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The map label for this gene is coaBC [H]

Identifier: 145301065

GI number: 145301065

Start: 4521190

End: 4522392

Strand: Direct

Name: coaBC [H]

Synonym: ASA_4230

Alternate gene names: 145301065

Gene position: 4521190-4522392 (Clockwise)

Preceding gene: 145301058

Following gene: 145301066

Centisome position: 96.15

GC content: 64.92

Gene sequence:

>1203_bases
ATGAGATTGGCCGATAAACGCATCCTGTTGGGTGTCAGTGGCGGGATCGCCGCCTACAAGAGTGCCGAACTGGTACGCCG
CCTGAAAGACCAGGGGGCCGAGGTACGGGTAGTGATGACCCGCTCCGCCAAGGAGTTCATCACCCCGCTGACCCTGCAGG
CGGTTTCCGGTCATCCGGTGGCCGACAGCTTGCTGGATCCGGCTGCCGAGGCGGGCATGGGCCACATAGAGCTGGCCAAG
TGGGCGGATCTGGTGCTGATCGCCCCGGCGAGCGCCAACCTGATGGCCCGCATGGCCGCCGGCATGGCCGACGAACTGCT
CACCACCCTCTGCGTGGCAACCCCGGCCCCCGTGGCACTGGCTCCCGCCATGAATCAGCAGATGTATCTCAACGCCGCCA
CCCAGGCCAATCTCAAGACCCTGGCCAGCCGCGGAATCCTGCTGTGGGGGCCGGATTCCGGCAGCCAGGCCTGTGGCGAC
GTAGGCCCGGGCCGGATGCTGGATCCCTTGGAACTGGTTGAGCGCTGCTGCCAGCAACTGGCTGCCGAGCCGCTGCTGGC
GGGCGTCAGACTGCTGCTCACCGCCGGACCGACCCGCGAAGCACTGGATCCGGTGCGCTACATCAGCAACCACAGCTCGG
GCAAGATGGGTTACGCCATCGCCCGCGCCGCCCGTGAGGCAGGGGCCGAAGTGACGCTGGTGAGCGGGCCGGTCGCCCTG
CCTGCACCGAGCGGGGTGGAGCGTGTCGATGTGGAGAGCGCCGAGCAGATGCATCAGGCGGTGATGAGCCGGGTCGGCGA
GTGCGACCTCTTTATCGGTTGCGCCGCAGTGGCCGACTATAGGCCCGAGCAAGTCGCCAGCCAGAAGATCAAAAAGACCG
GTGATAACGATCAGATGGTGCTGACCCTGGTCAAGAATCCCGACATCATAGCCGCCGTGGGGGCGTTATCAGACAAGCCC
TTCACCGTCGGATTTGCCGCCGAAACCGTGGATGTGGAACAATACGCCCTCGATAAATTGCAGCGAAAACGGCTGGACAT
GATCGCCGCCAACGATGTGTCTCGTGCGGGCCAGGGCTTCAATGCCGATGACAACGCTCTGACCGTGTTCTGGCAAGGGG
GTCAAGCCCCTCTGCCACTGGCCGATAAGCTGACGCTGGCTCGCCACCTCATCGCCCTGATTGCGCGCCACTACCGGCGC
TGA

Upstream 100 bases:

>100_bases
GGGAGGCCGGCCACAAGTCCCCCATGTCAGCCTCTGTCGTCGTCCGTTGCCTGTGGTATCTTAGCCGACCAGTCAGAGTG
AGCCGGAAGAGAAGCAGCAG

Downstream 100 bases:

>100_bases
GTGCAGACACATGGCACCCCGCTGGCATTGCCCATGCAGGACGCCCACACCAGCACTCGCTGAGCAACGATCAATTCATG
ACTGCCCGGACTGTACCGAG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MRLADKRILLGVSGGIAAYKSAELVRRLKDQGAEVRVVMTRSAKEFITPLTLQAVSGHPVADSLLDPAAEAGMGHIELAK
WADLVLIAPASANLMARMAAGMADELLTTLCVATPAPVALAPAMNQQMYLNAATQANLKTLASRGILLWGPDSGSQACGD
VGPGRMLDPLELVERCCQQLAAEPLLAGVRLLLTAGPTREALDPVRYISNHSSGKMGYAIARAAREAGAEVTLVSGPVAL
PAPSGVERVDVESAEQMHQAVMSRVGECDLFIGCAAVADYRPEQVASQKIKKTGDNDQMVLTLVKNPDIIAAVGALSDKP
FTVGFAAETVDVEQYALDKLQRKRLDMIAANDVSRAGQGFNADDNALTVFWQGGQAPLPLADKLTLARHLIALIARHYRR

Sequences:

>Translated_400_residues
MRLADKRILLGVSGGIAAYKSAELVRRLKDQGAEVRVVMTRSAKEFITPLTLQAVSGHPVADSLLDPAAEAGMGHIELAK
WADLVLIAPASANLMARMAAGMADELLTTLCVATPAPVALAPAMNQQMYLNAATQANLKTLASRGILLWGPDSGSQACGD
VGPGRMLDPLELVERCCQQLAAEPLLAGVRLLLTAGPTREALDPVRYISNHSSGKMGYAIARAAREAGAEVTLVSGPVAL
PAPSGVERVDVESAEQMHQAVMSRVGECDLFIGCAAVADYRPEQVASQKIKKTGDNDQMVLTLVKNPDIIAAVGALSDKP
FTVGFAAETVDVEQYALDKLQRKRLDMIAANDVSRAGQGFNADDNALTVFWQGGQAPLPLADKLTLARHLIALIARHYRR
>Mature_400_residues
MRLADKRILLGVSGGIAAYKSAELVRRLKDQGAEVRVVMTRSAKEFITPLTLQAVSGHPVADSLLDPAAEAGMGHIELAK
WADLVLIAPASANLMARMAAGMADELLTTLCVATPAPVALAPAMNQQMYLNAATQANLKTLASRGILLWGPDSGSQACGD
VGPGRMLDPLELVERCCQQLAAEPLLAGVRLLLTAGPTREALDPVRYISNHSSGKMGYAIARAAREAGAEVTLVSGPVAL
PAPSGVERVDVESAEQMHQAVMSRVGECDLFIGCAAVADYRPEQVASQKIKKTGDNDQMVLTLVKNPDIIAAVGALSDKP
FTVGFAAETVDVEQYALDKLQRKRLDMIAANDVSRAGQGFNADDNALTVFWQGGQAPLPLADKLTLARHLIALIARHYRR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=34.4632768361582, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI87082301, Length=400, Percent_Identity=63.75, Blast_Score=497, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17560194, Length=170, Percent_Identity=32.3529411764706, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=201, Percent_Identity=32.8358208955224, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322925, Length=115, Percent_Identity=33.0434782608696, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657262, Length=183, Percent_Identity=31.1475409836066, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42417; Mature: 42417

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLADKRILLGVSGGIAAYKSAELVRRLKDQGAEVRVVMTRSAKEFITPLTLQAVSGHPV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHCCCEEEECCCCCC
ADSLLDPAAEAGMGHIELAKWADLVLIAPASANLMARMAAGMADELLTTLCVATPAPVAL
HHHHHCHHHHCCCCCEEHHHHCCEEEECCCCHHHHHHHHHCHHHHHHHHHHHCCCCCEEE
APAMNQQMYLNAATQANLKTLASRGILLWGPDSGSQACGDVGPGRMLDPLELVERCCQQL
CCCCCCEEEEEHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAEPLLAGVRLLLTAGPTREALDPVRYISNHSSGKMGYAIARAAREAGAEVTLVSGPVAL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCEEC
PAPSGVERVDVESAEQMHQAVMSRVGECDLFIGCAAVADYRPEQVASQKIKKTGDNDQMV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHCCCCCCEE
LTLVKNPDIIAAVGALSDKPFTVGFAAETVDVEQYALDKLQRKRLDMIAANDVSRAGQGF
EEEECCCCEEEEECCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCC
NADDNALTVFWQGGQAPLPLADKLTLARHLIALIARHYRR
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLADKRILLGVSGGIAAYKSAELVRRLKDQGAEVRVVMTRSAKEFITPLTLQAVSGHPV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHCCCEEEECCCCCC
ADSLLDPAAEAGMGHIELAKWADLVLIAPASANLMARMAAGMADELLTTLCVATPAPVAL
HHHHHCHHHHCCCCCEEHHHHCCEEEECCCCHHHHHHHHHCHHHHHHHHHHHCCCCCEEE
APAMNQQMYLNAATQANLKTLASRGILLWGPDSGSQACGDVGPGRMLDPLELVERCCQQL
CCCCCCEEEEEHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAEPLLAGVRLLLTAGPTREALDPVRYISNHSSGKMGYAIARAAREAGAEVTLVSGPVAL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCEEC
PAPSGVERVDVESAEQMHQAVMSRVGECDLFIGCAAVADYRPEQVASQKIKKTGDNDQMV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHCCCCCCEE
LTLVKNPDIIAAVGALSDKPFTVGFAAETVDVEQYALDKLQRKRLDMIAANDVSRAGQGF
EEEECCCCEEEEECCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCC
NADDNALTVFWQGGQAPLPLADKLTLARHLIALIARHYRR
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]