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The map label for this gene is fhs

Identifier: 145299674

GI number: 145299674

Start: 2948070

End: 2949812

Strand: Direct

Name: fhs

Synonym: ASA_2749

Alternate gene names: 145299674

Gene position: 2948070-2949812 (Clockwise)

Preceding gene: 145299672

Following gene: 145299678

Centisome position: 62.69

GC content: 65.35

Gene sequence:

>1743_bases
ATGCTAAGCGATATCGAGATCTCCCGCCAGTCCCCCCGTCTCTCCATCCAGGCCCTGGCTTCGCGCCTGGGCATCCCGGC
CCATCTGCTCAGCCCTCACGGCCACTACAAGGGCAAGCTCAGTCTCGAATTGCTCAAGCAAGCCGCCAGCAAGCCCGGCA
AAAAAGCGGGCAAGCTGGTGCTGGTGAGCGCCATCACGCCGACGCCCCTTGGCGAGGGCAAGACGGTCACCACCCTAGGT
CTCTCCATGGGGCTCAACCATATTGGCCAGCCCAGCATGGCCACCATACGCCAGCCGAGTCTCGGTCCCGTATTCGGGGT
CAAGGGGGGCGCCGCCGGGGGTGGTCACGCCCAGGTGGTGCCGATGGAGGAGATGAACCTGCACCTGACCGGTGACTTCC
ACGCCCTCACCGCCGCCCACAACCTGGCGGCCGCCGCGCTGGATGCCCGCCTGTTCCATGAGACCAAACTCGGCACCGAG
TTCACCGCCAGGACGGGGCTGGCACGGCTCGATATCGATCCCGCCAACATCCTCTGGCCACGTACCCTCGACATGAACGA
ACGCGCCCTGCGCCACCTCACGATTGGGCAGGGGGCCGCCGCCGATGGCGTTGAACGCCAGGATCGCTTCGTCATCACCG
CCGCCTCCGAGCTGATGGCCATTCTGGCGCTGGCAAGCGATCTGAAAGACTTGCGCGCTCGCATCGGCCGCATCCAGCTG
GCCCTCGACAGCCAGGGCCAACCCATCACGGCCGAGCAACTGGAAGTCGCCGGCGCCATGACGGTGCTGCTCAAAGACGC
GCTGCAACCGACCCTGATGCAGACCACGGAGCAGACCCCTGTGCTGGTGCACGCCGGCCCCTTTGCCAACATAGCCCACG
GCAACTCTTCTGTGATCGCCGACCGCATGGCGCTGCAACTGACCGACTATGTGGTGACAGAGGCGGGTTTTGGCTCCGAC
ATGGGGCTGGAGAAGTTCTTCAACATCAAGCACCGCCAGTCCGGCATCACGCCGGCCTGCGTGGTACTGGTGGCAACGGT
ACGCGGCCTCAAGGCCAACAGCGGCCTGCTCGACATCCGCCCGGGCCAGCCGCTGCCTGCGAGCCTGCTGGGGGAAGACT
TGCCCACCCTTGAGAAGGGGTGTGCCAACCTTGCCTGGCACATCCACAACGCCCGCCGTTATGGACTGCCCGTTGTCGTC
GCGGTCAATAGCTTCCCCACCGACAGCAAGGCCGAGCTGGATCTGCTGATGCGCGAGGCGCGCCAAGCCGGTGCCTGTGG
TGCAGCCATCTCGACCGCCTTTGTAGAGGGCGGTGCGGGCGCCAGTGAACTGGCAAGGGCCGTGGTCGCCGCCTGCGAGA
TGCCAAGCCAGATCCAGCTGCTCTATCCCGATGAGATGAGCTTGTGTGCCAAACTCGCCACCCTGGTGGAGTGCGGCTAT
GGCGGCCGTGGTGTCATCCTCTCTGACAAGGCGCACCGACAGCTGGCAGCGCTCTCGGCTGCAGGCTGGGATCACCTGCC
CATCTGCGTGGCCAAGACGCCGCTCTCCATCAGCCACGATCCCGCCAGGAAGGGGGTACCGACCGATTTCGAGGTGCCCA
TCGACGAGGTGAAGCTGTGCGCCGGTGCCGGTTTCGTCTATGCGCTGGCGGGCCCCATCATGACAATGCCGGGGCTCGGC
AGTCTGCCGGCCTATCGCCATATAGATATCGGCGAGGACGGCGAGATAGTCGGACTGAGCTGA

Upstream 100 bases:

>100_bases
GCTCACGACTGCCGGATAAAATGTTATTACTCATTGGATAACCCTGTTGATTCCACTAGACTGCGCCGCATATTTGACCT
GACATGCCAACGAGGTGCTG

Downstream 100 bases:

>100_bases
TGTTCTTCATGCTCAAGATCGCCAGAAACAACAAGGCCCCGCCAATTGGCGGGGCCTTGTTTTATAACAGCGTTCACCCG
TTAAGTGACGGGGTTGCCCC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MLSDIEISRQSPRLSIQALASRLGIPAHLLSPHGHYKGKLSLELLKQAASKPGKKAGKLVLVSAITPTPLGEGKTVTTLG
LSMGLNHIGQPSMATIRQPSLGPVFGVKGGAAGGGHAQVVPMEEMNLHLTGDFHALTAAHNLAAAALDARLFHETKLGTE
FTARTGLARLDIDPANILWPRTLDMNERALRHLTIGQGAAADGVERQDRFVITAASELMAILALASDLKDLRARIGRIQL
ALDSQGQPITAEQLEVAGAMTVLLKDALQPTLMQTTEQTPVLVHAGPFANIAHGNSSVIADRMALQLTDYVVTEAGFGSD
MGLEKFFNIKHRQSGITPACVVLVATVRGLKANSGLLDIRPGQPLPASLLGEDLPTLEKGCANLAWHIHNARRYGLPVVV
AVNSFPTDSKAELDLLMREARQAGACGAAISTAFVEGGAGASELARAVVAACEMPSQIQLLYPDEMSLCAKLATLVECGY
GGRGVILSDKAHRQLAALSAAGWDHLPICVAKTPLSISHDPARKGVPTDFEVPIDEVKLCAGAGFVYALAGPIMTMPGLG
SLPAYRHIDIGEDGEIVGLS

Sequences:

>Translated_580_residues
MLSDIEISRQSPRLSIQALASRLGIPAHLLSPHGHYKGKLSLELLKQAASKPGKKAGKLVLVSAITPTPLGEGKTVTTLG
LSMGLNHIGQPSMATIRQPSLGPVFGVKGGAAGGGHAQVVPMEEMNLHLTGDFHALTAAHNLAAAALDARLFHETKLGTE
FTARTGLARLDIDPANILWPRTLDMNERALRHLTIGQGAAADGVERQDRFVITAASELMAILALASDLKDLRARIGRIQL
ALDSQGQPITAEQLEVAGAMTVLLKDALQPTLMQTTEQTPVLVHAGPFANIAHGNSSVIADRMALQLTDYVVTEAGFGSD
MGLEKFFNIKHRQSGITPACVVLVATVRGLKANSGLLDIRPGQPLPASLLGEDLPTLEKGCANLAWHIHNARRYGLPVVV
AVNSFPTDSKAELDLLMREARQAGACGAAISTAFVEGGAGASELARAVVAACEMPSQIQLLYPDEMSLCAKLATLVECGY
GGRGVILSDKAHRQLAALSAAGWDHLPICVAKTPLSISHDPARKGVPTDFEVPIDEVKLCAGAGFVYALAGPIMTMPGLG
SLPAYRHIDIGEDGEIVGLS
>Mature_580_residues
MLSDIEISRQSPRLSIQALASRLGIPAHLLSPHGHYKGKLSLELLKQAASKPGKKAGKLVLVSAITPTPLGEGKTVTTLG
LSMGLNHIGQPSMATIRQPSLGPVFGVKGGAAGGGHAQVVPMEEMNLHLTGDFHALTAAHNLAAAALDARLFHETKLGTE
FTARTGLARLDIDPANILWPRTLDMNERALRHLTIGQGAAADGVERQDRFVITAASELMAILALASDLKDLRARIGRIQL
ALDSQGQPITAEQLEVAGAMTVLLKDALQPTLMQTTEQTPVLVHAGPFANIAHGNSSVIADRMALQLTDYVVTEAGFGSD
MGLEKFFNIKHRQSGITPACVVLVATVRGLKANSGLLDIRPGQPLPASLLGEDLPTLEKGCANLAWHIHNARRYGLPVVV
AVNSFPTDSKAELDLLMREARQAGACGAAISTAFVEGGAGASELARAVVAACEMPSQIQLLYPDEMSLCAKLATLVECGY
GGRGVILSDKAHRQLAALSAAGWDHLPICVAKTPLSISHDPARKGVPTDFEVPIDEVKLCAGAGFVYALAGPIMTMPGLG
SLPAYRHIDIGEDGEIVGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=618, Percent_Identity=48.3818770226537, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=47.8964401294498, Blast_Score=511, Evalue=1e-144,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=40.6976744186046, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=621, Percent_Identity=47.3429951690821, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17568739, Length=621, Percent_Identity=47.3429951690821, Blast_Score=516, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6321643, Length=628, Percent_Identity=48.2484076433121, Blast_Score=532, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=46.9194312796209, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=46.1290322580645, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=46.1290322580645, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=46.1290322580645, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=46.1290322580645, Blast_Score=493, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_AERS4 (A4SPE5)

Other databases:

- EMBL:   CP000644
- RefSeq:   YP_001142515.1
- ProteinModelPortal:   A4SPE5
- SMR:   A4SPE5
- STRING:   A4SPE5
- GeneID:   4995845
- GenomeReviews:   CP000644_GR
- KEGG:   asa:ASA_2749
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   VVASEVM
- PhylomeDB:   A4SPE5
- ProtClustDB:   PRK13506
- BioCyc:   ASAL382245:ASA_2749-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60954; Mature: 60954

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDIEISRQSPRLSIQALASRLGIPAHLLSPHGHYKGKLSLELLKQAASKPGKKAGKLV
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCEEHHHHHHHHHCCCCCCCCCEE
LVSAITPTPLGEGKTVTTLGLSMGLNHIGQPSMATIRQPSLGPVFGVKGGAAGGGHAQVV
EEEECCCCCCCCCCEEEEEEHHHCHHHCCCCCHHHCCCCCCCCEEECCCCCCCCCCEEEE
PMEEMNLHLTGDFHALTAAHNLAAAALDARLFHETKLGTEFTARTGLARLDIDPANILWP
EHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCCCCEECC
RTLDMNERALRHLTIGQGAAADGVERQDRFVITAASELMAILALASDLKDLRARIGRIQL
CCCCCCHHHHHHEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEE
ALDSQGQPITAEQLEVAGAMTVLLKDALQPTLMQTTEQTPVLVHAGPFANIAHGNSSVIA
EECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCCCEECCCCCHHHH
DRMALQLTDYVVTEAGFGSDMGLEKFFNIKHRQSGITPACVVLVATVRGLKANSGLLDIR
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEC
PGQPLPASLLGEDLPTLEKGCANLAWHIHNARRYGLPVVVAVNSFPTDSKAELDLLMREA
CCCCCCHHHHCCCCCHHHHHHHHHEEEEECCHHCCCEEEEEECCCCCCCHHHHHHHHHHH
RQAGACGAAISTAFVEGGAGASELARAVVAACEMPSQIQLLYPDEMSLCAKLATLVECGY
HHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCC
GGRGVILSDKAHRQLAALSAAGWDHLPICVAKTPLSISHDPARKGVPTDFEVPIDEVKLC
CCCEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AGAGFVYALAGPIMTMPGLGSLPAYRHIDIGEDGEIVGLS
HCCCHHHHHHCHHHCCCCCCCCCCEEEECCCCCCCEEECC
>Mature Secondary Structure
MLSDIEISRQSPRLSIQALASRLGIPAHLLSPHGHYKGKLSLELLKQAASKPGKKAGKLV
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCEEHHHHHHHHHCCCCCCCCCEE
LVSAITPTPLGEGKTVTTLGLSMGLNHIGQPSMATIRQPSLGPVFGVKGGAAGGGHAQVV
EEEECCCCCCCCCCEEEEEEHHHCHHHCCCCCHHHCCCCCCCCEEECCCCCCCCCCEEEE
PMEEMNLHLTGDFHALTAAHNLAAAALDARLFHETKLGTEFTARTGLARLDIDPANILWP
EHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCCCCEECC
RTLDMNERALRHLTIGQGAAADGVERQDRFVITAASELMAILALASDLKDLRARIGRIQL
CCCCCCHHHHHHEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEE
ALDSQGQPITAEQLEVAGAMTVLLKDALQPTLMQTTEQTPVLVHAGPFANIAHGNSSVIA
EECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCCCEECCCCCHHHH
DRMALQLTDYVVTEAGFGSDMGLEKFFNIKHRQSGITPACVVLVATVRGLKANSGLLDIR
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEC
PGQPLPASLLGEDLPTLEKGCANLAWHIHNARRYGLPVVVAVNSFPTDSKAELDLLMREA
CCCCCCHHHHCCCCCHHHHHHHHHEEEEECCHHCCCEEEEEECCCCCCCHHHHHHHHHHH
RQAGACGAAISTAFVEGGAGASELARAVVAACEMPSQIQLLYPDEMSLCAKLATLVECGY
HHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCC
GGRGVILSDKAHRQLAALSAAGWDHLPICVAKTPLSISHDPARKGVPTDFEVPIDEVKLC
CCCEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AGAGFVYALAGPIMTMPGLGSLPAYRHIDIGEDGEIVGLS
HCCCHHHHHHCHHHCCCCCCCCCCEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA