| Definition | Aeromonas salmonicida subsp. salmonicida A449, complete genome. |
|---|---|
| Accession | NC_009348 |
| Length | 4,702,402 |
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The map label for this gene is metL [H]
Identifier: 145300664
GI number: 145300664
Start: 4088623
End: 4091031
Strand: Direct
Name: metL [H]
Synonym: ASA_3796
Alternate gene names: 145300664
Gene position: 4088623-4091031 (Clockwise)
Preceding gene: 145300663
Following gene: 145300671
Centisome position: 86.95
GC content: 63.68
Gene sequence:
>2409_bases TTGAAGCGGCGGCAGGTACACAAGTTCGGTGGCAGCAGTCTGGCGGATCCGGTCTGCTATCGCCGGGTCGCCGCTATCGT CGAACAGCAGGTTGGCGGGGATGAGCTCGTCGTGGTCTCCGCCGCCGGCAAGACCACCAACCGCTTGATCCAGTTGGTGG AGCTGGCCGATGCGGGGGATGAGGCGGCCGGTGAAGCCATCTCTGCGCTGCAAGCTTATAAGCAGAGCCTGATCGATGGC CTGCTGGAGGGAGAGCTGCAGCTTGATCTCAGCCAGCAGCTGGCCGATGACATGCAACTGATCGCCAAGACCCTGGAGGG GCAGTTTGACCGCTTCGCCCGTAACGGCCTGCTCGCCTTTGGCGAAGTGTGGTCGGCGCGCCTGCTGGCCGCCCTGCTCA GCAGCCGCGGTGAGAAGGCCATCTGGCTTGATGCCCGCAGCTTCCTGCGTGCCGAGGATGGTGCCCTGGTCAAGGTGGAT ACAGCCCTTTCCAGTGAACTGCTCAAGGCCCGTCTGGCCGAACATGCCGGTCGCATCGTGGTGACAGGTTTCATCGCCGC CGACATGGAGGGGCGCTCCCTGCTGTTCGGGCGCAACGGCTCCGACTACAGCGCCAGCCTCTTGGCAGCCCTGGCTGATG GCGAATCCACCACCATCTGGAGCGACGTGGCCGGTGTCTACAGCGCCGATCCGCGCCGAGTGAAGGAGGCGCGCCTGCTG GAGCGTCTCAGTCTGGCAGAAGCAAACGAGCTGGCTCGCCTCGGTTCGTCCGTACTGCACTCCCGTACCCTGCAACCGGT GGCGGACAGTCGCCAGCGTCTCACCCTGCGCTGCAGCTACAACCCGGATGAGGGCTGCACTCACATACTGCGCCGGGCAC CGCGCTCCGGTGGTGCCCGCATCGTCTCTTCGGTGGATCAGATCGCTCTCATCGAGCTGAAAGTGTTGCCGCAGACCCAC TATGAGCAGACGGTAGCGGCCATCGAAGCCCATCTGGCCCGTCATCGCCTCAATCCGCTCACCCTGCAGCGCCAGCCTGA TCGGCGGGTGCTGCGTCTGGCCTATACCCTGGAAGTGGCGGAAGGGGCGTTCGAGATACTGCGTGACTTCCAGCTGCAGG GCAGCTTCACCGGTCTCATCCAGAAAGAGGGGTTCAGTCTGGTGGCCCTGGTGGGCGCCGGTGTCACCGACAACGCAGAG CAGTGTCACCGCTTCTATCAGTTGCTGGCGGATCAGCCGCTGGAGTTCGTGCAGGTGGCCAGAGATGGCCTGAGCTTGGT GGCCGTGCTGCGTCAGGTGGTGCTGGAGCCCCTGCTCATCGCCTTGCACAGCGCCCTGTTCAGTCGCCCTACCCGGGTCG GGCTGGTGGTATTTGGCAAGGGCAACATAGGCGGCCACTGGCTCACCCTCTATGCCCGCGAGAAGGCGCGGCTCGAACAT GAGCTCAATCTGGCGTTGACCCTGTACGGGGTGTTCAGCTCGGAAGGGGGGCTGCTGGACGAAGAGGGGCTGGATCCCCT CAAGGTGCAGGACAAATTCAACCCCAAACCGCTGATCTGGCCCGAACTGCTGACCCAGCTGGAGCAGCACAGTTTCGATA CGCTGATTGCCCTGGACTTGACCGCCAGCGAGACGGTGAGTCGCTACTACCCGGATTTTGCCCAGCTCGGTATTCACATC ATCGCCGCCAACAAGTTTGCCGGTGCCGCCGAGAGCGAGTTCTACCAGCGCATCAAGCAGACCTGCCGCGATCATCAGGT GCAGTGGCGCTACAACGCCACCGTGGGCGCCGGGCTGCCGATCCAGTCCAGCATCCAGATGCTGCGCCAGAGCGGCGACC GCATTCAGGGGGTCTCGGGTATTTTCTCCGGCACCCTCTCCTGGCTGTTCCAGCAGTATGACGGCACTCGCCCCTTCTCC GAGCTGGTGGACGAGGCGTGGCAGCACGGCCTGACCGAGCCGGATCCCCGCGAGGATCTCTCCGGTCAGGATGTGCGCCG CAAGTTGCTGATCCTGGCGCGGGAGGCGGGTTTCGAGCTGGATTCCGCCGATATCGAACTGGAAAACCTGGTGCCGGTGA CACTGCGCAAGGTGAGCACGGATCAGTTCATGGACAGGCTCAAAGAGCTGGATGACCCGATCCAGACCGCATTTGAAGGT GCGCGTCGGGTTGGCAAGGTGCTGCGCTACGTCGCCCGCTTCGAGCACGATGGCAAGGCCAGGGTCGGGCTGGAGGCGCT GGAGCCTCACCACCCGTTCGCCAATTTGCTGCCTTGTGACAACGTGTTCGCCATCGAGAGCGACAGCTATCGTACCAACC CGCTGGTGATACAGGGACCGGGGGCAGGGCGTGAAGTGACGGCCGCCGCTATCCAGTATGACCTGTGGCAGATCTGCACT AGCCTCTGA
Upstream 100 bases:
>100_bases CCGATCTGGCTCAGGCTTTTGAACAGGCGCAGCTGGCAGAACAGGTGGCGAAGTAATGGAACAGCAGCAAGGAGATATAG CGGTGGCAACACAAGCAGGG
Downstream 100 bases:
>100_bases GAAGATCGCTAAGGTGGGGAAAGTGGCGCTCGGATCTGGCGCTGTCACCGCAAATAAACAGAGGGCGCCCGGTTGGCGCC CTCTTGCTATGGCTCGCCCG
Product: bifunctional aspartate kinase II/homoserine dehydrogenase II
Products: NA
Alternate protein names: Aspartokinase II/homoserine dehydrogenase II; AKII-HDII; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 802; Mature: 802
Protein sequence:
>802_residues MKRRQVHKFGGSSLADPVCYRRVAAIVEQQVGGDELVVVSAAGKTTNRLIQLVELADAGDEAAGEAISALQAYKQSLIDG LLEGELQLDLSQQLADDMQLIAKTLEGQFDRFARNGLLAFGEVWSARLLAALLSSRGEKAIWLDARSFLRAEDGALVKVD TALSSELLKARLAEHAGRIVVTGFIAADMEGRSLLFGRNGSDYSASLLAALADGESTTIWSDVAGVYSADPRRVKEARLL ERLSLAEANELARLGSSVLHSRTLQPVADSRQRLTLRCSYNPDEGCTHILRRAPRSGGARIVSSVDQIALIELKVLPQTH YEQTVAAIEAHLARHRLNPLTLQRQPDRRVLRLAYTLEVAEGAFEILRDFQLQGSFTGLIQKEGFSLVALVGAGVTDNAE QCHRFYQLLADQPLEFVQVARDGLSLVAVLRQVVLEPLLIALHSALFSRPTRVGLVVFGKGNIGGHWLTLYAREKARLEH ELNLALTLYGVFSSEGGLLDEEGLDPLKVQDKFNPKPLIWPELLTQLEQHSFDTLIALDLTASETVSRYYPDFAQLGIHI IAANKFAGAAESEFYQRIKQTCRDHQVQWRYNATVGAGLPIQSSIQMLRQSGDRIQGVSGIFSGTLSWLFQQYDGTRPFS ELVDEAWQHGLTEPDPREDLSGQDVRRKLLILAREAGFELDSADIELENLVPVTLRKVSTDQFMDRLKELDDPIQTAFEG ARRVGKVLRYVARFEHDGKARVGLEALEPHHPFANLLPCDNVFAIESDSYRTNPLVIQGPGAGREVTAAAIQYDLWQICT SL
Sequences:
>Translated_802_residues MKRRQVHKFGGSSLADPVCYRRVAAIVEQQVGGDELVVVSAAGKTTNRLIQLVELADAGDEAAGEAISALQAYKQSLIDG LLEGELQLDLSQQLADDMQLIAKTLEGQFDRFARNGLLAFGEVWSARLLAALLSSRGEKAIWLDARSFLRAEDGALVKVD TALSSELLKARLAEHAGRIVVTGFIAADMEGRSLLFGRNGSDYSASLLAALADGESTTIWSDVAGVYSADPRRVKEARLL ERLSLAEANELARLGSSVLHSRTLQPVADSRQRLTLRCSYNPDEGCTHILRRAPRSGGARIVSSVDQIALIELKVLPQTH YEQTVAAIEAHLARHRLNPLTLQRQPDRRVLRLAYTLEVAEGAFEILRDFQLQGSFTGLIQKEGFSLVALVGAGVTDNAE QCHRFYQLLADQPLEFVQVARDGLSLVAVLRQVVLEPLLIALHSALFSRPTRVGLVVFGKGNIGGHWLTLYAREKARLEH ELNLALTLYGVFSSEGGLLDEEGLDPLKVQDKFNPKPLIWPELLTQLEQHSFDTLIALDLTASETVSRYYPDFAQLGIHI IAANKFAGAAESEFYQRIKQTCRDHQVQWRYNATVGAGLPIQSSIQMLRQSGDRIQGVSGIFSGTLSWLFQQYDGTRPFS ELVDEAWQHGLTEPDPREDLSGQDVRRKLLILAREAGFELDSADIELENLVPVTLRKVSTDQFMDRLKELDDPIQTAFEG ARRVGKVLRYVARFEHDGKARVGLEALEPHHPFANLLPCDNVFAIESDSYRTNPLVIQGPGAGREVTAAAIQYDLWQICT SL >Mature_802_residues MKRRQVHKFGGSSLADPVCYRRVAAIVEQQVGGDELVVVSAAGKTTNRLIQLVELADAGDEAAGEAISALQAYKQSLIDG LLEGELQLDLSQQLADDMQLIAKTLEGQFDRFARNGLLAFGEVWSARLLAALLSSRGEKAIWLDARSFLRAEDGALVKVD TALSSELLKARLAEHAGRIVVTGFIAADMEGRSLLFGRNGSDYSASLLAALADGESTTIWSDVAGVYSADPRRVKEARLL ERLSLAEANELARLGSSVLHSRTLQPVADSRQRLTLRCSYNPDEGCTHILRRAPRSGGARIVSSVDQIALIELKVLPQTH YEQTVAAIEAHLARHRLNPLTLQRQPDRRVLRLAYTLEVAEGAFEILRDFQLQGSFTGLIQKEGFSLVALVGAGVTDNAE QCHRFYQLLADQPLEFVQVARDGLSLVAVLRQVVLEPLLIALHSALFSRPTRVGLVVFGKGNIGGHWLTLYAREKARLEH ELNLALTLYGVFSSEGGLLDEEGLDPLKVQDKFNPKPLIWPELLTQLEQHSFDTLIALDLTASETVSRYYPDFAQLGIHI IAANKFAGAAESEFYQRIKQTCRDHQVQWRYNATVGAGLPIQSSIQMLRQSGDRIQGVSGIFSGTLSWLFQQYDGTRPFS ELVDEAWQHGLTEPDPREDLSGQDVRRKLLILAREAGFELDSADIELENLVPVTLRKVSTDQFMDRLKELDDPIQTAFEG ARRVGKVLRYVARFEHDGKARVGLEALEPHHPFANLLPCDNVFAIESDSYRTNPLVIQGPGAGREVTAAAIQYDLWQICT SL
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]
Homologues:
Organism=Escherichia coli, GI1790376, Length=797, Percent_Identity=49.9372647427854, Blast_Score=731, Evalue=0.0, Organism=Escherichia coli, GI1786183, Length=822, Percent_Identity=30.4136253041363, Blast_Score=321, Evalue=1e-88, Organism=Escherichia coli, GI1790455, Length=408, Percent_Identity=28.1862745098039, Blast_Score=122, Evalue=1e-28, Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=32.3529411764706, Blast_Score=158, Evalue=3e-39, Organism=Saccharomyces cerevisiae, GI6320893, Length=306, Percent_Identity=29.7385620915033, Blast_Score=96, Evalue=2e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88565; Mature: 88565
Theoretical pI: Translated: 5.56; Mature: 5.56
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE ; PS00213 LIPOCALIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 0.6 %Met (Translated Protein) 1.5 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 0.6 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKRRQVHKFGGSSLADPVCYRRVAAIVEQQVGGDELVVVSAAGKTTNRLIQLVELADAGD CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCC EAAGEAISALQAYKQSLIDGLLEGELQLDLSQQLADDMQLIAKTLEGQFDRFARNGLLAF HHHHHHHHHHHHHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH GEVWSARLLAALLSSRGEKAIWLDARSFLRAEDGALVKVDTALSSELLKARLAEHAGRIV HHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCEE VTGFIAADMEGRSLLFGRNGSDYSASLLAALADGESTTIWSDVAGVYSADPRRVKEARLL EEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHH ERLSLAEANELARLGSSVLHSRTLQPVADSRQRLTLRCSYNPDEGCTHILRRAPRSGGAR HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCHH IVSSVDQIALIELKVLPQTHYEQTVAAIEAHLARHRLNPLTLQRQPDRRVLRLAYTLEVA HHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHH EGAFEILRDFQLQGSFTGLIQKEGFSLVALVGAGVTDNAEQCHRFYQLLADQPLEFVQVA HHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHH RDGLSLVAVLRQVVLEPLLIALHSALFSRPTRVGLVVFGKGNIGGHWLTLYAREKARLEH HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHHH ELNLALTLYGVFSSEGGLLDEEGLDPLKVQDKFNPKPLIWPELLTQLEQHSFDTLIALDL HCCEEEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEC TASETVSRYYPDFAQLGIHIIAANKFAGAAESEFYQRIKQTCRDHQVQWRYNATVGAGLP CHHHHHHHHCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCC IQSSIQMLRQSGDRIQGVSGIFSGTLSWLFQQYDGTRPFSELVDEAWQHGLTEPDPREDL HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCC SGQDVRRKLLILAREAGFELDSADIELENLVPVTLRKVSTDQFMDRLKELDDPIQTAFEG CHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHH ARRVGKVLRYVARFEHDGKARVGLEALEPHHPFANLLPCDNVFAIESDSYRTNPLVIQGP HHHHHHHHHHHHHHCCCCCCEECHHHCCCCCCCHHCCCCCCEEEEECCCCCCCCEEEECC GAGREVTAAAIQYDLWQICTSL CCCCHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MKRRQVHKFGGSSLADPVCYRRVAAIVEQQVGGDELVVVSAAGKTTNRLIQLVELADAGD CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCC EAAGEAISALQAYKQSLIDGLLEGELQLDLSQQLADDMQLIAKTLEGQFDRFARNGLLAF HHHHHHHHHHHHHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH GEVWSARLLAALLSSRGEKAIWLDARSFLRAEDGALVKVDTALSSELLKARLAEHAGRIV HHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCEE VTGFIAADMEGRSLLFGRNGSDYSASLLAALADGESTTIWSDVAGVYSADPRRVKEARLL EEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHH ERLSLAEANELARLGSSVLHSRTLQPVADSRQRLTLRCSYNPDEGCTHILRRAPRSGGAR HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCHH IVSSVDQIALIELKVLPQTHYEQTVAAIEAHLARHRLNPLTLQRQPDRRVLRLAYTLEVA HHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHH EGAFEILRDFQLQGSFTGLIQKEGFSLVALVGAGVTDNAEQCHRFYQLLADQPLEFVQVA HHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHH RDGLSLVAVLRQVVLEPLLIALHSALFSRPTRVGLVVFGKGNIGGHWLTLYAREKARLEH HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHHH ELNLALTLYGVFSSEGGLLDEEGLDPLKVQDKFNPKPLIWPELLTQLEQHSFDTLIALDL HCCEEEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEC TASETVSRYYPDFAQLGIHIIAANKFAGAAESEFYQRIKQTCRDHQVQWRYNATVGAGLP CHHHHHHHHCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCC IQSSIQMLRQSGDRIQGVSGIFSGTLSWLFQQYDGTRPFSELVDEAWQHGLTEPDPREDL HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCC SGQDVRRKLLILAREAGFELDSADIELENLVPVTLRKVSTDQFMDRLKELDDPIQTAFEG CHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHH ARRVGKVLRYVARFEHDGKARVGLEALEPHHPFANLLPCDNVFAIESDSYRTNPLVIQGP HHHHHHHHHHHHHHCCCCCCEECHHHCCCCCCCHHCCCCCCEEEEECCCCCCCCEEEECC GAGREVTAAAIQYDLWQICTSL CCCCHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 6298218; 8346018; 9278503 [H]