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The map label for this gene is copR [H]

Identifier: 146283707

GI number: 146283707

Start: 3665072

End: 3665806

Strand: Direct

Name: copR [H]

Synonym: PST_3390

Alternate gene names: 146283707

Gene position: 3665072-3665806 (Clockwise)

Preceding gene: 146283706

Following gene: 146283708

Centisome position: 80.24

GC content: 54.69

Gene sequence:

>735_bases
ATGGCGGCCTCGTTAACCTGCACACTGAGTCGAAACAAACTTTCGGAATCTGCCTGCATGAAATTACTGGTCGCTGAAGA
CGAACCCAAAACTGGTTCTTACCTGCAACAAGGACTTACCGAAGCTGGATTTACCGTCGACCGGGTCACGACTGGCACAG
ATGCGCTCCAATATGCGCTGAGTGAGGTTTATGACCTTTTAATCCTTGACGTGATGATGCCAGGGTTAGATGGATGGGAG
GTGCTACGCATGGTCAGATCAGCAGGGCACGAAATACCCGTACTGTTCTTGACCGCACGTGATGGCGTGGAAGACCGCGT
CAAAGGCCTGGAGCTGGGCGCGGACGACTACCTGATTAAGCCGTTCGCGTTCTCCGAACTTCTGGCAAGGGTCCGGACAT
TGCTTCGCAGGGGCAGCGGCTCCCCCACCCAAACCACCGTGAAAATTTCAGATCTCGAAGTGGACCTGCTAAAGCGCCGC
GCCGTTCGTGCTGGGAAGCGAATTGATCTGACGGCGAAGGAATTTTCACTGCTGGAATTGTTGATGCGCCGACGCGGCGA
GGTGCTTCCGAAGTCTCTGATTGCATCTCAGGTATGGGATATGAACTTCGACAGCGACACCAACGTTATCGAGGTCGCGG
TACGCCGTCTGCGCGCAAAAGTCGACGACGACTTCGAGCACAAACTGATCCATACCGTGCGTGGCATGGGCTATATGATG
GATGCACCGGAGTGA

Upstream 100 bases:

>100_bases
CTCATATTTTGCTCGAACATAGATTCCGACTTATGTGAAACACTATCACCTCCGCCTGTCAGCGAGCTGATTTGTACGTT
ACATTTTTGTAAGCTTCTAG

Downstream 100 bases:

>100_bases
GACTGCGTCACCTTTCGCTGACCGCCCGAATGAGTGTCATGTTCATGTCTGTGGTGGTTGTAGTTCTCACCATAGCTGGG
CTGAGCTTCAATTTGCTTAG

Product: transcriptional activator CopR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAASLTCTLSRNKLSESACMKLLVAEDEPKTGSYLQQGLTEAGFTVDRVTTGTDALQYALSEVYDLLILDVMMPGLDGWE
VLRMVRSAGHEIPVLFLTARDGVEDRVKGLELGADDYLIKPFAFSELLARVRTLLRRGSGSPTQTTVKISDLEVDLLKRR
AVRAGKRIDLTAKEFSLLELLMRRRGEVLPKSLIASQVWDMNFDSDTNVIEVAVRRLRAKVDDDFEHKLIHTVRGMGYMM
DAPE

Sequences:

>Translated_244_residues
MAASLTCTLSRNKLSESACMKLLVAEDEPKTGSYLQQGLTEAGFTVDRVTTGTDALQYALSEVYDLLILDVMMPGLDGWE
VLRMVRSAGHEIPVLFLTARDGVEDRVKGLELGADDYLIKPFAFSELLARVRTLLRRGSGSPTQTTVKISDLEVDLLKRR
AVRAGKRIDLTAKEFSLLELLMRRRGEVLPKSLIASQVWDMNFDSDTNVIEVAVRRLRAKVDDDFEHKLIHTVRGMGYMM
DAPE
>Mature_243_residues
AASLTCTLSRNKLSESACMKLLVAEDEPKTGSYLQQGLTEAGFTVDRVTTGTDALQYALSEVYDLLILDVMMPGLDGWEV
LRMVRSAGHEIPVLFLTARDGVEDRVKGLELGADDYLIKPFAFSELLARVRTLLRRGSGSPTQTTVKISDLEVDLLKRRA
VRAGKRIDLTAKEFSLLELLMRRRGEVLPKSLIASQVWDMNFDSDTNVIEVAVRRLRAKVDDDFEHKLIHTVRGMGYMMD
APE

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=61.7777777777778, Blast_Score=298, Evalue=2e-82,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=53.4246575342466, Blast_Score=239, Evalue=9e-65,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=42.5339366515837, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=37.5545851528384, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=34.2342342342342, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.920704845815, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=34.3612334801762, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=31.8181818181818, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=36.1990950226244, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=35.5855855855856, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=28.3842794759825, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.3185840707965, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=28.3898305084746, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=185, Percent_Identity=30.2702702702703, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=37.2727272727273, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=32.4074074074074, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=64, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=124, Percent_Identity=30.6451612903226, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27279; Mature: 27148

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00464 RIBOSOMAL_L22

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASLTCTLSRNKLSESACMKLLVAEDEPKTGSYLQQGLTEAGFTVDRVTTGTDALQYAL
CCCEEEEEECHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEHCCCCHHHHHHHH
SEVYDLLILDVMMPGLDGWEVLRMVRSAGHEIPVLFLTARDGVEDRVKGLELGADDYLIK
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEC
PFAFSELLARVRTLLRRGSGSPTQTTVKISDLEVDLLKRRAVRAGKRIDLTAKEFSLLEL
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEECHHHHHHHHHH
LMRRRGEVLPKSLIASQVWDMNFDSDTNVIEVAVRRLRAKVDDDFEHKLIHTVRGMGYMM
HHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DAPE
CCCC
>Mature Secondary Structure 
AASLTCTLSRNKLSESACMKLLVAEDEPKTGSYLQQGLTEAGFTVDRVTTGTDALQYAL
CCEEEEEECHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEHCCCCHHHHHHHH
SEVYDLLILDVMMPGLDGWEVLRMVRSAGHEIPVLFLTARDGVEDRVKGLELGADDYLIK
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEC
PFAFSELLARVRTLLRRGSGSPTQTTVKISDLEVDLLKRRAVRAGKRIDLTAKEFSLLEL
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEECHHHHHHHHHH
LMRRRGEVLPKSLIASQVWDMNFDSDTNVIEVAVRRLRAKVDDDFEHKLIHTVRGMGYMM
HHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DAPE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]