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The map label for this gene is blrB [H]

Identifier: 145301167

GI number: 145301167

Start: 4649807

End: 4651249

Strand: Direct

Name: blrB [H]

Synonym: ASA_4345

Alternate gene names: 145301167

Gene position: 4649807-4651249 (Clockwise)

Preceding gene: 145301166

Following gene: 145301168

Centisome position: 98.88

GC content: 62.3

Gene sequence:

>1443_bases
ATGAGAATAGGACTGCAACTGCTGTGCGGACTGGTGCTGATCTTCGCGCTGGCGGCCTGGTTTGTGCTGGAGATCTTCGT
CGAGGAGATAAAACCCGGGGTGCGCAGCGCCACCGAAGATACCCTGGTTGACATGGCCCAGATGCTGGCACCGCTGGCAC
TTGACGATCTGCAGGAAGGAAAAATGGCCGATGGCAGGCTGGCCAGCGCCTTCGCCCGCCTCAACCAGAGCCCCATCAAT
GCCCTGATCGACGGGCACCTCAAGCAACAAGCTGAATATCGCATCTATGTGACCGACGCTAAAGGCAAGGTGGTCTATGA
CTCGGACGGGGTGGATCTGGGCAAGGACTATTCGCGCTGGAACGACGTCTACCGTACCCTGCGCGGCCAGTACGGGGCTC
GCAGTACCCGCAGCGATCCGGATGATCCCGCCAGCTCCGTCATGCACGTGGCCGCGCCGCTGCGTGAAGGGGGGTGCATA
CTGGGCTCCCTCACGGTCGCCAAACCCAACCGCACTCTGATGCCAATGATAGAGCGCAGCGAACACCAGCTATTGCAGGC
GGCAGCCATGCTGTTGCTCATCTCGCTGCTGATCGGCGCCCTGCTGGCATGGTGGCTCAACCGCGCCATCGGCAAGCTGG
TGCACTACGCCGATGCGGTCAGTCACAACCAGCCCGCCACTCTGCCGGGACTCCACAGCCCGGAGCTGGAGCGACTCGGT
CGCTCCCTCGAAACCATGCGCCGTCAGCTCGATGGCAAGGCCTATATCGAATCCTATGTACACAGCCTGACCCACGAACT
CAAAAGCCCGCTGGCCGCCATTCGCGGGGCTGGAGAGCTGCTGGCCGAAGCGCCCCCCCCCGAGGTGGCCCGACGTTTCA
TCGGCAACATCAATCTGGAAACAGCCCGCATGCAGCAGTTGATAGAACGCATGCTGCAACTGGCCAAGCTGGAATCGGGG
CAGGGGCTGGATCGCCAGGCAACCGAACCCGCCAGACTGGGCAAGCGGGTGCTTGATGCCCGCCAGATCATAGCCCAGCG
TCGTCAGGTAACCTTGGTGGCCGAACTGGCCGACGCCTCAAAGCAGAAGTGGGATCCCCTGCTGGTAGAGCAGGCCCTCG
GCAACCTGCTGGACAACGCCCTCGACTTCTCCCCTGCCGGCAGCACTGTCAGATTGACCGGCGAGATGCATGCAGACGGC
TATCGCTTTCAGGTACGGGATCAGGGCCCCGGCATTCCGGACTATGCCCTGCCACGCATCTTCGAGCGTTTCTACTCCCT
GCCCAGACCCGACAAGGGCAAGAGCAGCGGTCTGGGGCTCAGTTTTGCCACAGAAGTGGCACGCCAGCATGGTGGTCGGC
TGAACCTCTGCAACCAGCCAGAAGGTGGCGTGCTGGCCGAACTCTGGCTGCCAGCAGGCGGACACTTCACATTGGGCACA
TAA

Upstream 100 bases:

>100_bases
CTGACCCATCGCGGGCTGGGCTACAGTCTGGAACTGGCATGAGGATCGGCCTGCAGCAAGCATATGGTCTGGCGCCCGGA
TACAAACGGATAGAACTGGT

Downstream 100 bases:

>100_bases
AGCGGCGCTATGCTGCCGCCTCCCGGCCCTTTGTCCCATTCTCCAAGGAGACCCCATGTCCCGGATCCTGTTACCCGGCC
TGCTCGCAGCAGGCCTGATA

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MRIGLQLLCGLVLIFALAAWFVLEIFVEEIKPGVRSATEDTLVDMAQMLAPLALDDLQEGKMADGRLASAFARLNQSPIN
ALIDGHLKQQAEYRIYVTDAKGKVVYDSDGVDLGKDYSRWNDVYRTLRGQYGARSTRSDPDDPASSVMHVAAPLREGGCI
LGSLTVAKPNRTLMPMIERSEHQLLQAAAMLLLISLLIGALLAWWLNRAIGKLVHYADAVSHNQPATLPGLHSPELERLG
RSLETMRRQLDGKAYIESYVHSLTHELKSPLAAIRGAGELLAEAPPPEVARRFIGNINLETARMQQLIERMLQLAKLESG
QGLDRQATEPARLGKRVLDARQIIAQRRQVTLVAELADASKQKWDPLLVEQALGNLLDNALDFSPAGSTVRLTGEMHADG
YRFQVRDQGPGIPDYALPRIFERFYSLPRPDKGKSSGLGLSFATEVARQHGGRLNLCNQPEGGVLAELWLPAGGHFTLGT

Sequences:

>Translated_480_residues
MRIGLQLLCGLVLIFALAAWFVLEIFVEEIKPGVRSATEDTLVDMAQMLAPLALDDLQEGKMADGRLASAFARLNQSPIN
ALIDGHLKQQAEYRIYVTDAKGKVVYDSDGVDLGKDYSRWNDVYRTLRGQYGARSTRSDPDDPASSVMHVAAPLREGGCI
LGSLTVAKPNRTLMPMIERSEHQLLQAAAMLLLISLLIGALLAWWLNRAIGKLVHYADAVSHNQPATLPGLHSPELERLG
RSLETMRRQLDGKAYIESYVHSLTHELKSPLAAIRGAGELLAEAPPPEVARRFIGNINLETARMQQLIERMLQLAKLESG
QGLDRQATEPARLGKRVLDARQIIAQRRQVTLVAELADASKQKWDPLLVEQALGNLLDNALDFSPAGSTVRLTGEMHADG
YRFQVRDQGPGIPDYALPRIFERFYSLPRPDKGKSSGLGLSFATEVARQHGGRLNLCNQPEGGVLAELWLPAGGHFTLGT
>Mature_480_residues
MRIGLQLLCGLVLIFALAAWFVLEIFVEEIKPGVRSATEDTLVDMAQMLAPLALDDLQEGKMADGRLASAFARLNQSPIN
ALIDGHLKQQAEYRIYVTDAKGKVVYDSDGVDLGKDYSRWNDVYRTLRGQYGARSTRSDPDDPASSVMHVAAPLREGGCI
LGSLTVAKPNRTLMPMIERSEHQLLQAAAMLLLISLLIGALLAWWLNRAIGKLVHYADAVSHNQPATLPGLHSPELERLG
RSLETMRRQLDGKAYIESYVHSLTHELKSPLAAIRGAGELLAEAPPPEVARRFIGNINLETARMQQLIERMLQLAKLESG
QGLDRQATEPARLGKRVLDARQIIAQRRQVTLVAELADASKQKWDPLLVEQALGNLLDNALDFSPAGSTVRLTGEMHADG
YRFQVRDQGPGIPDYALPRIFERFYSLPRPDKGKSSGLGLSFATEVARQHGGRLNLCNQPEGGVLAELWLPAGGHFTLGT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=477, Percent_Identity=53.6687631027254, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=30.316742081448, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=477, Percent_Identity=26.2054507337526, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=302, Percent_Identity=26.8211920529801, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=27.5590551181102, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=304, Percent_Identity=26.6447368421053, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=25.5060728744939, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790300, Length=235, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=24.8979591836735, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=209, Percent_Identity=29.1866028708134, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=26.3598326359833, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI87081816, Length=219, Percent_Identity=26.9406392694064, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=26.0089686098655, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=213, Percent_Identity=23.943661971831, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=24.5689655172414, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=26.3392857142857, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789149, Length=284, Percent_Identity=24.2957746478873, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=25.7462686567164, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=27.2340425531915, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787374, Length=356, Percent_Identity=25.2808988764045, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52737; Mature: 52737

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGLQLLCGLVLIFALAAWFVLEIFVEEIKPGVRSATEDTLVDMAQMLAPLALDDLQEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
KMADGRLASAFARLNQSPINALIDGHLKQQAEYRIYVTDAKGKVVYDSDGVDLGKDYSRW
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCHHHHH
NDVYRTLRGQYGARSTRSDPDDPASSVMHVAAPLREGGCILGSLTVAKPNRTLMPMIERS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHH
EHQLLQAAAMLLLISLLIGALLAWWLNRAIGKLVHYADAVSHNQPATLPGLHSPELERLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
RSLETMRRQLDGKAYIESYVHSLTHELKSPLAAIRGAGELLAEAPPPEVARRFIGNINLE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHCCCCCC
TARMQQLIERMLQLAKLESGQGLDRQATEPARLGKRVLDARQIIAQRRQVTLVAELADAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQKWDPLLVEQALGNLLDNALDFSPAGSTVRLTGEMHADGYRFQVRDQGPGIPDYALPRI
HHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCHHHHHH
FERFYSLPRPDKGKSSGLGLSFATEVARQHGGRLNLCNQPEGGVLAELWLPAGGHFTLGT
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCCCCEECCC
>Mature Secondary Structure
MRIGLQLLCGLVLIFALAAWFVLEIFVEEIKPGVRSATEDTLVDMAQMLAPLALDDLQEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
KMADGRLASAFARLNQSPINALIDGHLKQQAEYRIYVTDAKGKVVYDSDGVDLGKDYSRW
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCHHHHH
NDVYRTLRGQYGARSTRSDPDDPASSVMHVAAPLREGGCILGSLTVAKPNRTLMPMIERS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHH
EHQLLQAAAMLLLISLLIGALLAWWLNRAIGKLVHYADAVSHNQPATLPGLHSPELERLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
RSLETMRRQLDGKAYIESYVHSLTHELKSPLAAIRGAGELLAEAPPPEVARRFIGNINLE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHCCCCCC
TARMQQLIERMLQLAKLESGQGLDRQATEPARLGKRVLDARQIIAQRRQVTLVAELADAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQKWDPLLVEQALGNLLDNALDFSPAGSTVRLTGEMHADGYRFQVRDQGPGIPDYALPRI
HHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCHHHHHH
FERFYSLPRPDKGKSSGLGLSFATEVARQHGGRLNLCNQPEGGVLAELWLPAGGHFTLGT
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]