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The map label for this gene is aceA [C]

Identifier: 146282659

GI number: 146282659

Start: 2522256

End: 2523899

Strand: Direct

Name: aceA [C]

Synonym: PST_2311

Alternate gene names: 146282659

Gene position: 2522256-2523899 (Clockwise)

Preceding gene: 146282658

Following gene: 146282660

Centisome position: 55.22

GC content: 59.91

Gene sequence:

>1644_bases
GTGGGAAAAAGTCGGTGCTCAACCACACTTATTTTTGAAGGATTGAACATGTCCGCATATCAAGACGACATCAAGGCAGT
TGCCGCCCTGAAAGAGCAATACGGCAGCAGCTGGGCCGCCATCAACCCTGAGTCCGTCGCTCGCATGCGCGCCCAGAACC
GCTTCAAGACCGGTCTGGAAATCGCTCAGTACACCGCCGACATCATGCGCAAGGACATGGCCGAGTACGACGCCGACTCG
TCCGTCTACACGCAGTCCCTCGGCTGCTGGCACGGCTTCATTGGTCAGCAGAAGCTGATCTCCATCAAGAAGCACCTGAA
GACCACCAACAAGCGCTACCTCTACCTGTCCGGCTGGATGGTTGCTGCTCTGCGTTCCGAGTTCGGCCCGCTGCCGGACC
AGTCCATGCACGAGAAGACTGCCGTTTCCGACCTGATCGAGGAGCTGTACACCTTCCTGCGTCAGGCTGACAGCCGCGAA
CTGGACCTGCTGTTCACCGCCCTGGACGCTGCTCGTGAAGCTGGCGACAACGCCAAGGCTGCCGAGATCCAGAACCAGAT
CGACAACTACGAAACCCACATCGTACCGATCATCGCTGACATCGACGCTGGCTTCGGTAACCCGGAAGCCACCTACCTGC
TGGCCAAGCGCATGATCGAAGCAGGCGCTTGCTGCATCCAGATCGAGAACCAGGTTTCCGACGAGAAGCAGTGCGGCCAC
CAGGACGGTAAAGTAACCGTTCCGCACGCCGACTTCCTCGCCAAGATCGCTGCCGTTCGTTACGCCTTCCTCGAGCTGGG
CATCGACAACGGCGTGATCGTTGCTCGTACCGACTCCCTGGGTGCCGGCCTGACCAAGCAGATTGCCGTGACCAAAGAGC
CGGGCGACCTGGGCGACCTGTACAACTCCTTCCTGGATTGCGAAGAAATCTCCGAAGCCGAGCTGGGCAATGGCGACGTC
GTAATCAAGCGCGAAGGCAAGCTGCTGCGTCCGAAGCGTCTGCCGTCCAACCTGTTCCAGTTCCGCGCTGGCACCGGCGA
AGACCGCTGCGTTCTGGACTGCATCACCTCGCTGCAGAACGGCGCCGACCTGCTGTGGATCGAAACCGAGAAGCCGCACG
TTGGCCAGATCAAGGCCATGGTTGACCGCATCCGCGAAGTCATCCCGAACGCCAAGCTGGTCTACAACAACAGCCCGTCC
TTCAACTGGACCCTGAACTTCCGTCAGCAGGTGTTCGACGCTTTCGTTGCCGAAGGCAAGGACGTGTCCGCCTACGACCG
CGCCAAGCTGATGAGCGTCGAGTACGACGAAACCGAGCTGGCCCAGGTTGCAGACGAGAAGATCCGTACCTTCCAGCGCG
ACGGTTCGGCTCACGCCGGCATCTTCCACCACCTGATCACCCTGCCGACCTACCACACTGCTGCTCTGTCGACCGACAAC
CTGGCCAAGGGCTACTTTGCCGACCAGGGCATGCTGGCCTACGTCAAGGGCGTTCAGCGCGAGGAACTGCGTCAGGGTAT
CGCCTGCGTCAAGCACCAGAACATGGCTGGCTCTGACATCGGCGACAACCACAAGGAGTACTTCGCTGGCGAAGCTGCTC
TGAAGGCAAGCGGCAAAGACAACACCATGAACCAGTTCCACTAA

Upstream 100 bases:

>100_bases
CGTATCCCCCCCTTCCCCTTGGTTCAATCCTCGTCCCGGTCGATATTTCGACGCTCTGCCGCGTGTTGCCCGCACTGATC
AGCGATAGCACGTAGGTTCG

Downstream 100 bases:

>100_bases
GAACAGGTTCGCAGCCGCCCCGGCTGCGGTGTGAAAAAAGCCCTGGCGTGAGCCGGGGCTTTTTTTTGCGACGGATTGAG
TGGTGCACGGTTACGCTTCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MGKSRCSTTLIFEGLNMSAYQDDIKAVAALKEQYGSSWAAINPESVARMRAQNRFKTGLEIAQYTADIMRKDMAEYDADS
SVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWMVAALRSEFGPLPDQSMHEKTAVSDLIEELYTFLRQADSRE
LDLLFTALDAAREAGDNAKAAEIQNQIDNYETHIVPIIADIDAGFGNPEATYLLAKRMIEAGACCIQIENQVSDEKQCGH
QDGKVTVPHADFLAKIAAVRYAFLELGIDNGVIVARTDSLGAGLTKQIAVTKEPGDLGDLYNSFLDCEEISEAELGNGDV
VIKREGKLLRPKRLPSNLFQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPS
FNWTLNFRQQVFDAFVAEGKDVSAYDRAKLMSVEYDETELAQVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDN
LAKGYFADQGMLAYVKGVQREELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKDNTMNQFH

Sequences:

>Translated_547_residues
MGKSRCSTTLIFEGLNMSAYQDDIKAVAALKEQYGSSWAAINPESVARMRAQNRFKTGLEIAQYTADIMRKDMAEYDADS
SVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWMVAALRSEFGPLPDQSMHEKTAVSDLIEELYTFLRQADSRE
LDLLFTALDAAREAGDNAKAAEIQNQIDNYETHIVPIIADIDAGFGNPEATYLLAKRMIEAGACCIQIENQVSDEKQCGH
QDGKVTVPHADFLAKIAAVRYAFLELGIDNGVIVARTDSLGAGLTKQIAVTKEPGDLGDLYNSFLDCEEISEAELGNGDV
VIKREGKLLRPKRLPSNLFQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPS
FNWTLNFRQQVFDAFVAEGKDVSAYDRAKLMSVEYDETELAQVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDN
LAKGYFADQGMLAYVKGVQREELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKDNTMNQFH
>Mature_546_residues
GKSRCSTTLIFEGLNMSAYQDDIKAVAALKEQYGSSWAAINPESVARMRAQNRFKTGLEIAQYTADIMRKDMAEYDADSS
VYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWMVAALRSEFGPLPDQSMHEKTAVSDLIEELYTFLRQADSREL
DLLFTALDAAREAGDNAKAAEIQNQIDNYETHIVPIIADIDAGFGNPEATYLLAKRMIEAGACCIQIENQVSDEKQCGHQ
DGKVTVPHADFLAKIAAVRYAFLELGIDNGVIVARTDSLGAGLTKQIAVTKEPGDLGDLYNSFLDCEEISEAELGNGDVV
IKREGKLLRPKRLPSNLFQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPSF
NWTLNFRQQVFDAFVAEGKDVSAYDRAKLMSVEYDETELAQVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDNL
AKGYFADQGMLAYVKGVQREELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKDNTMNQFH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=445, Percent_Identity=27.4157303370787, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17561814, Length=432, Percent_Identity=26.8518518518519, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982926, Length=432, Percent_Identity=26.8518518518519, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=501, Percent_Identity=25.9481037924152, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6325263, Length=104, Percent_Identity=36.5384615384615, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 60710; Mature: 60579

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKSRCSTTLIFEGLNMSAYQDDIKAVAALKEQYGSSWAAINPESVARMRAQNRFKTGLE
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
IAQYTADIMRKDMAEYDADSSVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECHHH
VAALRSEFGPLPDQSMHEKTAVSDLIEELYTFLRQADSRELDLLFTALDAAREAGDNAKA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHH
AEIQNQIDNYETHIVPIIADIDAGFGNPEATYLLAKRMIEAGACCIQIENQVSDEKQCGH
HHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCC
QDGKVTVPHADFLAKIAAVRYAFLELGIDNGVIVARTDSLGAGLTKQIAVTKEPGDLGDL
CCCEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHH
YNSFLDCEEISEAELGNGDVVIKREGKLLRPKRLPSNLFQFRAGTGEDRCVLDCITSLQN
HHHHHCHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCC
GADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAFVAEGK
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCC
DVSAYDRAKLMSVEYDETELAQVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDN
CCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCC
LAKGYFADQGMLAYVKGVQREELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKD
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHEECCCCC
NTMNQFH
CCCCCCC
>Mature Secondary Structure 
GKSRCSTTLIFEGLNMSAYQDDIKAVAALKEQYGSSWAAINPESVARMRAQNRFKTGLE
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
IAQYTADIMRKDMAEYDADSSVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECHHH
VAALRSEFGPLPDQSMHEKTAVSDLIEELYTFLRQADSRELDLLFTALDAAREAGDNAKA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHH
AEIQNQIDNYETHIVPIIADIDAGFGNPEATYLLAKRMIEAGACCIQIENQVSDEKQCGH
HHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCC
QDGKVTVPHADFLAKIAAVRYAFLELGIDNGVIVARTDSLGAGLTKQIAVTKEPGDLGDL
CCCEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHH
YNSFLDCEEISEAELGNGDVVIKREGKLLRPKRLPSNLFQFRAGTGEDRCVLDCITSLQN
HHHHHCHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCC
GADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAFVAEGK
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCC
DVSAYDRAKLMSVEYDETELAQVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDN
CCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCC
LAKGYFADQGMLAYVKGVQREELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKD
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHEECCCCC
NTMNQFH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]