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The map label for this gene is moeB [H]

Identifier: 145299679

GI number: 145299679

Start: 2954158

End: 2954913

Strand: Direct

Name: moeB [H]

Synonym: ASA_2754

Alternate gene names: 145299679

Gene position: 2954158-2954913 (Clockwise)

Preceding gene: 145299678

Following gene: 145299700

Centisome position: 62.82

GC content: 65.08

Gene sequence:

>756_bases
GTGAGCGACATTCTCTCGGACGCAGAGCTCTTGCGCTACAACCGCCAGATAGTGCTCAAATCCTTCGACTTCGAGGGGCA
GGAGGCACTCAAGCAGGCCCGCGTGCTGGTGATCGGTGCGGGCGGCCTGGGCTGCGCCGCCAGCCAGTATCTGGCGGTGG
CCGGGGTCGGCCAGCTCACCCTGGTGGATTTTGACAAGGTGGAGCTCTCCAATCTGCAACGCCAGGTGCTGCACACGGAT
GCCCGCATCGGTCAGCACAAGGTGGATTCTGCGGCCGAGGCGCTGCGCGCGCTCAACCCCTGGCTCAAGGTGGAGACTCA
CGCCTCTGTTGCCGACGAGGCACTGCTCGATGCCCTGCTACCCAGCCACCAGCTGGTGCTCGACTGCACCGACAACCTGA
CTATCCGCAATCTGCTCAACCAATACGCGCGCAAACACAGGGTGCCGCTGGTCAGTGGCGCTGCCATCCGGCTGGAGGGG
CAGCTCTGCAGCTTCACCTGGCAGGAGGATGAGCCCTGCTACGCCTGCCTCAGCGCCCTGTTTGGCGAGCAGGCCCTTAC
CTGCGTCGAGGCGGGTGTGCTCGCCCCCATGGTCGGGCTAGTGGGCAGCCTGCAGGCACTGGAGGCGATAAAATTGCTGG
CGGGCACGGGGCGCAGCTACAGCGGCCGCCTCTTGATGATCGATGGCCTCACCGGCACCTTCCGCGAGATGAAGCTGCCC
AAACGCCCCGACTGCCCGGTTTGCTCGCACCCTTAA

Upstream 100 bases:

>100_bases
CACTGTCGCGGGCCAACTGCTACATAGTGCTTGAGCGTGAGCGGGGCAAGGTGGCGGCAGGAGAGACAGTCACCGTCGAA
CCATTCGGGGGCTTGCTGCT

Downstream 100 bases:

>100_bases
GTGATCCCTATCACCAATAACTCGCAGCCAATAAAAAAGCCGACCCCGTGGGGTCGGCTTTTTACATCATGGATACGATG
GGTAGTCAGCCTGCGCAGTA

Product: molybdopterin biosynthesis protein B

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSDILSDAELLRYNRQIVLKSFDFEGQEALKQARVLVIGAGGLGCAASQYLAVAGVGQLTLVDFDKVELSNLQRQVLHTD
ARIGQHKVDSAAEALRALNPWLKVETHASVADEALLDALLPSHQLVLDCTDNLTIRNLLNQYARKHRVPLVSGAAIRLEG
QLCSFTWQEDEPCYACLSALFGEQALTCVEAGVLAPMVGLVGSLQALEAIKLLAGTGRSYSGRLLMIDGLTGTFREMKLP
KRPDCPVCSHP

Sequences:

>Translated_251_residues
MSDILSDAELLRYNRQIVLKSFDFEGQEALKQARVLVIGAGGLGCAASQYLAVAGVGQLTLVDFDKVELSNLQRQVLHTD
ARIGQHKVDSAAEALRALNPWLKVETHASVADEALLDALLPSHQLVLDCTDNLTIRNLLNQYARKHRVPLVSGAAIRLEG
QLCSFTWQEDEPCYACLSALFGEQALTCVEAGVLAPMVGLVGSLQALEAIKLLAGTGRSYSGRLLMIDGLTGTFREMKLP
KRPDCPVCSHP
>Mature_250_residues
SDILSDAELLRYNRQIVLKSFDFEGQEALKQARVLVIGAGGLGCAASQYLAVAGVGQLTLVDFDKVELSNLQRQVLHTDA
RIGQHKVDSAAEALRALNPWLKVETHASVADEALLDALLPSHQLVLDCTDNLTIRNLLNQYARKHRVPLVSGAAIRLEGQ
LCSFTWQEDEPCYACLSALFGEQALTCVEAGVLAPMVGLVGSLQALEAIKLLAGTGRSYSGRLLMIDGLTGTFREMKLPK
RPDCPVCSHP

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=232, Percent_Identity=45.2586206896552, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI4885649, Length=150, Percent_Identity=31.3333333333333, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI23510338, Length=160, Percent_Identity=26.875, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510340, Length=160, Percent_Identity=26.875, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=62.6016260162602, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=41.2244897959184, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1789177, Length=156, Percent_Identity=30.1282051282051, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17540406, Length=247, Percent_Identity=39.6761133603239, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193203301, Length=154, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86565433, Length=159, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=159, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=250, Percent_Identity=38, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322639, Length=160, Percent_Identity=29.375, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320598, Length=157, Percent_Identity=26.1146496815287, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321965, Length=261, Percent_Identity=27.2030651340996, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=42.3387096774194, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24660640, Length=137, Percent_Identity=33.5766423357664, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129973, Length=109, Percent_Identity=35.7798165137615, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27194; Mature: 27063

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILSDAELLRYNRQIVLKSFDFEGQEALKQARVLVIGAGGLGCAASQYLAVAGVGQLT
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEEE
LVDFDKVELSNLQRQVLHTDARIGQHKVDSAAEALRALNPWLKVETHASVADEALLDALL
EEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHC
PSHQLVLDCTDNLTIRNLLNQYARKHRVPLVSGAAIRLEGQLCSFTWQEDEPCYACLSAL
CCCEEEEECCCCHHHHHHHHHHHHHHCCCEECCCEEEECCCEEEEECCCCCHHHHHHHHH
FGEQALTCVEAGVLAPMVGLVGSLQALEAIKLLAGTGRSYSGRLLMIDGLTGTFREMKLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHCCCC
KRPDCPVCSHP
CCCCCCCCCCC
>Mature Secondary Structure 
SDILSDAELLRYNRQIVLKSFDFEGQEALKQARVLVIGAGGLGCAASQYLAVAGVGQLT
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEEE
LVDFDKVELSNLQRQVLHTDARIGQHKVDSAAEALRALNPWLKVETHASVADEALLDALL
EEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHC
PSHQLVLDCTDNLTIRNLLNQYARKHRVPLVSGAAIRLEGQLCSFTWQEDEPCYACLSAL
CCCEEEEECCCCHHHHHHHHHHHHHHCCCEECCCEEEECCCEEEEECCCCCHHHHHHHHH
FGEQALTCVEAGVLAPMVGLVGSLQALEAIKLLAGTGRSYSGRLLMIDGLTGTFREMKLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHCCCC
KRPDCPVCSHP
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]