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The map label for this gene is aer [H]

Identifier: 145300392

GI number: 145300392

Start: 3806226

End: 3807869

Strand: Direct

Name: aer [H]

Synonym: ASA_3517

Alternate gene names: 145300392

Gene position: 3806226-3807869 (Clockwise)

Preceding gene: 145300391

Following gene: 145300394

Centisome position: 80.94

GC content: 58.94

Gene sequence:

>1644_bases
ATGAGAGTCAACCAACCCGTTACTCAGCGCGAACGCCTCTATCCGGACCACCAGAACCTGATATCCACCACGGATCTGGA
AAGTCGCATTACCTATGCCAACGATGAATTCTGTGACATCGCAGGATTCAGCCCTGACGAGTTACGAGGCCAACATCACA
ATCTGGTGCGCCATCCGGATATGCCCAAACAGGCCTTTGCAGATATGTGGCACCACATCAAGGAGGGAAAGAGCTGGATG
GGGCCGGTCAAGAATCGCTGCAAGAATGGCGACCACTACTGGGTCAGCGCCTTTGTCACCCCGATCAAAGACACAAATGG
ACGGATAGCCGAATTTCAATCGGTACATACTGCGCCGAGCGAAGCGCTCAAACAGCGTGCCGAGGGCGTCTATGCCGACC
TGCGCAATGACAAGGTTCCACTGGCTCTCAGGCTGCCCACCTTCTCCCATACCCTGACCATCAACCTCTGCCTGTTGCTA
AGTCTGGCGACCATGCTCGGCCTGGGTTACAGCCAGGGCATTAACTGGCAACTGACGCTGGCAGCCCTCCCGCTGGCACT
CGCGGCTGTGGTTATCCATGCCCTCTCCCGCCGTCTGGGCAAGCTTAACAAGATGGCTCGCAGCCGCTTCGACAACCCGC
TGATGCAGCTGCTCTATACCAACAAGGTCGACAACATCGCCGCCATCGAGCTCGCCATGCTGATGAATCAGGCCGAGTTC
AATGCCGTACTGGCCCGCACCCAGCAAACCTGCACTCAAATACTTCAGGCCGCAGAGGGGGATCTGCGCAACGCCGAATC
CATCACCGACAACCTGCAACAGCAGCAAGCCGAGACCAATCAGGTGGCCACCGCCATCACAGAGATGTCGGAGTCCATCC
GCGAGGTATCGCAAAGCTCCAGCGACGCCTCCAGCCTGCTGGACGAGACGACCGACCTGTTCAGGAACGGCAACAGCAGC
GTTGCCGAGACAGTGGCGGCCGTGGCAGGCATGAACAGCGAGCTGACTACCTCAAAGACGGTCATCAGCGAACTGGTTGG
CCACTGCCGCGATATCGACGGCATTCTCGATGTGATCAACAACATCGCCAACCAGACCAACTTGCTGGCGCTCAATGCGG
CAATTGAAGCTGCCCGCGCCGGTGAGGCTGGTCGGGGATTCTCGGTGGTGGCAGACGAAATCCGCTCGCTCGCCATCAAG
ACCCAAGCCTCCACCAGCGAAATCCAGAAGATGATCACAGAGCTGCAAACCAGCGCCGGAGATGCTGAGCAGGCAATGGA
GAAGGGGTGCCAGCTATCCGAGAGCTGCCAGCAGAAGGCGTCGGCGACCGGCAGCATACTGCAGCAGATCAACAGCATGT
TGCAGCAGGTTGCCTCAGGCAGCGGCCAGATTGCCCAGGCGGTACAGGAGCAATCTCATGTGACCGCCGAGATCAATCGC
AACGTACTCAGCATCAAGACACTGGCCGATGACTCCAGCACAGGCAGCCAGCACGCCGTGCACGGCATCACCCAGCTGGT
GAGTCAGTTGAGCGACCTCGATCGGCTGGTGCGTCAGTTCCAGAAGCCGGCACCGACAGCCCAAAACCGCCATGCACATG
CAGCAGCGGTCCCGAACGCCATGCCGGTACGCCAAGCCAGATAG

Upstream 100 bases:

>100_bases
AAAGCCTCTATTTACAAAATTATCACCAAAGGCGTCACCTTGGTGCGCCACTTGCACTGGCAATACGTCTTTCCTAACAA
CCCCATTCTGGAGCAGATCC

Downstream 100 bases:

>100_bases
CACCCCGCTGGCAATTGCCGCAAAACCCTATGGGCCCGCAGGCCCATAGGTTTTTTTAATGCCCGCCAACAAGAGGGCGA
CACTCACGGTTTCACCTTCC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MRVNQPVTQRERLYPDHQNLISTTDLESRITYANDEFCDIAGFSPDELRGQHHNLVRHPDMPKQAFADMWHHIKEGKSWM
GPVKNRCKNGDHYWVSAFVTPIKDTNGRIAEFQSVHTAPSEALKQRAEGVYADLRNDKVPLALRLPTFSHTLTINLCLLL
SLATMLGLGYSQGINWQLTLAALPLALAAVVIHALSRRLGKLNKMARSRFDNPLMQLLYTNKVDNIAAIELAMLMNQAEF
NAVLARTQQTCTQILQAAEGDLRNAESITDNLQQQQAETNQVATAITEMSESIREVSQSSSDASSLLDETTDLFRNGNSS
VAETVAAVAGMNSELTTSKTVISELVGHCRDIDGILDVINNIANQTNLLALNAAIEAARAGEAGRGFSVVADEIRSLAIK
TQASTSEIQKMITELQTSAGDAEQAMEKGCQLSESCQQKASATGSILQQINSMLQQVASGSGQIAQAVQEQSHVTAEINR
NVLSIKTLADDSSTGSQHAVHGITQLVSQLSDLDRLVRQFQKPAPTAQNRHAHAAAVPNAMPVRQAR

Sequences:

>Translated_547_residues
MRVNQPVTQRERLYPDHQNLISTTDLESRITYANDEFCDIAGFSPDELRGQHHNLVRHPDMPKQAFADMWHHIKEGKSWM
GPVKNRCKNGDHYWVSAFVTPIKDTNGRIAEFQSVHTAPSEALKQRAEGVYADLRNDKVPLALRLPTFSHTLTINLCLLL
SLATMLGLGYSQGINWQLTLAALPLALAAVVIHALSRRLGKLNKMARSRFDNPLMQLLYTNKVDNIAAIELAMLMNQAEF
NAVLARTQQTCTQILQAAEGDLRNAESITDNLQQQQAETNQVATAITEMSESIREVSQSSSDASSLLDETTDLFRNGNSS
VAETVAAVAGMNSELTTSKTVISELVGHCRDIDGILDVINNIANQTNLLALNAAIEAARAGEAGRGFSVVADEIRSLAIK
TQASTSEIQKMITELQTSAGDAEQAMEKGCQLSESCQQKASATGSILQQINSMLQQVASGSGQIAQAVQEQSHVTAEINR
NVLSIKTLADDSSTGSQHAVHGITQLVSQLSDLDRLVRQFQKPAPTAQNRHAHAAAVPNAMPVRQAR
>Mature_547_residues
MRVNQPVTQRERLYPDHQNLISTTDLESRITYANDEFCDIAGFSPDELRGQHHNLVRHPDMPKQAFADMWHHIKEGKSWM
GPVKNRCKNGDHYWVSAFVTPIKDTNGRIAEFQSVHTAPSEALKQRAEGVYADLRNDKVPLALRLPTFSHTLTINLCLLL
SLATMLGLGYSQGINWQLTLAALPLALAAVVIHALSRRLGKLNKMARSRFDNPLMQLLYTNKVDNIAAIELAMLMNQAEF
NAVLARTQQTCTQILQAAEGDLRNAESITDNLQQQQAETNQVATAITEMSESIREVSQSSSDASSLLDETTDLFRNGNSS
VAETVAAVAGMNSELTTSKTVISELVGHCRDIDGILDVINNIANQTNLLALNAAIEAARAGEAGRGFSVVADEIRSLAIK
TQASTSEIQKMITELQTSAGDAEQAMEKGCQLSESCQQKASATGSILQQINSMLQQVASGSGQIAQAVQEQSHVTAEINR
NVLSIKTLADDSSTGSQHAVHGITQLVSQLSDLDRLVRQFQKPAPTAQNRHAHAAAVPNAMPVRQAR

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=496, Percent_Identity=30.241935483871, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787690, Length=209, Percent_Identity=32.5358851674641, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788195, Length=213, Percent_Identity=27.6995305164319, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI2367378, Length=208, Percent_Identity=28.8461538461538, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788194, Length=277, Percent_Identity=29.9638989169675, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 59644; Mature: 59644

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50112 PAS ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVNQPVTQRERLYPDHQNLISTTDLESRITYANDEFCDIAGFSPDELRGQHHNLVRHPD
CCCCCCCHHHHHCCCCHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
MPKQAFADMWHHIKEGKSWMGPVKNRCKNGDHYWVSAFVTPIKDTNGRIAEFQSVHTAPS
CCHHHHHHHHHHHHHCHHHCCHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCHH
EALKQRAEGVYADLRNDKVPLALRLPTFSHTLTINLCLLLSLATMLGLGYSQGINWQLTL
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHH
AALPLALAAVVIHALSRRLGKLNKMARSRFDNPLMQLLYTNKVDNIAAIELAMLMNQAEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NAVLARTQQTCTQILQAAEGDLRNAESITDNLQQQQAETNQVATAITEMSESIREVSQSS
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDASSLLDETTDLFRNGNSSVAETVAAVAGMNSELTTSKTVISELVGHCRDIDGILDVIN
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NIANQTNLLALNAAIEAARAGEAGRGFSVVADEIRSLAIKTQASTSEIQKMITELQTSAG
HHHCCHHEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
DAEQAMEKGCQLSESCQQKASATGSILQQINSMLQQVASGSGQIAQAVQEQSHVTAEINR
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
NVLSIKTLADDSSTGSQHAVHGITQLVSQLSDLDRLVRQFQKPAPTAQNRHAHAAAVPNA
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
MPVRQAR
CCCCCCC
>Mature Secondary Structure
MRVNQPVTQRERLYPDHQNLISTTDLESRITYANDEFCDIAGFSPDELRGQHHNLVRHPD
CCCCCCCHHHHHCCCCHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
MPKQAFADMWHHIKEGKSWMGPVKNRCKNGDHYWVSAFVTPIKDTNGRIAEFQSVHTAPS
CCHHHHHHHHHHHHHCHHHCCHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCHH
EALKQRAEGVYADLRNDKVPLALRLPTFSHTLTINLCLLLSLATMLGLGYSQGINWQLTL
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHH
AALPLALAAVVIHALSRRLGKLNKMARSRFDNPLMQLLYTNKVDNIAAIELAMLMNQAEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NAVLARTQQTCTQILQAAEGDLRNAESITDNLQQQQAETNQVATAITEMSESIREVSQSS
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDASSLLDETTDLFRNGNSSVAETVAAVAGMNSELTTSKTVISELVGHCRDIDGILDVIN
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NIANQTNLLALNAAIEAARAGEAGRGFSVVADEIRSLAIKTQASTSEIQKMITELQTSAG
HHHCCHHEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
DAEQAMEKGCQLSESCQQKASATGSILQQINSMLQQVASGSGQIAQAVQEQSHVTAEINR
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
NVLSIKTLADDSSTGSQHAVHGITQLVSQLSDLDRLVRQFQKPAPTAQNRHAHAAAVPNA
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
MPVRQAR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]