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The map label for this gene is ykgC [H]

Identifier: 145297000

GI number: 145297000

Start: 3216027

End: 3217325

Strand: Direct

Name: ykgC [H]

Synonym: cgR_2899

Alternate gene names: 145297000

Gene position: 3216027-3217325 (Clockwise)

Preceding gene: 145296996

Following gene: 145297004

Centisome position: 97.04

GC content: 54.89

Gene sequence:

>1299_bases
ATGGACACTGAATTTGATCTCATTGTTGTTGGTTTCGGCAAAGCAGGCAAGACTATCGCGATGAAACGCTCGGCAGCGGG
GGATAAGGTCGCACTGATTGAGCAGAGTCCACAGATGTATGGCGGTACCTGCATCAATGTAGGTTGCATCCCCACGAAGA
AGTTGTTGTTTGAGACTGCAACGGGCAAGGATTTCCCGGATGCGGTTGCTGCGCGTGATCAGTTGATTGGCAAGCTGAAT
GCCAAGAATCTTGCGATGGCCACAGACAAGGGTGTCACCGTCATTGATGGAAAAGCTACGTTTACAGCTAGCCACGAAAT
CACAGTAACTTCAGGTAGTGACACTCTTGTGCTGTATGCGCCAACGATTGTGATCAACACGGGCTCCACGCCGGTCATAC
CCAATGTCCCAGGCACCGACAATCCGCATGTTTTTGATTCCACTGGCATTCAGCACATTTCGCCCCTGCCGAAGCACCTC
GCGATCATCGGTGGTGGCCCAATCGGCCTGGAGTTCGCCACGCTTTTCAGTGGACAAGGCTCCAAAGTCACCATCATAGA
CCGTGGCGAATTACCGCTGAAAAATTTCGACAGGGAAGTGGCGGAGCTGGCCAAAACCGATCTAGAGGCCCGCGGAATTA
CTTTCCTCAACAACGCTGAACTCACCGGTTTCAGCGGCGATCTCACCATCGCACTTCAAGACCGCGACATCGACGCCGAC
GCAGCCCTTATTACCATCGGCCGACGCCCGGCCACCGACGGGCTCGGCCTTGAACAGGCGGGCATCAAAACAGGCACGCG
TGGGGAGGTGCTTGTCGACGCCCACCTCCGGACCAACATCGACGGCATCTTCGCTGTAGGTGATGTCAATGGCGGCCCGC
AGTTTACCTACGTGTCCTACGATGACCACCGCATTGTGCTGGATCAACTAGCCGGACCTGGTGAGAAATCCACCGAACAC
AGACTGATCCCCACCACCACATTTATCGAACCGCCGTTGTCCACCATCGGTGACAACACTGAAGGGGAAAATGTGGTGGT
GAAAAAGGCCTTGATTGCAGATATGCCGATCGTTCCCCGACCAAAGATTATTAACCAACCTCACGGTATGGTGAAGTTTT
TCGTCGACAAGCAATCTGATGCGCTGCTCGGCGCGACCTTGTACTGCGCCGACTCCCAGGAGCTCATCAACACCGTGGCG
CTTGCCATGCGGCATGGCGTCACCGCCTCCGAGCTTGGCGACGGCATCTACACCCATCCCGCAACCTCGGAGATCTTCAA
CCAATTATTGGGCAGTTAA

Upstream 100 bases:

>100_bases
TATGGCCAACCCTAGGGGGATGGCCTGTGTGTTCACTGTTAGGTTTCCTCAAAATCTTTAGCGAACAACGAACAGCTTGC
CCGAGAGTATCTTGGGTCGC

Downstream 100 bases:

>100_bases
CGCAGCGGATCGAACGGCTTGATGATCGGGTTGGTGTTGCCCGTAGCCATCAGCTCCGCCAAATACTTACCGGTGGCAGG
GCCCAGCACCACACCCCACA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MDTEFDLIVVGFGKAGKTIAMKRSAAGDKVALIEQSPQMYGGTCINVGCIPTKKLLFETATGKDFPDAVAARDQLIGKLN
AKNLAMATDKGVTVIDGKATFTASHEITVTSGSDTLVLYAPTIVINTGSTPVIPNVPGTDNPHVFDSTGIQHISPLPKHL
AIIGGGPIGLEFATLFSGQGSKVTIIDRGELPLKNFDREVAELAKTDLEARGITFLNNAELTGFSGDLTIALQDRDIDAD
AALITIGRRPATDGLGLEQAGIKTGTRGEVLVDAHLRTNIDGIFAVGDVNGGPQFTYVSYDDHRIVLDQLAGPGEKSTEH
RLIPTTTFIEPPLSTIGDNTEGENVVVKKALIADMPIVPRPKIINQPHGMVKFFVDKQSDALLGATLYCADSQELINTVA
LAMRHGVTASELGDGIYTHPATSEIFNQLLGS

Sequences:

>Translated_432_residues
MDTEFDLIVVGFGKAGKTIAMKRSAAGDKVALIEQSPQMYGGTCINVGCIPTKKLLFETATGKDFPDAVAARDQLIGKLN
AKNLAMATDKGVTVIDGKATFTASHEITVTSGSDTLVLYAPTIVINTGSTPVIPNVPGTDNPHVFDSTGIQHISPLPKHL
AIIGGGPIGLEFATLFSGQGSKVTIIDRGELPLKNFDREVAELAKTDLEARGITFLNNAELTGFSGDLTIALQDRDIDAD
AALITIGRRPATDGLGLEQAGIKTGTRGEVLVDAHLRTNIDGIFAVGDVNGGPQFTYVSYDDHRIVLDQLAGPGEKSTEH
RLIPTTTFIEPPLSTIGDNTEGENVVVKKALIADMPIVPRPKIINQPHGMVKFFVDKQSDALLGATLYCADSQELINTVA
LAMRHGVTASELGDGIYTHPATSEIFNQLLGS
>Mature_432_residues
MDTEFDLIVVGFGKAGKTIAMKRSAAGDKVALIEQSPQMYGGTCINVGCIPTKKLLFETATGKDFPDAVAARDQLIGKLN
AKNLAMATDKGVTVIDGKATFTASHEITVTSGSDTLVLYAPTIVINTGSTPVIPNVPGTDNPHVFDSTGIQHISPLPKHL
AIIGGGPIGLEFATLFSGQGSKVTIIDRGELPLKNFDREVAELAKTDLEARGITFLNNAELTGFSGDLTIALQDRDIDAD
AALITIGRRPATDGLGLEQAGIKTGTRGEVLVDAHLRTNIDGIFAVGDVNGGPQFTYVSYDDHRIVLDQLAGPGEKSTEH
RLIPTTTFIEPPLSTIGDNTEGENVVVKKALIADMPIVPRPKIINQPHGMVKFFVDKQSDALLGATLYCADSQELINTVA
LAMRHGVTASELGDGIYTHPATSEIFNQLLGS

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=29.0393013100437, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=27.6086956521739, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI22035672, Length=453, Percent_Identity=25.8278145695364, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI291045266, Length=432, Percent_Identity=26.1574074074074, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=24.1299303944316, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=24.1299303944316, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=24.1299303944316, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=24.1299303944316, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI148277071, Length=431, Percent_Identity=24.1299303944316, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI291045268, Length=424, Percent_Identity=25.9433962264151, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI87081717, Length=437, Percent_Identity=41.4187643020595, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=28.6697247706422, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=25.382932166302, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082354, Length=453, Percent_Identity=26.0485651214128, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081763, Length=202, Percent_Identity=29.2079207920792, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=29.2576419213974, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=28, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=27.3127753303965, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=27.3127753303965, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=25.2066115702479, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17559934, Length=202, Percent_Identity=29.7029702970297, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=27.2921108742004, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=26.4830508474576, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=24.8380129589633, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=31.1688311688312, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=26.6949152542373, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=26.6949152542373, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=26.6949152542373, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=26.3157894736842, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 45710; Mature: 45710

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTEFDLIVVGFGKAGKTIAMKRSAAGDKVALIEQSPQMYGGTCINVGCIPTKKLLFETA
CCCCEEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCHHHEEEEC
TGKDFPDAVAARDQLIGKLNAKNLAMATDKGVTVIDGKATFTASHEITVTSGSDTLVLYA
CCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCEEEEECEEEEEECCCCEEEEEE
PTIVINTGSTPVIPNVPGTDNPHVFDSTGIQHISPLPKHLAIIGGGPIGLEFATLFSGQG
EEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCC
SKVTIIDRGELPLKNFDREVAELAKTDLEARGITFLNNAELTGFSGDLTIALQDRDIDAD
CEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCCC
AALITIGRRPATDGLGLEQAGIKTGTRGEVLVDAHLRTNIDGIFAVGDVNGGPQFTYVSY
EEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCEEEEEECCCCCCCEEEEEE
DDHRIVLDQLAGPGEKSTEHRLIPTTTFIEPPLSTIGDNTEGENVVVKKALIADMPIVPR
CCCEEEEEHHCCCCCCCCCCEECCEEEECCCCHHHHCCCCCCCEEEEEEEHHHCCCCCCC
PKIINQPHGMVKFFVDKQSDALLGATLYCADSQELINTVALAMRHGVTASELGDGIYTHP
CHHCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCCCC
ATSEIFNQLLGS
CHHHHHHHHHCC
>Mature Secondary Structure
MDTEFDLIVVGFGKAGKTIAMKRSAAGDKVALIEQSPQMYGGTCINVGCIPTKKLLFETA
CCCCEEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCHHHEEEEC
TGKDFPDAVAARDQLIGKLNAKNLAMATDKGVTVIDGKATFTASHEITVTSGSDTLVLYA
CCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCEEEEECEEEEEECCCCEEEEEE
PTIVINTGSTPVIPNVPGTDNPHVFDSTGIQHISPLPKHLAIIGGGPIGLEFATLFSGQG
EEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCC
SKVTIIDRGELPLKNFDREVAELAKTDLEARGITFLNNAELTGFSGDLTIALQDRDIDAD
CEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCCC
AALITIGRRPATDGLGLEQAGIKTGTRGEVLVDAHLRTNIDGIFAVGDVNGGPQFTYVSY
EEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCEEEEEECCCCCCCEEEEEE
DDHRIVLDQLAGPGEKSTEHRLIPTTTFIEPPLSTIGDNTEGENVVVKKALIADMPIVPR
CCCEEEEEHHCCCCCCCCCCEECCEEEECCCCHHHHCCCCCCCEEEEEEEHHHCCCCCCC
PKIINQPHGMVKFFVDKQSDALLGATLYCADSQELINTVALAMRHGVTASELGDGIYTHP
CHHCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCCCC
ATSEIFNQLLGS
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]