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The map label for this gene is atoB [H]

Identifier: 146283545

GI number: 146283545

Start: 3476588

End: 3477769

Strand: Direct

Name: atoB [H]

Synonym: PST_3220

Alternate gene names: 146283545

Gene position: 3476588-3477769 (Clockwise)

Preceding gene: 146283544

Following gene: 146283546

Centisome position: 76.12

GC content: 68.87

Gene sequence:

>1182_bases
ATGCAAGACGTCGTCATCGTAGCTGCAACCCGCACCGCCATCGGCAGTTTCCAGGGCTCGCTGGCCAATGTGCCGGCAGT
CGAACTGGGCGCCACCGTGATCCGCGCTCTGCTGGAAAAGACCGGCATCGACCCGACTCAGGTCGATGAAGTCATCCTCG
GCCAGGTGCTCACCGCCGGCGCCGGGCAGAACACCGCGCGCCAGGCCTCGATCAAGGCCGGCCTGCCCCACGCCGTTCCG
TCCATGACGCTGAACAAGGTCTGCGGCTCGGGCCTCAAGGCCGTGCATCTGGCCGTGCAGGCGATCCGCTGCGGCGATGC
CGAAGTGGTCATCGCCGGCGGCATGGAGAACATGAGCCTGGCGCCCTACGTTCTGCCCGGCGCACGCACCGGCCTGCGCA
TGGGCCACGCGCAGATCGTCGATACCATGATCACCGACGGCCTGTGGGACGCCTTCAACGACTACCACATGGGCATCACC
GCGGAGAACCTGGCCGACAAGTACGGCATCGACCGCGCCCAGCAGGACGCCTTCGCCGCACAGTCGCAGCAGCGTGCCGC
GGCGGCCATCGAAAGCGGCCGCTTCGATGCCGAGATCACCCCGGTCATGATTCCCCAGCGCAAGGGCGACCCGGTCGCCT
TCGCCCGTGACGAGCAGCCGCGCGCCGGCACCACGGCCGAATCCCTCGGCGGCCTGCGTGCAGCCTTCAAGAAGGACGGC
TGCGTCACCGCCGGCAACGCCTCGACCCTCAACGACGGCGCCGCCGCGGTGGTGCTGATGAGCGCCAGCAAGGCCGAGGC
CCTGGGCCTGCCGGTGCTGGCCAAGATCGCCGGCTACGCCAACGCCGGCGTCGACCCGGCGATCATGGGCATCGGCCCGG
TCACCGCCACCCGTCGCTGCCTGGAAAAGGCCGGCTGGACGCTGGCCGAGCTGGACCTGATCGAAGCCAACGAAGCCTTC
GCCGTGCAGGCGTTGTCGGTCGGTAAGGAATTGGGCTGGGATGCCGATAAGGTCAACGTGAACGGCGGGGCCATCGCCCT
CGGTCACCCGATCGGCGCCTCGGGCTGCCGCATCCTGGTGACCCTGCTGCACGAGATGCAGCGCCGCGACGCGCGCAAGG
GCCTGGCGACACTGTGCATCGGTGGTGGTCAGGGAGTAGCCTTGGCAGTCGAACGCCCCTGA

Upstream 100 bases:

>100_bases
TTGCCCCCTGTCGTTCGAGGGCACCCTTTCCCGGAGCCAGGCCGCGTGCCTGGTCCTCGCGTTACGCCCCGGCGTAGCGC
TTTTTTATTCGGAGTCCGTC

Downstream 100 bases:

>100_bases
GCGAATCACACGGCGCGGGGCAGACATACGCGCCCGGATCACCGGGCGTGACAGAGGATGATCGGAAGGAATCATGGCTA
AACAGACCTACAGCATTTCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MQDVVIVAATRTAIGSFQGSLANVPAVELGATVIRALLEKTGIDPTQVDEVILGQVLTAGAGQNTARQASIKAGLPHAVP
SMTLNKVCGSGLKAVHLAVQAIRCGDAEVVIAGGMENMSLAPYVLPGARTGLRMGHAQIVDTMITDGLWDAFNDYHMGIT
AENLADKYGIDRAQQDAFAAQSQQRAAAAIESGRFDAEITPVMIPQRKGDPVAFARDEQPRAGTTAESLGGLRAAFKKDG
CVTAGNASTLNDGAAAVVLMSASKAEALGLPVLAKIAGYANAGVDPAIMGIGPVTATRRCLEKAGWTLAELDLIEANEAF
AVQALSVGKELGWDADKVNVNGGAIALGHPIGASGCRILVTLLHEMQRRDARKGLATLCIGGGQGVALAVERP

Sequences:

>Translated_393_residues
MQDVVIVAATRTAIGSFQGSLANVPAVELGATVIRALLEKTGIDPTQVDEVILGQVLTAGAGQNTARQASIKAGLPHAVP
SMTLNKVCGSGLKAVHLAVQAIRCGDAEVVIAGGMENMSLAPYVLPGARTGLRMGHAQIVDTMITDGLWDAFNDYHMGIT
AENLADKYGIDRAQQDAFAAQSQQRAAAAIESGRFDAEITPVMIPQRKGDPVAFARDEQPRAGTTAESLGGLRAAFKKDG
CVTAGNASTLNDGAAAVVLMSASKAEALGLPVLAKIAGYANAGVDPAIMGIGPVTATRRCLEKAGWTLAELDLIEANEAF
AVQALSVGKELGWDADKVNVNGGAIALGHPIGASGCRILVTLLHEMQRRDARKGLATLCIGGGQGVALAVERP
>Mature_393_residues
MQDVVIVAATRTAIGSFQGSLANVPAVELGATVIRALLEKTGIDPTQVDEVILGQVLTAGAGQNTARQASIKAGLPHAVP
SMTLNKVCGSGLKAVHLAVQAIRCGDAEVVIAGGMENMSLAPYVLPGARTGLRMGHAQIVDTMITDGLWDAFNDYHMGIT
AENLADKYGIDRAQQDAFAAQSQQRAAAAIESGRFDAEITPVMIPQRKGDPVAFARDEQPRAGTTAESLGGLRAAFKKDG
CVTAGNASTLNDGAAAVVLMSASKAEALGLPVLAKIAGYANAGVDPAIMGIGPVTATRRCLEKAGWTLAELDLIEANEAF
AVQALSVGKELGWDADKVNVNGGAIALGHPIGASGCRILVTLLHEMQRRDARKGLATLCIGGGQGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=52.6854219948849, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=43.1818181818182, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.765903307888, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=43.3249370277078, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=29.5774647887324, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.5521628498728, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=66.8367346938776, Blast_Score=533, Evalue=1e-153,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=62.8498727735369, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=46.1346633416459, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=43.609022556391, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=32.7628361858191, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=44.1025641025641, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=40.0516795865633, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.4223918575064, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.3155216284987, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=30.9133489461358, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=44.1919191919192, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=39.0428211586902, Blast_Score=243, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.3979591836735, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=45.7800511508951, Blast_Score=317, Evalue=7e-87,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=42.8205128205128, Blast_Score=304, Evalue=6e-83,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=30.5164319248826, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40445; Mature: 40445

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDVVIVAATRTAIGSFQGSLANVPAVELGATVIRALLEKTGIDPTQVDEVILGQVLTAG
CCCEEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNTARQASIKAGLPHAVPSMTLNKVCGSGLKAVHLAVQAIRCGDAEVVIAGGMENMSL
CCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APYVLPGARTGLRMGHAQIVDTMITDGLWDAFNDYHMGITAENLADKYGIDRAQQDAFAA
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCHHHHHHHHH
QSQQRAAAAIESGRFDAEITPVMIPQRKGDPVAFARDEQPRAGTTAESLGGLRAAFKKDG
HHHHHHHHHHHCCCCCCEECEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
CVTAGNASTLNDGAAAVVLMSASKAEALGLPVLAKIAGYANAGVDPAIMGIGPVTATRRC
CEECCCCCCCCCCCEEEEEEECCCHHHCCCHHHHHHHCCCCCCCCCEEEECCCHHHHHHH
LEKAGWTLAELDLIEANEAFAVQALSVGKELGWDADKVNVNGGAIALGHPIGASGCRILV
HHHHCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHEMQRRDARKGLATLCIGGGQGVALAVERP
HHHHHHHHHHHHCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MQDVVIVAATRTAIGSFQGSLANVPAVELGATVIRALLEKTGIDPTQVDEVILGQVLTAG
CCCEEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNTARQASIKAGLPHAVPSMTLNKVCGSGLKAVHLAVQAIRCGDAEVVIAGGMENMSL
CCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APYVLPGARTGLRMGHAQIVDTMITDGLWDAFNDYHMGITAENLADKYGIDRAQQDAFAA
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCHHHHHHHHH
QSQQRAAAAIESGRFDAEITPVMIPQRKGDPVAFARDEQPRAGTTAESLGGLRAAFKKDG
HHHHHHHHHHHCCCCCCEECEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
CVTAGNASTLNDGAAAVVLMSASKAEALGLPVLAKIAGYANAGVDPAIMGIGPVTATRRC
CEECCCCCCCCCCCEEEEEEECCCHHHCCCHHHHHHHCCCCCCCCCEEEECCCHHHHHHH
LEKAGWTLAELDLIEANEAFAVQALSVGKELGWDADKVNVNGGAIALGHPIGASGCRILV
HHHHCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHEMQRRDARKGLATLCIGGGQGVALAVERP
HHHHHHHHHHHHCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]