Click here to switch to the map view.

The map label for this gene is zraS [C]

Identifier: 146283221

GI number: 146283221

Start: 3106616

End: 3108301

Strand: Direct

Name: zraS [C]

Synonym: PST_2886

Alternate gene names: 146283221

Gene position: 3106616-3108301 (Clockwise)

Preceding gene: 146283220

Following gene: 146283227

Centisome position: 68.02

GC content: 68.27

Gene sequence:

>1686_bases
ATGACGACACCTACTAAACGTGACAGCCCCACCGTAGTCGTCTTTGCCCCCATCGGTCGGGACGGCCCCGCCTCGGCCGA
GCTGCTCAACCGCAGCGGCATGGAAGCCGTGGTCTGCCACAGCCTCGAGGAAGTGCTCCAGCGCGCGGAAACGGAAGCCG
ACGCCGTATTCATCGCCGAGGAAGGCCTGTTCGGCCATGACCTCGCGGCTCTGGCCGCCTGGGTCGACCGACAGCCGGCC
TGGTCCGATTTTCCCTTCGTGGTGCTCACCAGCAAGCATCAGCAACCGGCCGTGGCCGCTTGGCGCCAGCGCATGGTCGC
CGCGCTGCGCAACGTCTCGCTGCTGGAACGTCCGGTGCAGAGCATCACCCTCACCAGTGCCATGAAGGCGGCGCTGCGCG
GGCGGCATCGCCAGTACGAGGTGCGCGCGCTGCTCGAAGCGCGCGAACGTGCCTCGCACGAGCTCGAAGCGCTGGTGGTC
GAACGGACCAGCGAGCTGGAAAAGGCCAACCAGGAACTGCGCACGCAGATGGCCGAACGCACCCGTATCGAGGAGACCCT
GCGCCAGGCGCAGAAAATCGAGGCCATCGGCCAGCTCACCGGCGGCATCGCCCATGACTTCAACAACCTGCTGATGGTGA
TTTCCGGCGGGCTCGACATGCTCGACCGCCGTGCCGATCCCGCACGCCGCGAACGCCTGATGGCCGGCATGCGCCAGGCG
GCCCAGCGCGGCACATCCCTCACCCGCCAGCTGTTGGCCTTCTCCCGGCGCCAGTCGCTGGCGCCGGAATCCGTCGACCT
GGTGCTGCGCATCGGGCGGATGCGCGAGCTGCTCGACCGCAGCCTGAGCGGCGACGTGCACGTGCAGGTGCAGTTCGCCC
CGGACCTGTGGCCCGTGGAAGTCGATCCGGGCGAGCTGGAGCTGGTGATTCTCAACCTCGCGGTCAACGCCCGCGACGCC
ATGCCCGATGGCGGCTCGATCCTGATCGAGGCACGCAATGCGCCGGATGAACCGGTCATGGGCCTGCGCGGCGACTTCGT
CCGCCTCGCGGTCATCGACGACGGCACCGGTATCCCGGAGGACGTCCGCGCACGGGTGTTCGATCCCTTCTTCACCACCA
AGGAAATCGGCAAGGGCTCGGGGCTCGGCCTGGCCCAGGTCTACGGCTTCGCCCGGCAATCGGGCGGCACCGTCTGGATC
GAAAGCGAATGCGGGCGCGGCACCAGCGTGATCATGCTGCTGCCGCGTTCGGCACGTGTACCCGAGCAGCCCGCCGAGGA
TGAACGCGCCGCCGACGATGCCGCCGACCCTTCCCTCGGCAGCGTGCTGCTGGTGGATGACGACGAGGAAGTGGCCGCGC
TGGTGGGCGAGATGCTCGAGCACCTGGGGTACCGCGTCAGCCACGCCGACAGTGCCACCGCTGCGCTGAATGCGCTGGCC
AACGGCTGCAAGGTGGACGTCGTGTTCTCCGACGTGATGATGCCAGGTGGCATGAATGGCGTTGAGCTGGCCAGGGAGAT
TCGAGTGCGCGCCCTGGGCGTTCCGGTGCTGCTCACCAGCGGCTATGCCGAGGCCGCTCAGCAATCGGCTGCGGCCGAGG
GGGTGCACGTGCTGGCCAAGCCCTATCGGCTCGAAGACCTGGCCGCCTCGCTGCACGACGCGATCGAGGGCGCGAAGGAC
GTCTAG

Upstream 100 bases:

>100_bases
ACCGGCATCCAGGTCGGGCCGCCCCTGAGTCACTTCAACGGCATCCTTTCGGGCACACCGGAATACACCGGCGATGCGGC
TCAGCTACTGAAAGACGAGC

Downstream 100 bases:

>100_bases
ATTGCCCTTCCGACCCTGACTGAAGCCGGCGGTGGCTCAGTCGATTCGCCAATAGCGATAGTGCTGCGGCTTGAATACCT
GATTGAAATGCCGGCCCAGC

Product: sensory box histidine kinase/response regulator

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MTTPTKRDSPTVVVFAPIGRDGPASAELLNRSGMEAVVCHSLEEVLQRAETEADAVFIAEEGLFGHDLAALAAWVDRQPA
WSDFPFVVLTSKHQQPAVAAWRQRMVAALRNVSLLERPVQSITLTSAMKAALRGRHRQYEVRALLEARERASHELEALVV
ERTSELEKANQELRTQMAERTRIEETLRQAQKIEAIGQLTGGIAHDFNNLLMVISGGLDMLDRRADPARRERLMAGMRQA
AQRGTSLTRQLLAFSRRQSLAPESVDLVLRIGRMRELLDRSLSGDVHVQVQFAPDLWPVEVDPGELELVILNLAVNARDA
MPDGGSILIEARNAPDEPVMGLRGDFVRLAVIDDGTGIPEDVRARVFDPFFTTKEIGKGSGLGLAQVYGFARQSGGTVWI
ESECGRGTSVIMLLPRSARVPEQPAEDERAADDAADPSLGSVLLVDDDEEVAALVGEMLEHLGYRVSHADSATAALNALA
NGCKVDVVFSDVMMPGGMNGVELAREIRVRALGVPVLLTSGYAEAAQQSAAAEGVHVLAKPYRLEDLAASLHDAIEGAKD
V

Sequences:

>Translated_561_residues
MTTPTKRDSPTVVVFAPIGRDGPASAELLNRSGMEAVVCHSLEEVLQRAETEADAVFIAEEGLFGHDLAALAAWVDRQPA
WSDFPFVVLTSKHQQPAVAAWRQRMVAALRNVSLLERPVQSITLTSAMKAALRGRHRQYEVRALLEARERASHELEALVV
ERTSELEKANQELRTQMAERTRIEETLRQAQKIEAIGQLTGGIAHDFNNLLMVISGGLDMLDRRADPARRERLMAGMRQA
AQRGTSLTRQLLAFSRRQSLAPESVDLVLRIGRMRELLDRSLSGDVHVQVQFAPDLWPVEVDPGELELVILNLAVNARDA
MPDGGSILIEARNAPDEPVMGLRGDFVRLAVIDDGTGIPEDVRARVFDPFFTTKEIGKGSGLGLAQVYGFARQSGGTVWI
ESECGRGTSVIMLLPRSARVPEQPAEDERAADDAADPSLGSVLLVDDDEEVAALVGEMLEHLGYRVSHADSATAALNALA
NGCKVDVVFSDVMMPGGMNGVELAREIRVRALGVPVLLTSGYAEAAQQSAAAEGVHVLAKPYRLEDLAASLHDAIEGAKD
V
>Mature_560_residues
TTPTKRDSPTVVVFAPIGRDGPASAELLNRSGMEAVVCHSLEEVLQRAETEADAVFIAEEGLFGHDLAALAAWVDRQPAW
SDFPFVVLTSKHQQPAVAAWRQRMVAALRNVSLLERPVQSITLTSAMKAALRGRHRQYEVRALLEARERASHELEALVVE
RTSELEKANQELRTQMAERTRIEETLRQAQKIEAIGQLTGGIAHDFNNLLMVISGGLDMLDRRADPARRERLMAGMRQAA
QRGTSLTRQLLAFSRRQSLAPESVDLVLRIGRMRELLDRSLSGDVHVQVQFAPDLWPVEVDPGELELVILNLAVNARDAM
PDGGSILIEARNAPDEPVMGLRGDFVRLAVIDDGTGIPEDVRARVFDPFFTTKEIGKGSGLGLAQVYGFARQSGGTVWIE
SECGRGTSVIMLLPRSARVPEQPAEDERAADDAADPSLGSVLLVDDDEEVAALVGEMLEHLGYRVSHADSATAALNALAN
GCKVDVVFSDVMMPGGMNGVELAREIRVRALGVPVLLTSGYAEAAQQSAAAEGVHVLAKPYRLEDLAASLHDAIEGAKDV

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=32.1138211382114, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=28.4552845528455, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=217, Percent_Identity=31.7972350230415, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=27.3408239700375, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788713, Length=263, Percent_Identity=25.8555133079848, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790300, Length=243, Percent_Identity=30.0411522633745, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60908; Mature: 60777

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTKRDSPTVVVFAPIGRDGPASAELLNRSGMEAVVCHSLEEVLQRAETEADAVFIAE
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEC
EGLFGHDLAALAAWVDRQPAWSDFPFVVLTSKHQQPAVAAWRQRMVAALRNVSLLERPVQ
CCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SITLTSAMKAALRGRHRQYEVRALLEARERASHELEALVVERTSELEKANQELRTQMAER
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIEETLRQAQKIEAIGQLTGGIAHDFNNLLMVISGGLDMLDRRADPARRERLMAGMRQA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHCEEEEEECCHHHHHCCCCHHHHHHHHHHHHHH
AQRGTSLTRQLLAFSRRQSLAPESVDLVLRIGRMRELLDRSLSGDVHVQVQFAPDLWPVE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEE
VDPGELELVILNLAVNARDAMPDGGSILIEARNAPDEPVMGLRGDFVRLAVIDDGTGIPE
ECCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCH
DVRARVFDPFFTTKEIGKGSGLGLAQVYGFARQSGGTVWIESECGRGTSVIMLLPRSARV
HHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCC
PEQPAEDERAADDAADPSLGSVLLVDDDEEVAALVGEMLEHLGYRVSHADSATAALNALA
CCCCCCHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
NGCKVDVVFSDVMMPGGMNGVELAREIRVRALGVPVLLTSGYAEAAQQSAAAEGVHVLAK
CCCEEEEEEECHHCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCHHHHCC
PYRLEDLAASLHDAIEGAKDV
CCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTPTKRDSPTVVVFAPIGRDGPASAELLNRSGMEAVVCHSLEEVLQRAETEADAVFIAE
CCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEC
EGLFGHDLAALAAWVDRQPAWSDFPFVVLTSKHQQPAVAAWRQRMVAALRNVSLLERPVQ
CCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SITLTSAMKAALRGRHRQYEVRALLEARERASHELEALVVERTSELEKANQELRTQMAER
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIEETLRQAQKIEAIGQLTGGIAHDFNNLLMVISGGLDMLDRRADPARRERLMAGMRQA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHCEEEEEECCHHHHHCCCCHHHHHHHHHHHHHH
AQRGTSLTRQLLAFSRRQSLAPESVDLVLRIGRMRELLDRSLSGDVHVQVQFAPDLWPVE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEE
VDPGELELVILNLAVNARDAMPDGGSILIEARNAPDEPVMGLRGDFVRLAVIDDGTGIPE
ECCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCH
DVRARVFDPFFTTKEIGKGSGLGLAQVYGFARQSGGTVWIESECGRGTSVIMLLPRSARV
HHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCC
PEQPAEDERAADDAADPSLGSVLLVDDDEEVAALVGEMLEHLGYRVSHADSATAALNALA
CCCCCCHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
NGCKVDVVFSDVMMPGGMNGVELAREIRVRALGVPVLLTSGYAEAAQQSAAAEGVHVLAK
CCCEEEEEEECHHCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCHHHHCC
PYRLEDLAASLHDAIEGAKDV
CCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA