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The map label for this gene is merA [H]

Identifier: 145299732

GI number: 145299732

Start: 3010227

End: 3012392

Strand: Direct

Name: merA [H]

Synonym: ASA_2809

Alternate gene names: 145299732

Gene position: 3010227-3012392 (Clockwise)

Preceding gene: 145299731

Following gene: 145299733

Centisome position: 64.01

GC content: 63.76

Gene sequence:

>2166_bases
ATGAAGCGCGCCCGCCTGCTGCTTCTGCTGGTGATGGGGTGCCTGATTGGCGCCTTTTTCGCCCTCGATCTCGGCCGCTA
CCTGAGCCTGTCCCAGTTGCAGGCCCACCAGGATGCACTGGCACAGCTGGTCAACACCCATTTTGTCGCCGCCTGCCTGC
TGTTTGTGGCTCTCTATGTGATCAGTACCGCCCTCTCACTGCCCGGCGCCAGCCTGCTGACCCTGGGGGGCAGCGCTGTA
TTCGGTATTGGCTGGGGGCTGCTGCTGGTCTCCTTTGCCAGTACGATCGGAGCGACACTGGCTTTTCTCAGCGCCCGCTT
TCTGCTGCGCGACTGGGTGCTCAGGCACTTTGGCGACAAGCTGGCCACGTTTCAGGCCGGCATGGCAAAAGACGGCGCCG
CCTACCTGCTGAGCCTGCGCCTCATCCCGCTCTTCCCCTTCTTTCTGGTCAATCTGTTGATGGGGCTCACTCCCATCAGA
GTCAGTACCTACTACTGGGTGAGCCAGCTTGGCATGCTGCCCGGCACCTTCGTCTATGTGCTGGCGGGGAGTGAGCTGGC
GACCCTCACCAGCACGGGCAATATTCTCTCCCCCGGCCTGATGGTGGCGCTGACCTTGCTGGGACTGATGCCCTTTTTGA
TGAAGAGGGCGATGACATGGCTGGCCCAGCGTCGCCTCCATGCCCCCTATCAAAAGCCAAGCCGCTATGACTACAACCTG
CTGGTGATAGGTGCCGGCGCCGGTGGTCTGGTGACCAGCTATATCGCCGCGGCGGTGAAGGCCAACGTCGCCCTTATCGA
GAAGCACAGGATGGGCGGGGACTGCCTCAATACCGGCTGCGTTCCCTCCAAGGCACTGATCCGAAGTAGCCGCTTTGCCG
CCGAGCAGCGCAAGGCCGGGGAACTGGGCTTTAGCCCAAGTCACTCCCGCGCCGATTTTGCCGCCGTGATGGAGCGGGTG
GCACAGGTGATCAAGGAGGTCGAACCCCACGACTCGGTGGCGCGCTATCAGAACCTGGGCGTGGAGTGCATCGAGGGCGA
AGCAAAACTGGTCTCCCCCTGGGAGGTGGAGGTGAATGGCCGGCGCCTCACCAGCCGCCATATCGTGATCGCCACCGGGG
CCAGGCCCCTGGTGCCCAACCTGCCCGGATTGGCCGACACGCCTTATCTCACCTCGGATACCCTCTGGCAGCTGCGCACC
CCGCCCCGCCGCCTGCTGGTGCTTGGCGGCGGCCCCATCGGCTGCGAGCTGGCCCAGAGTTTTGCCCTGCTTGGCATCCC
GGTAACCCAAGTGGAGCTGGCCGATCAGCTGCTGCCTCGTGAAGAGCGCGACGTAGCCGATGCCCTGCAACACCAGATGG
TAGCGGACGGCGTCACCCTGCTCACCGGCTGGCGTGCCGAGCGGGTCGACTATGTGCCGCAAGAAGGGAGTGAGCAAGGG
GAACACCTCCCCATCCGGCTCCACCTGTGTCGGGGCGATCAACGCCTGATGGTTGAAGGGGATCAACTGCTGCTGGCACT
GGGACGGGTTGCAAATGTCAGCGGCTTCGGCCTCGAAACGCTGGGGGTCGAGCTGGCGCCACGCGGCACCATTGCTGTCG
ATGGTTTTCTCGCCACCAACTACCCCAGCATACTGGCGGTGGGGGACGTGGCAGGCCCCTACCAGTTCACTCATTTTGCC
GCCCATCAGGCCTGGCATGCCGCCGTCAATGCCCTGTTCGGCCAGTTCAAACGCTTCAAGGCAGATTACAGCGTGATCCC
TGCGGCGACCTACACCAGCCCTGAAATAGCCAGGGTGGGTCTCAACCGCAAGGAGGCCATGGCTCAAGGAATCCCCTTCG
AGGTGACCCGCTTCGCGCTAGGGGAGCTGGATCGCGCCATTGCCGATGGGGAGCGCCATGGCTTTATCGAGGTGCTGACG
GTGCCCGGCAAAGACAAGATCCTCGGCGCCACCATAGTGGGCACTCACGCCGGTGAGCGGCTCGCCGAATTCGTGCTCGC
CATGCGCCACCAGCTGGGGCTTGGCAAAATACTCGCCACCATCCACGCCTATCCCACCCTGATGGAGGGGAACAAGTACG
TGGCCGGTGAATGGAAACGGGCCCATCAGCCCACTCGGGTGCTGGCCCTGCTGGCCCGTTATCACCACTGGCGCCGCGGC
GCCTGA

Upstream 100 bases:

>100_bases
ATGCGGCCCTCGATATTGCCCCCCAGGGTTTCTGCCAGTTGCCGGTGCAACCTGAGCGCCCCGTGGCAGCTCAAGAACAG
CAGCCCGGCAAGGACGCCTG

Downstream 100 bases:

>100_bases
CCCTTTGCCCAAGGTAACGCCCATGTTCAAGACCCTGCCTTTGCTCAAATCCCTGTTGTGCGCCCTGCCCCTGCTGGCAA
GCTGCACACTCTTTGCCGAT

Product: hypothetical protein

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MKRARLLLLLVMGCLIGAFFALDLGRYLSLSQLQAHQDALAQLVNTHFVAACLLFVALYVISTALSLPGASLLTLGGSAV
FGIGWGLLLVSFASTIGATLAFLSARFLLRDWVLRHFGDKLATFQAGMAKDGAAYLLSLRLIPLFPFFLVNLLMGLTPIR
VSTYYWVSQLGMLPGTFVYVLAGSELATLTSTGNILSPGLMVALTLLGLMPFLMKRAMTWLAQRRLHAPYQKPSRYDYNL
LVIGAGAGGLVTSYIAAAVKANVALIEKHRMGGDCLNTGCVPSKALIRSSRFAAEQRKAGELGFSPSHSRADFAAVMERV
AQVIKEVEPHDSVARYQNLGVECIEGEAKLVSPWEVEVNGRRLTSRHIVIATGARPLVPNLPGLADTPYLTSDTLWQLRT
PPRRLLVLGGGPIGCELAQSFALLGIPVTQVELADQLLPREERDVADALQHQMVADGVTLLTGWRAERVDYVPQEGSEQG
EHLPIRLHLCRGDQRLMVEGDQLLLALGRVANVSGFGLETLGVELAPRGTIAVDGFLATNYPSILAVGDVAGPYQFTHFA
AHQAWHAAVNALFGQFKRFKADYSVIPAATYTSPEIARVGLNRKEAMAQGIPFEVTRFALGELDRAIADGERHGFIEVLT
VPGKDKILGATIVGTHAGERLAEFVLAMRHQLGLGKILATIHAYPTLMEGNKYVAGEWKRAHQPTRVLALLARYHHWRRG
A

Sequences:

>Translated_721_residues
MKRARLLLLLVMGCLIGAFFALDLGRYLSLSQLQAHQDALAQLVNTHFVAACLLFVALYVISTALSLPGASLLTLGGSAV
FGIGWGLLLVSFASTIGATLAFLSARFLLRDWVLRHFGDKLATFQAGMAKDGAAYLLSLRLIPLFPFFLVNLLMGLTPIR
VSTYYWVSQLGMLPGTFVYVLAGSELATLTSTGNILSPGLMVALTLLGLMPFLMKRAMTWLAQRRLHAPYQKPSRYDYNL
LVIGAGAGGLVTSYIAAAVKANVALIEKHRMGGDCLNTGCVPSKALIRSSRFAAEQRKAGELGFSPSHSRADFAAVMERV
AQVIKEVEPHDSVARYQNLGVECIEGEAKLVSPWEVEVNGRRLTSRHIVIATGARPLVPNLPGLADTPYLTSDTLWQLRT
PPRRLLVLGGGPIGCELAQSFALLGIPVTQVELADQLLPREERDVADALQHQMVADGVTLLTGWRAERVDYVPQEGSEQG
EHLPIRLHLCRGDQRLMVEGDQLLLALGRVANVSGFGLETLGVELAPRGTIAVDGFLATNYPSILAVGDVAGPYQFTHFA
AHQAWHAAVNALFGQFKRFKADYSVIPAATYTSPEIARVGLNRKEAMAQGIPFEVTRFALGELDRAIADGERHGFIEVLT
VPGKDKILGATIVGTHAGERLAEFVLAMRHQLGLGKILATIHAYPTLMEGNKYVAGEWKRAHQPTRVLALLARYHHWRRG
A
>Mature_721_residues
MKRARLLLLLVMGCLIGAFFALDLGRYLSLSQLQAHQDALAQLVNTHFVAACLLFVALYVISTALSLPGASLLTLGGSAV
FGIGWGLLLVSFASTIGATLAFLSARFLLRDWVLRHFGDKLATFQAGMAKDGAAYLLSLRLIPLFPFFLVNLLMGLTPIR
VSTYYWVSQLGMLPGTFVYVLAGSELATLTSTGNILSPGLMVALTLLGLMPFLMKRAMTWLAQRRLHAPYQKPSRYDYNL
LVIGAGAGGLVTSYIAAAVKANVALIEKHRMGGDCLNTGCVPSKALIRSSRFAAEQRKAGELGFSPSHSRADFAAVMERV
AQVIKEVEPHDSVARYQNLGVECIEGEAKLVSPWEVEVNGRRLTSRHIVIATGARPLVPNLPGLADTPYLTSDTLWQLRT
PPRRLLVLGGGPIGCELAQSFALLGIPVTQVELADQLLPREERDVADALQHQMVADGVTLLTGWRAERVDYVPQEGSEQG
EHLPIRLHLCRGDQRLMVEGDQLLLALGRVANVSGFGLETLGVELAPRGTIAVDGFLATNYPSILAVGDVAGPYQFTHFA
AHQAWHAAVNALFGQFKRFKADYSVIPAATYTSPEIARVGLNRKEAMAQGIPFEVTRFALGELDRAIADGERHGFIEVLT
VPGKDKILGATIVGTHAGERLAEFVLAMRHQLGLGKILATIHAYPTLMEGNKYVAGEWKRAHQPTRVLALLARYHHWRRG
A

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=30, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=28.4796573875803, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI148277065, Length=489, Percent_Identity=25.1533742331288, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI148277071, Length=489, Percent_Identity=25.1533742331288, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI33519430, Length=488, Percent_Identity=25.2049180327869, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI33519428, Length=488, Percent_Identity=25.2049180327869, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI33519426, Length=488, Percent_Identity=25.2049180327869, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI22035672, Length=481, Percent_Identity=26.4033264033264, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI291045266, Length=438, Percent_Identity=24.6575342465753, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI18087813, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI291045268, Length=339, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=30.7860262008734, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI87082354, Length=482, Percent_Identity=29.045643153527, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87081717, Length=463, Percent_Identity=26.7818574514039, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=28.246013667426, Blast_Score=129, Evalue=9e-31,
Organism=Escherichia coli, GI87081964, Length=138, Percent_Identity=42.0289855072464, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI32565766, Length=501, Percent_Identity=28.1437125748503, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17557007, Length=496, Percent_Identity=26.2096774193548, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=374, Percent_Identity=28.3422459893048, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=374, Percent_Identity=28.3422459893048, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=497, Percent_Identity=24.1448692152917, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17532687, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533280, Length=177, Percent_Identity=25.9887005649718, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=28.5106382978723, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=26.3713080168776, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=24.3697478991597, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=29.5744680851064, Blast_Score=186, Evalue=7e-47,
Organism=Drosophila melanogaster, GI17737741, Length=503, Percent_Identity=26.441351888668, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640549, Length=495, Percent_Identity=27.6767676767677, Blast_Score=119, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640551, Length=512, Percent_Identity=27.1484375, Blast_Score=119, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640553, Length=501, Percent_Identity=27.1457085828343, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 78325; Mature: 78325

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRARLLLLLVMGCLIGAFFALDLGRYLSLSQLQAHQDALAQLVNTHFVAACLLFVALYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISTALSLPGASLLTLGGSAVFGIGWGLLLVSFASTIGATLAFLSARFLLRDWVLRHFGDK
HHHHHHCCCCCEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
LATFQAGMAKDGAAYLLSLRLIPLFPFFLVNLLMGLTPIRVSTYYWVSQLGMLPGTFVYV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEE
LAGSELATLTSTGNILSPGLMVALTLLGLMPFLMKRAMTWLAQRRLHAPYQKPSRYDYNL
EECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LVIGAGAGGLVTSYIAAAVKANVALIEKHRMGGDCLNTGCVPSKALIRSSRFAAEQRKAG
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ELGFSPSHSRADFAAVMERVAQVIKEVEPHDSVARYQNLGVECIEGEAKLVSPWEVEVNG
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCCEEECCEEEEECC
RRLTSRHIVIATGARPLVPNLPGLADTPYLTSDTLWQLRTPPRRLLVLGGGPIGCELAQS
EEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCHHHHHH
FALLGIPVTQVELADQLLPREERDVADALQHQMVADGVTLLTGWRAERVDYVPQEGSEQG
HHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHCCCCCCCCCCCC
EHLPIRLHLCRGDQRLMVEGDQLLLALGRVANVSGFGLETLGVELAPRGTIAVDGFLATN
CCCCEEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCHHHHCEEECCCCCEEECCEEECC
YPSILAVGDVAGPYQFTHFAAHQAWHAAVNALFGQFKRFKADYSVIPAATYTSPEIARVG
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHC
LNRKEAMAQGIPFEVTRFALGELDRAIADGERHGFIEVLTVPGKDKILGATIVGTHAGER
CCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCHHH
LAEFVLAMRHQLGLGKILATIHAYPTLMEGNKYVAGEWKRAHQPTRVLALLARYHHWRRG
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHCCHHHHHHHHHHHHHHCCC
A
C
>Mature Secondary Structure
MKRARLLLLLVMGCLIGAFFALDLGRYLSLSQLQAHQDALAQLVNTHFVAACLLFVALYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISTALSLPGASLLTLGGSAVFGIGWGLLLVSFASTIGATLAFLSARFLLRDWVLRHFGDK
HHHHHHCCCCCEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
LATFQAGMAKDGAAYLLSLRLIPLFPFFLVNLLMGLTPIRVSTYYWVSQLGMLPGTFVYV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEE
LAGSELATLTSTGNILSPGLMVALTLLGLMPFLMKRAMTWLAQRRLHAPYQKPSRYDYNL
EECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LVIGAGAGGLVTSYIAAAVKANVALIEKHRMGGDCLNTGCVPSKALIRSSRFAAEQRKAG
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ELGFSPSHSRADFAAVMERVAQVIKEVEPHDSVARYQNLGVECIEGEAKLVSPWEVEVNG
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCCEEECCEEEEECC
RRLTSRHIVIATGARPLVPNLPGLADTPYLTSDTLWQLRTPPRRLLVLGGGPIGCELAQS
EEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCHHHHHH
FALLGIPVTQVELADQLLPREERDVADALQHQMVADGVTLLTGWRAERVDYVPQEGSEQG
HHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHCCCCCCCCCCCC
EHLPIRLHLCRGDQRLMVEGDQLLLALGRVANVSGFGLETLGVELAPRGTIAVDGFLATN
CCCCEEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCHHHHCEEECCCCCEEECCEEECC
YPSILAVGDVAGPYQFTHFAAHQAWHAAVNALFGQFKRFKADYSVIPAATYTSPEIARVG
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHC
LNRKEAMAQGIPFEVTRFALGELDRAIADGERHGFIEVLTVPGKDKILGATIVGTHAGER
CCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCHHH
LAEFVLAMRHQLGLGKILATIHAYPTLMEGNKYVAGEWKRAHQPTRVLALLARYHHWRRG
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHCCHHHHHHHHHHHHHHCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]