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The map label for this gene is ham1 [C]

Identifier: 145300322

GI number: 145300322

Start: 3734736

End: 3735461

Strand: Direct

Name: ham1 [C]

Synonym: ASA_3446

Alternate gene names: 145300322

Gene position: 3734736-3735461 (Clockwise)

Preceding gene: 145300319

Following gene: 145300323

Centisome position: 79.42

GC content: 59.92

Gene sequence:

>726_bases
ATGCATGTTATTTGCACCTCCACCGTGATCAAAGTAGTGGCAAGCCTCGGAGGTATTGAGGGCAATTGGCGCTTTTACTC
AAGGCGTGCCCCGCATAGAATGCGCAGATTATTTTTGCGGAGGTGCTCGATGAACAAGCTTGTCCTGGCAACAGGGAACC
AGAAAAAGGTGAAGGAATTGGCCACCATGCTGGCCGATATGAAGATCCAGGTGATCCCACAGAGCGAGTTTGCTGTGCCT
GATGCCGACGAGACCGGCACCACCTTCGTCGAGAATGCCATCATCAAGGCCCGTCACGCCGCCCGCATCACAGGTCTGCC
CGCCGTCGCCGACGACTCGGGACTGGAAGTGGATCTGCTGCACGGTCGCCCCGGCGTCTACTCCGCCCGCTTTGCAGGCG
CCGGTGCCAGCGACAAGGAGAACATCGACAAGCTGCTGGCCGAGCTCAAGGGTGCCCCCGACTATCTCAAGAGTGCCCGC
TTCTGGTGCGTGCTGGTCTACATGCGTCACGCCGACGATCCTACTCCCATCATCTGCCAGGCGAGCTGGGAGGGGATGAT
CATCGACGAGCCCCGCGGCCAGCACGGCTTTGGCTATGATCCCGTGTTCTTTGTCCCCGACCATGACTGCACCTCGGCCC
AGATGCCGAGCGAGCTGAAAAACCAGCTGAGTCATCGCGGCCAGGCGCTGACCAAGCTGAAAGCCGCTCTGGCTGCGACT
CACTGA

Upstream 100 bases:

>100_bases
CCTCATGGCTTACGGAAAATCGATTGGGGCGCGAGTCTACTGACTCACAGTAATGAATTGAAATGGTATTTAATCACTTT
GGTTATTCCTATACGGAAAC

Downstream 100 bases:

>100_bases
GTTCGCCGCCTCTCGCCAATCAAGCATTGTCATCTACAATGGGGGCCGTCAGCCCCCGTTTTTATTTTTGATTATTGGAA
GCCCCATGCTGCAACTGCCG

Product: HAM1 protein

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MHVICTSTVIKVVASLGGIEGNWRFYSRRAPHRMRRLFLRRCSMNKLVLATGNQKKVKELATMLADMKIQVIPQSEFAVP
DADETGTTFVENAIIKARHAARITGLPAVADDSGLEVDLLHGRPGVYSARFAGAGASDKENIDKLLAELKGAPDYLKSAR
FWCVLVYMRHADDPTPIICQASWEGMIIDEPRGQHGFGYDPVFFVPDHDCTSAQMPSELKNQLSHRGQALTKLKAALAAT
H

Sequences:

>Translated_241_residues
MHVICTSTVIKVVASLGGIEGNWRFYSRRAPHRMRRLFLRRCSMNKLVLATGNQKKVKELATMLADMKIQVIPQSEFAVP
DADETGTTFVENAIIKARHAARITGLPAVADDSGLEVDLLHGRPGVYSARFAGAGASDKENIDKLLAELKGAPDYLKSAR
FWCVLVYMRHADDPTPIICQASWEGMIIDEPRGQHGFGYDPVFFVPDHDCTSAQMPSELKNQLSHRGQALTKLKAALAAT
H
>Mature_241_residues
MHVICTSTVIKVVASLGGIEGNWRFYSRRAPHRMRRLFLRRCSMNKLVLATGNQKKVKELATMLADMKIQVIPQSEFAVP
DADETGTTFVENAIIKARHAARITGLPAVADDSGLEVDLLHGRPGVYSARFAGAGASDKENIDKLLAELKGAPDYLKSAR
FWCVLVYMRHADDPTPIICQASWEGMIIDEPRGQHGFGYDPVFFVPDHDCTSAQMPSELKNQLSHRGQALTKLKAALAAT
H

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=191, Percent_Identity=29.8429319371728, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789324, Length=194, Percent_Identity=56.701030927835, Blast_Score=241, Evalue=3e-65,
Organism=Drosophila melanogaster, GI19920712, Length=188, Percent_Identity=33.5106382978723, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 26571; Mature: 26571

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVICTSTVIKVVASLGGIEGNWRFYSRRAPHRMRRLFLRRCSMNKLVLATGNQKKVKEL
CEEEEHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
ATMLADMKIQVIPQSEFAVPDADETGTTFVENAIIKARHAARITGLPAVADDSGLEVDLL
HHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
HGRPGVYSARFAGAGASDKENIDKLLAELKGAPDYLKSARFWCVLVYMRHADDPTPIICQ
CCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
ASWEGMIIDEPRGQHGFGYDPVFFVPDHDCTSAQMPSELKNQLSHRGQALTKLKAALAAT
CCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
H
C
>Mature Secondary Structure
MHVICTSTVIKVVASLGGIEGNWRFYSRRAPHRMRRLFLRRCSMNKLVLATGNQKKVKEL
CEEEEHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
ATMLADMKIQVIPQSEFAVPDADETGTTFVENAIIKARHAARITGLPAVADDSGLEVDLL
HHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
HGRPGVYSARFAGAGASDKENIDKLLAELKGAPDYLKSARFWCVLVYMRHADDPTPIICQ
CCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
ASWEGMIIDEPRGQHGFGYDPVFFVPDHDCTSAQMPSELKNQLSHRGQALTKLKAALAAT
CCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA