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The map label for this gene is lysC [H]

Identifier: 145300679

GI number: 145300679

Start: 4105353

End: 4106600

Strand: Direct

Name: lysC [H]

Synonym: ASA_3812

Alternate gene names: 145300679

Gene position: 4105353-4106600 (Clockwise)

Preceding gene: 145300678

Following gene: 145300680

Centisome position: 87.3

GC content: 60.26

Gene sequence:

>1248_bases
GTGGCACTCTATGTACAGAAGTACGGCGGCACCTCGGTCGGCACGCTGGAGCGGATCGAGGCGGTGGCTGAGCGGGTTCA
ACTGACCCGCGCCCAGGGACATGACGTGGTGGTAGTGGTCTCTGCCATGTCGGGGGAAACCAACCGGTTGCTGGGTATGG
CCCAGCGGCTGGATCCTGATGCCAACCGGCGCGAGATGGATGTGCTCGTCTCCACCGGTGAGCAGGTCACCATAGCGCTG
CTGGCGATCGCGTTGAACAAACGCGGTTGCGCTGCGGTCTCTATGACCGGCGATCAGGTACGCATTCATACCGACTCCGC
CTATGGCAAGGCACGTATCAGCCACATCGACACCGAACAGGTTCAGGCTGAACTGGGGGCGGGCAAGGTGGTGGTGATCG
CCGGTTTCCAGGGCCGTGATGAGCACAATGCCATCACGACCCTGGGGCGCGGTGGTTCGGATACCACGGCAGTAGCGGTA
GCCGCGGCCATCAAAGCCGATGAATGCCAGATCTTTACCGATGTGGATGGGGTCTATACCACGGATCCGCGCATCGAGCC
CAAGGCCCGTCGTCTTTCCACCATCACCTTCGAGGAGATGCTGGAGATGGCGAGCCTGGGGGCCAAGGTGCTGCAGATCC
GTTCGGTGGAGTTCGCGGGCAAGTACCGCGTACCACTACGGGTGCTGTCGAGCTTTGTCGATGGAGAGGGAACCTTAATC
ACATATGGAGGTGAGAGGATGGAAGCTCCCCTGGTATCCGGGATAGCCTTCAATCGCAACGAGGCCAGTCTGACCATTCT
GGGTGTGCCGGACAGGCCCACAGTTGCGGCGCAGATCCTGAATCCGATCAGCGACGCCAACATTGATGTCGACATGATAG
TGCAGAACACGCTGGGGGATGGCACAGCAGACTTCACCTTTACGGTGAATCGCGATGACTATCGCCGGGCGCGCGCCTTG
CTGGAGGAGACCGCCAGTGAACTGGGGGCCGCCTGCGTGCAGGGCAACGGCGAGATAGCCAAGGTGTCCATTGTCGGTGT
CGGCATGTGGAACCACCCCGGTGTCGCCCGCACCATGTTCAAGGTATTGGGCGAGGAGGGGATCAACATGCAGTTGATTT
CCACCTCTGAAATCAAAATATCCGTGGTGATTGACGAGAAGTACCTGGAGCTGGCCGTGCGAGCCTTGCACGCCGCTTTC
GGGCTGGATAATGAGCCTCATGAGCAGCCCTTGGGGAACAATCCCTGA

Upstream 100 bases:

>100_bases
ATGGCTCAGGCGGGTGGCACTCAGCCAGAAGCTGTGCCTGCGGCACTGCAATCCGTTCACTCCTGGCTGGAAGAGCGCCT
GTAAAAGGGCGAGGTGATCT

Downstream 100 bases:

>100_bases
TTGATTTAGTTTCAACCATTTACCATATCGGTATCTTTGTAAGATAATGTCGCATATCGATATAAATACAAAACAGGATA
CAGGAGCAAGCGAATGCTTA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MALYVQKYGGTSVGTLERIEAVAERVQLTRAQGHDVVVVVSAMSGETNRLLGMAQRLDPDANRREMDVLVSTGEQVTIAL
LAIALNKRGCAAVSMTGDQVRIHTDSAYGKARISHIDTEQVQAELGAGKVVVIAGFQGRDEHNAITTLGRGGSDTTAVAV
AAAIKADECQIFTDVDGVYTTDPRIEPKARRLSTITFEEMLEMASLGAKVLQIRSVEFAGKYRVPLRVLSSFVDGEGTLI
TYGGERMEAPLVSGIAFNRNEASLTILGVPDRPTVAAQILNPISDANIDVDMIVQNTLGDGTADFTFTVNRDDYRRARAL
LEETASELGAACVQGNGEIAKVSIVGVGMWNHPGVARTMFKVLGEEGINMQLISTSEIKISVVIDEKYLELAVRALHAAF
GLDNEPHEQPLGNNP

Sequences:

>Translated_415_residues
MALYVQKYGGTSVGTLERIEAVAERVQLTRAQGHDVVVVVSAMSGETNRLLGMAQRLDPDANRREMDVLVSTGEQVTIAL
LAIALNKRGCAAVSMTGDQVRIHTDSAYGKARISHIDTEQVQAELGAGKVVVIAGFQGRDEHNAITTLGRGGSDTTAVAV
AAAIKADECQIFTDVDGVYTTDPRIEPKARRLSTITFEEMLEMASLGAKVLQIRSVEFAGKYRVPLRVLSSFVDGEGTLI
TYGGERMEAPLVSGIAFNRNEASLTILGVPDRPTVAAQILNPISDANIDVDMIVQNTLGDGTADFTFTVNRDDYRRARAL
LEETASELGAACVQGNGEIAKVSIVGVGMWNHPGVARTMFKVLGEEGINMQLISTSEIKISVVIDEKYLELAVRALHAAF
GLDNEPHEQPLGNNP
>Mature_414_residues
ALYVQKYGGTSVGTLERIEAVAERVQLTRAQGHDVVVVVSAMSGETNRLLGMAQRLDPDANRREMDVLVSTGEQVTIALL
AIALNKRGCAAVSMTGDQVRIHTDSAYGKARISHIDTEQVQAELGAGKVVVIAGFQGRDEHNAITTLGRGGSDTTAVAVA
AAIKADECQIFTDVDGVYTTDPRIEPKARRLSTITFEEMLEMASLGAKVLQIRSVEFAGKYRVPLRVLSSFVDGEGTLIT
YGGERMEAPLVSGIAFNRNEASLTILGVPDRPTVAAQILNPISDANIDVDMIVQNTLGDGTADFTFTVNRDDYRRARALL
EETASELGAACVQGNGEIAKVSIVGVGMWNHPGVARTMFKVLGEEGINMQLISTSEIKISVVIDEKYLELAVRALHAAFG
LDNEPHEQPLGNNP

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=346, Percent_Identity=31.7919075144509, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790455, Length=452, Percent_Identity=28.5398230088496, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790376, Length=375, Percent_Identity=24.2666666666667, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=490, Percent_Identity=26.3265306122449, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44522; Mature: 44391

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYVQKYGGTSVGTLERIEAVAERVQLTRAQGHDVVVVVSAMSGETNRLLGMAQRLDPD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCC
ANRREMDVLVSTGEQVTIALLAIALNKRGCAAVSMTGDQVRIHTDSAYGKARISHIDTEQ
CCCCEEEEEEECCCCEEEEEEEEHHCCCCCEEEEECCCEEEEEECCCCCCEEEECCCHHH
VQAELGAGKVVVIAGFQGRDEHNAITTLGRGGSDTTAVAVAAAIKADECQIFTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHEEEEEHEECCCEEEEECCCCEEE
TDPRIEPKARRLSTITFEEMLEMASLGAKVLQIRSVEFAGKYRVPLRVLSSFVDGEGTLI
CCCCCCCHHHHHEEECHHHHHHHHHCCHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCEE
TYGGERMEAPLVSGIAFNRNEASLTILGVPDRPTVAAQILNPISDANIDVDMIVQNTLGD
EECCCCCCCCHHCCEEECCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCC
GTADFTFTVNRDDYRRARALLEETASELGAACVQGNGEIAKVSIVGVGMWNHPGVARTMF
CCCEEEEEECCHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEEEEECCCCCCHHHHHH
KVLGEEGINMQLISTSEIKISVVIDEKYLELAVRALHAAFGLDNEPHEQPLGNNP
HHHCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALYVQKYGGTSVGTLERIEAVAERVQLTRAQGHDVVVVVSAMSGETNRLLGMAQRLDPD
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCC
ANRREMDVLVSTGEQVTIALLAIALNKRGCAAVSMTGDQVRIHTDSAYGKARISHIDTEQ
CCCCEEEEEEECCCCEEEEEEEEHHCCCCCEEEEECCCEEEEEECCCCCCEEEECCCHHH
VQAELGAGKVVVIAGFQGRDEHNAITTLGRGGSDTTAVAVAAAIKADECQIFTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHEEEEEHEECCCEEEEECCCCEEE
TDPRIEPKARRLSTITFEEMLEMASLGAKVLQIRSVEFAGKYRVPLRVLSSFVDGEGTLI
CCCCCCCHHHHHEEECHHHHHHHHHCCHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCEE
TYGGERMEAPLVSGIAFNRNEASLTILGVPDRPTVAAQILNPISDANIDVDMIVQNTLGD
EECCCCCCCCHHCCEEECCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCC
GTADFTFTVNRDDYRRARALLEETASELGAACVQGNGEIAKVSIVGVGMWNHPGVARTMF
CCCEEEEEECCHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEEEEECCCCCCHHHHHH
KVLGEEGINMQLISTSEIKISVVIDEKYLELAVRALHAAFGLDNEPHEQPLGNNP
HHHCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]