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The map label for this gene is lpsI [H]

Identifier: 146283543

GI number: 146283543

Start: 3475001

End: 3475696

Strand: Direct

Name: lpsI [H]

Synonym: PST_3218

Alternate gene names: 146283543

Gene position: 3475001-3475696 (Clockwise)

Preceding gene: 146283542

Following gene: 146283544

Centisome position: 76.08

GC content: 64.8

Gene sequence:

>696_bases
ATGAACAAGATTTACCCCAACGCCGCCCACGCCCTGGAAGGGTTGGTTCAGGACGGCATGACCATCGCCGTCGGCGGCTT
CGGCCTGTGCGGCATCCCCGAGCAGCTGATCGGCGCGCTGCGCGACAGCGGCAAGAAGGACCTGACTGCCATCAGCAACA
ACGCCGGTGTCGACGGTTTCGGCCTCGGCCTGCTGCTGGAGACGCGGCAGATCAGCAAGATGATTTCCTCCTACGTGGGT
GAGAACAAGGAGTTCGAGCGCCAGTACCTGGCCGGCGAGCTGGCCCTGGAGTTCACCCCGCAGGGCACCCTGGCGGAGAA
GCTGCGTGCCGGCGGCGCGGGCATCCCGGCGTTCTACACCAGGACCGGCTACGGCACCCTGGTGGCCGAAGGCAAGGAAA
CCCGCCAGTTCAACGGCGAGTGGTACGTGATGGAAGAATCGCTGACCGCGGACCTGGCCCTGGTCAAGGCATGGAAGGCC
GACAAGGCCGGCAACCTGCTGTTTCGCAAGACCGCGCGCAACTTCAACCCGCTGGCAGCGATGGCCGGCGAGGTCTGCGT
CGTCGAGGTGGAGGAGATCGTCGAGACCGGCGAGCTGGACCCGGACCAGATTCACCTGCCGGGCATCTACGTGCATCGCA
TCGTGCACAACCCGAACCCGGAAAAACGCATCGAAAAACGCACGGTGAGGAGCTGA

Upstream 100 bases:

>100_bases
AGGCATGCCGGTTAGCGGCACCGTTCTTGCTAAACCCTATTCGTCGGGCGCCCATTCAGGTAGCGCCCGGCACGGACAGA
ACAACAAGTAGAGGTAATTC

Downstream 100 bases:

>100_bases
GACCATGGCCTGGACACGTGAACAGATGGCGCAACGCGCCGCCCAGGAGCTGCAGGACGGCTTCTACGTCAACCTCGGTA
TCGGCCTGCCTACCCTGGTC

Product: CoA transferase, subunit A

Products: NA

Alternate protein names: Succinyl CoA:3-oxoacid CoA-transferase; OXCT A [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNKIYPNAAHALEGLVQDGMTIAVGGFGLCGIPEQLIGALRDSGKKDLTAISNNAGVDGFGLGLLLETRQISKMISSYVG
ENKEFERQYLAGELALEFTPQGTLAEKLRAGGAGIPAFYTRTGYGTLVAEGKETRQFNGEWYVMEESLTADLALVKAWKA
DKAGNLLFRKTARNFNPLAAMAGEVCVVEVEEIVETGELDPDQIHLPGIYVHRIVHNPNPEKRIEKRTVRS

Sequences:

>Translated_231_residues
MNKIYPNAAHALEGLVQDGMTIAVGGFGLCGIPEQLIGALRDSGKKDLTAISNNAGVDGFGLGLLLETRQISKMISSYVG
ENKEFERQYLAGELALEFTPQGTLAEKLRAGGAGIPAFYTRTGYGTLVAEGKETRQFNGEWYVMEESLTADLALVKAWKA
DKAGNLLFRKTARNFNPLAAMAGEVCVVEVEEIVETGELDPDQIHLPGIYVHRIVHNPNPEKRIEKRTVRS
>Mature_231_residues
MNKIYPNAAHALEGLVQDGMTIAVGGFGLCGIPEQLIGALRDSGKKDLTAISNNAGVDGFGLGLLLETRQISKMISSYVG
ENKEFERQYLAGELALEFTPQGTLAEKLRAGGAGIPAFYTRTGYGTLVAEGKETRQFNGEWYVMEESLTADLALVKAWKA
DKAGNLLFRKTARNFNPLAAMAGEVCVVEVEEIVETGELDPDQIHLPGIYVHRIVHNPNPEKRIEKRTVRS

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=247, Percent_Identity=58.2995951417004, Blast_Score=294, Evalue=4e-80,
Organism=Homo sapiens, GI11545841, Length=232, Percent_Identity=55.1724137931034, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1788551, Length=202, Percent_Identity=46.039603960396, Blast_Score=190, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17531517, Length=244, Percent_Identity=56.1475409836066, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI21358325, Length=242, Percent_Identity=56.6115702479339, Blast_Score=267, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24655794, Length=242, Percent_Identity=56.6115702479339, Blast_Score=267, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.5 [H]

Molecular weight: Translated: 25165; Mature: 25165

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01273 COA_TRANSF_1 ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIYPNAAHALEGLVQDGMTIAVGGFGLCGIPEQLIGALRDSGKKDLTAISNNAGVDGF
CCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCCHHEECCCCCCCCC
GLGLLLETRQISKMISSYVGENKEFERQYLAGELALEFTPQGTLAEKLRAGGAGIPAFYT
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCCCCCEEE
RTGYGTLVAEGKETRQFNGEWYVMEESLTADLALVKAWKADKAGNLLFRKTARNFNPLAA
ECCCEEEEECCCHHHEECCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEHHCCCCCHHHH
MAGEVCVVEVEEIVETGELDPDQIHLPGIYVHRIVHNPNPEKRIEKRTVRS
HCCCEEEEEHHHHHHHCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNKIYPNAAHALEGLVQDGMTIAVGGFGLCGIPEQLIGALRDSGKKDLTAISNNAGVDGF
CCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCCHHEECCCCCCCCC
GLGLLLETRQISKMISSYVGENKEFERQYLAGELALEFTPQGTLAEKLRAGGAGIPAFYT
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCCCCCEEE
RTGYGTLVAEGKETRQFNGEWYVMEESLTADLALVKAWKADKAGNLLFRKTARNFNPLAA
ECCCEEEEECCCHHHEECCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEHHCCCCCHHHH
MAGEVCVVEVEEIVETGELDPDQIHLPGIYVHRIVHNPNPEKRIEKRTVRS
HCCCEEEEEHHHHHHHCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9385134; 11589581 [H]