Click here to switch to the map view.

The map label for this gene is yngE [H]

Identifier: 146283539

GI number: 146283539

Start: 3469481

End: 3471088

Strand: Direct

Name: yngE [H]

Synonym: PST_3214

Alternate gene names: 146283539

Gene position: 3469481-3471088 (Clockwise)

Preceding gene: 146283538

Following gene: 146283540

Centisome position: 75.96

GC content: 67.91

Gene sequence:

>1608_bases
ATGGCCATCCTGCACACCCAGATCAATACCCGTTCGCCAGAGTTCGCCGCCAACAGCGCGGCGATGCTCGAACAGGTGAA
CAACCTGCGCGCCCTGCTCGGCCGTGTCAGCGAAGGCGGCGGCGCCACCGCCCAGCAGCGCCACGTCTCGCGCGGCAAGC
TGCTGGTGCGCGAGCGCATCGACACCCTGCTCGACGCCGGCTCGGCCTTTCTCGAACTCGCGCCGCTGGCCGCCCATGAG
GTCTATGGCGAAGACGTCGCTGCTGCCGGCGTGGTGGCCGGTATCGGCCGCGTCGAAGGCGTCGAGTGCATGATCATCGC
CAATGACGCCACCGTGAAAGGCGGCACCTACTACCCGCTGACGGTGAAGAAGCACCTGCGCGCGCAGACCGTCGCCCGCG
AGAACCGCCTGCCCTGCATCTACCTGGTGGACTCCGGCGGCGCCAACCTGCCGCGACAGGACGAGGTGTTCCCGGACCGC
GAGCACTTCGGTCGTATCTTCTTCAACCAGGCCAACATGAGCGCCATGGGCATCCCGCAGATCGCCGTGGTGATGGGCTC
CTGCACTGCCGGCGGCGCCTACGTGCCAGCGATGGCCGACGAGACCATCATGGTGCGCAACCAGGCGACCATCTTTCTCG
CCGGCCCGCCGCTGGTGAAGGCTGCCACCGGCGAAGTGGTGACCGCCGAGGAGCTGGGCGGCGCCGACGTGCACTGCAAG
ACCTCGGGCGTCGCCGACCACTACGCCGAGAACGACGAGCACGCGCTTTCCATCGCCCGCCGCTGCGTGGCCAACCTCAA
CTGGCGCAAGCTCGGCCAGCTGCAGACCCGCGAACCGCGCGCACCGCTGTATGCCGCCGACGAGCTGTACGGCGTGATCC
CGGCACAGGCCAAGCAGCCTTATGACGTGCGCGAAGTGATCGCACGACTGGTGGACGGCAGCGAGTTCGATGAATTCAAG
GCGCTGTTCGGCACCACCCTGGTCTGCGGCTTCGCCCATCTGCACGGCTACCCGATCGCCATCCTCGCCAACAACGGCAT
CCTCTTCGCCGAGGCGGCGCAGAAAGGCGCGCACTTCATCGAGCTGGCCTGCCAGCGGGGCATTCCGCTGCTGTTCCTGC
AGAACATCACCGGTTTCATGGTCGGGCAGAAATACGAGGCCGGTGGCATCGCCAAGCACGGCGCCAAGCTGGTCACCGCG
GTGGCCTGCGCCCAGGTGCCGAAGTTCACCGTGCTCATCGGCGGCAGCTTCGGTGCCGGCAACTACGGCATGTGCGGCCG
CGCCTACGACCCGCGCTTCCTCTGGATGTGGCCCAACGCGCGCATCGCCGTGATGGGTGGCGAACAGGCCGCCGGGGTGC
TCGCCCAGGTCAAGCAGGAGCAGAGCGAGCGCGCCGGCAAGAGCCTCGGCGACGATGAGGTGGCGGCCATCAAGCAGCCG
ATCCTCGAACAGTACGAGCGCCAGGGCCATCCCTATTACTCCAGCGCGCGGCTGTGGGACGACGGCGTGATCGACCCGGC
GCAGACCCGCGAGGTGCTGGGGCTGGCGCTGTCCGCCGCGTTGAATGCGCCGATCGAGCCGACCCGCTTCGGCGTGTTCC
GCATGTAA

Upstream 100 bases:

>100_bases
GGTACAACGCCCAACTCGTAGGGTGGAAAACCGCGAAGCGTTTTCCACCGCAGTCGGTGGATGGCAGAGCCATCCATGAT
GGAATTGAACGGAGCCAACC

Downstream 100 bases:

>100_bases
TCCGTGCCGCCGGCAGCCGAGCGCGCCGGCGCCTGCAGTCGCATCGAGGATGCCGAGATGACCGATTTCCAGACCATCGA
ACTGAACAAAGACGCGCGCG

Product: acyl-CoA carboxyltransferase subunit beta

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MAILHTQINTRSPEFAANSAAMLEQVNNLRALLGRVSEGGGATAQQRHVSRGKLLVRERIDTLLDAGSAFLELAPLAAHE
VYGEDVAAAGVVAGIGRVEGVECMIIANDATVKGGTYYPLTVKKHLRAQTVARENRLPCIYLVDSGGANLPRQDEVFPDR
EHFGRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADETIMVRNQATIFLAGPPLVKAATGEVVTAEELGGADVHCK
TSGVADHYAENDEHALSIARRCVANLNWRKLGQLQTREPRAPLYAADELYGVIPAQAKQPYDVREVIARLVDGSEFDEFK
ALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTA
VACAQVPKFTVLIGGSFGAGNYGMCGRAYDPRFLWMWPNARIAVMGGEQAAGVLAQVKQEQSERAGKSLGDDEVAAIKQP
ILEQYERQGHPYYSSARLWDDGVIDPAQTREVLGLALSAALNAPIEPTRFGVFRM

Sequences:

>Translated_535_residues
MAILHTQINTRSPEFAANSAAMLEQVNNLRALLGRVSEGGGATAQQRHVSRGKLLVRERIDTLLDAGSAFLELAPLAAHE
VYGEDVAAAGVVAGIGRVEGVECMIIANDATVKGGTYYPLTVKKHLRAQTVARENRLPCIYLVDSGGANLPRQDEVFPDR
EHFGRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADETIMVRNQATIFLAGPPLVKAATGEVVTAEELGGADVHCK
TSGVADHYAENDEHALSIARRCVANLNWRKLGQLQTREPRAPLYAADELYGVIPAQAKQPYDVREVIARLVDGSEFDEFK
ALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTA
VACAQVPKFTVLIGGSFGAGNYGMCGRAYDPRFLWMWPNARIAVMGGEQAAGVLAQVKQEQSERAGKSLGDDEVAAIKQP
ILEQYERQGHPYYSSARLWDDGVIDPAQTREVLGLALSAALNAPIEPTRFGVFRM
>Mature_534_residues
AILHTQINTRSPEFAANSAAMLEQVNNLRALLGRVSEGGGATAQQRHVSRGKLLVRERIDTLLDAGSAFLELAPLAAHEV
YGEDVAAAGVVAGIGRVEGVECMIIANDATVKGGTYYPLTVKKHLRAQTVARENRLPCIYLVDSGGANLPRQDEVFPDRE
HFGRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADETIMVRNQATIFLAGPPLVKAATGEVVTAEELGGADVHCKT
SGVADHYAENDEHALSIARRCVANLNWRKLGQLQTREPRAPLYAADELYGVIPAQAKQPYDVREVIARLVDGSEFDEFKA
LFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAV
ACAQVPKFTVLIGGSFGAGNYGMCGRAYDPRFLWMWPNARIAVMGGEQAAGVLAQVKQEQSERAGKSLGDDEVAAIKQPI
LEQYERQGHPYYSSARLWDDGVIDPAQTREVLGLALSAALNAPIEPTRFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=64.7388059701492, Blast_Score=715, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=525, Percent_Identity=31.8095238095238, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI295821216, Length=545, Percent_Identity=30.8256880733945, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI310133460, Length=146, Percent_Identity=55.4794520547945, Blast_Score=143, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17552936, Length=537, Percent_Identity=62.756052141527, Blast_Score=717, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=549, Percent_Identity=32.9690346083789, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI25147359, Length=547, Percent_Identity=33.0895795246801, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=64.5454545454545, Blast_Score=752, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57457; Mature: 57326

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILHTQINTRSPEFAANSAAMLEQVNNLRALLGRVSEGGGATAQQRHVSRGKLLVRERI
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
DTLLDAGSAFLELAPLAAHEVYGEDVAAAGVVAGIGRVEGVECMIIANDATVKGGTYYPL
HHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQTVARENRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAMGIPQ
EHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMADETIMVRNQATIFLAGPPLVKAATGEVVTAEELGGADVHCK
EEEEEECCCCCCEEECCCCCCEEEEECCEEEEEECCCEEEECCCCEEEHHHCCCCCEEEE
TSGVADHYAENDEHALSIARRCVANLNWRKLGQLQTREPRAPLYAADELYGVIPAQAKQP
CCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEECCHHHCCCCCCCCCC
YDVREVIARLVDGSEFDEFKALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCCHHH
ELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACAQVPKFTVLIGGSFGAG
HHHHHCCCCEEEECCCHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARIAVMGGEQAAGVLAQVKQEQSERAGKSLGDDEVAAIKQP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ILEQYERQGHPYYSSARLWDDGVIDPAQTREVLGLALSAALNAPIEPTRFGVFRM
HHHHHHHCCCCEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AILHTQINTRSPEFAANSAAMLEQVNNLRALLGRVSEGGGATAQQRHVSRGKLLVRERI
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
DTLLDAGSAFLELAPLAAHEVYGEDVAAAGVVAGIGRVEGVECMIIANDATVKGGTYYPL
HHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQTVARENRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAMGIPQ
EHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMADETIMVRNQATIFLAGPPLVKAATGEVVTAEELGGADVHCK
EEEEEECCCCCCEEECCCCCCEEEEECCEEEEEECCCEEEECCCCEEEHHHCCCCCEEEE
TSGVADHYAENDEHALSIARRCVANLNWRKLGQLQTREPRAPLYAADELYGVIPAQAKQP
CCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEECCHHHCCCCCCCCCC
YDVREVIARLVDGSEFDEFKALFGTTLVCGFAHLHGYPIAILANNGILFAEAAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCCHHH
ELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACAQVPKFTVLIGGSFGAG
HHHHHCCCCEEEECCCHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARIAVMGGEQAAGVLAQVKQEQSERAGKSLGDDEVAAIKQP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ILEQYERQGHPYYSSARLWDDGVIDPAQTREVLGLALSAALNAPIEPTRFGVFRM
HHHHHHHCCCCEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]