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The map label for this gene is galE [H]

Identifier: 146283227

GI number: 146283227

Start: 3114423

End: 3115487

Strand: Direct

Name: galE [H]

Synonym: PST_2892

Alternate gene names: 146283227

Gene position: 3114423-3115487 (Clockwise)

Preceding gene: 146283221

Following gene: 146283230

Centisome position: 68.19

GC content: 65.73

Gene sequence:

>1065_bases
ATGATTCTGGTGACAGGAGGGGCCGGTTACATCGGCTCACACGCGGTGCTCGAACTGCTGCAGGCCGGGCATGAGGTGCT
GGTACTGGACAACCTGTGCAACAGCTCGCAGCTGGCTCTGGACCGCGTGGAGCAACTGGCCGGCCGGCCACTGCACTTCG
TCAAGGGCGACGTGCGCAATCGCTCGCTGCTCAAGGCGCTCTTCGCTGCCTACCCGATCACTGCGGTGATGCACTTCGCC
GGCCTGAAGGCGGTTGGCGAGAGCGTGCGCGAGCCGCTGCGCTACTACGAAACCAATGTCGGCGGCAGCATCGCGCTGTG
CCAGGCCATGGCCGAAGCCGGAGTGTTCAAGCTGGTGTTCAGCTCCTCGGCCACCGTCTATGGCGAGTCGCCGGTGATGC
CCATCACCGAGGATCGTCCCACTGGCGTGCCGACCAACCCCTACGGCCAGTCCAAACTGATGGCCGAGAACGTGCTCAAG
GGCCTGGCCGACTCCGACCCGCGCTGGTCCATCGCGCTGCTGCGCTACTTCAACCCTATCGGCGCTCATGAGTCGGGGCT
GATCGGCGAAGACCCCAACGGCGTGCCGAACAACCTGCTGCCGTACATGCTGCAGGTGGCGGTGGGTCGGCGAAAGCAGC
TCAGCGTCTACGGCGACGACTACCCGACGCCAGATGGCACCGGCATCCGCGATTACATCCATGTGGTGGACCTGGTCAAA
GGCCATTTGAAGGCGCTGGAGCGTCTTAATCTCGTGCACGGCGCGCAGGTGTGGAACCTCGGCGCCGGCAAGGGCCATTC
GGTGCGCGAAATGATCACAGCTTTCGAGGAAGTCACCGGGCGCCCGTTGCCCCACGTGATCAAGCCACGCCGTGCCGGCG
ACATCGCCCAGTGCTGGTCCGACCCGAGCAAGGCCGAGCGCGAGCTTGGCTGGCGCGCCGAAAAGGACCTGATCACCATG
CTCGCCGACGCCTGGCGCTGGCAGAGCCGCAACCCTCGCGGTTATGCCGCCGACAAGGTCGCCGCGGCGGACGCGGAAAC
CACGCAGACCGCTCTGGCCAGCTGA

Upstream 100 bases:

>100_bases
TTTCGCCGAACCCAAATTACGGAGACTCATGCAGCGCCAGCCATGGCCAGCCGCAGTGTCCCGAGCGTGTCGAAAGACTG
CGAACTTCGGAGGTAGACAG

Downstream 100 bases:

>100_bases
ACGGCCCCCGCGCGGCCCGCCTCGGGCTGCGCAAGCCGCCCGCGAGCGACCATGGTTCCCAGCGTATCGCCAATCGCTAT
TGGCGGACGATCCGGTGGCC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MILVTGGAGYIGSHAVLELLQAGHEVLVLDNLCNSSQLALDRVEQLAGRPLHFVKGDVRNRSLLKALFAAYPITAVMHFA
GLKAVGESVREPLRYYETNVGGSIALCQAMAEAGVFKLVFSSSATVYGESPVMPITEDRPTGVPTNPYGQSKLMAENVLK
GLADSDPRWSIALLRYFNPIGAHESGLIGEDPNGVPNNLLPYMLQVAVGRRKQLSVYGDDYPTPDGTGIRDYIHVVDLVK
GHLKALERLNLVHGAQVWNLGAGKGHSVREMITAFEEVTGRPLPHVIKPRRAGDIAQCWSDPSKAERELGWRAEKDLITM
LADAWRWQSRNPRGYAADKVAAADAETTQTALAS

Sequences:

>Translated_354_residues
MILVTGGAGYIGSHAVLELLQAGHEVLVLDNLCNSSQLALDRVEQLAGRPLHFVKGDVRNRSLLKALFAAYPITAVMHFA
GLKAVGESVREPLRYYETNVGGSIALCQAMAEAGVFKLVFSSSATVYGESPVMPITEDRPTGVPTNPYGQSKLMAENVLK
GLADSDPRWSIALLRYFNPIGAHESGLIGEDPNGVPNNLLPYMLQVAVGRRKQLSVYGDDYPTPDGTGIRDYIHVVDLVK
GHLKALERLNLVHGAQVWNLGAGKGHSVREMITAFEEVTGRPLPHVIKPRRAGDIAQCWSDPSKAERELGWRAEKDLITM
LADAWRWQSRNPRGYAADKVAAADAETTQTALAS
>Mature_354_residues
MILVTGGAGYIGSHAVLELLQAGHEVLVLDNLCNSSQLALDRVEQLAGRPLHFVKGDVRNRSLLKALFAAYPITAVMHFA
GLKAVGESVREPLRYYETNVGGSIALCQAMAEAGVFKLVFSSSATVYGESPVMPITEDRPTGVPTNPYGQSKLMAENVLK
GLADSDPRWSIALLRYFNPIGAHESGLIGEDPNGVPNNLLPYMLQVAVGRRKQLSVYGDDYPTPDGTGIRDYIHVVDLVK
GHLKALERLNLVHGAQVWNLGAGKGHSVREMITAFEEVTGRPLPHVIKPRRAGDIAQCWSDPSKAERELGWRAEKDLITM
LADAWRWQSRNPRGYAADKVAAADAETTQTALAS

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=52.6470588235294, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=52.6470588235294, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=52.6470588235294, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI7657641, Length=330, Percent_Identity=26.3636363636364, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1786974, Length=334, Percent_Identity=55.0898203592814, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI48994969, Length=360, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788353, Length=366, Percent_Identity=23.7704918032787, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=51.0144927536232, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=50.7204610951009, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17539532, Length=343, Percent_Identity=25.9475218658892, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=351, Percent_Identity=50.7122507122507, Blast_Score=355, Evalue=8e-99,
Organism=Drosophila melanogaster, GI19923002, Length=343, Percent_Identity=53.3527696793003, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI21356223, Length=329, Percent_Identity=25.8358662613982, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 38458; Mature: 38458

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGYIGSHAVLELLQAGHEVLVLDNLCNSSQLALDRVEQLAGRPLHFVKGDVRN
CEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCH
RSLLKALFAAYPITAVMHFAGLKAVGESVREPLRYYETNVGGSIALCQAMAEAGVFKLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEE
SSSATVYGESPVMPITEDRPTGVPTNPYGQSKLMAENVLKGLADSDPRWSIALLRYFNPI
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
GAHESGLIGEDPNGVPNNLLPYMLQVAVGRRKQLSVYGDDYPTPDGTGIRDYIHVVDLVK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
GHLKALERLNLVHGAQVWNLGAGKGHSVREMITAFEEVTGRPLPHVIKPRRAGDIAQCWS
HHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHCC
DPSKAERELGWRAEKDLITMLADAWRWQSRNPRGYAADKVAAADAETTQTALAS
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MILVTGGAGYIGSHAVLELLQAGHEVLVLDNLCNSSQLALDRVEQLAGRPLHFVKGDVRN
CEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCH
RSLLKALFAAYPITAVMHFAGLKAVGESVREPLRYYETNVGGSIALCQAMAEAGVFKLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEE
SSSATVYGESPVMPITEDRPTGVPTNPYGQSKLMAENVLKGLADSDPRWSIALLRYFNPI
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
GAHESGLIGEDPNGVPNNLLPYMLQVAVGRRKQLSVYGDDYPTPDGTGIRDYIHVVDLVK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
GHLKALERLNLVHGAQVWNLGAGKGHSVREMITAFEEVTGRPLPHVIKPRRAGDIAQCWS
HHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHCC
DPSKAERELGWRAEKDLITMLADAWRWQSRNPRGYAADKVAAADAETTQTALAS
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]