACGTACGCAGCAGCGCAAACCTTG
CTGAGGAGCTACCGCAGTTGCGAGCTCTGCTAGGTGCCCATCATGATTTAGCGGCGACCATCTTGAGCGAAGATGGCAGA
GTGCTCTTTTCTGATCCCAAGACAGTCGACGTCCCGGAAAGCTATAGGGACGCAGAACAGCAGAATATGTGGGAATGGAA
ATATGCCGGCCGCCTGTATAGAGGATTGACTGCCCGAATCTCGGTAGCAGACCAGCCCGAACCACTTACAGCACTGTTGA
TTCTTGATGTCACTAACCACGCGCATTTCTTTCAGACTTTGCAGCGTTGGTTCGGCGTTGGATTAAGCGTCAGCGCTCTA
ATTAGTGCTGCGCTTGGCTGGATGGTAGTTAGAAGCGGTCTCAGGCCTCTGAGGCAAGTTACCCATCTCGCCGCATCGAT
GTCAGCAAGGTCGTTGCAGGAACGAATGCCGCTTGAACCGATACCGCTTGAGTTACAGCAATTGGTTCTGTCCTTCAATG
CGATGTTAGATCGCTTGGAAGATGCCTTTGTTCGGCTTTCCAATTTCTCGGCGGACATTGCTCATGAACTGCGAACCCCT
GTTAGCAACCTCATGACCCACACCGAGGTGGTGCTGACCAAAAAGCGGAATATTGATGCTTATGAGGAGAATCTTTACTC
CAATCTAGAGGAGTTGAAGCGTATGTCACGCATTATTGACGACATGCTCTTTTTGGCCAAATCCGACAACGGCTTGATTA
TTCCCGAACAAGCGTCTATCGAACTAGCTGATGTCGTTGCTAAACTGCTTGCGTATTACCACTTAGTGGCTGACGAACGC
GATATCCGTCTCTCAGTCTCAGGCGCAGGAAATGTGCTGGGAGATAAATTAATGATTGATAGAGCGGTCTCCAATTTGTT
ATCCAACGCGCTGCGTTACACCCCGGTAGGGGAAACTATTTCTGTAACGATTCACGAGGCGGAAAGAACGGTAACCCTCA
GCGTCGAGAATCCCGGAGGGACGATCGAGCCCGAGCACCTGGACAAGCTCTTTTATCGCTTCTATCGGGTCGATCCTGCC
CGGCGCGAGGGTAGTCCAAGCAACGCTGGCCTCGGCTTGGCTATTACCAGATCTATTGTTGAGGCCCATAAAGGCAGAAT
CTGGTGCACCTCATTAGACGGCGTGACGGGCTTTCACATGGAATTTCCCCGCCAATAA

Upstream 100 bases:

>100_bases
TCGAGCACAAACTGATCCATACCGTGCGTGGCATGGGCTATATGATGGATGCACCGGAGTGAGACTGCGTCACCTTTCGC
TGACCGCCCGAATGAGTGTC

Downstream 100 bases:

>100_bases
TAAAATATCGAATAAAGGTAAATATTTTAAAATCAGCCGCATAGCGATCATAAGGGACCTTACACGATTGTAATGTTAAC
CATTGGAACGGACGAACTCT

Product: sensor protein CopS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFMSVVVVVLTIAGLSFNLLSQHHFEVLDRQALVEKLESTKKIFNNVRSSANLAEELPQLRALLGAHHDLAATILSEDGR
VLFSDPKTVDVPESYRDAEQQNMWEWKYAGRLYRGLTARISVADQPEPLTALLILDVTNHAHFFQTLQRWFGVGLSVSAL
ISAALGWMVVRSGLRPLRQVTHLAASMSARSLQERMPLEPIPLELQQLVLSFNAMLDRLEDAFVRLSNFSADIAHELRTP
VSNLMTHTEVVLTKKRNIDAYEENLYSNLEELKRMSRIIDDMLFLAKSDNGLIIPEQASIELADVVAKLLAYYHLVADER
DIRLSVSGAGNVLGDKLMIDRAVSNLLSNALRYTPVGETISVTIHEAERTVTLSVENPGGTIEPEHLDKLFYRFYRVDPA
RREGSPSNAGLGLAITRSIVEAHKGRIWCTSLDGVTGFHMEFPRQ

Sequences:

>Translated_445_residues
MFMSVVVVVLTIAGLSFNLLSQHHFEVLDRQALVEKLESTKKIFNNVRSSANLAEELPQLRALLGAHHDLAATILSEDGR
VLFSDPKTVDVPESYRDAEQQNMWEWKYAGRLYRGLTARISVADQPEPLTALLILDVTNHAHFFQTLQRWFGVGLSVSAL
ISAALGWMVVRSGLRPLRQVTHLAASMSARSLQERMPLEPIPLELQQLVLSFNAMLDRLEDAFVRLSNFSADIAHELRTP
VSNLMTHTEVVLTKKRNIDAYEENLYSNLEELKRMSRIIDDMLFLAKSDNGLIIPEQASIELADVVAKLLAYYHLVADER
DIRLSVSGAGNVLGDKLMIDRAVSNLLSNALRYTPVGETISVTIHEAERTVTLSVENPGGTIEPEHLDKLFYRFYRVDPA
RREGSPSNAGLGLAITRSIVEAHKGRIWCTSLDGVTGFHMEFPRQ
>Mature_445_residues
MFMSVVVVVLTIAGLSFNLLSQHHFEVLDRQALVEKLESTKKIFNNVRSSANLAEELPQLRALLGAHHDLAATILSEDGR
VLFSDPKTVDVPESYRDAEQQNMWEWKYAGRLYRGLTARISVADQPEPLTALLILDVTNHAHFFQTLQRWFGVGLSVSAL
ISAALGWMVVRSGLRPLRQVTHLAASMSARSLQERMPLEPIPLELQQLVLSFNAMLDRLEDAFVRLSNFSADIAHELRTP
VSNLMTHTEVVLTKKRNIDAYEENLYSNLEELKRMSRIIDDMLFLAKSDNGLIIPEQASIELADVVAKLLAYYHLVADER
DIRLSVSGAGNVLGDKLMIDRAVSNLLSNALRYTPVGETISVTIHEAERTVTLSVENPGGTIEPEHLDKLFYRFYRVDPA
RREGSPSNAGLGLAITRSIVEAHKGRIWCTSLDGVTGFHMEFPRQ

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=442, Percent_Identity=37.7828054298643, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1788279, Length=291, Percent_Identity=31.6151202749141, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=32.3008849557522, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790346, Length=286, Percent_Identity=27.972027972028, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=202, Percent_Identity=30.6930693069307, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=410, Percent_Identity=26.8292682926829, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787894, Length=249, Percent_Identity=30.1204819277108, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=26.8817204301075, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789808, Length=277, Percent_Identity=29.6028880866426, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=273, Percent_Identity=26.7399267399267, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=283, Percent_Identity=25.0883392226148, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=24.6696035242291, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=23.7154150197628, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=25.3393665158371, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=23.0496453900709, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=24.7706422018349, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49849; Mature: 49849

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMSVVVVVLTIAGLSFNLLSQHHFEVLDRQALVEKLESTKKIFNNVRSSANLAEELPQL
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALLGAHHDLAATILSEDGRVLFSDPKTVDVPESYRDAEQQNMWEWKYAGRLYRGLTARI
HHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCEEEE
SVADQPEPLTALLILDVTNHAHFFQTLQRWFGVGLSVSALISAALGWMVVRSGLRPLRQV
EECCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THLAASMSARSLQERMPLEPIPLELQQLVLSFNAMLDRLEDAFVRLSNFSADIAHELRTP
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
VSNLMTHTEVVLTKKRNIDAYEENLYSNLEELKRMSRIIDDMLFLAKSDNGLIIPEQASI
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCC
ELADVVAKLLAYYHLVADERDIRLSVSGAGNVLGDKLMIDRAVSNLLSNALRYTPVGETI
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
SVTIHEAERTVTLSVENPGGTIEPEHLDKLFYRFYRVDPARREGSPSNAGLGLAITRSIV
EEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHH
EAHKGRIWCTSLDGVTGFHMEFPRQ
HHHCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MFMSVVVVVLTIAGLSFNLLSQHHFEVLDRQALVEKLESTKKIFNNVRSSANLAEELPQL
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALLGAHHDLAATILSEDGRVLFSDPKTVDVPESYRDAEQQNMWEWKYAGRLYRGLTARI
HHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCEEEE
SVADQPEPLTALLILDVTNHAHFFQTLQRWFGVGLSVSALISAALGWMVVRSGLRPLRQV
EECCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THLAASMSARSLQERMPLEPIPLELQQLVLSFNAMLDRLEDAFVRLSNFSADIAHELRTP
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
VSNLMTHTEVVLTKKRNIDAYEENLYSNLEELKRMSRIIDDMLFLAKSDNGLIIPEQASI
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCC
ELADVVAKLLAYYHLVADERDIRLSVSGAGNVLGDKLMIDRAVSNLLSNALRYTPVGETI
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
SVTIHEAERTVTLSVENPGGTIEPEHLDKLFYRFYRVDPARREGSPSNAGLGLAITRSIV
EEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHH
EAHKGRIWCTSLDGVTGFHMEFPRQ
HHHCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]