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The map label for this gene is arnA [H]

Identifier: 145300198

GI number: 145300198

Start: 3576995

End: 3578986

Strand: Direct

Name: arnA [H]

Synonym: ASA_3309

Alternate gene names: 145300198

Gene position: 3576995-3578986 (Clockwise)

Preceding gene: 145300197

Following gene: 145300199

Centisome position: 76.07

GC content: 61.3

Gene sequence:

>1992_bases
ATGAAAGCTGTCGTCTTTGCTTATCATGATATCGGCTGCACCGGTATCGAGGCCCTGCTCGAGGCAGGTTACGAGATCCA
GGCCGTCTTCACCCATGCCGACGACCCGAGTGAGAACCGCTTCTTCGGCTCCGTGGCCCAGCTCTGTGCCGAACACGGTC
TGCCGGTCTACTCCCCGGAAGATGTCAACCATCCGCTCTGGGTCGAGCACATCAAGGGGTTGGCGCCCCAGGCTCTCTTC
TCTTTTTATTACCGCCACATGCTCAAGCAGGAGATCCTGGATATCCCCTCCGCCGGCGCCTTCAACCTCCATGGCTCCCT
GTTGCCTGCCTATCGCGGCCGTGCCCCCATCAACTGGTGTCTGGTCAATGGTGAACAGCTGACGGGTATCACACTGCACC
AGATGACGATGCGCCCGGATGCCGGTGCCATCGTCGCCCAGCAGGCCGTCGCCATCAAATAGGCCGACACAGCGCTGACC
CTGCATGGCAAGGTGCGCCTCGCCGCCAAAGCCTTGCTGGACGCCGAATTGCCCAAGCTGCGGACGGGCGACATCAGCCT
CACCCCGCAGGATGAGTCCAGAGCCAGCTACTATGGTCGCCGCACCCCGGCCGATGGCGAGCTGCACTGGGATAAATCCG
CCAGGGATCTCTACAACCTAGTGCGCGCCGTCACCCAGCCCTATCCGGGCGCCTTCAGCTTCGCCGGTGATCGCAAGCTG
ACGGTGTGGAAGGCAACCCACATAGCCCAGGATAGCGACATGCTACCCGGCACCATCCTCAGCCAGGATCCGCTGCGCAT
TGCCTGCGGTGAAGGGGTACTGGAAATCGTGGCCGGTCAGGCGGAAGGGGGACTCTATGTGCGCGGTGCCCAGCTCGCCC
GTGAACTGGGCCTGGTGGCAGGCATGCGCCTCGGCGCCAAAGCCAGCAGTGCCCTGCGCAAGGAGCGATTGACCCGGGTG
CTGATCCTCGGGGTCAACGGCTTCATCGGCAACCACCTGACCGAGCGTCTGCTCAAGGATGGCCGTTACGAGATCTATGG
GCTGGATATCAGCGCCAGCGCTCTCGGACGCTTCATCGACCACCCCCATTTCCATTTCGTGGAAGGGGACATCAGCATCC
ACACAGAGTGGATCGAGTATCACATCAAGAAGTGCGACGTGATCCTGCCGCTGGTGGCCATCGCCACCCCCATCGAATAC
ACCCGCAACCCGCTGCGCGTGTTCGAGCTCGATTTTGAAGAGAACCTCAAGATCGTCCGCTACTGCGTGAAGTACAACAA
GCGCATCATATTTCCCTCCACCTCCGAGGTGTACGGGATGTGCGACGATCACAGCTTCGATGAAGACGAGTCCCGCCTCA
TCGTCGGCCCCATCCACAAGCAGCGCTGGATCTACTCCGTCTCCAAGCAGCTGCTGGATCGGGTGATCTGGGCCTATGGC
AAGAAAGAGGGGCTCAATTTCACACTGTTCCGCCCCTTCAACTGGATGGGACCGCGACTGGACAGCCTGGACTCAGCCCG
CATCGGCAGCTCCCGCGCCATCACCCAGCTGATTCTGAATCTGGTGGACGGCACCCCGATCCAGCTGGTGGACGGCGGCG
CCCAGAAGCGCTGCTTCACCGACATAGAGGACGGCATCGAGGCCCTGTTCCGCATCATAGAGAACAAGGGCAACCGCTGT
GATGGCCAGATCATCAACATCGGCAGCCCGGACAACGAAGCCAGCATCCTCCAGATGGCCGAAGTGCTGCTCGGCAAGTT
CGAGGCCCACCCGCTGCGCCACCACTTCCCGCCGTTTGCCGGTTTCAAGCGAGTGGAGAGCAAGTCCTTCTACGGTGACG
GCTATCAGGATGTCTCCCACCGTCGTCCCAGCATCAAGAATGCCCGCCGCCTGCTCGACTGGGAACCGACCATCGAAATG
GAAGAGACCATCGGCAAGACCCTGGACTTCTTCCTGCAAGGGGCGGTCAGCACGGGAGTCGAGCATGATTGA

Upstream 100 bases:

>100_bases
AATACATAGGCCGCATGTACACAGATGTGCGCGCCCGCCCCCGTTACTTCATCCATCAGATAGTGCGCACCGCCACCCCT
TCGCAACAGGAAACTGAACA

Downstream 100 bases:

>100_bases
TGTGGGTCTGCGGATCGACGTTGATACCTTCAGGGGGACCCGTGACGGGGTTCCCCGCTTGCTGCAAACCCTCGACCGGC
ATCAGATCAAGGCCAGCTTC

Product: bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MKAVVFAYHDIGCTGIEALLEAGYEIQAVFTHADDPSENRFFGSVAQLCAEHGLPVYSPEDVNHPLWVEHIKGLAPQALF
SFYYRHMLKQEILDIPSAGAFNLHGSLLPAYRGRAPINWCLVNGEQLTGITLHQMTMRPDAGAIVAQQAVAIKWADTALT
LHGKVRLAAKALLDAELPKLRTGDISLTPQDESRASYYGRRTPADGELHWDKSARDLYNLVRAVTQPYPGAFSFAGDRKL
TVWKATHIAQDSDMLPGTILSQDPLRIACGEGVLEIVAGQAEGGLYVRGAQLARELGLVAGMRLGAKASSALRKERLTRV
LILGVNGFIGNHLTERLLKDGRYEIYGLDISASALGRFIDHPHFHFVEGDISIHTEWIEYHIKKCDVILPLVAIATPIEY
TRNPLRVFELDFEENLKIVRYCVKYNKRIIFPSTSEVYGMCDDHSFDEDESRLIVGPIHKQRWIYSVSKQLLDRVIWAYG
KKEGLNFTLFRPFNWMGPRLDSLDSARIGSSRAITQLILNLVDGTPIQLVDGGAQKRCFTDIEDGIEALFRIIENKGNRC
DGQIINIGSPDNEASILQMAEVLLGKFEAHPLRHHFPPFAGFKRVESKSFYGDGYQDVSHRRPSIKNARRLLDWEPTIEM
EETIGKTLDFFLQGAVSTGVEHD

Sequences:

>Translated_663_residues
MKAVVFAYHDIGCTGIEALLEAGYEIQAVFTHADDPSENRFFGSVAQLCAEHGLPVYSPEDVNHPLWVEHIKGLAPQALF
SFYYRHMLKQEILDIPSAGAFNLHGSLLPAYRGRAPINWCLVNGEQLTGITLHQMTMRPDAGAIVAQQAVAIK*ADTALT
LHGKVRLAAKALLDAELPKLRTGDISLTPQDESRASYYGRRTPADGELHWDKSARDLYNLVRAVTQPYPGAFSFAGDRKL
TVWKATHIAQDSDMLPGTILSQDPLRIACGEGVLEIVAGQAEGGLYVRGAQLARELGLVAGMRLGAKASSALRKERLTRV
LILGVNGFIGNHLTERLLKDGRYEIYGLDISASALGRFIDHPHFHFVEGDISIHTEWIEYHIKKCDVILPLVAIATPIEY
TRNPLRVFELDFEENLKIVRYCVKYNKRIIFPSTSEVYGMCDDHSFDEDESRLIVGPIHKQRWIYSVSKQLLDRVIWAYG
KKEGLNFTLFRPFNWMGPRLDSLDSARIGSSRAITQLILNLVDGTPIQLVDGGAQKRCFTDIEDGIEALFRIIENKGNRC
DGQIINIGSPDNEASILQMAEVLLGKFEAHPLRHHFPPFAGFKRVESKSFYGDGYQDVSHRRPSIKNARRLLDWEPTIEM
EETIGKTLDFFLQGAVSTGVEHD
>Mature_663_residues
MKAVVFAYHDIGCTGIEALLEAGYEIQAVFTHADDPSENRFFGSVAQLCAEHGLPVYSPEDVNHPLWVEHIKGLAPQALF
SFYYRHMLKQEILDIPSAGAFNLHGSLLPAYRGRAPINWCLVNGEQLTGITLHQMTMRPDAGAIVAQQAVAIK*ADTALT
LHGKVRLAAKALLDAELPKLRTGDISLTPQDESRASYYGRRTPADGELHWDKSARDLYNLVRAVTQPYPGAFSFAGDRKL
TVWKATHIAQDSDMLPGTILSQDPLRIACGEGVLEIVAGQAEGGLYVRGAQLARELGLVAGMRLGAKASSALRKERLTRV
LILGVNGFIGNHLTERLLKDGRYEIYGLDISASALGRFIDHPHFHFVEGDISIHTEWIEYHIKKCDVILPLVAIATPIEY
TRNPLRVFELDFEENLKIVRYCVKYNKRIIFPSTSEVYGMCDDHSFDEDESRLIVGPIHKQRWIYSVSKQLLDRVIWAYG
KKEGLNFTLFRPFNWMGPRLDSLDSARIGSSRAITQLILNLVDGTPIQLVDGGAQKRCFTDIEDGIEALFRIIENKGNRC
DGQIINIGSPDNEASILQMAEVLLGKFEAHPLRHHFPPFAGFKRVESKSFYGDGYQDVSHRRPSIKNARRLLDWEPTIEM
EETIGKTLDFFLQGAVSTGVEHD

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=339, Percent_Identity=27.4336283185841, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI21614513, Length=249, Percent_Identity=25.7028112449799, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI238814322, Length=187, Percent_Identity=27.807486631016, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1788589, Length=653, Percent_Identity=69.0658499234303, Blast_Score=956, Evalue=0.0,
Organism=Escherichia coli, GI1789683, Length=309, Percent_Identity=29.7734627831715, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17539532, Length=344, Percent_Identity=26.1627906976744, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356223, Length=339, Percent_Identity=25.6637168141593, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45550868, Length=143, Percent_Identity=32.8671328671329, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28571984, Length=143, Percent_Identity=32.8671328671329, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 73968; Mature: 73968

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVFAYHDIGCTGIEALLEAGYEIQAVFTHADDPSENRFFGSVAQLCAEHGLPVYSPE
CCEEEEEEECCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCC
DVNHPLWVEHIKGLAPQALFSFYYRHMLKQEILDIPSAGAFNLHGSLLPAYRGRAPINWC
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEE
LVNGEQLTGITLHQMTMRPDAGAIVAQQAVAIKADTALTLHGKVRLAAKALLDAELPKLR
EECCCEEEEEEEEEEEECCCCCHHHHHHEEEEEECCEEEEECHHHHHHHHHHHHCCCCCC
TGDISLTPQDESRASYYGRRTPADGELHWDKSARDLYNLVRAVTQPYPGAFSFAGDRKLT
CCCEEECCCCCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCEECCCCCEEE
VWKATHIAQDSDMLPGTILSQDPLRIACGEGVLEIVAGQAEGGLYVRGAQLARELGLVAG
EEEEEHHCCCCCCCCCCEECCCCCEEECCCCCEEHHCCCCCCCEEEEHHHHHHHHHHHHH
MRLGAKASSALRKERLTRVLILGVNGFIGNHLTERLLKDGRYEIYGLDISASALGRFIDH
HHCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCC
PHFHFVEGDISIHTEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRY
CCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHCHHHHHH
CVKYNKRIIFPSTSEVYGMCDDHSFDEDESRLIVGPIHKQRWIYSVSKQLLDRVIWAYGK
HHHHCCEEECCCCHHHEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KEGLNFTLFRPFNWMGPRLDSLDSARIGSSRAITQLILNLVDGTPIQLVDGGAQKRCFTD
CCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHH
IEDGIEALFRIIENKGNRCDGQIINIGSPDNEASILQMAEVLLGKFEAHPLRHHFPPFAG
HHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCHH
FKRVESKSFYGDGYQDVSHRRPSIKNARRLLDWEPTIEMEETIGKTLDFFLQGAVSTGVE
HHHHCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
HD
CC
>Mature Secondary Structure
MKAVVFAYHDIGCTGIEALLEAGYEIQAVFTHADDPSENRFFGSVAQLCAEHGLPVYSPE
CCEEEEEEECCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCC
DVNHPLWVEHIKGLAPQALFSFYYRHMLKQEILDIPSAGAFNLHGSLLPAYRGRAPINWC
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEE
LVNGEQLTGITLHQMTMRPDAGAIVAQQAVAIKADTALTLHGKVRLAAKALLDAELPKLR
EECCCEEEEEEEEEEEECCCCCHHHHHHEEEEEECCEEEEECHHHHHHHHHHHHCCCCCC
TGDISLTPQDESRASYYGRRTPADGELHWDKSARDLYNLVRAVTQPYPGAFSFAGDRKLT
CCCEEECCCCCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCEECCCCCEEE
VWKATHIAQDSDMLPGTILSQDPLRIACGEGVLEIVAGQAEGGLYVRGAQLARELGLVAG
EEEEEHHCCCCCCCCCCEECCCCCEEECCCCCEEHHCCCCCCCEEEEHHHHHHHHHHHHH
MRLGAKASSALRKERLTRVLILGVNGFIGNHLTERLLKDGRYEIYGLDISASALGRFIDH
HHCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCC
PHFHFVEGDISIHTEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRY
CCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHCHHHHHH
CVKYNKRIIFPSTSEVYGMCDDHSFDEDESRLIVGPIHKQRWIYSVSKQLLDRVIWAYGK
HHHHCCEEECCCCHHHEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KEGLNFTLFRPFNWMGPRLDSLDSARIGSSRAITQLILNLVDGTPIQLVDGGAQKRCFTD
CCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHH
IEDGIEALFRIIENKGNRCDGQIINIGSPDNEASILQMAEVLLGKFEAHPLRHHFPPFAG
HHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCHH
FKRVESKSFYGDGYQDVSHRRPSIKNARRLLDWEPTIEMEETIGKTLDFFLQGAVSTGVE
HHHHCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
HD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA