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The map label for this gene is csgA [H]

Identifier: 146283406

GI number: 146283406

Start: 3309826

End: 3310593

Strand: Direct

Name: csgA [H]

Synonym: PST_3077

Alternate gene names: 146283406

Gene position: 3309826-3310593 (Clockwise)

Preceding gene: 146283404

Following gene: 146283407

Centisome position: 72.47

GC content: 66.54

Gene sequence:

>768_bases
GTGGTCGATTGCCGCACGCCGGCCCGCTGCGCGCGAGGCTGGTCCTCGCGCTATTCTTGCCCACGTCATGACCTTCGAGA
TTGCTCCATGCCAAAGAACATACTGATTGTCGGCGCCTCCCGCGGCCTGGGCCTCGGCCTGGCGAAGCAGTTCTCCAGCG
CAGGCTGGCAGGTGATCGCCACCGTCCGCGATCCACAGCGTGCCGAAGCGCTAAACGGGTTGCCGCAGCTGCGCATCGAG
ACCCTGGACATGGACGACGCGGCCAGCGTCGATCAACTGGCCGCACGCCTGGCCGGCACCCCGATCGACGTCCTGTTCGT
CAACGCCGGCATCGCCGGGCCGCAGGACAAACCGACCACCGAAGCCAGCCAGGCGGAAGTCGGCCAGCTGTTCTTCACCA
ACGCCGTCGCTCCGGTGCGCCTGGCCGAACGACTGTTGCCACTGGTGAACCCGGATCAGGGCGTGGTCGTCTTCATGAGT
TCCATTCTCGGCAGCGTCGAAGTCGGCCCAGGCATGGGCATGGACCTCTACGGTGCGAGCAAGGCCGCGCTGAACCACAT
GACCCGAACCTTCGTTGCCAAGCTCGGCGAGACGAAGCTGACCGTGCTGTCGATGCATCCGGGCTGGGTCAAGACCGACA
TGGGTGGCGATCAGGCCCCGCTGGATGTCGAGACCAGCGCTCGCGGCATGGCCGAGCAGGTGACGCGGGCCATCGGCCAG
GGCGGGCATCGGTACATCGACTATCTGGGGGACGCGCTGCCCTGGTGA

Upstream 100 bases:

>100_bases
GCGGATGATTCGTTGCCGGGCGCACTGCAAAACTAGCCCATGAGAGCCGAAACAGAGCGGTTCTGACCATCGCAACGAAA
CGGCTTGCAACACTCGGGCA

Downstream 100 bases:

>100_bases
GGAGGCAAGACCGTGATCGACCGTGAACGGACTCACCCCGGTGTCCCGGTCGCGGTCGGGACCGCTCCGCTAACCGGCCC
TTGGCAGCCCCTGGGGCATC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: C signal [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MVDCRTPARCARGWSSRYSCPRHDLRDCSMPKNILIVGASRGLGLGLAKQFSSAGWQVIATVRDPQRAEALNGLPQLRIE
TLDMDDAASVDQLAARLAGTPIDVLFVNAGIAGPQDKPTTEASQAEVGQLFFTNAVAPVRLAERLLPLVNPDQGVVVFMS
SILGSVEVGPGMGMDLYGASKAALNHMTRTFVAKLGETKLTVLSMHPGWVKTDMGGDQAPLDVETSARGMAEQVTRAIGQ
GGHRYIDYLGDALPW

Sequences:

>Translated_255_residues
MVDCRTPARCARGWSSRYSCPRHDLRDCSMPKNILIVGASRGLGLGLAKQFSSAGWQVIATVRDPQRAEALNGLPQLRIE
TLDMDDAASVDQLAARLAGTPIDVLFVNAGIAGPQDKPTTEASQAEVGQLFFTNAVAPVRLAERLLPLVNPDQGVVVFMS
SILGSVEVGPGMGMDLYGASKAALNHMTRTFVAKLGETKLTVLSMHPGWVKTDMGGDQAPLDVETSARGMAEQVTRAIGQ
GGHRYIDYLGDALPW
>Mature_255_residues
MVDCRTPARCARGWSSRYSCPRHDLRDCSMPKNILIVGASRGLGLGLAKQFSSAGWQVIATVRDPQRAEALNGLPQLRIE
TLDMDDAASVDQLAARLAGTPIDVLFVNAGIAGPQDKPTTEASQAEVGQLFFTNAVAPVRLAERLLPLVNPDQGVVVFMS
SILGSVEVGPGMGMDLYGASKAALNHMTRTFVAKLGETKLTVLSMHPGWVKTDMGGDQAPLDVETSARGMAEQVTRAIGQ
GGHRYIDYLGDALPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=199, Percent_Identity=32.1608040201005, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=31.5508021390374, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=29.6703296703297, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=25.9259259259259, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532177, Length=258, Percent_Identity=31.3953488372093, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17559964, Length=236, Percent_Identity=34.3220338983051, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559962, Length=227, Percent_Identity=32.15859030837, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI72001658, Length=239, Percent_Identity=32.6359832635983, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558994, Length=240, Percent_Identity=31.6666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193207563, Length=229, Percent_Identity=31.0043668122271, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17558990, Length=221, Percent_Identity=32.579185520362, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558996, Length=225, Percent_Identity=29.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541382, Length=244, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558992, Length=249, Percent_Identity=26.5060240963855, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=191, Percent_Identity=29.8429319371728, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=194, Percent_Identity=30.4123711340206, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=204, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322067, Length=212, Percent_Identity=29.2452830188679, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24640547, Length=247, Percent_Identity=34.412955465587, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24643142, Length=188, Percent_Identity=35.1063829787234, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007236, Length=221, Percent_Identity=31.6742081447964, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358495, Length=232, Percent_Identity=28.448275862069, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27231; Mature: 27231

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDCRTPARCARGWSSRYSCPRHDLRDCSMPKNILIVGASRGLGLGLAKQFSSAGWQVIA
CCCCCCHHHHHCCHHHCCCCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEE
TVRDPQRAEALNGLPQLRIETLDMDDAASVDQLAARLAGTPIDVLFVNAGIAGPQDKPTT
EECCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
EASQAEVGQLFFTNAVAPVRLAERLLPLVNPDQGVVVFMSSILGSVEVGPGMGMDLYGAS
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCH
KAALNHMTRTFVAKLGETKLTVLSMHPGWVKTDMGGDQAPLDVETSARGMAEQVTRAIGQ
HHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGHRYIDYLGDALPW
CCHHHHHHHHHCCCC
>Mature Secondary Structure
MVDCRTPARCARGWSSRYSCPRHDLRDCSMPKNILIVGASRGLGLGLAKQFSSAGWQVIA
CCCCCCHHHHHCCHHHCCCCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEE
TVRDPQRAEALNGLPQLRIETLDMDDAASVDQLAARLAGTPIDVLFVNAGIAGPQDKPTT
EECCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
EASQAEVGQLFFTNAVAPVRLAERLLPLVNPDQGVVVFMSSILGSVEVGPGMGMDLYGAS
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCH
KAALNHMTRTFVAKLGETKLTVLSMHPGWVKTDMGGDQAPLDVETSARGMAEQVTRAIGQ
HHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGHRYIDYLGDALPW
CCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]