Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 145299678

GI number: 145299678

Start: 2952929

End: 2954161

Strand: Direct

Name: moeA [H]

Synonym: ASA_2753

Alternate gene names: 145299678

Gene position: 2952929-2954161 (Clockwise)

Preceding gene: 145299674

Following gene: 145299679

Centisome position: 62.8

GC content: 65.77

Gene sequence:

>1233_bases
ATGACGATGGGATTTGATACCAGCGGACTACTCCCCCTGAGCGATGCCCTGCAAGGGATGCTGGACCAACTCGCCTGCTG
CTGCGACACAGAACAAGTGCCCCTGCCCCAGGCCCTCGGCCGGGTACTCGCGGCAGATATCGCCTCCCCCTTGTCAGTGC
CTCCGTTCGACAACGCCGCCATGGACGGTTACGCCGTGCGGCTGGCCGATCTCGCTGCCGGCATCCCGCTCATCATGGTG
GGCAAAGCCTTCGCCGGTCAGCCCTATCAGGGGGAGTGGCCCGCGGGTCACTGCGTGCGGATCATGACCGGTGCTCCGAT
ACCCGCAGGCACAGACGCTGTGGTGATGCAGGAAGAAACGCAGGTCGACGGCAACCAGATCACCTTTCTGGTGCCGCCCA
CCCTGGGCCAGAATATCCGCCGTCGCGGCGAAGATATCCGCGAGGGCGCCAGCGTGCTCTGCGCCGGTACCCGGCTCACT
CCACGCGAGCTGCCACTGCTGGCCTCCTTGGGTATCGCCACCGTCAGCGTGCGCCGCCCGCTGAGAGTGGCCATCTTCAG
CACCGGCGACGAGCTCAAGCCGGTCGGCACCCCGCTCGCCCATGGCGACATCTATGACTCCAACCGTTACGGGGTCAAGG
CCATGCTGGCGCGCCTTGGCTGCGACTGCCTCGACCTTGGCATCATACCGGACCACCCCGCGCAGCTGCGCGCCGCCTTC
CTGCAGGCCGACCGCGAGGCCGATGCCCTCATCACCACGGGAGGCGTCTCGGTCGGTGAGGCAGACTTCACCAAACAGCT
GCTCGAGGAACTCGGCGAGATCGGCTTCTGGAAGCTGGCTATCAAACCGGGCAAGCCATTCGCCTTCGGTCGCCTGCCCA
ACGCCTGGTTCTTCGGTCTGCCGGGCAACCCTGTCTCCGCCATGGTCACCTTCGATCAGCTGGTGCAGCCTGCGCTGGCC
AAGCTGGCCGGGCAGCAGTTCGAGCGTCCGCTGCAACTGCAGGCCGTCGCCGGCGAGACTCTGAAAAAAGCGCCGGGTCG
ACTCGACTTCCAGCGCGGCATTCTGAGCCAGGGGCCAGACGGCCTCGAAGTGCGCAGCACAGGCTCCCAGGATTCCGCTG
TGTTCAGCTCACTGTCGCGGGCCAACTGCTACATAGTGCTTGAGCGTGAGCGGGGCAAGGTGGCGGCAGGAGAGACAGTC
ACCGTCGAACCATTCGGGGGCTTGCTGCTGTGA

Upstream 100 bases:

>100_bases
ACCACCCCCTGTACCAGGCAGCCTGGTGTCAGCCCCTGATAAGCCTGCCCATCCACCCTGATTTTTGGGATAATCCGCCC
TCAACCACACCAAAGAGGTA

Downstream 100 bases:

>100_bases
GCGACATTCTCTCGGACGCAGAGCTCTTGCGCTACAACCGCCAGATAGTGCTCAAATCCTTCGACTTCGAGGGGCAGGAG
GCACTCAAGCAGGCCCGCGT

Product: molybdopterin biosynthesis protein A

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTMGFDTSGLLPLSDALQGMLDQLACCCDTEQVPLPQALGRVLAADIASPLSVPPFDNAAMDGYAVRLADLAAGIPLIMV
GKAFAGQPYQGEWPAGHCVRIMTGAPIPAGTDAVVMQEETQVDGNQITFLVPPTLGQNIRRRGEDIREGASVLCAGTRLT
PRELPLLASLGIATVSVRRPLRVAIFSTGDELKPVGTPLAHGDIYDSNRYGVKAMLARLGCDCLDLGIIPDHPAQLRAAF
LQADREADALITTGGVSVGEADFTKQLLEELGEIGFWKLAIKPGKPFAFGRLPNAWFFGLPGNPVSAMVTFDQLVQPALA
KLAGQQFERPLQLQAVAGETLKKAPGRLDFQRGILSQGPDGLEVRSTGSQDSAVFSSLSRANCYIVLERERGKVAAGETV
TVEPFGGLLL

Sequences:

>Translated_410_residues
MTMGFDTSGLLPLSDALQGMLDQLACCCDTEQVPLPQALGRVLAADIASPLSVPPFDNAAMDGYAVRLADLAAGIPLIMV
GKAFAGQPYQGEWPAGHCVRIMTGAPIPAGTDAVVMQEETQVDGNQITFLVPPTLGQNIRRRGEDIREGASVLCAGTRLT
PRELPLLASLGIATVSVRRPLRVAIFSTGDELKPVGTPLAHGDIYDSNRYGVKAMLARLGCDCLDLGIIPDHPAQLRAAF
LQADREADALITTGGVSVGEADFTKQLLEELGEIGFWKLAIKPGKPFAFGRLPNAWFFGLPGNPVSAMVTFDQLVQPALA
KLAGQQFERPLQLQAVAGETLKKAPGRLDFQRGILSQGPDGLEVRSTGSQDSAVFSSLSRANCYIVLERERGKVAAGETV
TVEPFGGLLL
>Mature_409_residues
TMGFDTSGLLPLSDALQGMLDQLACCCDTEQVPLPQALGRVLAADIASPLSVPPFDNAAMDGYAVRLADLAAGIPLIMVG
KAFAGQPYQGEWPAGHCVRIMTGAPIPAGTDAVVMQEETQVDGNQITFLVPPTLGQNIRRRGEDIREGASVLCAGTRLTP
RELPLLASLGIATVSVRRPLRVAIFSTGDELKPVGTPLAHGDIYDSNRYGVKAMLARLGCDCLDLGIIPDHPAQLRAAFL
QADREADALITTGGVSVGEADFTKQLLEELGEIGFWKLAIKPGKPFAFGRLPNAWFFGLPGNPVSAMVTFDQLVQPALAK
LAGQQFERPLQLQAVAGETLKKAPGRLDFQRGILSQGPDGLEVRSTGSQDSAVFSSLSRANCYIVLERERGKVAAGETVT
VEPFGGLLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=38.25, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=38.25, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1787049, Length=405, Percent_Identity=61.4814814814815, Blast_Score=477, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25147659, Length=392, Percent_Identity=31.8877551020408, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=379, Percent_Identity=26.3852242744063, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17136978, Length=297, Percent_Identity=34.3434343434343, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24638841, Length=297, Percent_Identity=34.3434343434343, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43472; Mature: 43340

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMGFDTSGLLPLSDALQGMLDQLACCCDTEQVPLPQALGRVLAADIASPLSVPPFDNAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
MDGYAVRLADLAAGIPLIMVGKAFAGQPYQGEWPAGHCVRIMTGAPIPAGTDAVVMQEET
CCCHHEEHHHHHCCCCEEEECHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCC
QVDGNQITFLVPPTLGQNIRRRGEDIREGASVLCAGTRLTPRELPLLASLGIATVSVRRP
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHCCHHHHCCCEEEEECCC
LRVAIFSTGDELKPVGTPLAHGDIYDSNRYGVKAMLARLGCDCLDLGIIPDHPAQLRAAF
EEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
LQADREADALITTGGVSVGEADFTKQLLEELGEIGFWKLAIKPGKPFAFGRLPNAWFFGL
HHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEECC
PGNPVSAMVTFDQLVQPALAKLAGQQFERPLQLQAVAGETLKKAPGRLDFQRGILSQGPD
CCCCHHHEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHCCCC
GLEVRSTGSQDSAVFSSLSRANCYIVLERERGKVAAGETVTVEPFGGLLL
CCEEECCCCCHHHHHHHHCCCCEEEEEECCCCCEECCCEEEECCCCCCCC
>Mature Secondary Structure 
TMGFDTSGLLPLSDALQGMLDQLACCCDTEQVPLPQALGRVLAADIASPLSVPPFDNAA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
MDGYAVRLADLAAGIPLIMVGKAFAGQPYQGEWPAGHCVRIMTGAPIPAGTDAVVMQEET
CCCHHEEHHHHHCCCCEEEECHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCC
QVDGNQITFLVPPTLGQNIRRRGEDIREGASVLCAGTRLTPRELPLLASLGIATVSVRRP
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHCCHHHHCCCEEEEECCC
LRVAIFSTGDELKPVGTPLAHGDIYDSNRYGVKAMLARLGCDCLDLGIIPDHPAQLRAAF
EEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
LQADREADALITTGGVSVGEADFTKQLLEELGEIGFWKLAIKPGKPFAFGRLPNAWFFGL
HHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEECC
PGNPVSAMVTFDQLVQPALAKLAGQQFERPLQLQAVAGETLKKAPGRLDFQRGILSQGPD
CCCCHHHEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHCCCC
GLEVRSTGSQDSAVFSSLSRANCYIVLERERGKVAAGETVTVEPFGGLLL
CCEEECCCCCHHHHHHHHCCCCEEEEEECCCCCEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]