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The map label for this gene is ychM [C]

Identifier: 146282865

GI number: 146282865

Start: 2755914

End: 2757692

Strand: Direct

Name: ychM [C]

Synonym: PST_2524

Alternate gene names: 146282865

Gene position: 2755914-2757692 (Clockwise)

Preceding gene: 146282864

Following gene: 146282866

Centisome position: 60.34

GC content: 66.16

Gene sequence:

>1779_bases
ATGAAGCAGCGCCTGGCCCGCTATCTACCCATGCTGGCGTGGGCCAGGCACTACGATCGCGCGGCCGCGACGAAGGACAG
TCTGGCCGCACTGATCGTGACATTGATGCTGATCCCGCAGAGCCTGGCCTACGCCATGCTCGCCGGCCTGCCGCCGGTGA
CCGGCCTGTACGCCAGCATGCTGCCACTGATCGCCTATACGCTGTTCGGCACCAGCCGCACCCTGGCGGTCGGCCCGGTA
GCGGTGGTTTCGCTGATGACCGCCGCCGCTCTCGGGCCGCTGTTCGCCCCGGGCAGCGCGGAATACGCCGCAGCGGCCAT
GTTGCTGGCGCTGCTTTCCGGCGCGGTGCTGCTGCTCATGGCGGCGCTGCGCCTGGGCTTCCTGGCGAACTTCCTCAGCC
ATCCGGTGATTTCCGGCTTCATCAGCGCGTCGGGGATTCTCATCGCCCTCGGCCAGCTCAAGCACATCCTCGGCATCTCG
ATCGACGGCGAGAACGCCGTGCAGCTGCTTGCCGCGCTGCTCACGGCGCTGCCTGGGGCGCATCTGCCGACGCTCGCCAT
CGGTGGCAACACCCTGCTATTCCTCTATCTGGTCCGCAGCCGGCTCTCCACCTGGCTGCAGCATCTGGGCATGAACGCGC
ATATTGCCGGCACGCTGACCAAGATCGGCCCGGTCGCCGCCCTGCTACTGGCCATCGCGGCGGTCAGCGCCTTCGGGCTT
GCCGATGCCGGCGTGCGGGTCGTCGGCGAAGTACCGCGCGGACTGCCCTCGCTGAGTCTGCCAATGCTGGAGCCGGCACT
GATTCTGCAGCTGTTGCCTGCGGCGGTGCTGATCAGCCTGGTCGGCTTCGTCGAGTCGGTGTCGGTGGCGCAAACCTTGG
CAGCCAAGCGTCGCGAGCGCATCGAGCCCAATCAGGAACTGGTTGCGCTCGGCGGCGCCAATGTCGCCGCGGCCCTCAGT
GGCGGCTTTCCGGTGACCGGCGGTTTCGCCCGCTCGGTGGTCAATTTCGACGCCGGCGCGCAGACGCCGCTGGCCGGCGT
CCTCACCGCCCTGGGCATCGGCATTACCGTGCTGCTGTTCACTCCGCTATTCCACAACCTGCCTCACGCAGTGCTGGCCG
CGACGATCATCGTCGCCGTGCTCAGCCTGGTGGACCTCTCCGCACTCAGGCGCACATGGCGCTACTCCCGACAGGACGCC
GCCGCTATGGCGGCAACCATGCTCGGCGTGCTGCTGATTGGTGTGGAGAGCGGCATTCTCCTGGGTGTCGGCCTGTCGCT
GTTGCTCTTTCTCTGGCGCACCAGCCAGCCACATATCGCCGTGGTCGGGCAGCTGCCGGGCAGCGAACATTTCCGCAACG
TCGAGCGTTTCGCCGTGGTGCAGAGCCCCCGTGTCCTCTCGGTACGGGTCGACGAAAGCCTCTATTTTCCCAACGCGCGC
TTTCTCGAAGACCGCATCGCCGAGCTGATCGGCCGTCATCCGCAGGCCGAACACCTGGTGCTGATGTGTCCAGGCGTCAA
CCTCATCGACGCCAGTGCGCTGGAGAGCCTAGAGGCCATCACGGCACGACTGCACGCCGCCGGCATCCAGCTGCATCTGT
CCGAAGTCAAAGGACCGGTCATGGATCGGCTGCGCCACAGCGATTTCCTCTCTCACTTCGGCGGCCAGGTTTTCATCAGC
CAGTACGAGGCGCTGCTTGCACTGGACCCGGATACCACCTTTCACGCACTAGAACGGCCGCGTGAACGCTTTGCCAGCAT
CAAGGAGAACGCAGGATGA

Upstream 100 bases:

>100_bases
TCAAGGGGCATGAGTGGCTGGCCGAACCGAAGCATCTGGACTTCGAACCGCGCTCGGCCGAGGCACGCAACGCCTGCGAC
TTCACCCAGGAGAAGAAGGG

Downstream 100 bases:

>100_bases
AGAACGCACACGAACTCGTCGAACAGGCCCGGCGCCACATCCAGGAAATACCGCTCGCTGACGCCGAGGCGGCGATTCAG
GCAGCGGATGTGCTGATCGA

Product: sulfate transporter

Products: Proton [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MKQRLARYLPMLAWARHYDRAAATKDSLAALIVTLMLIPQSLAYAMLAGLPPVTGLYASMLPLIAYTLFGTSRTLAVGPV
AVVSLMTAAALGPLFAPGSAEYAAAAMLLALLSGAVLLLMAALRLGFLANFLSHPVISGFISASGILIALGQLKHILGIS
IDGENAVQLLAALLTALPGAHLPTLAIGGNTLLFLYLVRSRLSTWLQHLGMNAHIAGTLTKIGPVAALLLAIAAVSAFGL
ADAGVRVVGEVPRGLPSLSLPMLEPALILQLLPAAVLISLVGFVESVSVAQTLAAKRRERIEPNQELVALGGANVAAALS
GGFPVTGGFARSVVNFDAGAQTPLAGVLTALGIGITVLLFTPLFHNLPHAVLAATIIVAVLSLVDLSALRRTWRYSRQDA
AAMAATMLGVLLIGVESGILLGVGLSLLLFLWRTSQPHIAVVGQLPGSEHFRNVERFAVVQSPRVLSVRVDESLYFPNAR
FLEDRIAELIGRHPQAEHLVLMCPGVNLIDASALESLEAITARLHAAGIQLHLSEVKGPVMDRLRHSDFLSHFGGQVFIS
QYEALLALDPDTTFHALERPRERFASIKENAG

Sequences:

>Translated_592_residues
MKQRLARYLPMLAWARHYDRAAATKDSLAALIVTLMLIPQSLAYAMLAGLPPVTGLYASMLPLIAYTLFGTSRTLAVGPV
AVVSLMTAAALGPLFAPGSAEYAAAAMLLALLSGAVLLLMAALRLGFLANFLSHPVISGFISASGILIALGQLKHILGIS
IDGENAVQLLAALLTALPGAHLPTLAIGGNTLLFLYLVRSRLSTWLQHLGMNAHIAGTLTKIGPVAALLLAIAAVSAFGL
ADAGVRVVGEVPRGLPSLSLPMLEPALILQLLPAAVLISLVGFVESVSVAQTLAAKRRERIEPNQELVALGGANVAAALS
GGFPVTGGFARSVVNFDAGAQTPLAGVLTALGIGITVLLFTPLFHNLPHAVLAATIIVAVLSLVDLSALRRTWRYSRQDA
AAMAATMLGVLLIGVESGILLGVGLSLLLFLWRTSQPHIAVVGQLPGSEHFRNVERFAVVQSPRVLSVRVDESLYFPNAR
FLEDRIAELIGRHPQAEHLVLMCPGVNLIDASALESLEAITARLHAAGIQLHLSEVKGPVMDRLRHSDFLSHFGGQVFIS
QYEALLALDPDTTFHALERPRERFASIKENAG
>Mature_592_residues
MKQRLARYLPMLAWARHYDRAAATKDSLAALIVTLMLIPQSLAYAMLAGLPPVTGLYASMLPLIAYTLFGTSRTLAVGPV
AVVSLMTAAALGPLFAPGSAEYAAAAMLLALLSGAVLLLMAALRLGFLANFLSHPVISGFISASGILIALGQLKHILGIS
IDGENAVQLLAALLTALPGAHLPTLAIGGNTLLFLYLVRSRLSTWLQHLGMNAHIAGTLTKIGPVAALLLAIAAVSAFGL
ADAGVRVVGEVPRGLPSLSLPMLEPALILQLLPAAVLISLVGFVESVSVAQTLAAKRRERIEPNQELVALGGANVAAALS
GGFPVTGGFARSVVNFDAGAQTPLAGVLTALGIGITVLLFTPLFHNLPHAVLAATIIVAVLSLVDLSALRRTWRYSRQDA
AAMAATMLGVLLIGVESGILLGVGLSLLLFLWRTSQPHIAVVGQLPGSEHFRNVERFAVVQSPRVLSVRVDESLYFPNAR
FLEDRIAELIGRHPQAEHLVLMCPGVNLIDASALESLEAITARLHAAGIQLHLSEVKGPVMDRLRHSDFLSHFGGQVFIS
QYEALLALDPDTTFHALERPRERFASIKENAG

Specific function: Expression in E.coli induces sulfate uptake during early-to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein [H]

COG id: COG0659

COG function: function code P; Sulfate permease and related transporters (MFS superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

Organism=Homo sapiens, GI94721259, Length=512, Percent_Identity=31.8359375, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI94721255, Length=512, Percent_Identity=31.8359375, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI94721253, Length=512, Percent_Identity=31.8359375, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI94721257, Length=509, Percent_Identity=33.0058939096267, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI45827800, Length=515, Percent_Identity=28.9320388349515, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI39752683, Length=515, Percent_Identity=28.9320388349515, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI100913030, Length=641, Percent_Identity=26.0530421216849, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI47131207, Length=642, Percent_Identity=28.816199376947, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI20336272, Length=642, Percent_Identity=28.816199376947, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI45827802, Length=465, Percent_Identity=29.8924731182796, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI269784651, Length=514, Percent_Identity=27.0428015564202, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4557535, Length=519, Percent_Identity=25.4335260115607, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4505697, Length=521, Percent_Identity=25.3358925143954, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI16306483, Length=523, Percent_Identity=24.4741873804971, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI20336282, Length=523, Percent_Identity=24.4741873804971, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI16418413, Length=516, Percent_Identity=24.6124031007752, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI217272867, Length=516, Percent_Identity=24.6124031007752, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI65506789, Length=379, Percent_Identity=32.9815303430079, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI262206105, Length=378, Percent_Identity=27.5132275132275, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI262206075, Length=378, Percent_Identity=27.5132275132275, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI262206069, Length=378, Percent_Identity=27.5132275132275, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI262206063, Length=378, Percent_Identity=27.5132275132275, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI16418457, Length=520, Percent_Identity=24.4230769230769, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI301601599, Length=520, Percent_Identity=24.4230769230769, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI45827804, Length=170, Percent_Identity=33.5294117647059, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI301601602, Length=201, Percent_Identity=24.3781094527363, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI87081859, Length=540, Percent_Identity=28.5185185185185, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI86564196, Length=621, Percent_Identity=24.4766505636071, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17566848, Length=605, Percent_Identity=27.603305785124, Blast_Score=194, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551690, Length=500, Percent_Identity=25.8, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562578, Length=621, Percent_Identity=24.9597423510467, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI86564876, Length=653, Percent_Identity=24.8085758039816, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI86565215, Length=566, Percent_Identity=26.3250883392226, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI193203292, Length=538, Percent_Identity=24.3494423791822, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI86565213, Length=276, Percent_Identity=28.2608695652174, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI86565209, Length=241, Percent_Identity=26.9709543568465, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI86565211, Length=241, Percent_Identity=26.9709543568465, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982567, Length=475, Percent_Identity=21.8947368421053, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325260, Length=593, Percent_Identity=24.4519392917369, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323121, Length=483, Percent_Identity=26.2939958592132, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319771, Length=471, Percent_Identity=25.9023354564756, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24649801, Length=469, Percent_Identity=30.9168443496802, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651449, Length=518, Percent_Identity=27.992277992278, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24663084, Length=572, Percent_Identity=29.1958041958042, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21357695, Length=572, Percent_Identity=29.1958041958042, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19922482, Length=559, Percent_Identity=25.9391771019678, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI21355087, Length=475, Percent_Identity=26.1052631578947, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24647160, Length=477, Percent_Identity=26.4150943396226, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI85815873, Length=464, Percent_Identity=28.2327586206897, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21358229, Length=545, Percent_Identity=27.8899082568807, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21358633, Length=522, Percent_Identity=27.5862068965517, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24666186, Length=550, Percent_Identity=26.9090909090909, Blast_Score=152, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002645
- InterPro:   IPR001902
- InterPro:   IPR011547 [H]

Pfam domain/function: PF01740 STAS; PF00916 Sulfate_transp [H]

EC number: NA

Molecular weight: Translated: 62421; Mature: 62421

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRLARYLPMLAWARHYDRAAATKDSLAALIVTLMLIPQSLAYAMLAGLPPVTGLYASM
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LPLIAYTLFGTSRTLAVGPVAVVSLMTAAALGPLFAPGSAEYAAAAMLLALLSGAVLLLM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AALRLGFLANFLSHPVISGFISASGILIALGQLKHILGISIDGENAVQLLAALLTALPGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCC
HLPTLAIGGNTLLFLYLVRSRLSTWLQHLGMNAHIAGTLTKIGPVAALLLAIAAVSAFGL
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCC
ADAGVRVVGEVPRGLPSLSLPMLEPALILQLLPAAVLISLVGFVESVSVAQTLAAKRRER
HHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEPNQELVALGGANVAAALSGGFPVTGGFARSVVNFDAGAQTPLAGVLTALGIGITVLLF
CCCCCCEEEECCCCHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TPLFHNLPHAVLAATIIVAVLSLVDLSALRRTWRYSRQDAAAMAATMLGVLLIGVESGIL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LGVGLSLLLFLWRTSQPHIAVVGQLPGSEHFRNVERFAVVQSPRVLSVRVDESLYFPNAR
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCEECCCHH
FLEDRIAELIGRHPQAEHLVLMCPGVNLIDASALESLEAITARLHAAGIQLHLSEVKGPV
HHHHHHHHHHCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHEEHHHHCCHH
MDRLRHSDFLSHFGGQVFISQYEALLALDPDTTFHALERPRERFASIKENAG
HHHHHHHHHHHHCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQRLARYLPMLAWARHYDRAAATKDSLAALIVTLMLIPQSLAYAMLAGLPPVTGLYASM
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LPLIAYTLFGTSRTLAVGPVAVVSLMTAAALGPLFAPGSAEYAAAAMLLALLSGAVLLLM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AALRLGFLANFLSHPVISGFISASGILIALGQLKHILGISIDGENAVQLLAALLTALPGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCC
HLPTLAIGGNTLLFLYLVRSRLSTWLQHLGMNAHIAGTLTKIGPVAALLLAIAAVSAFGL
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCC
ADAGVRVVGEVPRGLPSLSLPMLEPALILQLLPAAVLISLVGFVESVSVAQTLAAKRRER
HHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEPNQELVALGGANVAAALSGGFPVTGGFARSVVNFDAGAQTPLAGVLTALGIGITVLLF
CCCCCCEEEECCCCHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TPLFHNLPHAVLAATIIVAVLSLVDLSALRRTWRYSRQDAAAMAATMLGVLLIGVESGIL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LGVGLSLLLFLWRTSQPHIAVVGQLPGSEHFRNVERFAVVQSPRVLSVRVDESLYFPNAR
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCEECCCHH
FLEDRIAELIGRHPQAEHLVLMCPGVNLIDASALESLEAITARLHAAGIQLHLSEVKGPV
HHHHHHHHHHCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHEEHHHHCCHH
MDRLRHSDFLSHFGGQVFISQYEALLALDPDTTFHALERPRERFASIKENAG
HHHHHHHHHHHHCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; SO42- [Periplasm] [C]

Specific reaction: Proton [Periplasm] + SO42- [Periplasm] = Proton [Cytoplasm] + SO42- [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]