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The map label for this gene is gufA [H]

Identifier: 145299580

GI number: 145299580

Start: 2836969

End: 2837745

Strand: Direct

Name: gufA [H]

Synonym: ASA_2651

Alternate gene names: 145299580

Gene position: 2836969-2837745 (Clockwise)

Preceding gene: 145299578

Following gene: 145299581

Centisome position: 60.33

GC content: 65.12

Gene sequence:

>777_bases
GTGCAGGCTCGCCCACTGACCGCCCTCGGTCTGCTCATCGCGCTGGCCGCCGTCTTGCTGCTGCTATTGCAGAGCCTCAT
CATGCTGGCGACTGACGATATGAGCACAGGCGTCCGTTATGGTCTCATCGGCGGGGTAGCAGGCTTTGCCGCCAGCGCCT
TCTCCCTGCTGCTGCCGGGGCTCGAAGCAGCAGAAGGGATCACAGGGGATGGCTTTCTCGCCGCAGCCGTAGTGGTAGCC
GGTATGACCCTGGGGGTACTGCTGATGCTGGGGCTGGATCAGTTCACCCCTCATGAACACGACAAGACAGGCCCCTGCGG
CCCAGGCCACCAGCAGTGCTCCCGGGTCTGGCTGTTCGTGTTTGCCATTGCCCTGCACAACCTGCCGGAGGGGATGGCCA
TCGGGGTCAGCTTCTCTCAGGGGGATATGTCGGTGGGGCTGCCGTTGACCACGGCCATCGCCCTGCAAGACATTCCGGAA
GGGCTGGCGGTGGCGCTGGCCATGTGCGCCGCCGGATTCAGACCCTGGGTTGCGGTATTGGTCGCCATAGCAAGCGGCTT
GCTCGAACCCCTCGGCGCCCTGCTTGGGGTCGGCCTCTCCAGCGGCATGGCCATCGCCTACCCTATAGGGCTGGGGCTGG
CCGCAGGCGCCATGCTGTTTGTGGTCTCCCACGAGGTGATCCCGGAAACGCACCGCAATGGTCACCAGACCCACGCCACC
CTGGGGCTGATGGCCGGCTTTGCCCTGATGATGACCCTCGACACCGCCTTGGGTTGA

Upstream 100 bases:

>100_bases
ATGGTTACAAGCCATCCTCATCTGCTGTAGAGAGGTCTAGTTTATGGATAATGCATCGGCGCTGCCGGTTTCCTCCTGGT
CAATCCAACTGCGCGAGCAG

Downstream 100 bases:

>100_bases
TAACATGCTGATAAATAGCCTGATATCTCATTCGTTGACGATACTGACATAGCTGGCATCGGGATCTCCCCGAGCCTTCA
TCGAGGGCCTGCATGACATG

Product: divalent heavy-metal cations transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MQARPLTALGLLIALAAVLLLLLQSLIMLATDDMSTGVRYGLIGGVAGFAASAFSLLLPGLEAAEGITGDGFLAAAVVVA
GMTLGVLLMLGLDQFTPHEHDKTGPCGPGHQQCSRVWLFVFAIALHNLPEGMAIGVSFSQGDMSVGLPLTTAIALQDIPE
GLAVALAMCAAGFRPWVAVLVAIASGLLEPLGALLGVGLSSGMAIAYPIGLGLAAGAMLFVVSHEVIPETHRNGHQTHAT
LGLMAGFALMMTLDTALG

Sequences:

>Translated_258_residues
MQARPLTALGLLIALAAVLLLLLQSLIMLATDDMSTGVRYGLIGGVAGFAASAFSLLLPGLEAAEGITGDGFLAAAVVVA
GMTLGVLLMLGLDQFTPHEHDKTGPCGPGHQQCSRVWLFVFAIALHNLPEGMAIGVSFSQGDMSVGLPLTTAIALQDIPE
GLAVALAMCAAGFRPWVAVLVAIASGLLEPLGALLGVGLSSGMAIAYPIGLGLAAGAMLFVVSHEVIPETHRNGHQTHAT
LGLMAGFALMMTLDTALG
>Mature_258_residues
MQARPLTALGLLIALAAVLLLLLQSLIMLATDDMSTGVRYGLIGGVAGFAASAFSLLLPGLEAAEGITGDGFLAAAVVVA
GMTLGVLLMLGLDQFTPHEHDKTGPCGPGHQQCSRVWLFVFAIALHNLPEGMAIGVSFSQGDMSVGLPLTTAIALQDIPE
GLAVALAMCAAGFRPWVAVLVAIASGLLEPLGALLGVGLSSGMAIAYPIGLGLAAGAMLFVVSHEVIPETHRNGHQTHAT
LGLMAGFALMMTLDTALG

Specific function: Mediates Zinc Uptake. May Also Transport Other Divalent Cations Such As Copper And Cadmium Ions. [C]

COG id: COG0428

COG function: function code P; Predicted divalent heavy-metal cations transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI229577422, Length=160, Percent_Identity=37.5, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI229577418, Length=160, Percent_Identity=37.5, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1789419, Length=144, Percent_Identity=37.5, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17507805, Length=160, Percent_Identity=38.75, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24652846, Length=168, Percent_Identity=38.0952380952381, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003689 [H]

Pfam domain/function: PF02535 Zip [H]

EC number: NA

Molecular weight: Translated: 26201; Mature: 26201

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQARPLTALGLLIALAAVLLLLLQSLIMLATDDMSTGVRYGLIGGVAGFAASAFSLLLPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCC
LEAAEGITGDGFLAAAVVVAGMTLGVLLMLGLDQFTPHEHDKTGPCGPGHQQCSRVWLFV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCHHHHHHHHHHH
FAIALHNLPEGMAIGVSFSQGDMSVGLPLTTAIALQDIPEGLAVALAMCAAGFRPWVAVL
HHHHHHCCCCCEEEEEEECCCCCEECCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
VAIASGLLEPLGALLGVGLSSGMAIAYPIGLGLAAGAMLFVVSHEVIPETHRNGHQTHAT
HHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHH
LGLMAGFALMMTLDTALG
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQARPLTALGLLIALAAVLLLLLQSLIMLATDDMSTGVRYGLIGGVAGFAASAFSLLLPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCC
LEAAEGITGDGFLAAAVVVAGMTLGVLLMLGLDQFTPHEHDKTGPCGPGHQQCSRVWLFV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCHHHHHHHHHHH
FAIALHNLPEGMAIGVSFSQGDMSVGLPLTTAIALQDIPEGLAVALAMCAAGFRPWVAVL
HHHHHHCCCCCEEEEEEECCCCCEECCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
VAIASGLLEPLGALLGVGLSSGMAIAYPIGLGLAAGAMLFVVSHEVIPETHRNGHQTHAT
HHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHH
LGLMAGFALMMTLDTALG
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934835 [H]