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The map label for this gene is mmgC [H]

Identifier: 146283538

GI number: 146283538

Start: 3468208

End: 3469371

Strand: Direct

Name: mmgC [H]

Synonym: PST_3213

Alternate gene names: 146283538

Gene position: 3468208-3469371 (Clockwise)

Preceding gene: 146283527

Following gene: 146283539

Centisome position: 75.93

GC content: 64.52

Gene sequence:

>1164_bases
ATGAACTACTCCAGCCTCAATTTCGCCCTCGGTGAAACCATCGACATGCTGCGCGAGCAGGTCCAGGCCTTCGTCGCCGC
CGAGCTGGCGCCGCGCGCCGAGGCCATCGACCAGGACAACCTGTTCCCGGCCGACATGTGGAAGAAATTCGGCGAGATGG
GTCTGCTCGGCGTCACCGTCTCCGAGGAATACGGCGGCGCCGGCCTTGGCTACCTGGCCCACGTGGTGGCGATGGAAGAG
ATCAGCCGCGGCTCGGCCTCGGTCGCCCTTTCCTACGGCGCCCACTCAAACCTGTGCGTCAACCAGATCAACCGCAACGG
CAACCCCGAGCAGAAGGCCCGCTACCTGCCCAAGCTGATCAGCGGCGAACACGTCGGCGCGCTGGCCATGAGCGAGCCGA
ATGCCGGCTCCGACGTGGTCTCCATGAAGCTGCGCGCCGAAAAGCGCGGCGACCGCTACGTGCTCAACGGCAGCAAGACC
TGGATCACCAACGGCCCGGACGCCAACACCTACGTGATCTACGCCAAGACCGACCTGGACAAGGGTCCGCACGGCATCAC
CGCGTTCATCGTCGAGCGCGACTGGAAAGGTTTCTCCCGCGGCAACAAGTTCGACAAGCTCGGCATGCGTGGCTCCAACA
CCTGCGAGCTGTTCTTCGATGACGTCGAGGTGCCGCAAGAGAACGTGCTGGGCGTCGAGAACGGCGGCGTCAAGGTGCTG
ATGAGCGGCCTGGATTACGAGCGCGTGGTACTGGCCGGCGGCCCGACCGGGATCATGCAGGCCTGCCTCGACGTGGTGGT
GCCCTACATCCACGACCGCAAGCAGTTCGGTCAGAGCATCGGCGAGTTCCAGTTCATTCAGGGCAAGGTGGCGGACATGT
ACACCCAGCTCAACGCCAGCCGTGCCTATCTCTACGCCGTCGCCCAGGCCTGCGACCGTGGCGAGACCACCCGCAAGGAC
GCCGCCGGGGTGATTCTCTATACCGCCGAAAACGCCACGCAGATGGCCCTGCAGGCGATCCAGATCCTCGGTGGCAACGG
CTATATCAACGAATTCCCCACCGGCCGCCTGCTGCGTGACGCCAAGCTCTACGAGATTGGCGCCGGCACCAGCGAGATCC
GCCGCATGCTGATCGGCCGCGAGCTGTTCAACGAATCCAGGTGA

Upstream 100 bases:

>100_bases
TCCCGAAGGCGCTCAGGCTGCGACCGGAGCGCCGGCCGGAACCCGCCGGATGCACGAATTCTCTGAACACAGAACAATTA
CAAGACAAGCAGGTGGCCCC

Downstream 100 bases:

>100_bases
GCTGCGGGCGGTACAACGCCCAACTCGTAGGGTGGAAAACCGCGAAGCGTTTTCCACCGCAGTCGGTGGATGGCAGAGCC
ATCCATGATGGAATTGAACG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNYSSLNFALGETIDMLREQVQAFVAAELAPRAEAIDQDNLFPADMWKKFGEMGLLGVTVSEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGNPEQKARYLPKLISGEHVGALAMSEPNAGSDVVSMKLRAEKRGDRYVLNGSKT
WITNGPDANTYVIYAKTDLDKGPHGITAFIVERDWKGFSRGNKFDKLGMRGSNTCELFFDDVEVPQENVLGVENGGVKVL
MSGLDYERVVLAGGPTGIMQACLDVVVPYIHDRKQFGQSIGEFQFIQGKVADMYTQLNASRAYLYAVAQACDRGETTRKD
AAGVILYTAENATQMALQAIQILGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESR

Sequences:

>Translated_387_residues
MNYSSLNFALGETIDMLREQVQAFVAAELAPRAEAIDQDNLFPADMWKKFGEMGLLGVTVSEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGNPEQKARYLPKLISGEHVGALAMSEPNAGSDVVSMKLRAEKRGDRYVLNGSKT
WITNGPDANTYVIYAKTDLDKGPHGITAFIVERDWKGFSRGNKFDKLGMRGSNTCELFFDDVEVPQENVLGVENGGVKVL
MSGLDYERVVLAGGPTGIMQACLDVVVPYIHDRKQFGQSIGEFQFIQGKVADMYTQLNASRAYLYAVAQACDRGETTRKD
AAGVILYTAENATQMALQAIQILGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESR
>Mature_387_residues
MNYSSLNFALGETIDMLREQVQAFVAAELAPRAEAIDQDNLFPADMWKKFGEMGLLGVTVSEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGNPEQKARYLPKLISGEHVGALAMSEPNAGSDVVSMKLRAEKRGDRYVLNGSKT
WITNGPDANTYVIYAKTDLDKGPHGITAFIVERDWKGFSRGNKFDKLGMRGSNTCELFFDDVEVPQENVLGVENGGVKVL
MSGLDYERVVLAGGPTGIMQACLDVVVPYIHDRKQFGQSIGEFQFIQGKVADMYTQLNASRAYLYAVAQACDRGETTRKD
AAGVILYTAENATQMALQAIQILGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64.8, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=64.5945945945946, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=42.0634920634921, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=37.0572207084469, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=38.6920980926431, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.8441558441558, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.8441558441558, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=32.171581769437, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI7656849, Length=366, Percent_Identity=33.0601092896175, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=36.4705882352941, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=36.4705882352941, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4503943, Length=373, Percent_Identity=31.6353887399464, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI7669494, Length=369, Percent_Identity=32.2493224932249, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=23.5915492957746, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=23.5915492957746, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=29.1666666666667, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=28.7206266318538, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=27.4131274131274, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081702, Length=330, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=63.6125654450262, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=37.007874015748, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=36.745406824147, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=35.7702349869452, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=34.1269841269841, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17508101, Length=360, Percent_Identity=33.8888888888889, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=32.2751322751323, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.8571428571429, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=39.2086330935252, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=31.7204301075269, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.036496350365, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=29.5039164490862, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.0952380952381, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=35.2112676056338, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=361, Percent_Identity=28.808864265928, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=30.4878048780488, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=64.9350649350649, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=40.5835543766578, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=41.3793103448276, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=36.1643835616438, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=38.0208333333333, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=35.9773371104816, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI19920834, Length=370, Percent_Identity=30, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24652780, Length=357, Percent_Identity=23.249299719888, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42313; Mature: 42313

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYSSLNFALGETIDMLREQVQAFVAAELAPRAEAIDQDNLFPADMWKKFGEMGLLGVTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHCCCCEEEEEE
SEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQINRNGNPEQKARYLPKLI
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLRAEKRGDRYVLNGSKTWITNGPDANTYVIYAKTDLD
CCCCCCEEEECCCCCCCCEEEEEEEHHCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
KGPHGITAFIVERDWKGFSRGNKFDKLGMRGSNTCELFFDDVEVPQENVLGVENGGVKVL
CCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHCCEECCCCEEEE
MSGLDYERVVLAGGPTGIMQACLDVVVPYIHDRKQFGQSIGEFQFIQGKVADMYTQLNAS
EECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHCCC
RAYLYAVAQACDRGETTRKDAAGVILYTAENATQMALQAIQILGGNGYINEFPTGRLLRD
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRMLIGRELFNESR
CEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNYSSLNFALGETIDMLREQVQAFVAAELAPRAEAIDQDNLFPADMWKKFGEMGLLGVTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHCCCCEEEEEE
SEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQINRNGNPEQKARYLPKLI
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLRAEKRGDRYVLNGSKTWITNGPDANTYVIYAKTDLD
CCCCCCEEEECCCCCCCCEEEEEEEHHCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
KGPHGITAFIVERDWKGFSRGNKFDKLGMRGSNTCELFFDDVEVPQENVLGVENGGVKVL
CCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHCCEECCCCEEEE
MSGLDYERVVLAGGPTGIMQACLDVVVPYIHDRKQFGQSIGEFQFIQGKVADMYTQLNAS
EECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHCCC
RAYLYAVAQACDRGETTRKDAAGVILYTAENATQMALQAIQILGGNGYINEFPTGRLLRD
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRMLIGRELFNESR
CEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]