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The map label for this gene is cynR [H]

Identifier: 145299571

GI number: 145299571

Start: 2824834

End: 2825742

Strand: Direct

Name: cynR [H]

Synonym: ASA_2641

Alternate gene names: 145299571

Gene position: 2824834-2825742 (Clockwise)

Preceding gene: 145299568

Following gene: 145299578

Centisome position: 60.07

GC content: 61.83

Gene sequence:

>909_bases
ATGAACATCAAGCAACTGCACTATTTCCACGAACTGGCCAGGCATCGGCATTTTGCCAAGGCCGCCAAAGCCTGCCACAT
CACCCAGCCGACCCTGTCGGCCAGCATCACGGCACTGGAAAAAAACCTGGGCACGGATCTGGTGGTACGCACCAGCCAGT
TCGTCGCCCTCACCGAGGCGGGCGAGCTGGTGCGCCAGTACGCCGAGCGGATGCTGCTGGAGCAGGAGGCGCTCAAGCAG
GAGCTGGCGCTATTTCACGGCGAACTGTCGGGCACCTTGCGCATCGGCATAGTGCCCCAATCCAATGTCGACATCATGCC
GCTCATTGCCAGGTGCAAGCAGCGCTACCCAGATATCGTCATTCGCCTGTTGGTGCTGAGCAACGAAGCCCTGCTGTCAC
AGCTGGCGCTGCACCAATGCGACATAGGTTTGGGGTTTGACGAGCCCCCTGGTGAACCTGGCAGGCACGCCTTCAACCTT
TACCCTCAAGGTCACAACCGGATGGCGGTGCTGATGAACCGCGGCGCGGTGGAACCCCTCCCCTCCTCTGCGCCCATGAC
CCTGGCCAGTCTGCAAACCCGGCCACTGGTGCTGCCAAGCCGCTCCATGCAGTTTCGCCGATACCTGGATCTCGCCGCCG
AGCGCGCACGGATAAATCTGAATGTGGTGCTGGAGACAGACTCCCTGTTCCATCTGGTGAGTGCGGTGCGCCACCAGCTG
GGCTGGGCCATCGTCAGCGCTGGCCTCGCCCACTCCGCCAGCAAGCTCTCTGATCTGGTCTGTCACCCCCTAGAACCGAT
CGAAGCCGGCAGCACCGTCTTCCTCACTCGCCAGCACAGCATCACTCCCGCCATAAGGGCCTTTCTGGATCTGGTGGCAG
AAGACGCCACCATAGGCCGGGGGCAATAA

Upstream 100 bases:

>100_bases
ATGAATTAAATCTATCTCCCGATAGAATCACTCTATTGACGATGAATTTTCAATTGATTAATTTTAAGTATCACCCCGCC
AGACGCCTCGCAACACCGCC

Downstream 100 bases:

>100_bases
CGAAGAAGCCCGCCAATGGCGGGCTTCTTCGTTATGCAAGGAGCACAGACAGGATCAGGTCGCCATCTGCTCGTGGGGCG
ATCCATGATGGCGCAGCCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNIKQLHYFHELARHRHFAKAAKACHITQPTLSASITALEKNLGTDLVVRTSQFVALTEAGELVRQYAERMLLEQEALKQ
ELALFHGELSGTLRIGIVPQSNVDIMPLIARCKQRYPDIVIRLLVLSNEALLSQLALHQCDIGLGFDEPPGEPGRHAFNL
YPQGHNRMAVLMNRGAVEPLPSSAPMTLASLQTRPLVLPSRSMQFRRYLDLAAERARINLNVVLETDSLFHLVSAVRHQL
GWAIVSAGLAHSASKLSDLVCHPLEPIEAGSTVFLTRQHSITPAIRAFLDLVAEDATIGRGQ

Sequences:

>Translated_302_residues
MNIKQLHYFHELARHRHFAKAAKACHITQPTLSASITALEKNLGTDLVVRTSQFVALTEAGELVRQYAERMLLEQEALKQ
ELALFHGELSGTLRIGIVPQSNVDIMPLIARCKQRYPDIVIRLLVLSNEALLSQLALHQCDIGLGFDEPPGEPGRHAFNL
YPQGHNRMAVLMNRGAVEPLPSSAPMTLASLQTRPLVLPSRSMQFRRYLDLAAERARINLNVVLETDSLFHLVSAVRHQL
GWAIVSAGLAHSASKLSDLVCHPLEPIEAGSTVFLTRQHSITPAIRAFLDLVAEDATIGRGQ
>Mature_302_residues
MNIKQLHYFHELARHRHFAKAAKACHITQPTLSASITALEKNLGTDLVVRTSQFVALTEAGELVRQYAERMLLEQEALKQ
ELALFHGELSGTLRIGIVPQSNVDIMPLIARCKQRYPDIVIRLLVLSNEALLSQLALHQCDIGLGFDEPPGEPGRHAFNL
YPQGHNRMAVLMNRGAVEPLPSSAPMTLASLQTRPLVLPSRSMQFRRYLDLAAERARINLNVVLETDSLFHLVSAVRHQL
GWAIVSAGLAHSASKLSDLVCHPLEPIEAGSTVFLTRQHSITPAIRAFLDLVAEDATIGRGQ

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=303, Percent_Identity=30.3630363036304, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790399, Length=143, Percent_Identity=41.2587412587413, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790208, Length=227, Percent_Identity=27.7533039647577, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787601, Length=229, Percent_Identity=27.5109170305677, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=297, Percent_Identity=26.5993265993266, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788887, Length=145, Percent_Identity=33.7931034482759, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=26.4900662251656, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788296, Length=227, Percent_Identity=25.5506607929515, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=160, Percent_Identity=30, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788481, Length=294, Percent_Identity=26.1904761904762, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=27.3972602739726, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33384; Mature: 33384

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKQLHYFHELARHRHFAKAAKACHITQPTLSASITALEKNLGTDLVVRTSQFVALTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEHHH
GELVRQYAERMLLEQEALKQELALFHGELSGTLRIGIVPQSNVDIMPLIARCKQRYPDIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCHHHH
IRLLVLSNEALLSQLALHQCDIGLGFDEPPGEPGRHAFNLYPQGHNRMAVLMNRGAVEPL
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCC
PSSAPMTLASLQTRPLVLPSRSMQFRRYLDLAAERARINLNVVLETDSLFHLVSAVRHQL
CCCCCEEHHHCCCCCEECCCCHHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHH
GWAIVSAGLAHSASKLSDLVCHPLEPIEAGSTVFLTRQHSITPAIRAFLDLVAEDATIGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCC
GQ
CC
>Mature Secondary Structure
MNIKQLHYFHELARHRHFAKAAKACHITQPTLSASITALEKNLGTDLVVRTSQFVALTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEHHH
GELVRQYAERMLLEQEALKQELALFHGELSGTLRIGIVPQSNVDIMPLIARCKQRYPDIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCHHHH
IRLLVLSNEALLSQLALHQCDIGLGFDEPPGEPGRHAFNLYPQGHNRMAVLMNRGAVEPL
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCC
PSSAPMTLASLQTRPLVLPSRSMQFRRYLDLAAERARINLNVVLETDSLFHLVSAVRHQL
CCCCCEEHHHCCCCCEECCCCHHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHH
GWAIVSAGLAHSASKLSDLVCHPLEPIEAGSTVFLTRQHSITPAIRAFLDLVAEDATIGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCC
GQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]