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The map label for this gene is fhuB [H]

Identifier: 145301186

GI number: 145301186

Start: 4669839

End: 4671485

Strand: Direct

Name: fhuB [H]

Synonym: ASA_4364

Alternate gene names: 145301186

Gene position: 4669839-4671485 (Clockwise)

Preceding gene: 145301185

Following gene: 145301187

Centisome position: 99.31

GC content: 61.38

Gene sequence:

>1647_bases
ATGGAACTCTTGTCTCTGGTTTACCGCCAATATCGTTGGCCCTTCATCGCCATTACTCTGCTCAGCCTGCTTAGCGCAGT
GAGCGGGATCGGCGTTATTGCCTTTATTAATCAATCTCTTGTCGAATCCGTCGGCGATCCGCTGCCGGTACTTGGCCAAC
TGCTTGGCCTGATCCTGTTGCTGCTGGTGATCACACTCGGATCTCAATTGGCCCTGACCACACTCGGTCATCATTTCGTC
TACCGGTTGCGGGGCCGTCTGCTCAAGCAACTGCTGGATACCGATGTCGCCCGCATTCGCCAGCTTGGCCAGGGGCCGCT
GCTGGCGTCCCTCTCCAGCGACATAGGCCAGATCACCATCGCCTTCGTGCGCCTGCCCGAGCTGGTGCAGGGGTTGGTGC
TCACTGTTGGTTCGGCCCTCTATCTCGGCTGGCTGTCACCGGCCCTGCTCGGCGTCACAGCACTCTGGGTCACTGTGACC
ATGGTGGTGGGCTGGCTGCTGGTGAACCGTGTTTATCGCCATCTCTCCCACATGCGTCAGGCGGAGGATCGCCTTTATCA
GAACTATCAGGCCATCATAGCGGGCAGCAAAGAGCTGGCGCTCAATCGCGAGCGGGCCCATTTCGTCTACCACCAGCTCT
ATGAGCAGAACGCCCGTGACTATCGCCAGCAGATCATTCGCGCCGACACCTATCACCTGAGCGCGGTGAACTGGTCGAAT
ATCATGATGCTGGGAGCCATAGGCCTGGTCTTCTTCCTGGCCAATGGCCTCGGCTGGGCCAACACCAATGTGGCCGCCAC
CTTTGCCCTGACCCTGCTGTTCCTGCGCACTCCGCTGTTGCAGGGGATAGGCGCCTTGCCGACCCTGCTTTCCGCCCAGG
TAGCGTTCGACAAGATAGCCGCACTGGCGCTGGCCGAGCCGGATCCCGACTTCCCGCTGCCACCGGCACCCCGTGCCTGG
CAACGCATCCAGCTGGAGCAGGTGAGCTTTCACTATCAGGGGGAGGGTGGCTTCGCGGTGGGCCCCATCAATCTCACCAT
TGAGAAGGGGGAGCAGGTCTTCATCATAGGTGGCAACGGCTCCGGCAAATCGACCCTGGCCATGCTGCTGACCGGTCTCT
ATCAGCCTGTGTCGGGCCGGATCCTGCTGGATGGTGAACCCGTCACGGATCGCAACGCCTATCTGGCGCTCTTCTCCGCC
ATCTTCACCGATTACCACCTGTTCCAGCATTTGCTGGGGCCCGAGCCCAAGGCCGAGCTGATCGCCGAGTGGCTGGATCG
GTTGCAGATGGGCAGCAAGCTCGCCATCGAGGACAACTTTATCGCCGATATCGATCTCTCCCAGGGGCAGCGCAAGCGGG
TCGCTCTGCTGCTGGCACTGGCTGAGCAGCGCGAGGTGATGCTGTTTGATGAATGGGCCGCGGATCAGGATCCCCAGTTC
CGCCGCATCTTTTATCAGCTGCTGCTGCCGCGCCTCAAGGCGATGGGCAAGACGGTGATCGCCATCAGCCACGACGATCA
CTACTTCCCGCTGGCCGACCGCTTGCTGGAGATGCGTCAGGGCCAGCTCACCGAACTGACCGGCGAGCGGCGCGAGCAGG
TCAGCCGGGATGCCGTCGCCCATCTGGATTGCGAGGTGCCGGCTTGA

Upstream 100 bases:

>100_bases
CGAGCCGCGCAGTGTGGTGGGCAGCATCAACTACCGCTGGTAACAGAGGTCGGGCGGGAGTCGTGACTTCCGCCCTTTTT
TCCCCGCATACAGGCCCGTC

Downstream 100 bases:

>100_bases
TGCCGGCACCGATGAGACTGGCATCAGGCCAGCACAGGAACAGCTTATGTTTGAGATGAAAGCCGCCAGCTTCGCGGTAA
ACGGCCGCAAGCTGCTGCAC

Product: multidrug transporter membrane component/ATP-binding component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MELLSLVYRQYRWPFIAITLLSLLSAVSGIGVIAFINQSLVESVGDPLPVLGQLLGLILLLLVITLGSQLALTTLGHHFV
YRLRGRLLKQLLDTDVARIRQLGQGPLLASLSSDIGQITIAFVRLPELVQGLVLTVGSALYLGWLSPALLGVTALWVTVT
MVVGWLLVNRVYRHLSHMRQAEDRLYQNYQAIIAGSKELALNRERAHFVYHQLYEQNARDYRQQIIRADTYHLSAVNWSN
IMMLGAIGLVFFLANGLGWANTNVAATFALTLLFLRTPLLQGIGALPTLLSAQVAFDKIAALALAEPDPDFPLPPAPRAW
QRIQLEQVSFHYQGEGGFAVGPINLTIEKGEQVFIIGGNGSGKSTLAMLLTGLYQPVSGRILLDGEPVTDRNAYLALFSA
IFTDYHLFQHLLGPEPKAELIAEWLDRLQMGSKLAIEDNFIADIDLSQGQRKRVALLLALAEQREVMLFDEWAADQDPQF
RRIFYQLLLPRLKAMGKTVIAISHDDHYFPLADRLLEMRQGQLTELTGERREQVSRDAVAHLDCEVPA

Sequences:

>Translated_548_residues
MELLSLVYRQYRWPFIAITLLSLLSAVSGIGVIAFINQSLVESVGDPLPVLGQLLGLILLLLVITLGSQLALTTLGHHFV
YRLRGRLLKQLLDTDVARIRQLGQGPLLASLSSDIGQITIAFVRLPELVQGLVLTVGSALYLGWLSPALLGVTALWVTVT
MVVGWLLVNRVYRHLSHMRQAEDRLYQNYQAIIAGSKELALNRERAHFVYHQLYEQNARDYRQQIIRADTYHLSAVNWSN
IMMLGAIGLVFFLANGLGWANTNVAATFALTLLFLRTPLLQGIGALPTLLSAQVAFDKIAALALAEPDPDFPLPPAPRAW
QRIQLEQVSFHYQGEGGFAVGPINLTIEKGEQVFIIGGNGSGKSTLAMLLTGLYQPVSGRILLDGEPVTDRNAYLALFSA
IFTDYHLFQHLLGPEPKAELIAEWLDRLQMGSKLAIEDNFIADIDLSQGQRKRVALLLALAEQREVMLFDEWAADQDPQF
RRIFYQLLLPRLKAMGKTVIAISHDDHYFPLADRLLEMRQGQLTELTGERREQVSRDAVAHLDCEVPA
>Mature_548_residues
MELLSLVYRQYRWPFIAITLLSLLSAVSGIGVIAFINQSLVESVGDPLPVLGQLLGLILLLLVITLGSQLALTTLGHHFV
YRLRGRLLKQLLDTDVARIRQLGQGPLLASLSSDIGQITIAFVRLPELVQGLVLTVGSALYLGWLSPALLGVTALWVTVT
MVVGWLLVNRVYRHLSHMRQAEDRLYQNYQAIIAGSKELALNRERAHFVYHQLYEQNARDYRQQIIRADTYHLSAVNWSN
IMMLGAIGLVFFLANGLGWANTNVAATFALTLLFLRTPLLQGIGALPTLLSAQVAFDKIAALALAEPDPDFPLPPAPRAW
QRIQLEQVSFHYQGEGGFAVGPINLTIEKGEQVFIIGGNGSGKSTLAMLLTGLYQPVSGRILLDGEPVTDRNAYLALFSA
IFTDYHLFQHLLGPEPKAELIAEWLDRLQMGSKLAIEDNFIADIDLSQGQRKRVALLLALAEQREVMLFDEWAADQDPQF
RRIFYQLLLPRLKAMGKTVIAISHDDHYFPLADRLLEMRQGQLTELTGERREQVSRDAVAHLDCEVPA

Specific function: Mediates resistance to the antibacterial peptide microcin J25. Functions as an efflux pump for microcin J25. Requires TolC for export of microcin J25 [H]

COG id: COG4615

COG function: function code QP; ABC-type siderophore export system, fused ATPase and permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI73747915, Length=516, Percent_Identity=24.4186046511628, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI73747917, Length=471, Percent_Identity=24.416135881104, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI190343023, Length=571, Percent_Identity=23.8178633975482, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI42741659, Length=287, Percent_Identity=21.9512195121951, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788540, Length=545, Percent_Identity=63.4862385321101, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI87081709, Length=196, Percent_Identity=34.6938775510204, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87081791, Length=239, Percent_Identity=30.1255230125523, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1787143, Length=513, Percent_Identity=22.8070175438596, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786253, Length=171, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081834, Length=225, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787370, Length=210, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789672, Length=224, Percent_Identity=29.9107142857143, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787029, Length=226, Percent_Identity=30.9734513274336, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787105, Length=197, Percent_Identity=34.010152284264, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787112, Length=484, Percent_Identity=23.7603305785124, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786654, Length=548, Percent_Identity=23.7226277372263, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788761, Length=199, Percent_Identity=30.1507537688442, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994943, Length=224, Percent_Identity=28.125, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789891, Length=230, Percent_Identity=29.1304347826087, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787758, Length=205, Percent_Identity=28.2926829268293, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786398, Length=226, Percent_Identity=28.3185840707965, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787712, Length=211, Percent_Identity=27.0142180094787, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082267, Length=213, Percent_Identity=28.6384976525822, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789032, Length=208, Percent_Identity=29.3269230769231, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=203, Percent_Identity=30.5418719211823, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788225, Length=212, Percent_Identity=31.1320754716981, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790467, Length=198, Percent_Identity=29.2929292929293, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788450, Length=200, Percent_Identity=29.5, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=24.6073298429319, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789586, Length=195, Percent_Identity=31.7948717948718, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17543740, Length=558, Percent_Identity=23.8351254480287, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17511077, Length=577, Percent_Identity=22.1837088388215, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565938, Length=280, Percent_Identity=27.5, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115533592, Length=507, Percent_Identity=22.6824457593688, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17567265, Length=273, Percent_Identity=27.4725274725275, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193202349, Length=524, Percent_Identity=22.1374045801527, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567269, Length=260, Percent_Identity=28.0769230769231, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115534520, Length=222, Percent_Identity=28.3783783783784, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17541710, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115535101, Length=276, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=221, Percent_Identity=26.6968325791855, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17533971, Length=570, Percent_Identity=21.9298245614035, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193208177, Length=275, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212646699, Length=234, Percent_Identity=24.7863247863248, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324985, Length=492, Percent_Identity=20.5284552845528, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322640, Length=308, Percent_Identity=25.3246753246753, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24659289, Length=219, Percent_Identity=27.3972602739726, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR005898 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 60994; Mature: 60994

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCC
>Mature Secondary Structure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HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]