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The map label for this gene is kefC [H]

Identifier: 145299446

GI number: 145299446

Start: 2675965

End: 2677584

Strand: Direct

Name: kefC [H]

Synonym: ASA_2508

Alternate gene names: 145299446

Gene position: 2675965-2677584 (Clockwise)

Preceding gene: 145299445

Following gene: 145299447

Centisome position: 56.91

GC content: 61.3

Gene sequence:

>1620_bases
ATGGAACCGCTCTTCATTGCCGTCGCCTTCGCCTGCGGCATGCTGGTCAACCTGGTGGGGCTGCCTCCCCTGATCGGTTT
TCTTGCCGCCGGTTTTGTGCTCAATGCCCTCGGCTATCAAAACTCCGAAGTGCTGACGACGGTGGCGGAGCTGGGGGTGA
CCCTGATGCTGTTCACCATAGGCCTCAAGCTCAACATCAAGACCTTGCTGCGCCGGGACGTATGGGGTACGGCTACCGTC
CATATCCTGCTCTCCAGCGGGCTGTTCTGGGTGATCCTGCTCGCCTGCAAGGGGCTCGGCATGACCTTGATGCTGGATCT
GGAGTGGCCCCACGCCATCATGCTCGGGTTTGCCCTCTCTTTTTCCAGTACCGTTTTTGCGGTCAAGGTGCTGGAGGATC
GCAGCGACATGAATGCCCTCTATGCCAAGCTGGCCATCGGGGTGCTGATCATGCAGGACATCTTCGCGGTGGGCTTTCTG
ACCGCCTCCACCGGCAAATTGCCCAGCATCTGGGCGATCTGGATACTGGCGCTGCCCTTCTTGCGCCCCCTGCTGTTCAA
GCTGCTGGAGCGGGCCGGTCACGGTGAATTGCAGATGCTGATGGGGATCACCCTGGCCCTGGTGCTGGGGGCCGCCGCCT
TTGAGGCTGTCGGCTTGAAGCCGGACTTGGGGGCCCTGGTGATCGGCATGTTGCTGGCTTCCCACCCGGCGGCGGCGGGG
ATGGCCAAATCCCTGTTCAGCCTCAAGGATCTGTTCCTCATCTGCTTTTTCCTCTCCATCGGCCTCAACGGCATGCCGAC
CCAGGAAACCATGTGGATGGCACTGGTGCTGATGCTGGCACTGCCGCTCAAAAGCGCCCTCTACTATCTGGTCTACAGCG
GTGCCCGGCTGCGGGTACGAACCGCGTTGCTCTCGACGCTGGCTCTCACCAACTACTCTGAGTTCGGCCTGATCGTGGCC
GCCATTGCCGCCAAGGCGGGCTGGCTCTCCCACGAATGGCTGGTCGCCCTCTCGCTGGCACTGGCGGGCAGCTTCATGCT
GTCGGCCCCGCTCAATAGCTACAGCGAGTGGATCTATCAGCACATAGGCCCCTGGTTGCGCCGCCTGCAATCGGACACCC
TGCACCTGGATGACAGGCCCATCGAACTGGGGGATGCAGAGGTGATCATCCTCGGCATGGGCCGCATCGGACAGGGCGCC
TATCATGAGCTGGAGCGCAAATACGGCAACGTCATACTGGGGGTCGAAAACAACGGGGACAAGGCCCCCCTGCTGCGCGA
ACAGGGGATGAACGTGCTGGAAGGGGATGCCACCGATACCGACTTCTGGGACAAGGTGATCCTCTCCCATCAGGTTCAGC
TGGTGATCCTCGCCATGCCCCATCACTCGGGCAACCTCTACGCCATCGACAAGCTGCGCAGCCACGGTTTTCACGGCAAG
ATAGCGGCCATAGTCCGCTTCGAGGATGATATCGCCTCCCTGCGTGAACAGGGAGTCGATGCGGTGTTCAACGTCTACGA
CGAGGCAGGCAGCGGCTTCGCTCGCCACGTCATCAGGGAGTTGCAGCCACTCGACACAGAGGCACCCCTTGTCAAGGAGT
GGCCACCTCGTTTAACTTAA

Upstream 100 bases:

>100_bases
GCAATGTCGCGGATATCGATCGCATGCCGTTTCGCCCGAACCACATCTTCGACTCAGTCGTGGATATCGATATCGTCTGA
TGTGATCACAGGAGTCATCC

Downstream 100 bases:

>100_bases
CGTCAACATTGTTAAACAAACTAAACGAGTGCGGGGCCAGGAAGGCCCCGCACTCTCAATCCCTCACTCACCATTGGCAA
GGATGCACCATGAAAACCCT

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MEPLFIAVAFACGMLVNLVGLPPLIGFLAAGFVLNALGYQNSEVLTTVAELGVTLMLFTIGLKLNIKTLLRRDVWGTATV
HILLSSGLFWVILLACKGLGMTLMLDLEWPHAIMLGFALSFSSTVFAVKVLEDRSDMNALYAKLAIGVLIMQDIFAVGFL
TASTGKLPSIWAIWILALPFLRPLLFKLLERAGHGELQMLMGITLALVLGAAAFEAVGLKPDLGALVIGMLLASHPAAAG
MAKSLFSLKDLFLICFFLSIGLNGMPTQETMWMALVLMLALPLKSALYYLVYSGARLRVRTALLSTLALTNYSEFGLIVA
AIAAKAGWLSHEWLVALSLALAGSFMLSAPLNSYSEWIYQHIGPWLRRLQSDTLHLDDRPIELGDAEVIILGMGRIGQGA
YHELERKYGNVILGVENNGDKAPLLREQGMNVLEGDATDTDFWDKVILSHQVQLVILAMPHHSGNLYAIDKLRSHGFHGK
IAAIVRFEDDIASLREQGVDAVFNVYDEAGSGFARHVIRELQPLDTEAPLVKEWPPRLT

Sequences:

>Translated_539_residues
MEPLFIAVAFACGMLVNLVGLPPLIGFLAAGFVLNALGYQNSEVLTTVAELGVTLMLFTIGLKLNIKTLLRRDVWGTATV
HILLSSGLFWVILLACKGLGMTLMLDLEWPHAIMLGFALSFSSTVFAVKVLEDRSDMNALYAKLAIGVLIMQDIFAVGFL
TASTGKLPSIWAIWILALPFLRPLLFKLLERAGHGELQMLMGITLALVLGAAAFEAVGLKPDLGALVIGMLLASHPAAAG
MAKSLFSLKDLFLICFFLSIGLNGMPTQETMWMALVLMLALPLKSALYYLVYSGARLRVRTALLSTLALTNYSEFGLIVA
AIAAKAGWLSHEWLVALSLALAGSFMLSAPLNSYSEWIYQHIGPWLRRLQSDTLHLDDRPIELGDAEVIILGMGRIGQGA
YHELERKYGNVILGVENNGDKAPLLREQGMNVLEGDATDTDFWDKVILSHQVQLVILAMPHHSGNLYAIDKLRSHGFHGK
IAAIVRFEDDIASLREQGVDAVFNVYDEAGSGFARHVIRELQPLDTEAPLVKEWPPRLT
>Mature_539_residues
MEPLFIAVAFACGMLVNLVGLPPLIGFLAAGFVLNALGYQNSEVLTTVAELGVTLMLFTIGLKLNIKTLLRRDVWGTATV
HILLSSGLFWVILLACKGLGMTLMLDLEWPHAIMLGFALSFSSTVFAVKVLEDRSDMNALYAKLAIGVLIMQDIFAVGFL
TASTGKLPSIWAIWILALPFLRPLLFKLLERAGHGELQMLMGITLALVLGAAAFEAVGLKPDLGALVIGMLLASHPAAAG
MAKSLFSLKDLFLICFFLSIGLNGMPTQETMWMALVLMLALPLKSALYYLVYSGARLRVRTALLSTLALTNYSEFGLIVA
AIAAKAGWLSHEWLVALSLALAGSFMLSAPLNSYSEWIYQHIGPWLRRLQSDTLHLDDRPIELGDAEVIILGMGRIGQGA
YHELERKYGNVILGVENNGDKAPLLREQGMNVLEGDATDTDFWDKVILSHQVQLVILAMPHHSGNLYAIDKLRSHGFHGK
IAAIVRFEDDIASLREQGVDAVFNVYDEAGSGFARHVIRELQPLDTEAPLVKEWPPRLT

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG4651

COG function: function code P; Kef-type K+ transport system, predicted NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=512, Percent_Identity=27.734375, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1786685, Length=536, Percent_Identity=24.8134328358209, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1789749, Length=464, Percent_Identity=25.6465517241379, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 58859; Mature: 58859

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLFIAVAFACGMLVNLVGLPPLIGFLAAGFVLNALGYQNSEVLTTVAELGVTLMLFTI
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLKLNIKTLLRRDVWGTATVHILLSSGLFWVILLACKGLGMTLMLDLEWPHAIMLGFALS
CCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
FSSTVFAVKVLEDRSDMNALYAKLAIGVLIMQDIFAVGFLTASTGKLPSIWAIWILALPF
HCCHHEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LRPLLFKLLERAGHGELQMLMGITLALVLGAAAFEAVGLKPDLGALVIGMLLASHPAAAG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHH
MAKSLFSLKDLFLICFFLSIGLNGMPTQETMWMALVLMLALPLKSALYYLVYSGARLRVR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TALLSTLALTNYSEFGLIVAAIAAKAGWLSHEWLVALSLALAGSFMLSAPLNSYSEWIYQ
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HIGPWLRRLQSDTLHLDDRPIELGDAEVIILGMGRIGQGAYHELERKYGNVILGVENNGD
HHHHHHHHHCCCCEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCC
KAPLLREQGMNVLEGDATDTDFWDKVILSHQVQLVILAMPHHSGNLYAIDKLRSHGFHGK
CCCCHHHCCCCEECCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCEEEEHHHHHCCCCCE
IAAIVRFEDDIASLREQGVDAVFNVYDEAGSGFARHVIRELQPLDTEAPLVKEWPPRLT
EEEEEEECHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MEPLFIAVAFACGMLVNLVGLPPLIGFLAAGFVLNALGYQNSEVLTTVAELGVTLMLFTI
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLKLNIKTLLRRDVWGTATVHILLSSGLFWVILLACKGLGMTLMLDLEWPHAIMLGFALS
CCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
FSSTVFAVKVLEDRSDMNALYAKLAIGVLIMQDIFAVGFLTASTGKLPSIWAIWILALPF
HCCHHEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LRPLLFKLLERAGHGELQMLMGITLALVLGAAAFEAVGLKPDLGALVIGMLLASHPAAAG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHH
MAKSLFSLKDLFLICFFLSIGLNGMPTQETMWMALVLMLALPLKSALYYLVYSGARLRVR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TALLSTLALTNYSEFGLIVAAIAAKAGWLSHEWLVALSLALAGSFMLSAPLNSYSEWIYQ
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HIGPWLRRLQSDTLHLDDRPIELGDAEVIILGMGRIGQGAYHELERKYGNVILGVENNGD
HHHHHHHHHCCCCEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCC
KAPLLREQGMNVLEGDATDTDFWDKVILSHQVQLVILAMPHHSGNLYAIDKLRSHGFHGK
CCCCHHHCCCCEECCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCEEEEHHHHHCCCCCE
IAAIVRFEDDIASLREQGVDAVFNVYDEAGSGFARHVIRELQPLDTEAPLVKEWPPRLT
EEEEEEECHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA